Torpedo_number
Kinetic parameters
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Torpedo_number Report for: 331,288

human-ACHE
MutationKin.TypeEvaluation systemEffectReference
F295S/
F338A		 sdmAcyl specificityAcyl pocket 800-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295T/
F338A		 sdmAcyl specificityAcyl pocket 3400-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295N/
F338A		 sdmAcyl specificityAcyl pocket 110-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295M/
F338A		 sdmAcyl specificity Acyl pocket Only 6-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295V/
F338A		 sdmAcyl specificityAcyl pocket 380-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295I/
F338A		 sdmAcyl specificityAcyl pocket 1130-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295L/
F338A		 sdmAcyl specificityAcyl pocket 55-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295L/
F338A		 sdmOxime interactionCochran_2011_J.Biol.Chem_286_29718
F295A/
F338A		 sdmAcyl specificityAcyl pocket 680-fold decreased catalytic activity, orientation of His 447Barak_2002_Biochemistry_41_8245,
Shafferman_2005_Chem.Biol.Interact_157-158_123,
Barak_2005_Chem.Biol.Interact_157-158_219
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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