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Torpedo_number Report for: 280
eleel-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
L280H
sdm
Fab epitope
abolished inhibition by Elec-403
Simon_1999_J.Biol.Chem_274_27740
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
H287C
sdm
Omega loop
Omega loop conformation test incorporation of the fluorophore acrylodan
Boyd_2000_J.Biol.Chem_275_22401
,
Shi_2001_J.Biol.Chem_276_42196
mouse-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
H287C
sdm
Gorge entrance
Omega loop conformation test incorporation of the fluorophore acrylodan
Boyd_2000_J.Biol.Chem_275_22401
,
Shi_2001_J.Biol.Chem_276_42196
H287C
sdm
Omega loop
Omega loop conformation test incorporation of the fluorophore acrylodan
Boyd_2000_J.Biol.Chem_275_22401
,
Shi_2001_J.Biol.Chem_276_42196
ratno-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
L76S/
H284Q/
H287L
sdm
Fab epitope
created inhibition by Elec-403
Simon_1999_J.Biol.Chem_274_27740
tetur-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G119S/
A280T/
F331W
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
G119S/
A280T
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
A280T/
F331W
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
A280T
nat
OP-resistance
Insecticide resistance
Khajehali_2010_Pest.Manag.Sci_66_220
A280T
nat
OP-resistance
Insecticide resistance
Kwon_2010_Pestic.Biochem.Physiol_96_36
A280T
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2010_Insect.Mol.Biol_19_195
A280T
nat
OP-resistance
Insecticide resistance, amplified allele
Kwon_2012_Insect.Biochem.Mol.Biol_42_212
torma-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
N280Q
sdm
Peripheral Anionic Site
No increased thermal inactivation as L282mutants No increased reactivity of C231
Morel_1999_Mol.Pharmacol_55_982
N280Q/
L282S
sdm
Peripheral Anionic Site
Increased thermal inactivation Increased reactivity of C231
Morel_1999_Mol.Pharmacol_55_982
C231S/
N280Q/
L282S
sdm
Peripheral Anionic Site
No increased thermal inactivation as L282mutants No increased reactivity of C231
Morel_1999_Mol.Pharmacol_55_982
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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