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Chemical Report for: 2-phenylpiperidine-1-carboxylic-acid
Name
Class
2-phenylpiperidine-1-carboxylic-acid
Other_Name
(2~{r})-2-Phenylpiperidine-1-Carbaldehyde
2-phenylpiperidine-1-carboxylic acid
6WG
Chemical_Nomenclature
(2R)-2-phenylpiperidine-1-carboxylic acid
Formula
C12H15NO2
Structure
6VHD
6VHE
5KRE
MW
205.25
Paper
Ahn_2016_ACS.Chem.Biol_11_2529
Fellner_2020_ACS.Infect.Dis_6_2771
Comment
The adduct in the structure is the small (R)-2-phenylpiperidine-1-carbonyl. N1-substituted triazole urea previously disclosed as an inhibitor of ABHD6
KT195
was modified as N2-substituted isomer and shown to inhibit LYPLAL1. The compound 2 inhibited also other alpha/beta hydrolases and some SGNH hydrolase-type esterase (PAFAH1B2-3), but compound 12 and 13 are specific. The adduct in the structure is the small (R)-2-phenylpiperidine-1-carbonyl
CID
121231485
Family
LYsophospholipase_carboxylesterase
A85-EsteraseD-FGH
Gene_locus
human-LYPLAL1
staau-SA2422
InChIKey
VFOFBQDZFDIMFR-LLVKDONJSA-N
CanonicalSMILES
C1CCN(C(C1)C2=CC=CC=C2)C(=O)O
InChI
InChI=1S/C12H15NO2/c14-12(15)13-9-5-4-8-11(13)10-6-2-1-3-7-10/h1-3,6-7,11H,4-5,8-9H2,(H,14,15)/t11-/m1/s1
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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