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Torpedo_number Report for: 201

9neop-ACHE1
MutationKin.TypeEvaluation systemEffectReference
A314S natOP-resistance Triazophos carbofuran resistanceJiang_2009_Biochem.Biophys.Res.Commun_378_269

aphgo-ACHE1
MutationKin.TypeEvaluation systemEffectReference
A302S natOP-resistance F139L_aphgo-ACHE2 and A302S_aphgo-ACHE1 found together in resistant strainsLi_2004_Insect.Biochem.Mol.Biol_34_397
A302S natOP-resistance F139L_aphgo-ACHE2 and A302S_aphgo-ACHE1 found together in resistant strainsAndrews_2004_Insect.Mol.Biol_13_555
A302S natOP-resistance F139L_aphgo-ACHE2 and A302S_aphgo-ACHE1 found together in resistant strainsToda_2004_Insect.Mol.Biol_13_549
A302S/
S431F
 natOP-resistanceOP and carbamate resistanceAndrews_2004_Insect.Mol.Biol_13_555
A302S/
S431F
 natOP-resistanceOP and carbamate resistanceToda_2004_Insect.Mol.Biol_13_549

apolu-ACHE1
MutationKin.TypeEvaluation systemEffectReference
A216S natOP-resistance Chlorpyrifos Trichlorfon Malathion Carbosulfan resistanceWu_2015_Insect.Biochem.Mol.Biol_65_75

bacsu-pnbae
MutationKin.TypeEvaluation systemEffectReference
A107H/
A190C
 sdmSearch for phosphotriesterase activity50-fold increase in paraoxonase activityLegler_2014_Front.Chem_2_46

bommo-ACHE1
MutationKin.TypeEvaluation systemEffectReference
A303S/
G329A/
L554S
 sdmOP-resistance Wang_2014_Mol.Biol.Rep_41_429

culpi-ACHE1
MutationKin.TypeEvaluation systemEffectReference
A328S natOP-resistanceresistance to propoxur but not to dichlorvosZhao_2014_PLoS.One_9_e952607

human-BCHE
MutationKin.TypeEvaluation systemEffectReference
A199S/
F227A/
P285A/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysis 4400-fold improved catalytic efficiency against-cocaine E9 Zheng_2014_Nat.Commun_5_3457
A199S/
F227A/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysis 2000-fold improved catalytic efficiency against-cocaine E9 Zheng_2008_J.Am.Chem.Soc_130_12148
A199S/
F227A/
S287G/
A328W/
Y332G/
F364C/
M532C
 sdmCocaine hydrolysisimproved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bondsFang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
V377C/
A516C
 sdmCocaine hydrolysisimproved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bondsFang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
N535C
 sdmCocaine hydrolysisimproved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bondsFang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
F329V
 sdmCocaine hydrolysis E11 Zheng_2010_Biochemistry_49_9113
A199S/
F227L/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysis 1000-fold improved catalytic efficiency against-cocaine E Zheng_2010_Biochemistry_49_9113
A199S/
F227A/
S287G/
A328W/
E441D
 sdmCocaine hydrolysis improved catalytic efficiency against-cocaine E Xue_2011_Mol.Pharmacol_79_290
A199S/
F227I/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysis 1000-fold improved catalytic efficiency against-cocaine E Zheng_2010_Biochemistry_49_9113
A199S/
F227V/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysis 1000-fold improved catalytic efficiency against-cocaine E Zheng_2010_Biochemistry_49_9113
A199S/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysisCocH1 456-fold improved catalytic efficiency against (-)-cocaine Pan_2005_Proc.Natl.Acad.Sci.U.S.A_102_16656
A199S/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysisSelectively blocks cocaine toxicity and reinstatement of drug seeking in rats (mutant fused to albumin TV-1380)Brimijoin_2008_Neuropsychopharmacology_33_2715
A199S/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysisYang_2010_Chem.Biol.Interact_187_148
A199S/
S287G/
A328W/
Y332G/
L286I
 sdmCocaine hydrolysisE10Zheng_2010_Biochemistry_49_9113
A199V natSilent variant Natural mutation Low activitySakamoto_1998_Clin.Chim.Acta_274_159

mouse-BCHE
MutationKin.TypeEvaluation systemEffectReference
A199S/
F227A/
S287G/
A328W/
Y332G
 sdmCocaine hydrolysis Chen_2015_Biochem.J_466_243

musdo-ACHE
MutationKin.TypeEvaluation systemEffectReference
A236S natOP-resistanceinsensitivity to OPKozaki_2009_Pestic.Biochem.Physiol_95_6

pluxy-ACHE1
MutationKin.TypeEvaluation systemEffectReference
A201S natOP-resistance G227A A201S A441G (G324A,A298S,A324G) found together in resistant strains but G227A likely to be importantBaek_2005_Pestic.Biochem.Physiol_81_164
A201S natOP-resistance D131G A201S A441G (D229G,,A298S,A324G) found together in resistant strains but G227A likely to be importantLee_2007_Biochem.Biophys.Res.Commun_353_591
A201S natOP-resistance G227A A201S (G324A,A298S) found together in resistant strains but A201S likely to be importantKim_2012_J.Asia.Pac.Entomol_15_401
A201S natOP-resistance A298S and G324A mutations showed no correlation with levels of resistance to acephateSonoda_2014_Insect.Biochem.Mol.Biol_48_83

spolt-ACHE1
MutationKin.TypeEvaluation systemEffectReference

tetur-ACHE
MutationKin.TypeEvaluation systemEffectReference
A201S natOP-resistanceInsecticide resistanceKhajehali_2010_Pest.Manag.Sci_66_220

tutab-ACHE1
MutationKin.TypeEvaluation systemEffectReference
A201S natOP-resistance A201S present in resistant strainHaddi_2017_J.Appl.Entomol_141_612

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