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Chemical Report for: 2-phenylpiperidine-1-carboxylic-acid

Name Class
2-phenylpiperidine-1-carboxylic-acidOther_Name(2~{r})-2-Phenylpiperidine-1-Carbaldehyde
2-phenylpiperidine-1-carboxylic acid
6WG
Chemical_Nomenclature(2R)-2-phenylpiperidine-1-carboxylic acid
FormulaC12H15NO2
Structure6VHD
6VHE
5KRE
MW205.25
PaperAhn_2016_ACS.Chem.Biol_11_2529
Fellner_2020_ACS.Infect.Dis_6_2771
CommentThe adduct in the structure is the small (R)-2-phenylpiperidine-1-carbonyl. N1-substituted triazole urea previously disclosed as an inhibitor of ABHD6 KT195 was modified as N2-substituted isomer and shown to inhibit LYPLAL1. The compound 2 inhibited also other alpha/beta hydrolases and some SGNH hydrolase-type esterase (PAFAH1B2-3), but compound 12 and 13 are specific. The adduct in the structure is the small (R)-2-phenylpiperidine-1-carbonyl
CID121231485
FamilyLYsophospholipase_carboxylesterase
A85-EsteraseD-FGH
Gene_locushuman-LYPLAL1
staau-SA2422
InChIKeyVFOFBQDZFDIMFR-LLVKDONJSA-N
CanonicalSMILESC1CCN(C(C1)C2=CC=CC=C2)C(=O)O
InChIInChI=1S/C12H15NO2/c14-12(15)13-9-5-4-8-11(13)10-6-2-1-3-7-10/h1-3,6-7,11H,4-5,8-9H2,(H,14,15)/t11-/m1/s1

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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