Torpedo_number

Kinetic parameters

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Torpedo_number Report for: 70,121

human-ACHE : (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
Y72N/
Y124Q
kinsdmAcyl specificity replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHEKaplan_2001_Biochemistry_40_7433
Y72D/
Y124H
 sdmSearch for phosphotriesterase activityPhosphotriesterase activityTrovaslet-Leroy_2011_Toxicol.Lett_206_14_
Y72A/
Y124A
kinsdmPeripheral Anionic Sitesmall effect on Km and kcat, resistance to inhibitionBarak_1994_J.Biol.Chem_269_6296,
Shafferman_1995_5th.ChE.Meeting.Madras__189

mouse-ACHE: (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
Y72N/
Y124Q
kinsdmPeripheral Anionic Siteincrease Ki of PAS ligandsRadic_1993_Biochemistry_32_12074,
Radic_1994_J.Biol.Chem_269_11233

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