Torpedo_number

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Torpedo_number Report for: 122

bunfa-ACHE
MutationKin.TypeEvaluation systemEffectReference
G119H/
Y121Q/
S122T
 sdmOP-hydrolaseOP-hydrolase but 4 fold less kcat/Km for ACh than WTPoyot_2006_Biochim.Biophys.Acta_1764_1470

human-BCHE : (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
T120EkinsdmPeripheral Anionic Siteno changes in Kcat Km for estersLoewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
T120GkinsdmPeripheral Anionic Siteno changes in Kcat Km for estersLoewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
T120HkinsdmPeripheral Anionic Site^Ki of various ligandsLoewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
T120KkinsdmPeripheral Anionic SiteNo inhibition by tested ligandsLoewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423

human-CES1
MutationKin.TypeEvaluation systemEffectReference
V146H/
L363E
 sdmOP-hydrolasespontaneous reactivationHemmert_2011_PLoS.One_6_e17441
V146H/
L363Q
 sdmOP-hydrolasespontaneous reactivationHemmert_2011_PLoS.One_6_e17441
V146Q/
L363Q
 sdmOP-hydrolasespontaneous reactivationHemmert_2011_PLoS.One_6_e17441
V146Q/
L363E
 sdmOP-hydrolasespontaneous reactivationHemmert_2011_PLoS.One_6_e17441
V146H sdmOP-hydrolasespontaneous reactivationHemmert_2011_PLoS.One_6_e17441
V146Q sdmOP-hydrolasespontaneous reactivationHemmert_2011_PLoS.One_6_e17441

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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