ESTHER
Database
Home
Search
Text search
aql query
In Class
Query Builder
Preformed queries
Species
Structures
Mutations
Interactants
Diseases
Genes
Insecticides
Other
Full List
Queries for insecticide resistance
AQL exemples
Tools
Blast
HMMER
Clustal
Psiblast
Intra
Families
Overall Table
Tree Table &
Old Table
Tree Table
Old Table
Explore genes with AQL
Explore species with AQL
All figures of families
Biological
data
Structures
Table
Explore structure with AQL
Mutations
Mutation Viewer
Mutalign
Mutalign 2
Mutalign for insecticide resistance
Queries for insecticide resistance
Explore mutation with AQL
Interactants
Substrates
Inhibitors
Reactivators
Kinetic comparison tool
Inhibitor types
Substrate types
Reactivator types
Explore interactants with AQL
Diseases
Table
Explore disease with AQL
Basics on AChE
Kinetics notes
Gene structures
Molecular forms
AChE Family
Human AChE
ESTHER definition
What is up?
Likid
DB Explorer
Meetings
Suplementary Data
Latest modifications
Bibliography (all years)
Acknowledgments
& disclaimer
Torpedo_number
Kinetic parameters
Tree Display
AceDB Schema
XML Display
Feedback
Torpedo_number Report for: 231
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G234A
sdm
PROSS algorithm
Expression in E Coli
Goldenzweig_2016_Mol.Cell_63_337
ratno-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G234C
sdm
Inactivation by sulfydryl
Increased thermal inactivation
Morel_1999_Mol.Pharmacol_55_982
G234C/
L289A
sdm
Peripheral Anionic Site
Increased thermal inactivation Increased reactivity of C234
Morel_1999_Mol.Pharmacol_55_982
torma-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
C231A
sdm
Inactivation by sulfydryl
No inactivation by sulfydryl
Morel_1999_Mol.Pharmacol_55_982
C231S
sdm
Inactivation by sulfydryl
No inactivation by sulfydryl
Morel_1999_Mol.Pharmacol_55_982
C231S
sdm
Back door hypothesis
No effect of mutation
Faerman_1996_FEBS.Lett_386_65
V431C/
C231S
sdm
Back door hypothesis
Faerman_1996_FEBS.Lett_386_65
G80C/
C231S
sdm
Back door hypothesis
Faerman_1996_FEBS.Lett_386_65
G80C/
C231S/
V431C
sdm
Back door hypothesis
Faerman_1996_FEBS.Lett_386_65
V129R/
C231S
sdm
Back door hypothesis
No effect of mutation
Faerman_1996_FEBS.Lett_386_65
V129K/
C231S
sdm
Back door hypothesis
No effect of mutation
Faerman_1996_FEBS.Lett_386_65
C231S/
L282A
sdm
Peripheral Anionic Site
Increased thermal inactivation Increased reactivity of C231
Morel_1999_Mol.Pharmacol_55_982
C231S/
N280Q/
L282S
sdm
Peripheral Anionic Site
No increased thermal inactivation as L282mutants No increased reactivity of C231
Morel_1999_Mol.Pharmacol_55_982
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page
and
ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster
Acknowledgements and disclaimer