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LongText Report for: 2DQY-pdb

Name Class
2DQY-pdb
HEADER    HYDROLASE                               02-JUN-06   2DQY              
TITLE     CRYSTAL STRUCTURE OF HUMAN CARBOXYLESTERASE IN COMPLEX WITH           
TITLE    2 CHOLATE AND PALMITATE                                                
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: LIVER CARBOXYLESTERASE 1;                                  
COMPND   3 CHAIN: A, B, C;                                                      
COMPND   4 FRAGMENT: RESIDUES 19-561;                                           
COMPND   5 SYNONYM: ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE, ACAT,          
COMPND   6 MONOCYTE/MACROPHAGE SERINE ESTERASE, HMSE, SERINE ESTERASE           
COMPND   7 1, BRAIN CARBOXYLESTERASE HBR1, TRIACYLGLYCEROL HYDROLASE,           
COMPND   8 TGH, EGASYN;                                                         
COMPND   9 EC: 3.1.1.1;                                                         
COMPND  10 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE   5 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE   6 EXPRESSION_SYSTEM_CELL_LINE: SF9;                                    
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS                           
KEYWDS    CHOLESTEROL METABOLISM, FOAM CELLS, MACROPHAGE, MONOCYTE,             
KEYWDS   2 ATHEROSCLEROSIS                                                      
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    S.BENCHARIT,C.C.EDWARDS,C.L.MORTON,E.L.HOWARD-WILLIAMS,               
AUTHOR   2 P.M.POTTER,M.R.REDINBO                                               
REVDAT   1   29-AUG-06 2DQY    0                                                
JRNL        AUTH   S.BENCHARIT,C.C.EDWARDS,C.L.MORTON,                          
JRNL        AUTH 2 E.L.HOWARD-WILLIAMS,P.KUHN,P.M.POTTER,M.R.REDINBO            
JRNL        TITL   MULTISITE PROMISCUITY ENABLES HUMAN                          
JRNL        TITL 2 CARBOXYLESTERASE 1 TO METABOLIZE A VARIETY OF                
JRNL        TITL 3 ENDOGENOUS SUBSTRATES                                        
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. 3.00 ANGSTROMS.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.1                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,             
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : ENGH & HUBER                                    
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.93                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 1.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 2305620.660                    
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000                         
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 93.0                           
REMARK   3   NUMBER OF REFLECTIONS             : 38284                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.226                           
REMARK   3   FREE R VALUE                     : 0.271                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 7.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2693                            
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.005                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 6                            
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.00                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.19                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 83.60                        
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 5219                         
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3020                       
REMARK   3   BIN FREE R VALUE                    : 0.3530                       
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 7.50                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 424                          
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.017                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 12390                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 276                                     
REMARK   3   SOLVENT ATOMS            : 301                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 31.60                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -6.01000                                             
REMARK   3    B22 (A**2) : 5.10000                                              
REMARK   3    B33 (A**2) : 0.91000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.38                            
REMARK   3   ESD FROM SIGMAA              (A) : 0.47                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.45                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.57                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.009                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.20                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 22.60                           
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.82                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED                                
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : 1.150 ; 1.500                
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : 2.050 ; 2.000                
REMARK   3   SIDE-CHAIN BOND              (A**2) : 1.420 ; 2.000                
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : 2.330 ; 2.500                
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : FLAT MODEL                                           
REMARK   3   KSOL        : 0.39                                                 
REMARK   3   BSOL        : 36.79                                                
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM                              
REMARK   3  PARAMETER FILE  2  : CARBOHYDRATE.PARAM                             
REMARK   3  PARAMETER FILE  3  : WATER_REP.PARAM                                
REMARK   3  PARAMETER FILE  4  : ION.PARAM                                      
REMARK   3  PARAMETER FILE  5  : CHD.PARAM                                      
REMARK   3  PARAMETER FILE  6  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP                                    
REMARK   3  TOPOLOGY FILE  2   : CARBOHYDRATE.TOP                               
REMARK   3  TOPOLOGY FILE  3   : WATER.TOP                                      
REMARK   3  TOPOLOGY FILE  4   : ION.TOP                                        
REMARK   3  TOPOLOGY FILE  5   : CHD.TOP                                        
REMARK   3  TOPOLOGY FILE  6   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 2DQY COMPLIES WITH FORMAT V. 2.3, 09-JULY-1998                       
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 06-JUN-2006.                
REMARK 100 THE RCSB ID CODE IS RCSB025739.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 14-APR-2001                        
REMARK 200  TEMPERATURE           (KELVIN) : NULL                               
REMARK 200  PH                             : 5.60                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : N                                  
REMARK 200  RADIATION SOURCE               : SEALED TUBE                        
REMARK 200  BEAMLINE                       : NULL                               
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU                             
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS IV                    
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : CRYSTALCLEAR                       
REMARK 200  DATA SCALING SOFTWARE          : MOSFLM                             
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 38284                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 93.0                               
REMARK 200  DATA REDUNDANCY                : 13.000                             
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.11000                            
REMARK 200   FOR THE DATA SET  : 7.8000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.00                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.20                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 83.6                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : 0.34100                            
REMARK 200   FOR SHELL         : 2.400                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: AMORE                                                 
REMARK 200 STARTING MODEL: 1MX1                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 55.90                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.79                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 8% PEG 3350, 0.4M LI2SO4, 0.1M           
REMARK 280  NACL, 0.1M LICL, 0.1M CITRATE (PH 5.5), 5% GLYCEROL , PH 5.6,       
REMARK 280  VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 298K                     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   1/2-X,-Y,1/2+Z                                          
REMARK 290       3555   -X,1/2+Y,1/2-Z                                          
REMARK 290       4555   1/2+X,1/2-Y,-Z                                          
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       27.64600            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      100.66150            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       89.93850            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      100.66150            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       27.64600            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       89.93850            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT             
REMARK 300 WHICH CONSISTS OF 3 CHAIN(S). SEE REMARK 350 FOR                     
REMARK 300 INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S).                
REMARK 350                                                                      
REMARK 350 GENERATING THE BIOMOLECULE                                           
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     HIS A  1019                                                      
REMARK 465     PRO A  1020                                                      
REMARK 465     LYS A  1554                                                      
REMARK 465     ALA A  1555                                                      
REMARK 465     VAL A  1556                                                      
REMARK 465     GLU A  1557                                                      
REMARK 465     LYS A  1558                                                      
REMARK 465     PRO A  1559                                                      
REMARK 465     PRO A  1560                                                      
REMARK 465     GLN A  1561                                                      
REMARK 465     HIS B  2019                                                      
REMARK 465     PRO B  2020                                                      
REMARK 465     LYS B  2554                                                      
REMARK 465     ALA B  2555                                                      
REMARK 465     VAL B  2556                                                      
REMARK 465     GLU B  2557                                                      
REMARK 465     LYS B  2558                                                      
REMARK 465     PRO B  2559                                                      
REMARK 465     PRO B  2560                                                      
REMARK 465     GLN B  2561                                                      
REMARK 465     HIS C  3019                                                      
REMARK 465     PRO C  3020                                                      
REMARK 465     LYS C  3554                                                      
REMARK 465     ALA C  3555                                                      
REMARK 465     VAL C  3556                                                      
REMARK 465     GLU C  3557                                                      
REMARK 465     LYS C  3558                                                      
REMARK 465     PRO C  3559                                                      
REMARK 465     PRO C  3560                                                      
REMARK 465     GLN C  3561                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),F6.3)                  
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991                                
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    GLN A1069   CB    GLN A1069   CG    -0.051                        
REMARK 500    ALA A1206   CA    ALA A1206   CB    -0.053                        
REMARK 500    MET A1326   SD    MET A1326   CE     0.055                        
REMARK 500    MET A1364   CG    MET A1364   SD    -0.059                        
REMARK 500    MET A1364   SD    MET A1364   CE    -0.075                        
REMARK 500    MET A1425   SD    MET A1425   CE    -0.074                        
REMARK 500    MET A1459   SD    MET A1459   CE     0.114                        
REMARK 500    GLN B2069   CB    GLN B2069   CG    -0.054                        
REMARK 500    MET B2136   SD    MET B2136   CE     0.053                        
REMARK 500    MET B2145   SD    MET B2145   CE     0.073                        
REMARK 500    MET B2326   SD    MET B2326   CE     0.073                        
REMARK 500    MET B2459   SD    MET B2459   CE     0.097                        
REMARK 500    GLN C3069   CB    GLN C3069   CG    -0.051                        
REMARK 500    THR C3102   CA    THR C3102   CB    -0.051                        
REMARK 500    ARG C3171   CG    ARG C3171   CD    -0.052                        
REMARK 500    MET C3425   SD    MET C3425   CE    -0.053                        
REMARK 500    MET C3459   SD    MET C3459   CE     0.093                        
REMARK 500    MET C3495   SD    MET C3495   CE    -0.052                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: ENGH AND HUBER, 1991                                
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A1040   N   -  CA  -  C   ANGL. DEV. = -8.1 DEGREES           
REMARK 500    GLY A1052   N   -  CA  -  C   ANGL. DEV. =  7.4 DEGREES           
REMARK 500    SER A1305   N   -  CA  -  C   ANGL. DEV. =  8.0 DEGREES           
REMARK 500    LEU A1318   CA  -  CB  -  CG  ANGL. DEV. = -9.0 DEGREES           
REMARK 500    LEU A1318   N   -  CA  -  C   ANGL. DEV. = 13.1 DEGREES           
REMARK 500    LEU A1319   N   -  CA  -  C   ANGL. DEV. =-20.8 DEGREES           
REMARK 500    LEU A1319   C   -  N   -  CA  ANGL. DEV. =  7.1 DEGREES           
REMARK 500    LEU A1420   CA  -  CB  -  CG  ANGL. DEV. =  7.2 DEGREES           
REMARK 500    LEU B2040   N   -  CA  -  C   ANGL. DEV. = -8.4 DEGREES           
REMARK 500    GLY B2052   N   -  CA  -  C   ANGL. DEV. =  7.1 DEGREES           
REMARK 500    PRO B2317   C   -  N   -  CA  ANGL. DEV. =  7.0 DEGREES           
REMARK 500    SER B2369   N   -  CA  -  C   ANGL. DEV. =  8.0 DEGREES           
REMARK 500    LEU B2420   CA  -  CB  -  CG  ANGL. DEV. =  7.2 DEGREES           
REMARK 500    LEU C3040   N   -  CA  -  C   ANGL. DEV. = -8.6 DEGREES           
REMARK 500    SER C3253   N   -  CA  -  C   ANGL. DEV. =  9.2 DEGREES           
REMARK 500    LEU C3420   CA  -  CB  -  CG  ANGL. DEV. =  8.1 DEGREES           
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER C3221     -118.90     55.55                                   
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 2H7C   RELATED DB: PDB                                   
REMARK 900 SAME PROTEIN IN COMPLEX WITH COENZYME A                              
REMARK 900 RELATED ID: 2DQZ   RELATED DB: PDB                                   
REMARK 900 SAME PROTEIN IN COMPLEX WITH HOMATROPINE, COENZYME A, AND            
REMARK 900 PALMITATE                                                            
REMARK 900 RELATED ID: 2DR0   RELATED DB: PDB                                   
REMARK 900 SAME PROTEIN IN COMPLEX WITH TAUROCHOLATE                            
DBREF  2DQY A 1019  1561  UNP    P23141   EST1_HUMAN      19    561             
DBREF  2DQY B 2019  2561  UNP    P23141   EST1_HUMAN      19    561             
DBREF  2DQY C 3019  3561  UNP    P23141   EST1_HUMAN      19    561             
SEQADV 2DQY     A       UNP  P23141    GLN   362 DELETION                       
SEQADV 2DQY     B       UNP  P23141    GLN   362 DELETION                       
SEQADV 2DQY     C       UNP  P23141    GLN   362 DELETION                       
SEQRES   1 A  542  HIS PRO SER SER PRO PRO VAL VAL ASP THR VAL HIS GLY          
SEQRES   2 A  542  LYS VAL LEU GLY LYS PHE VAL SER LEU GLU GLY PHE ALA          
SEQRES   3 A  542  GLN PRO VAL ALA ILE PHE LEU GLY ILE PRO PHE ALA LYS          
SEQRES   4 A  542  PRO PRO LEU GLY PRO LEU ARG PHE THR PRO PRO GLN PRO          
SEQRES   5 A  542  ALA GLU PRO TRP SER PHE VAL LYS ASN ALA THR SER TYR          
SEQRES   6 A  542  PRO PRO MET CYS THR GLN ASP PRO LYS ALA GLY GLN LEU          
SEQRES   7 A  542  LEU SER GLU LEU PHE THR ASN ARG LYS GLU ASN ILE PRO          
SEQRES   8 A  542  LEU LYS LEU SER GLU ASP CYS LEU TYR LEU ASN ILE TYR          
SEQRES   9 A  542  THR PRO ALA ASP LEU THR LYS LYS ASN ARG LEU PRO VAL          
SEQRES  10 A  542  MET VAL TRP ILE HIS GLY GLY GLY LEU MET VAL GLY ALA          
SEQRES  11 A  542  ALA SER THR TYR ASP GLY LEU ALA LEU ALA ALA HIS GLU          
SEQRES  12 A  542  ASN VAL VAL VAL VAL THR ILE GLN TYR ARG LEU GLY ILE          
SEQRES  13 A  542  TRP GLY PHE PHE SER THR GLY ASP GLU HIS SER ARG GLY          
SEQRES  14 A  542  ASN TRP GLY HIS LEU ASP GLN VAL ALA ALA LEU ARG TRP          
SEQRES  15 A  542  VAL GLN ASP ASN ILE ALA SER PHE GLY GLY ASN PRO GLY          
SEQRES  16 A  542  SER VAL THR ILE PHE GLY GLU SER ALA GLY GLY GLU SER          
SEQRES  17 A  542  VAL SER VAL LEU VAL LEU SER PRO LEU ALA LYS ASN LEU          
SEQRES  18 A  542  PHE HIS ARG ALA ILE SER GLU SER GLY VAL ALA LEU THR          
SEQRES  19 A  542  SER VAL LEU VAL LYS LYS GLY ASP VAL LYS PRO LEU ALA          
SEQRES  20 A  542  GLU GLN ILE ALA ILE THR ALA GLY CYS LYS THR THR THR          
SEQRES  21 A  542  SER ALA VAL MET VAL HIS CYS LEU ARG GLN LYS THR GLU          
SEQRES  22 A  542  GLU GLU LEU LEU GLU THR THR LEU LYS MET LYS PHE LEU          
SEQRES  23 A  542  SER LEU ASP LEU GLN GLY ASP PRO ARG GLU SER GLN PRO          
SEQRES  24 A  542  LEU LEU GLY THR VAL ILE ASP GLY MET LEU LEU LEU LYS          
SEQRES  25 A  542  THR PRO GLU GLU LEU GLN ALA GLU ARG ASN PHE HIS THR          
SEQRES  26 A  542  VAL PRO TYR MET VAL GLY ILE ASN LYS GLN GLU PHE GLY          
SEQRES  27 A  542  TRP LEU ILE PRO MET LEU MET SER TYR PRO LEU SER GLU          
SEQRES  28 A  542  GLY GLN LEU ASP GLN LYS THR ALA MET SER LEU LEU TRP          
SEQRES  29 A  542  LYS SER TYR PRO LEU VAL CYS ILE ALA LYS GLU LEU ILE          
SEQRES  30 A  542  PRO GLU ALA THR GLU LYS TYR LEU GLY GLY THR ASP ASP          
SEQRES  31 A  542  THR VAL LYS LYS LYS ASP LEU PHE LEU ASP LEU ILE ALA          
SEQRES  32 A  542  ASP VAL MET PHE GLY VAL PRO SER VAL ILE VAL ALA ARG          
SEQRES  33 A  542  ASN HIS ARG ASP ALA GLY ALA PRO THR TYR MET TYR GLU          
SEQRES  34 A  542  PHE GLN TYR ARG PRO SER PHE SER SER ASP MET LYS PRO          
SEQRES  35 A  542  LYS THR VAL ILE GLY ASP HIS GLY ASP GLU LEU PHE SER          
SEQRES  36 A  542  VAL PHE GLY ALA PRO PHE LEU LYS GLU GLY ALA SER GLU          
SEQRES  37 A  542  GLU GLU ILE ARG LEU SER LYS MET VAL MET LYS PHE TRP          
SEQRES  38 A  542  ALA ASN PHE ALA ARG ASN GLY ASN PRO ASN GLY GLU GLY          
SEQRES  39 A  542  LEU PRO HIS TRP PRO GLU TYR ASN GLN LYS GLU GLY TYR          
SEQRES  40 A  542  LEU GLN ILE GLY ALA ASN THR GLN ALA ALA GLN LYS LEU          
SEQRES  41 A  542  LYS ASP LYS GLU VAL ALA PHE TRP THR ASN LEU PHE ALA          
SEQRES  42 A  542  LYS LYS ALA VAL GLU LYS PRO PRO GLN                          
SEQRES   1 B  542  HIS PRO SER SER PRO PRO VAL VAL ASP THR VAL HIS GLY          
SEQRES   2 B  542  LYS VAL LEU GLY LYS PHE VAL SER LEU GLU GLY PHE ALA          
SEQRES   3 B  542  GLN PRO VAL ALA ILE PHE LEU GLY ILE PRO PHE ALA LYS          
SEQRES   4 B  542  PRO PRO LEU GLY PRO LEU ARG PHE THR PRO PRO GLN PRO          
SEQRES   5 B  542  ALA GLU PRO TRP SER PHE VAL LYS ASN ALA THR SER TYR          
SEQRES   6 B  542  PRO PRO MET CYS THR GLN ASP PRO LYS ALA GLY GLN LEU          
SEQRES   7 B  542  LEU SER GLU LEU PHE THR ASN ARG LYS GLU ASN ILE PRO          
SEQRES   8 B  542  LEU LYS LEU SER GLU ASP CYS LEU TYR LEU ASN ILE TYR          
SEQRES   9 B  542  THR PRO ALA ASP LEU THR LYS LYS ASN ARG LEU PRO VAL          
SEQRES  10 B  542  MET VAL TRP ILE HIS GLY GLY GLY LEU MET VAL GLY ALA          
SEQRES  11 B  542  ALA SER THR TYR ASP GLY LEU ALA LEU ALA ALA HIS GLU          
SEQRES  12 B  542  ASN VAL VAL VAL VAL THR ILE GLN TYR ARG LEU GLY ILE          
SEQRES  13 B  542  TRP GLY PHE PHE SER THR GLY ASP GLU HIS SER ARG GLY          
SEQRES  14 B  542  ASN TRP GLY HIS LEU ASP GLN VAL ALA ALA LEU ARG TRP          
SEQRES  15 B  542  VAL GLN ASP ASN ILE ALA SER PHE GLY GLY ASN PRO GLY          
SEQRES  16 B  542  SER VAL THR ILE PHE GLY GLU SER ALA GLY GLY GLU SER          
SEQRES  17 B  542  VAL SER VAL LEU VAL LEU SER PRO LEU ALA LYS ASN LEU          
SEQRES  18 B  542  PHE HIS ARG ALA ILE SER GLU SER GLY VAL ALA LEU THR          
SEQRES  19 B  542  SER VAL LEU VAL LYS LYS GLY ASP VAL LYS PRO LEU ALA          
SEQRES  20 B  542  GLU GLN ILE ALA ILE THR ALA GLY CYS LYS THR THR THR          
SEQRES  21 B  542  SER ALA VAL MET VAL HIS CYS LEU ARG GLN LYS THR GLU          
SEQRES  22 B  542  GLU GLU LEU LEU GLU THR THR LEU LYS MET LYS PHE LEU          
SEQRES  23 B  542  SER LEU ASP LEU GLN GLY ASP PRO ARG GLU SER GLN PRO          
SEQRES  24 B  542  LEU LEU GLY THR VAL ILE ASP GLY MET LEU LEU LEU LYS          
SEQRES  25 B  542  THR PRO GLU GLU LEU GLN ALA GLU ARG ASN PHE HIS THR          
SEQRES  26 B  542  VAL PRO TYR MET VAL GLY ILE ASN LYS GLN GLU PHE GLY          
SEQRES  27 B  542  TRP LEU ILE PRO MET LEU MET SER TYR PRO LEU SER GLU          
SEQRES  28 B  542  GLY GLN LEU ASP GLN LYS THR ALA MET SER LEU LEU TRP          
SEQRES  29 B  542  LYS SER TYR PRO LEU VAL CYS ILE ALA LYS GLU LEU ILE          
SEQRES  30 B  542  PRO GLU ALA THR GLU LYS TYR LEU GLY GLY THR ASP ASP          
SEQRES  31 B  542  THR VAL LYS LYS LYS ASP LEU PHE LEU ASP LEU ILE ALA          
SEQRES  32 B  542  ASP VAL MET PHE GLY VAL PRO SER VAL ILE VAL ALA ARG          
SEQRES  33 B  542  ASN HIS ARG ASP ALA GLY ALA PRO THR TYR MET TYR GLU          
SEQRES  34 B  542  PHE GLN TYR ARG PRO SER PHE SER SER ASP MET LYS PRO          
SEQRES  35 B  542  LYS THR VAL ILE GLY ASP HIS GLY ASP GLU LEU PHE SER          
SEQRES  36 B  542  VAL PHE GLY ALA PRO PHE LEU LYS GLU GLY ALA SER GLU          
SEQRES  37 B  542  GLU GLU ILE ARG LEU SER LYS MET VAL MET LYS PHE TRP          
SEQRES  38 B  542  ALA ASN PHE ALA ARG ASN GLY ASN PRO ASN GLY GLU GLY          
SEQRES  39 B  542  LEU PRO HIS TRP PRO GLU TYR ASN GLN LYS GLU GLY TYR          
SEQRES  40 B  542  LEU GLN ILE GLY ALA ASN THR GLN ALA ALA GLN LYS LEU          
SEQRES  41 B  542  LYS ASP LYS GLU VAL ALA PHE TRP THR ASN LEU PHE ALA          
SEQRES  42 B  542  LYS LYS ALA VAL GLU LYS PRO PRO GLN                          
SEQRES   1 C  542  HIS PRO SER SER PRO PRO VAL VAL ASP THR VAL HIS GLY          
SEQRES   2 C  542  LYS VAL LEU GLY LYS PHE VAL SER LEU GLU GLY PHE ALA          
SEQRES   3 C  542  GLN PRO VAL ALA ILE PHE LEU GLY ILE PRO PHE ALA LYS          
SEQRES   4 C  542  PRO PRO LEU GLY PRO LEU ARG PHE THR PRO PRO GLN PRO          
SEQRES   5 C  542  ALA GLU PRO TRP SER PHE VAL LYS ASN ALA THR SER TYR          
SEQRES   6 C  542  PRO PRO MET CYS THR GLN ASP PRO LYS ALA GLY GLN LEU          
SEQRES   7 C  542  LEU SER GLU LEU PHE THR ASN ARG LYS GLU ASN ILE PRO          
SEQRES   8 C  542  LEU LYS LEU SER GLU ASP CYS LEU TYR LEU ASN ILE TYR          
SEQRES   9 C  542  THR PRO ALA ASP LEU THR LYS LYS ASN ARG LEU PRO VAL          
SEQRES  10 C  542  MET VAL TRP ILE HIS GLY GLY GLY LEU MET VAL GLY ALA          
SEQRES  11 C  542  ALA SER THR TYR ASP GLY LEU ALA LEU ALA ALA HIS GLU          
SEQRES  12 C  542  ASN VAL VAL VAL VAL THR ILE GLN TYR ARG LEU GLY ILE          
SEQRES  13 C  542  TRP GLY PHE PHE SER THR GLY ASP GLU HIS SER ARG GLY          
SEQRES  14 C  542  ASN TRP GLY HIS LEU ASP GLN VAL ALA ALA LEU ARG TRP          
SEQRES  15 C  542  VAL GLN ASP ASN ILE ALA SER PHE GLY GLY ASN PRO GLY          
SEQRES  16 C  542  SER VAL THR ILE PHE GLY GLU SER ALA GLY GLY GLU SER          
SEQRES  17 C  542  VAL SER VAL LEU VAL LEU SER PRO LEU ALA LYS ASN LEU          
SEQRES  18 C  542  PHE HIS ARG ALA ILE SER GLU SER GLY VAL ALA LEU THR          
SEQRES  19 C  542  SER VAL LEU VAL LYS LYS GLY ASP VAL LYS PRO LEU ALA          
SEQRES  20 C  542  GLU GLN ILE ALA ILE THR ALA GLY CYS LYS THR THR THR          
SEQRES  21 C  542  SER ALA VAL MET VAL HIS CYS LEU ARG GLN LYS THR GLU          
SEQRES  22 C  542  GLU GLU LEU LEU GLU THR THR LEU LYS MET LYS PHE LEU          
SEQRES  23 C  542  SER LEU ASP LEU GLN GLY ASP PRO ARG GLU SER GLN PRO          
SEQRES  24 C  542  LEU LEU GLY THR VAL ILE ASP GLY MET LEU LEU LEU LYS          
SEQRES  25 C  542  THR PRO GLU GLU LEU GLN ALA GLU ARG ASN PHE HIS THR          
SEQRES  26 C  542  VAL PRO TYR MET VAL GLY ILE ASN LYS GLN GLU PHE GLY          
SEQRES  27 C  542  TRP LEU ILE PRO MET LEU MET SER TYR PRO LEU SER GLU          
SEQRES  28 C  542  GLY GLN LEU ASP GLN LYS THR ALA MET SER LEU LEU TRP          
SEQRES  29 C  542  LYS SER TYR PRO LEU VAL CYS ILE ALA LYS GLU LEU ILE          
SEQRES  30 C  542  PRO GLU ALA THR GLU LYS TYR LEU GLY GLY THR ASP ASP          
SEQRES  31 C  542  THR VAL LYS LYS LYS ASP LEU PHE LEU ASP LEU ILE ALA          
SEQRES  32 C  542  ASP VAL MET PHE GLY VAL PRO SER VAL ILE VAL ALA ARG          
SEQRES  33 C  542  ASN HIS ARG ASP ALA GLY ALA PRO THR TYR MET TYR GLU          
SEQRES  34 C  542  PHE GLN TYR ARG PRO SER PHE SER SER ASP MET LYS PRO          
SEQRES  35 C  542  LYS THR VAL ILE GLY ASP HIS GLY ASP GLU LEU PHE SER          
SEQRES  36 C  542  VAL PHE GLY ALA PRO PHE LEU LYS GLU GLY ALA SER GLU          
SEQRES  37 C  542  GLU GLU ILE ARG LEU SER LYS MET VAL MET LYS PHE TRP          
SEQRES  38 C  542  ALA ASN PHE ALA ARG ASN GLY ASN PRO ASN GLY GLU GLY          
SEQRES  39 C  542  LEU PRO HIS TRP PRO GLU TYR ASN GLN LYS GLU GLY TYR          
SEQRES  40 C  542  LEU GLN ILE GLY ALA ASN THR GLN ALA ALA GLN LYS LEU          
SEQRES  41 C  542  LYS ASP LYS GLU VAL ALA PHE TRP THR ASN LEU PHE ALA          
SEQRES  42 C  542  LYS LYS ALA VAL GLU LYS PRO PRO GLN                          
MODRES 2DQY ASN A 1079  ASN  GLYCOSYLATION SITE                                 
MODRES 2DQY ASN B 2079  ASN  GLYCOSYLATION SITE                                 
MODRES 2DQY ASN C 3079  ASN  GLYCOSYLATION SITE                                 
HET    NAG  A 179      14                                                       
HET    SIA    182      21                                                       
HET    NAG  B 279      14                                                       
HET    SIA    282      21                                                       
HET    NAG  C 379      14                                                       
HET    SIA    382      21                                                       
HET    SO4    184       5                                                       
HET    SO4    185       5                                                       
HET    SO4    284       5                                                       
HET    SO4    285       5                                                       
HET    SO4    384       5                                                       
HET    SO4    385       5                                                       
HET    CHD      1      29                                                       
HET    CHD      2      29                                                       
HET    CHD      3      29                                                       
HET    PLM     11      18                                                       
HET    PLM     12      18                                                       
HET    PLM     13      18                                                       
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE                                           
HETNAM     SIA O-SIALIC ACID                                                    
HETNAM     SO4 SULFATE ION                                                      
HETNAM     CHD CHOLIC ACID                                                      
HETNAM     PLM PALMITIC ACID                                                    
HETSYN     NAG NAG                                                              
FORMUL   4  NAG    3(C8 H15 N1 O6)                                              
FORMUL   5  SIA    3(C11 H19 N1 O9)                                             
FORMUL  10  SO4    6(O4 S1 2-)                                                  
FORMUL  16  CHD    3(C24 H40 O5)                                                
FORMUL  19  PLM    3(C16 H32 O2)                                                
FORMUL  22  HOH   *301(H2 O1)                                                   
HELIX    1   1 LEU A 1060  ARG A 1064  5                                   5    
HELIX    2   2 ASP A 1090  THR A 1102  1                                  13    
HELIX    3   3 GLY A 1154  ASN A 1162  1                                   9    
HELIX    4   4 LEU A 1172  PHE A 1178  1                                   7    
HELIX    5   5 ASN A 1188  ASP A 1203  1                                  16    
HELIX    6   6 ASN A 1204  PHE A 1208  5                                   5    
HELIX    7   7 SER A 1221  SER A 1233  1                                  13    
HELIX    8   8 THR A 1252  VAL A 1256  5                                   5    
HELIX    9   9 VAL A 1261  ALA A 1272  1                                  12    
HELIX   10  10 THR A 1278  LYS A 1289  1                                  12    
HELIX   11  11 THR A 1290  LYS A 1302  1                                  13    
HELIX   12  12 ASP A 1311  SER A 1315  5                                   5    
HELIX   13  13 THR A 1331  ALA A 1337  1                                   7    
HELIX   14  14 TRP A 1357  MET A 1364  1                                   7    
HELIX   15  15 ASP A 1374  SER A 1385  1                                  12    
HELIX   16  16 SER A 1385  CYS A 1390  1                                   6    
HELIX   17  17 LEU A 1395  GLY A 1405  1                                  11    
HELIX   18  18 ASP A 1409  PHE A 1426  1                                  18    
HELIX   19  19 PHE A 1426  GLY A 1441  1                                  16    
HELIX   20  20 GLU A 1471  PHE A 1476  1                                   6    
HELIX   21  21 GLY A 1477  LEU A 1481  5                                   5    
HELIX   22  22 SER A 1486  GLY A 1507  1                                  22    
HELIX   23  23 LYS A 1540  ALA A 1552  1                                  13    
HELIX   24  24 LEU B 2060  ARG B 2064  5                                   5    
HELIX   25  25 ASP B 2090  THR B 2102  1                                  13    
HELIX   26  26 GLY B 2154  ASN B 2162  1                                   9    
HELIX   27  27 LEU B 2172  PHE B 2178  1                                   7    
HELIX   28  28 ASN B 2188  ILE B 2205  1                                  18    
HELIX   29  29 ALA B 2206  PHE B 2208  5                                   3    
HELIX   30  30 SER B 2221  SER B 2233  1                                  13    
HELIX   31  31 THR B 2252  VAL B 2256  5                                   5    
HELIX   32  32 VAL B 2261  ALA B 2272  1                                  12    
HELIX   33  33 THR B 2278  LYS B 2289  1                                  12    
HELIX   34  34 THR B 2290  MET B 2301  1                                  12    
HELIX   35  35 ASP B 2311  SER B 2315  5                                   5    
HELIX   36  36 THR B 2331  ALA B 2337  1                                   7    
HELIX   37  37 TRP B 2357  MET B 2364  1                                   7    
HELIX   38  38 PRO B 2367  GLY B 2371  5                                   5    
HELIX   39  39 ASP B 2374  SER B 2385  1                                  12    
HELIX   40  40 SER B 2385  CYS B 2390  1                                   6    
HELIX   41  41 LEU B 2395  GLY B 2405  1                                  11    
HELIX   42  42 ASP B 2409  PHE B 2426  1                                  18    
HELIX   43  43 PHE B 2426  GLY B 2441  1                                  16    
HELIX   44  44 GLU B 2471  PHE B 2476  1                                   6    
HELIX   45  45 GLY B 2477  LEU B 2481  5                                   5    
HELIX   46  46 SER B 2486  GLY B 2507  1                                  22    
HELIX   47  47 LYS B 2540  ALA B 2552  1                                  13    
HELIX   48  48 LEU C 3060  ARG C 3064  5                                   5    
HELIX   49  49 ASP C 3090  THR C 3102  1                                  13    
HELIX   50  50 GLY C 3154  ASN C 3162  1                                   9    
HELIX   51  51 LEU C 3172  PHE C 3178  1                                   7    
HELIX   52  52 ASN C 3188  ASP C 3203  1                                  16    
HELIX   53  53 ASN C 3204  PHE C 3208  5                                   5    
HELIX   54  54 SER C 3221  SER C 3233  1                                  13    
HELIX   55  55 THR C 3252  VAL C 3256  5                                   5    
HELIX   56  56 VAL C 3261  ALA C 3272  1                                  12    
HELIX   57  57 THR C 3278  LYS C 3289  1                                  12    
HELIX   58  58 THR C 3290  LYS C 3302  1                                  13    
HELIX   59  59 ASP C 3311  SER C 3315  5                                   5    
HELIX   60  60 THR C 3331  ALA C 3337  1                                   7    
HELIX   61  61 TRP C 3357  SER C 3365  1                                   8    
HELIX   62  62 ASP C 3374  SER C 3385  1                                  12    
HELIX   63  63 SER C 3385  CYS C 3390  1                                   6    
HELIX   64  64 LEU C 3395  GLY C 3405  1                                  11    
HELIX   65  65 ASP C 3409  PHE C 3426  1                                  18    
HELIX   66  66 PHE C 3426  GLY C 3441  1                                  16    
HELIX   67  67 GLU C 3471  PHE C 3476  1                                   6    
HELIX   68  68 GLY C 3477  LEU C 3481  5                                   5    
HELIX   69  69 SER C 3486  GLY C 3507  1                                  22    
HELIX   70  70 LYS C 3540  ALA C 3552  1                                  13    
SHEET    1   A 3 VAL A1025  THR A1028  0                                        
SHEET    2   A 3 GLY A1031  LEU A1034 -1  O  VAL A1033   N  VAL A1026           
SHEET    3   A 3 LYS A1078  ASN A1079  1  O  LYS A1078   N  LEU A1034           
SHEET    1   B11 LYS A1036  VAL A1038  0                                        
SHEET    2   B11 VAL A1047  PRO A1054 -1  O  ILE A1049   N  LYS A1036           
SHEET    3   B11 TYR A1118  THR A1123 -1  O  THR A1123   N  ALA A1048           
SHEET    4   B11 VAL A1164  ILE A1168 -1  O  VAL A1165   N  TYR A1122           
SHEET    5   B11 LEU A1133  ILE A1139  1  N  TRP A1138   O  VAL A1166           
SHEET    6   B11 GLY A1210  GLU A1220  1  O  ASN A1211   N  LEU A1133           
SHEET    7   B11 ARG A1242  GLU A1246  1  O  ARG A1242   N  ILE A1217           
SHEET    8   B11 TYR A1346  ASN A1351  1  O  MET A1347   N  SER A1245           
SHEET    9   B11 THR A1444  GLN A1450  1  O  TYR A1445   N  VAL A1348           
SHEET   10   B11 GLY A1525  GLY A1530  1  O  ILE A1529   N  GLN A1450           
SHEET   11   B11 GLN A1534  GLN A1537 -1  O  GLN A1534   N  GLN A1528           
SHEET    1   C 2 MET A1086  CYS A1087  0                                        
SHEET    2   C 2 LEU A1112  SER A1113  1  O  SER A1113   N  MET A1086           
SHEET    1   D 3 VAL B2025  THR B2028  0                                        
SHEET    2   D 3 GLY B2031  LEU B2034 -1  O  VAL B2033   N  VAL B2026           
SHEET    3   D 3 LYS B2078  ASN B2079  1  O  LYS B2078   N  LEU B2034           
SHEET    1   E 9 LYS B2036  VAL B2038  0                                        
SHEET    2   E 9 VAL B2047  PRO B2054 -1  O  VAL B2047   N  VAL B2038           
SHEET    3   E 9 TYR B2118  THR B2123 -1  O  THR B2123   N  ALA B2048           
SHEET    4   E 9 VAL B2164  ILE B2168 -1  O  THR B2167   N  ASN B2120           
SHEET    5   E 9 LEU B2133  ILE B2139  1  N  TRP B2138   O  VAL B2166           
SHEET    6   E 9 GLY B2210  GLU B2220  1  O  ASN B2211   N  LEU B2133           
SHEET    7   E 9 ARG B2242  GLU B2246  1  O  ARG B2242   N  ILE B2217           
SHEET    8   E 9 TYR B2346  ASN B2351  1  O  MET B2347   N  SER B2245           
SHEET    9   E 9 THR B2444  PHE B2449  1  O  TYR B2445   N  VAL B2348           
SHEET    1   F 2 MET B2086  CYS B2087  0                                        
SHEET    2   F 2 LEU B2112  SER B2113  1  O  SER B2113   N  MET B2086           
SHEET    1   G 2 GLY B2525  GLN B2528  0                                        
SHEET    2   G 2 GLN B2534  GLN B2537 -1  O  GLN B2534   N  GLN B2528           
SHEET    1   H 3 VAL C3025  THR C3028  0                                        
SHEET    2   H 3 GLY C3031  LEU C3034 -1  O  VAL C3033   N  VAL C3026           
SHEET    3   H 3 LYS C3078  ASN C3079  1  O  LYS C3078   N  LEU C3034           
SHEET    1   I11 LYS C3036  VAL C3038  0                                        
SHEET    2   I11 VAL C3047  PRO C3054 -1  O  ILE C3049   N  LYS C3036           
SHEET    3   I11 TYR C3118  THR C3123 -1  O  THR C3123   N  ALA C3048           
SHEET    4   I11 VAL C3164  ILE C3168 -1  O  THR C3167   N  ASN C3120           
SHEET    5   I11 LEU C3133  ILE C3139  1  N  TRP C3138   O  VAL C3166           
SHEET    6   I11 GLY C3210  GLU C3220  1  O  ASN C3211   N  LEU C3133           
SHEET    7   I11 ARG C3242  GLU C3246  1  O  ARG C3242   N  ILE C3217           
SHEET    8   I11 TYR C3346  ASN C3351  1  O  MET C3347   N  SER C3245           
SHEET    9   I11 THR C3444  GLN C3450  1  O  TYR C3445   N  VAL C3348           
SHEET   10   I11 GLY C3525  GLY C3530  1  O  ILE C3529   N  GLN C3450           
SHEET   11   I11 GLN C3534  GLN C3537 -1  O  ALA C3536   N  TYR C3526           
SHEET    1   J 2 MET C3086  CYS C3087  0                                        
SHEET    2   J 2 LEU C3112  SER C3113  1  O  SER C3113   N  MET C3086           
SSBOND   1 CYS A 1087    CYS A 1116                                             
SSBOND   2 CYS A 1274    CYS A 1285                                             
SSBOND   3 CYS B 2087    CYS B 2116                                             
SSBOND   4 CYS B 2274    CYS B 2285                                             
SSBOND   5 CYS C 3087    CYS C 3116                                             
SSBOND   6 CYS C 3274    CYS C 3285                                             
LINK         ND2 ASN A1079                 C1  NAG A 179                        
LINK         ND2 ASN B2079                 C1  NAG B 279                        
LINK         ND2 ASN C3079                 C1  NAG C 379                        
CRYST1   55.292  179.877  201.323  90.00  90.00  90.00 P 21 21 21   12          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.018086  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.005559  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.004967        0.00000                         
TER    4131      LYS A1553                                                      
TER    8262      LYS B2553                                                      
TER   12393      LYS C3553                                                      
MASTER      341    0   18   70   48    0    0    612967    3  291  126          
END                                                                             

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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