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Substrate Report for: 12(13)-EpOME

Name Class
12(13)-EpOMETypeEpoxide
Fatty acid
Other_Name (6)
Chemical_Nomenclature(Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
FormulaC18H32O3
MW296.45
PaperZimmer_2018_Biochim.Biophys.Acta_1863_669
Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676
Bannehr_2019_Cardiovasc.Toxicol_19_365
Comment(CYP2C/CYP2J) CYP-derived oxidized linoleic acid metabolite epoxy octadecenoic acid. The epoxide is transformed in the diol by soluble epoxide hydrolse (sEH EPHX2) the resulting 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain 12,13-DiHOME induces thermal pain hypersensitivity via TRPV1
Gene_locushuman-EPHX2
CID5356421
FamilyEpoxide_hydrolase
InChIKeyCCPPLLJZDQAOHD-FLIBITNWSA-N
CanonicalSMILESCCCCCC1C(O1)CC=CCCCCCCCC(=O)O
InChIInChI=1S/C18H32O3/c1-2-3-10-13-16-17(21-16)14-11-8-6-4-5-7-9-12-15-18(19)20/h8,11,16-17H,2-7,9-10,12-15H2,1H3,(H,19,20)/b11-8-

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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