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Mutation Report for: D349N/E358Q/E389Q/D390N_human-ACHE

Name Class
D349N/E358Q/E389Q/D390N_human-ACHEGene_locushuman-ACHE
Torpedo_number (5)
AA_ChangeD349N/E358Q/E389Q/D390N
Mode_of_mutationSite directed mutagenesis
ModificationElectrostatic
SummaryElectrostatic;Electrostatic attraction hypothesis minor effect on catalysis;Shafferman_1994_EMBO.J_13_3448
PaperShafferman_1994_EMBO.J_13_3448
Kinetic_parameterAcetylthiocholine_D349N/E358Q/E389Q/D390N_human-ACHE
3,3-dimethylbutylthioacetate_D349N/E358Q/E389Q/D390N_human-ACHE
Edrophonium_D349N/E358Q/E389Q/D390N_human-ACHE
Commentp.D349N/E358Q/E389Q/D390N Asp349Asn/Glu358Gln/Glu420Gln/Asp390Asn (p.D380N/E389Q/E420Q/D421N Asp380Asn/Glu389Gln/Glu420Gln/Asp421Asn in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesis minor effect on catalysis

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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