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Torpedo_number Report for: 273
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
V280E
sdm
PROSS algorithm
Expression in E Coli
Goldenzweig_2016_Mol.Cell_63_337
human-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
E271X
nat
Natural mutation
Silent phenotype, Non producer
Primo-Parmo_1996_Am.J.Hum.Genet_58_52
mouse-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
D280V
sdm
Electrostatic
electrostatic influence reduced, influences FAS2 inhibition and its ionic strength dependance
Radic_1997_J.Biol.Chem_272_23265
D280V/
D283N
sdm
Electrostatic
electrostatic influence reduced
Radic_1997_J.Biol.Chem_272_23265
E84Q/
E91Q/
D280V/
D283N
sdm
Electrostatic
electrostatic influence reduced, influences FAS2 inhibition and its ionic strength dependance
Radic_1997_J.Biol.Chem_272_23265
E84Q/
E91Q/
D280V/
D283N/
D372N
sdm
Electrostatic
electrostatic influence reduced, influences FAS2 inhibition and its ionic strength dependance
Radic_1997_J.Biol.Chem_272_23265
E84Q/
E91Q/
D280V/
D283N/
E292Q/
D372N
sdm
Electrostatic
electrostatic influence reduced, influences FAS2 inhibition and its ionic strength dependance
Radic_1997_J.Biol.Chem_272_23265
D74N/
D280V/
D283N
sdm
Electrostatic
mixed active center and surface charge mutant
Radic_1997_J.Biol.Chem_272_23265
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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