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Substrate Report for: Idalopirdine-rivastigmine

Name Class
Idalopirdine-rivastigmineType (7)
Chemical_Nomenclature[3-[[2-(6-fluoro-1H-indol-3-yl)ethylamino]methyl]phenyl] N-ethyl-N-methylcarbamate'
FormulaC21H24FN3O2
MW369.43
PaperToublet_2020_Eur.J.Med.Chem_210_113059
Commentbutyrylcholinesterase inhibitor and 5-HT6 receptor antagonist. BuChE (IC50 = 0.97 microM). After hydrolysis a potent 5-HT6 receptors antagonist (Ki = 11.4 nM) related to idalopirdine is released
Gene_locushuman-BCHE
FamilyBCHE
InChIKeyQZGAFMLTVWNDEJ-UHFFFAOYSA-N
CanonicalSMILESC1(=C[N]C2=CC(=CC=C12)F)CCNCC3=CC(=CC=C3)OC(=O)N(C)CC
InChIInChI=1S/C21H24FN3O2/c1-3-25(2)21(26)27-18-6-4-5-15(11-18)13-23-10-9-16-14-24-20-12-17(22)7-8-19(16)20/h4-8,11-12,14,23-24H,3,9-10,13H2,1-2H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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