Substrate Report for: 12(13)-EpOME
| 12(13)-EpOME | Type | Epoxide |
|---|
| | Fatty acid |
| Other_Name (6) |
| Chemical_Nomenclature | (Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid |
| Formula | C18H32O3 |
| MW | 296.45 |
|  |
| Paper | Zimmer_2018_Biochim.Biophys.Acta_1863_669 |
| | Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676 |
| | Bannehr_2019_Cardiovasc.Toxicol_19_365 |
| Comment | (CYP2C/CYP2J) CYP-derived oxidized linoleic acid metabolite epoxy octadecenoic acid. The epoxide is transformed in the diol by soluble epoxide hydrolse (sEH EPHX2) the resulting 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain 12,13-DiHOME induces thermal pain hypersensitivity via TRPV1 |
| Gene_locus | human-EPHX2 |
| CID | 5356421 |
| Family | Epoxide_hydrolase |
| InChIKey | CCPPLLJZDQAOHD-FLIBITNWSA-N |
| CanonicalSMILES | CCCCCC1C(O1)CC=CCCCCCCCC(=O)O |
| InChI | InChI=1S/C18H32O3/c1-2-3-10-13-16-17(21-16)14-11-8-6-4-5-7-9-12-15-18(19)20/h8,11,16-17H,2-7,9-10,12-15H2,1H3,(H,19,20)/b11-8- |
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