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LongText Report for: 3OUR-pdb

Name Class
3OUR-pdb
HEADER    LYASE/TRANSFERASE                       15-SEP-10   3OUR              
TITLE     CRYSTAL STRUCTURE OF COMPLEX BETWEEN EIIA AND A NOVEL PYRUVATE        
TITLE    2 DECARBOXYLASE                                                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: UPF0255 PROTEIN VV1_0328;                                  
COMPND   3 CHAIN: A, C, E, G;                                                   
COMPND   4 SYNONYM: FERMENTATION/RESPIRATION SWITCH PROTEIN;                    
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: PHOSPHOTRANSFERASE SYSTEM IIA COMPONENT;                   
COMPND   8 CHAIN: B, D, F, H;                                                   
COMPND   9 SYNONYM: EIIA;                                                       
COMPND  10 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: VIBRIO VULNIFICUS;                              
SOURCE   3 ORGANISM_TAXID: 216895;                                              
SOURCE   4 STRAIN: CMCP6;                                                       
SOURCE   5 GENE: VV1_0328;                                                      
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: JM109;                                     
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PQE;                                      
SOURCE  11 MOL_ID: 2;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: VIBRIO VULNIFICUS;                              
SOURCE  13 ORGANISM_TAXID: 216895;                                              
SOURCE  14 STRAIN: CMCP6;                                                       
SOURCE  15 GENE: VV1_0212;                                                      
SOURCE  16 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  17 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  18 EXPRESSION_SYSTEM_STRAIN: JM109;                                     
SOURCE  19 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  20 EXPRESSION_SYSTEM_PLASMID: PQE                                       
KEYWDS    EXHIBIT NO HYDROLASE ACTIVITY1, LYASE-TRANSFERASE COMPLEX             
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    C.-S.JEONG,Y.J.AN,S.-S.CHA                                            
REVDAT   1   01-JUN-11 3OUR    0                                                
JRNL        AUTH   K.-J.LEE,C.-S.JEONG,Y.J.AN,H.-J.LEE,S.-J.PARK,Y.-J.SEOK,     
JRNL        AUTH 2 P.KIM,J.-H.LEE,K.-H.LEE,S.-S.CHA                             
JRNL        TITL   FRSA FUNCTIONS AS A COFACTOR-INDEPENDENT DECARBOXYLASE TO    
JRNL        TITL 2 CONTROL METABOLIC FLUX                                       
JRNL        REF    NAT.CHEM.BIOL.                             2011              
JRNL        REFN                   ESSN 1552-4469                               
JRNL        DOI    10.1038/NCHEMBIO.589                                         
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.20 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.1                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,              
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : NULL                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.20                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.37                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 1.100                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 44259.560                      
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000                         
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 90.5                           
REMARK   3   NUMBER OF REFLECTIONS             : 108181                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.201                           
REMARK   3   FREE R VALUE                     : 0.248                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 5459                            
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.003                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 6                            
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.20                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.34                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 75.80                        
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 14187                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2870                       
REMARK   3   BIN FREE R VALUE                    : 0.3120                       
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 5.10                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 757                          
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.011                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 16723                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 927                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 13.70                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 36.90                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -3.04000                                             
REMARK   3    B22 (A**2) : 3.22000                                              
REMARK   3    B33 (A**2) : -0.18000                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 1.44000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.26                            
REMARK   3   ESD FROM SIGMAA              (A) : 0.32                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.33                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.35                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.009                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.50                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 23.80                           
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.91                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED                                
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : FLAT MODEL                                           
REMARK   3   KSOL        : 0.32                                                 
REMARK   3   BSOL        : 43.33                                                
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM                              
REMARK   3  PARAMETER FILE  2  : ION.PARAM                                      
REMARK   3  PARAMETER FILE  3  : WATER_REP.PARAM                                
REMARK   3  PARAMETER FILE  4  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP                                    
REMARK   3  TOPOLOGY FILE  2   : ION.TOP                                        
REMARK   3  TOPOLOGY FILE  3   : WATER_REP.TOP                                  
REMARK   3  TOPOLOGY FILE  4   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 3OUR COMPLIES WITH FORMAT V. 3.20, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 01-OCT-10.                  
REMARK 100 THE RCSB ID CODE IS RCSB061598.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 23-FEB-10                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : PHOTON FACTORY                     
REMARK 200  BEAMLINE                       : BL-17A                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.98000                            
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 119307                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.190                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.5                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.19                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.23                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.1                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: CCP4                                                  
REMARK 200 STARTING MODEL: 3MVE, 1O2F                                           
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 42.75                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.15                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG MME 550, 0.1M MES PH 6.5,        
REMARK 280  0.01M ZN-ACETATE, MICROBATCH, TEMPERATURE 295K                      
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290       3555   X+1/2,Y+1/2,Z                                           
REMARK 290       4555   -X+1/2,Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000      161.43300            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       31.03350            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000      161.43300            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       31.03350            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4                                              
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1740 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 20920 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -10.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1750 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 21290 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -14.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1680 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 21210 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -11.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1730 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 20930 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -10.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, H                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -19                                                      
REMARK 465     ARG A   -18                                                      
REMARK 465     GLY A   -17                                                      
REMARK 465     SER A   -16                                                      
REMARK 465     HIS A   -15                                                      
REMARK 465     HIS A   -14                                                      
REMARK 465     HIS A   -13                                                      
REMARK 465     HIS A   -12                                                      
REMARK 465     HIS A   -11                                                      
REMARK 465     HIS A   -10                                                      
REMARK 465     GLY A    -9                                                      
REMARK 465     SER A    -8                                                      
REMARK 465     ALA A    -7                                                      
REMARK 465     CYS A    -6                                                      
REMARK 465     GLU A    -5                                                      
REMARK 465     LEU A    -4                                                      
REMARK 465     GLY A    -3                                                      
REMARK 465     THR A    -2                                                      
REMARK 465     PRO A    -1                                                      
REMARK 465     ASN A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     GLU A     3                                                      
REMARK 465     GLU A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     SER A     6                                                      
REMARK 465     LYS A     7                                                      
REMARK 465     ASN A     8                                                      
REMARK 465     LEU A     9                                                      
REMARK 465     SER A    10                                                      
REMARK 465     GLU A    11                                                      
REMARK 465     THR A    12                                                      
REMARK 465     LEU A    13                                                      
REMARK 465     PHE A    14                                                      
REMARK 465     VAL A    15                                                      
REMARK 465     LYS A    16                                                      
REMARK 465     HIS A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     GLN A    19                                                      
REMARK 465     ALA A    20                                                      
REMARK 465     ARG A   415                                                      
REMARK 465     MET B   -13                                                      
REMARK 465     ARG B   -12                                                      
REMARK 465     GLY B   -11                                                      
REMARK 465     SER B   -10                                                      
REMARK 465     HIS B    -9                                                      
REMARK 465     HIS B    -8                                                      
REMARK 465     HIS B    -7                                                      
REMARK 465     HIS B    -6                                                      
REMARK 465     HIS B    -5                                                      
REMARK 465     HIS B    -4                                                      
REMARK 465     GLY B    -3                                                      
REMARK 465     SER B    -2                                                      
REMARK 465     ASP B    -1                                                      
REMARK 465     THR B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     LEU B     3                                                      
REMARK 465     PHE B     4                                                      
REMARK 465     ASP B     5                                                      
REMARK 465     LYS B     6                                                      
REMARK 465     LEU B     7                                                      
REMARK 465     LYS B     8                                                      
REMARK 465     LYS B     9                                                      
REMARK 465     LEU B    10                                                      
REMARK 465     VAL B    11                                                      
REMARK 465     SER B    12                                                      
REMARK 465     ASP B    13                                                      
REMARK 465     ASP B    14                                                      
REMARK 465     SER B    15                                                      
REMARK 465     ALA B    16                                                      
REMARK 465     SER B    17                                                      
REMARK 465     ALA B    18                                                      
REMARK 465     GLY B    19                                                      
REMARK 465     MET C   -19                                                      
REMARK 465     ARG C   -18                                                      
REMARK 465     GLY C   -17                                                      
REMARK 465     SER C   -16                                                      
REMARK 465     HIS C   -15                                                      
REMARK 465     HIS C   -14                                                      
REMARK 465     HIS C   -13                                                      
REMARK 465     HIS C   -12                                                      
REMARK 465     HIS C   -11                                                      
REMARK 465     HIS C   -10                                                      
REMARK 465     GLY C    -9                                                      
REMARK 465     SER C    -8                                                      
REMARK 465     ALA C    -7                                                      
REMARK 465     CYS C    -6                                                      
REMARK 465     GLU C    -5                                                      
REMARK 465     LEU C    -4                                                      
REMARK 465     GLY C    -3                                                      
REMARK 465     THR C    -2                                                      
REMARK 465     PRO C    -1                                                      
REMARK 465     ASN C     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C     2                                                      
REMARK 465     GLU C     3                                                      
REMARK 465     GLU C     4                                                      
REMARK 465     VAL C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     ASN C     8                                                      
REMARK 465     LEU C     9                                                      
REMARK 465     SER C    10                                                      
REMARK 465     GLU C    11                                                      
REMARK 465     THR C    12                                                      
REMARK 465     LEU C    13                                                      
REMARK 465     PHE C    14                                                      
REMARK 465     VAL C    15                                                      
REMARK 465     LYS C    16                                                      
REMARK 465     HIS C    17                                                      
REMARK 465     LYS C    18                                                      
REMARK 465     ASN C    44                                                      
REMARK 465     LEU C   414                                                      
REMARK 465     ARG C   415                                                      
REMARK 465     MET D   -13                                                      
REMARK 465     ARG D   -12                                                      
REMARK 465     GLY D   -11                                                      
REMARK 465     SER D   -10                                                      
REMARK 465     HIS D    -9                                                      
REMARK 465     HIS D    -8                                                      
REMARK 465     HIS D    -7                                                      
REMARK 465     HIS D    -6                                                      
REMARK 465     HIS D    -5                                                      
REMARK 465     HIS D    -4                                                      
REMARK 465     GLY D    -3                                                      
REMARK 465     SER D    -2                                                      
REMARK 465     ASP D    -1                                                      
REMARK 465     THR D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLY D     2                                                      
REMARK 465     LEU D     3                                                      
REMARK 465     PHE D     4                                                      
REMARK 465     ASP D     5                                                      
REMARK 465     LYS D     6                                                      
REMARK 465     LEU D     7                                                      
REMARK 465     LYS D     8                                                      
REMARK 465     LYS D     9                                                      
REMARK 465     LEU D    10                                                      
REMARK 465     VAL D    11                                                      
REMARK 465     SER D    12                                                      
REMARK 465     ASP D    13                                                      
REMARK 465     ASP D    14                                                      
REMARK 465     SER D    15                                                      
REMARK 465     ALA D    16                                                      
REMARK 465     SER D    17                                                      
REMARK 465     ALA D    18                                                      
REMARK 465     GLY D    19                                                      
REMARK 465     MET E   -19                                                      
REMARK 465     ARG E   -18                                                      
REMARK 465     GLY E   -17                                                      
REMARK 465     SER E   -16                                                      
REMARK 465     HIS E   -15                                                      
REMARK 465     HIS E   -14                                                      
REMARK 465     HIS E   -13                                                      
REMARK 465     HIS E   -12                                                      
REMARK 465     HIS E   -11                                                      
REMARK 465     HIS E   -10                                                      
REMARK 465     GLY E    -9                                                      
REMARK 465     SER E    -8                                                      
REMARK 465     ALA E    -7                                                      
REMARK 465     CYS E    -6                                                      
REMARK 465     GLU E    -5                                                      
REMARK 465     LEU E    -4                                                      
REMARK 465     GLY E    -3                                                      
REMARK 465     THR E    -2                                                      
REMARK 465     PRO E    -1                                                      
REMARK 465     ASN E     0                                                      
REMARK 465     MET E     1                                                      
REMARK 465     SER E     2                                                      
REMARK 465     GLU E     3                                                      
REMARK 465     GLU E     4                                                      
REMARK 465     VAL E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     LYS E     7                                                      
REMARK 465     ASN E     8                                                      
REMARK 465     LEU E     9                                                      
REMARK 465     SER E    10                                                      
REMARK 465     GLU E    11                                                      
REMARK 465     THR E    12                                                      
REMARK 465     LEU E    13                                                      
REMARK 465     PHE E    14                                                      
REMARK 465     VAL E    15                                                      
REMARK 465     LYS E    16                                                      
REMARK 465     HIS E    17                                                      
REMARK 465     LYS E    18                                                      
REMARK 465     ARG E   415                                                      
REMARK 465     MET F   -13                                                      
REMARK 465     ARG F   -12                                                      
REMARK 465     GLY F   -11                                                      
REMARK 465     SER F   -10                                                      
REMARK 465     HIS F    -9                                                      
REMARK 465     HIS F    -8                                                      
REMARK 465     HIS F    -7                                                      
REMARK 465     HIS F    -6                                                      
REMARK 465     HIS F    -5                                                      
REMARK 465     HIS F    -4                                                      
REMARK 465     GLY F    -3                                                      
REMARK 465     SER F    -2                                                      
REMARK 465     ASP F    -1                                                      
REMARK 465     THR F     0                                                      
REMARK 465     MET F     1                                                      
REMARK 465     GLY F     2                                                      
REMARK 465     LEU F     3                                                      
REMARK 465     PHE F     4                                                      
REMARK 465     ASP F     5                                                      
REMARK 465     LYS F     6                                                      
REMARK 465     LEU F     7                                                      
REMARK 465     LYS F     8                                                      
REMARK 465     LYS F     9                                                      
REMARK 465     LEU F    10                                                      
REMARK 465     VAL F    11                                                      
REMARK 465     SER F    12                                                      
REMARK 465     ASP F    13                                                      
REMARK 465     ASP F    14                                                      
REMARK 465     SER F    15                                                      
REMARK 465     ALA F    16                                                      
REMARK 465     SER F    17                                                      
REMARK 465     ALA F    18                                                      
REMARK 465     GLY F    19                                                      
REMARK 465     MET G   -19                                                      
REMARK 465     ARG G   -18                                                      
REMARK 465     GLY G   -17                                                      
REMARK 465     SER G   -16                                                      
REMARK 465     HIS G   -15                                                      
REMARK 465     HIS G   -14                                                      
REMARK 465     HIS G   -13                                                      
REMARK 465     HIS G   -12                                                      
REMARK 465     HIS G   -11                                                      
REMARK 465     HIS G   -10                                                      
REMARK 465     GLY G    -9                                                      
REMARK 465     SER G    -8                                                      
REMARK 465     ALA G    -7                                                      
REMARK 465     CYS G    -6                                                      
REMARK 465     GLU G    -5                                                      
REMARK 465     LEU G    -4                                                      
REMARK 465     GLY G    -3                                                      
REMARK 465     THR G    -2                                                      
REMARK 465     PRO G    -1                                                      
REMARK 465     ASN G     0                                                      
REMARK 465     MET G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     GLU G     3                                                      
REMARK 465     GLU G     4                                                      
REMARK 465     VAL G     5                                                      
REMARK 465     SER G     6                                                      
REMARK 465     LYS G     7                                                      
REMARK 465     ASN G     8                                                      
REMARK 465     LEU G     9                                                      
REMARK 465     SER G    10                                                      
REMARK 465     GLU G    11                                                      
REMARK 465     THR G    12                                                      
REMARK 465     LEU G    13                                                      
REMARK 465     PHE G    14                                                      
REMARK 465     VAL G    15                                                      
REMARK 465     LYS G    16                                                      
REMARK 465     HIS G    17                                                      
REMARK 465     LYS G    18                                                      
REMARK 465     GLN G    19                                                      
REMARK 465     MET H   -13                                                      
REMARK 465     ARG H   -12                                                      
REMARK 465     GLY H   -11                                                      
REMARK 465     SER H   -10                                                      
REMARK 465     HIS H    -9                                                      
REMARK 465     HIS H    -8                                                      
REMARK 465     HIS H    -7                                                      
REMARK 465     HIS H    -6                                                      
REMARK 465     HIS H    -5                                                      
REMARK 465     HIS H    -4                                                      
REMARK 465     GLY H    -3                                                      
REMARK 465     SER H    -2                                                      
REMARK 465     ASP H    -1                                                      
REMARK 465     THR H     0                                                      
REMARK 465     MET H     1                                                      
REMARK 465     GLY H     2                                                      
REMARK 465     LEU H     3                                                      
REMARK 465     PHE H     4                                                      
REMARK 465     ASP H     5                                                      
REMARK 465     LYS H     6                                                      
REMARK 465     LEU H     7                                                      
REMARK 465     LYS H     8                                                      
REMARK 465     LYS H     9                                                      
REMARK 465     LEU H    10                                                      
REMARK 465     VAL H    11                                                      
REMARK 465     SER H    12                                                      
REMARK 465     ASP H    13                                                      
REMARK 465     ASP H    14                                                      
REMARK 465     SER H    15                                                      
REMARK 465     ALA H    16                                                      
REMARK 465     SER H    17                                                      
REMARK 465     ALA H    18                                                      
REMARK 465     GLY H    19                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A  21    CG   CD   CE   NZ                                   
REMARK 470     GLN A  28    CG   CD   OE1  NE2                                  
REMARK 470     GLN A  34    CG   CD   OE1  NE2                                  
REMARK 470     GLU A  39    CG   CD   OE1  OE2                                  
REMARK 470     ILE A  40    CG1  CG2  CD1                                       
REMARK 470     GLU A  42    CG   CD   OE1  OE2                                  
REMARK 470     LYS A  43    CG   CD   CE   NZ                                   
REMARK 470     GLU A 119    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 141    CG   CD   CE   NZ                                   
REMARK 470     LYS A 165    CG   CD   CE   NZ                                   
REMARK 470     LYS A 177    CG   CD   CE   NZ                                   
REMARK 470     LYS A 191    CG   CD   CE   NZ                                   
REMARK 470     LYS A 219    CG   CD   CE   NZ                                   
REMARK 470     LYS A 237    CG   CD   CE   NZ                                   
REMARK 470     GLN A 307    CG   CD   OE1  NE2                                  
REMARK 470     GLN A 310    CG   CD   OE1  NE2                                  
REMARK 470     GLN A 311    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 344    CG   CD   CE   NZ                                   
REMARK 470     ARG A 352    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 355    CG   CD   CE   NZ                                   
REMARK 470     GLU A 364    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 375    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 385    CG   CD   CE   NZ                                   
REMARK 470     LYS A 387    CG   CD   CE   NZ                                   
REMARK 470     LYS A 392    CG   CD   CE   NZ                                   
REMARK 470     GLN A 396    CG   CD   OE1  NE2                                  
REMARK 470     GLU A 399    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 400    CG   CD   OE1  NE2                                  
REMARK 470     SER A 401    OG                                                  
REMARK 470     LEU A 404    CG   CD1  CD2                                       
REMARK 470     LYS A 407    CG   CD   CE   NZ                                   
REMARK 470     LYS B 133    CG   CD   CE   NZ                                   
REMARK 470     GLN C  19    CG   CD   OE1  NE2                                  
REMARK 470     LYS C  21    CG   CD   CE   NZ                                   
REMARK 470     GLU C  42    CG   CD   OE1  OE2                                  
REMARK 470     LYS C  43    CG   CD   CE   NZ                                   
REMARK 470     GLU C 119    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 177    CG   CD   CE   NZ                                   
REMARK 470     LYS C 219    CG   CD   CE   NZ                                   
REMARK 470     LYS C 237    CG   CD   CE   NZ                                   
REMARK 470     GLN C 307    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 326    CG   CD   CE   NZ                                   
REMARK 470     VAL C 328    CG1  CG2                                            
REMARK 470     LYS C 355    CG   CD   CE   NZ                                   
REMARK 470     LYS C 387    CG   CD   CE   NZ                                   
REMARK 470     LYS C 392    CG   CD   CE   NZ                                   
REMARK 470     LYS C 407    CG   CD   CE   NZ                                   
REMARK 470     GLU D 130    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 149    CG   CD   OE1  OE2                                  
REMARK 470     GLN E  19    CG   CD   OE1  NE2                                  
REMARK 470     GLU E  39    CG   CD   OE1  OE2                                  
REMARK 470     GLU E  42    CG   CD   OE1  OE2                                  
REMARK 470     LYS E  43    CG   CD   CE   NZ                                   
REMARK 470     ASN E  44    CG   OD1                                            
REMARK 470     GLU E 108    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 112    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 141    CG   CD   CE   NZ                                   
REMARK 470     LYS E 165    CG   CD   CE   NZ                                   
REMARK 470     LYS E 177    CG   CD   CE   NZ                                   
REMARK 470     LYS E 179    CG   CD   CE   NZ                                   
REMARK 470     LYS E 219    CG   CD   CE   NZ                                   
REMARK 470     PRO E 259    CG   CD                                             
REMARK 470     TYR E 260    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS E 290    CG   CD   CE   NZ                                   
REMARK 470     GLN E 307    CG   CD   OE1  NE2                                  
REMARK 470     SER E 350    OG                                                  
REMARK 470     LYS E 355    CG   CD   CE   NZ                                   
REMARK 470     LYS E 385    CG   CD   CE   NZ                                   
REMARK 470     LYS E 387    CG   CD   CE   NZ                                   
REMARK 470     LYS E 392    CG   CD   CE   NZ                                   
REMARK 470     GLN E 396    CG   CD   OE1  NE2                                  
REMARK 470     TYR E 398    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN E 400    CG   CD   OE1  NE2                                  
REMARK 470     ASP E 403    CG   OD1  OD2                                       
REMARK 470     LYS E 407    CG   CD   CE   NZ                                   
REMARK 470     GLU F  30    CG   CD   OE1  OE2                                  
REMARK 470     LYS G  21    CG   CD   CE   NZ                                   
REMARK 470     LYS G  43    CG   CD   CE   NZ                                   
REMARK 470     GLU G 115    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 141    CG   CD   CE   NZ                                   
REMARK 470     GLN G 148    CG   CD   OE1  NE2                                  
REMARK 470     LYS G 177    CG   CD   CE   NZ                                   
REMARK 470     LYS G 219    CG   CD   CE   NZ                                   
REMARK 470     LYS G 237    CG   CD   CE   NZ                                   
REMARK 470     GLU G 242    CG   CD   OE1  OE2                                  
REMARK 470     GLN G 337    CG   CD   OE1  NE2                                  
REMARK 470     LYS G 385    CG   CD   CE   NZ                                   
REMARK 470     LYS G 392    CG   CD   CE   NZ                                   
REMARK 470     LYS G 407    CG   CD   CE   NZ                                   
REMARK 470     ARG G 415    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H 148    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU D  27   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU H  88   CA  -  CB  -  CG  ANGL. DEV. =  15.4 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A  23      -61.19    -23.33                                   
REMARK 500    GLU A  42        2.78    -60.12                                   
REMARK 500    PHE A  46      124.12     52.17                                   
REMARK 500    ARG A  53       55.79   -119.69                                   
REMARK 500    LEU A  87       -7.53    -59.13                                   
REMARK 500    THR A  89       40.78   -104.20                                   
REMARK 500    GLU A 115       47.49   -144.19                                   
REMARK 500    THR A 117     -164.97    -64.16                                   
REMARK 500    PHE A 175      142.72   -171.69                                   
REMARK 500    GLU A 176       59.26     31.80                                   
REMARK 500    THR A 189       45.09   -105.00                                   
REMARK 500    ASP A 190      -82.45    -84.78                                   
REMARK 500    ALA A 200     -154.91    -98.36                                   
REMARK 500    HIS A 216      -40.98   -145.48                                   
REMARK 500    SER A 231       -4.50     89.60                                   
REMARK 500    HIS A 263        0.85    -59.83                                   
REMARK 500    ARG A 272     -137.97     48.38                                   
REMARK 500    GLU A 285       40.22   -140.25                                   
REMARK 500    ILE A 299      -70.47    -69.06                                   
REMARK 500    HIS A 300      -57.26   -125.43                                   
REMARK 500    ASP A 301      -72.78    -31.05                                   
REMARK 500    SER A 305       78.31   -174.71                                   
REMARK 500    MET A 312      163.18    -38.30                                   
REMARK 500    MET A 338      -23.95    -38.46                                   
REMARK 500    PHE A 348      -35.23    -36.28                                   
REMARK 500    SER A 350      -66.77    167.14                                   
REMARK 500    SER A 351      -71.39   -109.51                                   
REMARK 500    PHE A 380       30.76    -68.80                                   
REMARK 500    LYS A 392      106.30    -47.55                                   
REMARK 500    THR A 393       71.47     49.45                                   
REMARK 500    TYR A 398      -60.42   -171.17                                   
REMARK 500    ASN B  58       15.39   -146.69                                   
REMARK 500    ASN B 143       60.25   -112.25                                   
REMARK 500    GLU B 161      -63.65   -125.04                                   
REMARK 500    ASP C  38        1.41    -65.46                                   
REMARK 500    SER C  47     -159.68   -153.36                                   
REMARK 500    ARG C  53       54.20   -112.48                                   
REMARK 500    SER C  95      139.48    -37.82                                   
REMARK 500    ASN C 118      -54.79    -23.27                                   
REMARK 500    GLU C 176       75.90     37.02                                   
REMARK 500    ASN C 188     -161.36   -175.27                                   
REMARK 500    LYS C 191      166.43    175.03                                   
REMARK 500    HIS C 216      -55.27   -135.23                                   
REMARK 500    THR C 241     -158.30    -63.44                                   
REMARK 500    ASP C 243       57.94   -105.52                                   
REMARK 500    HIS C 263        5.04    -66.49                                   
REMARK 500    ARG C 272     -134.57     48.95                                   
REMARK 500    HIS C 300      -61.29   -149.73                                   
REMARK 500    LYS C 326     -174.27    -49.15                                   
REMARK 500    SER C 327     -115.83   -114.81                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      96 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH A 421        DISTANCE =  5.54 ANGSTROMS                       
REMARK 525    HOH A 445        DISTANCE =  5.55 ANGSTROMS                       
REMARK 525    HOH A 446        DISTANCE =  5.11 ANGSTROMS                       
REMARK 525    HOH A 535        DISTANCE =  6.95 ANGSTROMS                       
REMARK 525    HOH A 564        DISTANCE =  5.82 ANGSTROMS                       
REMARK 525    HOH A 927        DISTANCE =  6.34 ANGSTROMS                       
REMARK 525    HOH A 930        DISTANCE =  5.17 ANGSTROMS                       
REMARK 525    HOH B 394        DISTANCE =  5.74 ANGSTROMS                       
REMARK 525    HOH B 667        DISTANCE =  5.34 ANGSTROMS                       
REMARK 525    HOH B 669        DISTANCE =  5.12 ANGSTROMS                       
REMARK 525    HOH B 923        DISTANCE =  5.42 ANGSTROMS                       
REMARK 525    HOH C 416        DISTANCE =  5.52 ANGSTROMS                       
REMARK 525    HOH C 469        DISTANCE =  5.02 ANGSTROMS                       
REMARK 525    HOH C 471        DISTANCE =  5.46 ANGSTROMS                       
REMARK 525    HOH C 502        DISTANCE =  5.06 ANGSTROMS                       
REMARK 525    HOH C 504        DISTANCE =  5.10 ANGSTROMS                       
REMARK 525    HOH C 522        DISTANCE =  5.19 ANGSTROMS                       
REMARK 525    HOH C 528        DISTANCE =  6.59 ANGSTROMS                       
REMARK 525    HOH C 531        DISTANCE =  6.03 ANGSTROMS                       
REMARK 525    HOH C 532        DISTANCE =  5.21 ANGSTROMS                       
REMARK 525    HOH C 534        DISTANCE =  5.79 ANGSTROMS                       
REMARK 525    HOH C 535        DISTANCE =  5.80 ANGSTROMS                       
REMARK 525    HOH C 539        DISTANCE =  6.69 ANGSTROMS                       
REMARK 525    HOH C 544        DISTANCE =  5.11 ANGSTROMS                       
REMARK 525    HOH C 550        DISTANCE =  6.81 ANGSTROMS                       
REMARK 525    HOH C 626        DISTANCE =  5.10 ANGSTROMS                       
REMARK 525    HOH C 634        DISTANCE =  5.12 ANGSTROMS                       
REMARK 525    HOH C 828        DISTANCE =  6.25 ANGSTROMS                       
REMARK 525    HOH C 864        DISTANCE =  5.10 ANGSTROMS                       
REMARK 525    HOH D 566        DISTANCE =  5.24 ANGSTROMS                       
REMARK 525    HOH D 727        DISTANCE =  5.16 ANGSTROMS                       
REMARK 525    HOH E 440        DISTANCE =  5.02 ANGSTROMS                       
REMARK 525    HOH E 443        DISTANCE =  5.35 ANGSTROMS                       
REMARK 525    HOH E 582        DISTANCE =  5.59 ANGSTROMS                       
REMARK 525    HOH E 587        DISTANCE =  5.04 ANGSTROMS                       
REMARK 525    HOH E 591        DISTANCE =  5.36 ANGSTROMS                       
REMARK 525    HOH E 601        DISTANCE =  5.76 ANGSTROMS                       
REMARK 525    HOH E 618        DISTANCE =  5.05 ANGSTROMS                       
REMARK 525    HOH E 826        DISTANCE =  6.04 ANGSTROMS                       
REMARK 525    HOH E 837        DISTANCE =  5.25 ANGSTROMS                       
REMARK 525    HOH G 449        DISTANCE =  7.67 ANGSTROMS                       
REMARK 525    HOH G 461        DISTANCE =  5.82 ANGSTROMS                       
REMARK 525    HOH G 462        DISTANCE =  5.82 ANGSTROMS                       
REMARK 525    HOH G 466        DISTANCE =  5.16 ANGSTROMS                       
REMARK 525    HOH G 469        DISTANCE =  5.28 ANGSTROMS                       
REMARK 525    HOH G 483        DISTANCE =  6.57 ANGSTROMS                       
REMARK 525    HOH G 484        DISTANCE =  5.81 ANGSTROMS                       
REMARK 525    HOH G 519        DISTANCE =  5.75 ANGSTROMS                       
REMARK 525    HOH G 520        DISTANCE =  6.16 ANGSTROMS                       
REMARK 525    HOH G 526        DISTANCE =  5.25 ANGSTROMS                       
REMARK 525    HOH G 674        DISTANCE =  5.09 ANGSTROMS                       
REMARK 525    HOH G 693        DISTANCE =  5.86 ANGSTROMS                       
REMARK 525    HOH H 486        DISTANCE =  6.08 ANGSTROMS                       
REMARK 525    HOH H 504        DISTANCE =  5.74 ANGSTROMS                       
REMARK 525    HOH H 515        DISTANCE =  5.48 ANGSTROMS                       
DBREF  3OUR A    1   415  UNP    Q8DF91   Y328_VIBVU       1    415             
DBREF  3OUR B    1   169  UNP    Q8DFJ9   Q8DFJ9_VIBVU     1    169             
DBREF  3OUR C    1   415  UNP    Q8DF91   Y328_VIBVU       1    415             
DBREF  3OUR D    1   169  UNP    Q8DFJ9   Q8DFJ9_VIBVU     1    169             
DBREF  3OUR E    1   415  UNP    Q8DF91   Y328_VIBVU       1    415             
DBREF  3OUR F    1   169  UNP    Q8DFJ9   Q8DFJ9_VIBVU     1    169             
DBREF  3OUR G    1   415  UNP    Q8DF91   Y328_VIBVU       1    415             
DBREF  3OUR H    1   169  UNP    Q8DFJ9   Q8DFJ9_VIBVU     1    169             
SEQADV 3OUR MET A  -19  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ARG A  -18  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY A  -17  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER A  -16  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS A  -15  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS A  -14  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS A  -13  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS A  -12  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS A  -11  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS A  -10  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY A   -9  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER A   -8  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ALA A   -7  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR CYS A   -6  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLU A   -5  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR LEU A   -4  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY A   -3  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR THR A   -2  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR PRO A   -1  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ASN A    0  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR MET B  -13  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ARG B  -12  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY B  -11  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER B  -10  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS B   -9  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS B   -8  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS B   -7  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS B   -6  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS B   -5  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS B   -4  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY B   -3  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER B   -2  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ASP B   -1  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR THR B    0  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR MET C  -19  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ARG C  -18  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY C  -17  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER C  -16  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS C  -15  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS C  -14  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS C  -13  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS C  -12  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS C  -11  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS C  -10  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY C   -9  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER C   -8  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ALA C   -7  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR CYS C   -6  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLU C   -5  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR LEU C   -4  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY C   -3  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR THR C   -2  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR PRO C   -1  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ASN C    0  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR MET D  -13  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ARG D  -12  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY D  -11  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER D  -10  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS D   -9  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS D   -8  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS D   -7  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS D   -6  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS D   -5  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS D   -4  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY D   -3  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER D   -2  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ASP D   -1  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR THR D    0  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR MET E  -19  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ARG E  -18  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY E  -17  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER E  -16  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS E  -15  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS E  -14  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS E  -13  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS E  -12  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS E  -11  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS E  -10  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY E   -9  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER E   -8  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ALA E   -7  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR CYS E   -6  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLU E   -5  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR LEU E   -4  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY E   -3  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR THR E   -2  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR PRO E   -1  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ASN E    0  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR MET F  -13  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ARG F  -12  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY F  -11  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER F  -10  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS F   -9  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS F   -8  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS F   -7  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS F   -6  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS F   -5  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS F   -4  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY F   -3  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER F   -2  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ASP F   -1  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR THR F    0  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR MET G  -19  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ARG G  -18  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY G  -17  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER G  -16  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS G  -15  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS G  -14  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS G  -13  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS G  -12  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS G  -11  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR HIS G  -10  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY G   -9  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR SER G   -8  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ALA G   -7  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR CYS G   -6  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLU G   -5  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR LEU G   -4  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR GLY G   -3  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR THR G   -2  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR PRO G   -1  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR ASN G    0  UNP  Q8DF91              EXPRESSION TAG                 
SEQADV 3OUR MET H  -13  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ARG H  -12  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY H  -11  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER H  -10  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS H   -9  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS H   -8  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS H   -7  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS H   -6  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS H   -5  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR HIS H   -4  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR GLY H   -3  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR SER H   -2  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR ASP H   -1  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQADV 3OUR THR H    0  UNP  Q8DFJ9              EXPRESSION TAG                 
SEQRES   1 A  435  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ALA          
SEQRES   2 A  435  CYS GLU LEU GLY THR PRO ASN MET SER GLU GLU VAL SER          
SEQRES   3 A  435  LYS ASN LEU SER GLU THR LEU PHE VAL LYS HIS LYS GLN          
SEQRES   4 A  435  ALA LYS GLU THR SER ALA LEU THR GLN TYR MET PRO THR          
SEQRES   5 A  435  SER GLN SER LEU LEU ASP GLU ILE LYS GLU LYS ASN GLY          
SEQRES   6 A  435  PHE SER TRP TYR ARG ASN LEU ARG ARG LEU GLN TRP VAL          
SEQRES   7 A  435  TRP GLN GLY VAL ASP PRO ILE GLU GLN GLU GLN VAL LEU          
SEQRES   8 A  435  ALA ARG ILE ALA SER SER LYS HIS SER ARG THR ASP GLU          
SEQRES   9 A  435  GLN TRP LEU ASP THR VAL MET GLY TYR HIS SER GLY ASN          
SEQRES  10 A  435  TRP ALA TYR GLU TRP THR ARG LEU GLY MET GLU HIS GLN          
SEQRES  11 A  435  LYS ARG ALA GLY GLU MET THR ASN GLU ALA ALA SER GLU          
SEQRES  12 A  435  ALA LEU PHE SER ALA SER LEU CYS TYR SER ILE ALA GLY          
SEQRES  13 A  435  TYR PRO HIS LEU LYS SER ASP ASN LEU ALA ILE GLN ALA          
SEQRES  14 A  435  GLN VAL LEU ALA ASN SER ALA TYR LEU GLU ALA ALA LYS          
SEQRES  15 A  435  LYS SER LYS TYR ILE ILE LYS GLN LEU GLU ILE PRO PHE          
SEQRES  16 A  435  GLU LYS GLY LYS ILE THR ALA HIS LEU HIS LEU THR ASN          
SEQRES  17 A  435  THR ASP LYS PRO HIS PRO VAL VAL ILE VAL SER ALA GLY          
SEQRES  18 A  435  LEU ASP SER LEU GLN THR ASP MET TRP ARG LEU PHE ARG          
SEQRES  19 A  435  ASP HIS LEU ALA LYS HIS ASP ILE ALA MET LEU THR VAL          
SEQRES  20 A  435  ASP MET PRO SER VAL GLY TYR SER SER LYS TYR PRO LEU          
SEQRES  21 A  435  THR GLU ASP TYR SER ARG LEU HIS GLN ALA VAL LEU ASN          
SEQRES  22 A  435  GLU LEU PHE SER ILE PRO TYR VAL ASP HIS HIS ARG VAL          
SEQRES  23 A  435  GLY LEU ILE GLY PHE ARG PHE GLY GLY ASN ALA MET VAL          
SEQRES  24 A  435  ARG LEU SER PHE LEU GLU GLN GLU LYS ILE LYS ALA CYS          
SEQRES  25 A  435  VAL ILE LEU GLY ALA PRO ILE HIS ASP ILE PHE ALA SER          
SEQRES  26 A  435  PRO GLN LYS LEU GLN GLN MET PRO LYS MET TYR LEU ASP          
SEQRES  27 A  435  VAL LEU ALA SER ARG LEU GLY LYS SER VAL VAL ASP ILE          
SEQRES  28 A  435  TYR SER LEU SER GLY GLN MET ALA ALA TRP SER LEU LYS          
SEQRES  29 A  435  VAL GLN GLY PHE LEU SER SER ARG LYS THR LYS VAL PRO          
SEQRES  30 A  435  ILE LEU ALA MET SER LEU GLU GLY ASP PRO VAL SER PRO          
SEQRES  31 A  435  TYR SER ASP ASN GLN MET VAL ALA PHE PHE SER THR TYR          
SEQRES  32 A  435  GLY LYS ALA LYS LYS ILE SER SER LYS THR ILE THR GLN          
SEQRES  33 A  435  GLY TYR GLU GLN SER LEU ASP LEU ALA ILE LYS TRP LEU          
SEQRES  34 A  435  GLU ASP GLU LEU LEU ARG                                      
SEQRES   1 B  183  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ASP          
SEQRES   2 B  183  THR MET GLY LEU PHE ASP LYS LEU LYS LYS LEU VAL SER          
SEQRES   3 B  183  ASP ASP SER ALA SER ALA GLY ALA ILE GLU ILE ILE ALA          
SEQRES   4 B  183  PRO LEU SER GLY GLU ILE VAL ASN ILE GLU ASP VAL PRO          
SEQRES   5 B  183  ASP VAL VAL PHE ALA GLU LYS ILE VAL GLY ASP GLY ILE          
SEQRES   6 B  183  ALA ILE LYS PRO THR GLY ASN LYS MET VAL ALA PRO VAL          
SEQRES   7 B  183  ASN GLY THR ILE GLY LYS ILE PHE GLU THR ASN HIS ALA          
SEQRES   8 B  183  PHE SER ILE GLU SER ASP ASP GLY VAL GLU LEU PHE VAL          
SEQRES   9 B  183  HIS PHE GLY ILE ASP THR VAL GLU LEU LYS GLY GLU GLY          
SEQRES  10 B  183  PHE THR ARG ILE ALA GLU GLU GLY GLN THR VAL LYS ALA          
SEQRES  11 B  183  GLY ASP THR VAL ILE GLU PHE ASP LEU ALA LEU LEU GLU          
SEQRES  12 B  183  GLU LYS ALA LYS SER THR LEU THR PRO VAL VAL ILE SER          
SEQRES  13 B  183  ASN MET ASP GLU ILE LYS GLU LEU ASN LYS LEU SER GLY          
SEQRES  14 B  183  SER VAL VAL VAL GLY GLU THR PRO VAL LEU ARG VAL THR          
SEQRES  15 B  183  LYS                                                          
SEQRES   1 C  435  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ALA          
SEQRES   2 C  435  CYS GLU LEU GLY THR PRO ASN MET SER GLU GLU VAL SER          
SEQRES   3 C  435  LYS ASN LEU SER GLU THR LEU PHE VAL LYS HIS LYS GLN          
SEQRES   4 C  435  ALA LYS GLU THR SER ALA LEU THR GLN TYR MET PRO THR          
SEQRES   5 C  435  SER GLN SER LEU LEU ASP GLU ILE LYS GLU LYS ASN GLY          
SEQRES   6 C  435  PHE SER TRP TYR ARG ASN LEU ARG ARG LEU GLN TRP VAL          
SEQRES   7 C  435  TRP GLN GLY VAL ASP PRO ILE GLU GLN GLU GLN VAL LEU          
SEQRES   8 C  435  ALA ARG ILE ALA SER SER LYS HIS SER ARG THR ASP GLU          
SEQRES   9 C  435  GLN TRP LEU ASP THR VAL MET GLY TYR HIS SER GLY ASN          
SEQRES  10 C  435  TRP ALA TYR GLU TRP THR ARG LEU GLY MET GLU HIS GLN          
SEQRES  11 C  435  LYS ARG ALA GLY GLU MET THR ASN GLU ALA ALA SER GLU          
SEQRES  12 C  435  ALA LEU PHE SER ALA SER LEU CYS TYR SER ILE ALA GLY          
SEQRES  13 C  435  TYR PRO HIS LEU LYS SER ASP ASN LEU ALA ILE GLN ALA          
SEQRES  14 C  435  GLN VAL LEU ALA ASN SER ALA TYR LEU GLU ALA ALA LYS          
SEQRES  15 C  435  LYS SER LYS TYR ILE ILE LYS GLN LEU GLU ILE PRO PHE          
SEQRES  16 C  435  GLU LYS GLY LYS ILE THR ALA HIS LEU HIS LEU THR ASN          
SEQRES  17 C  435  THR ASP LYS PRO HIS PRO VAL VAL ILE VAL SER ALA GLY          
SEQRES  18 C  435  LEU ASP SER LEU GLN THR ASP MET TRP ARG LEU PHE ARG          
SEQRES  19 C  435  ASP HIS LEU ALA LYS HIS ASP ILE ALA MET LEU THR VAL          
SEQRES  20 C  435  ASP MET PRO SER VAL GLY TYR SER SER LYS TYR PRO LEU          
SEQRES  21 C  435  THR GLU ASP TYR SER ARG LEU HIS GLN ALA VAL LEU ASN          
SEQRES  22 C  435  GLU LEU PHE SER ILE PRO TYR VAL ASP HIS HIS ARG VAL          
SEQRES  23 C  435  GLY LEU ILE GLY PHE ARG PHE GLY GLY ASN ALA MET VAL          
SEQRES  24 C  435  ARG LEU SER PHE LEU GLU GLN GLU LYS ILE LYS ALA CYS          
SEQRES  25 C  435  VAL ILE LEU GLY ALA PRO ILE HIS ASP ILE PHE ALA SER          
SEQRES  26 C  435  PRO GLN LYS LEU GLN GLN MET PRO LYS MET TYR LEU ASP          
SEQRES  27 C  435  VAL LEU ALA SER ARG LEU GLY LYS SER VAL VAL ASP ILE          
SEQRES  28 C  435  TYR SER LEU SER GLY GLN MET ALA ALA TRP SER LEU LYS          
SEQRES  29 C  435  VAL GLN GLY PHE LEU SER SER ARG LYS THR LYS VAL PRO          
SEQRES  30 C  435  ILE LEU ALA MET SER LEU GLU GLY ASP PRO VAL SER PRO          
SEQRES  31 C  435  TYR SER ASP ASN GLN MET VAL ALA PHE PHE SER THR TYR          
SEQRES  32 C  435  GLY LYS ALA LYS LYS ILE SER SER LYS THR ILE THR GLN          
SEQRES  33 C  435  GLY TYR GLU GLN SER LEU ASP LEU ALA ILE LYS TRP LEU          
SEQRES  34 C  435  GLU ASP GLU LEU LEU ARG                                      
SEQRES   1 D  183  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ASP          
SEQRES   2 D  183  THR MET GLY LEU PHE ASP LYS LEU LYS LYS LEU VAL SER          
SEQRES   3 D  183  ASP ASP SER ALA SER ALA GLY ALA ILE GLU ILE ILE ALA          
SEQRES   4 D  183  PRO LEU SER GLY GLU ILE VAL ASN ILE GLU ASP VAL PRO          
SEQRES   5 D  183  ASP VAL VAL PHE ALA GLU LYS ILE VAL GLY ASP GLY ILE          
SEQRES   6 D  183  ALA ILE LYS PRO THR GLY ASN LYS MET VAL ALA PRO VAL          
SEQRES   7 D  183  ASN GLY THR ILE GLY LYS ILE PHE GLU THR ASN HIS ALA          
SEQRES   8 D  183  PHE SER ILE GLU SER ASP ASP GLY VAL GLU LEU PHE VAL          
SEQRES   9 D  183  HIS PHE GLY ILE ASP THR VAL GLU LEU LYS GLY GLU GLY          
SEQRES  10 D  183  PHE THR ARG ILE ALA GLU GLU GLY GLN THR VAL LYS ALA          
SEQRES  11 D  183  GLY ASP THR VAL ILE GLU PHE ASP LEU ALA LEU LEU GLU          
SEQRES  12 D  183  GLU LYS ALA LYS SER THR LEU THR PRO VAL VAL ILE SER          
SEQRES  13 D  183  ASN MET ASP GLU ILE LYS GLU LEU ASN LYS LEU SER GLY          
SEQRES  14 D  183  SER VAL VAL VAL GLY GLU THR PRO VAL LEU ARG VAL THR          
SEQRES  15 D  183  LYS                                                          
SEQRES   1 E  435  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ALA          
SEQRES   2 E  435  CYS GLU LEU GLY THR PRO ASN MET SER GLU GLU VAL SER          
SEQRES   3 E  435  LYS ASN LEU SER GLU THR LEU PHE VAL LYS HIS LYS GLN          
SEQRES   4 E  435  ALA LYS GLU THR SER ALA LEU THR GLN TYR MET PRO THR          
SEQRES   5 E  435  SER GLN SER LEU LEU ASP GLU ILE LYS GLU LYS ASN GLY          
SEQRES   6 E  435  PHE SER TRP TYR ARG ASN LEU ARG ARG LEU GLN TRP VAL          
SEQRES   7 E  435  TRP GLN GLY VAL ASP PRO ILE GLU GLN GLU GLN VAL LEU          
SEQRES   8 E  435  ALA ARG ILE ALA SER SER LYS HIS SER ARG THR ASP GLU          
SEQRES   9 E  435  GLN TRP LEU ASP THR VAL MET GLY TYR HIS SER GLY ASN          
SEQRES  10 E  435  TRP ALA TYR GLU TRP THR ARG LEU GLY MET GLU HIS GLN          
SEQRES  11 E  435  LYS ARG ALA GLY GLU MET THR ASN GLU ALA ALA SER GLU          
SEQRES  12 E  435  ALA LEU PHE SER ALA SER LEU CYS TYR SER ILE ALA GLY          
SEQRES  13 E  435  TYR PRO HIS LEU LYS SER ASP ASN LEU ALA ILE GLN ALA          
SEQRES  14 E  435  GLN VAL LEU ALA ASN SER ALA TYR LEU GLU ALA ALA LYS          
SEQRES  15 E  435  LYS SER LYS TYR ILE ILE LYS GLN LEU GLU ILE PRO PHE          
SEQRES  16 E  435  GLU LYS GLY LYS ILE THR ALA HIS LEU HIS LEU THR ASN          
SEQRES  17 E  435  THR ASP LYS PRO HIS PRO VAL VAL ILE VAL SER ALA GLY          
SEQRES  18 E  435  LEU ASP SER LEU GLN THR ASP MET TRP ARG LEU PHE ARG          
SEQRES  19 E  435  ASP HIS LEU ALA LYS HIS ASP ILE ALA MET LEU THR VAL          
SEQRES  20 E  435  ASP MET PRO SER VAL GLY TYR SER SER LYS TYR PRO LEU          
SEQRES  21 E  435  THR GLU ASP TYR SER ARG LEU HIS GLN ALA VAL LEU ASN          
SEQRES  22 E  435  GLU LEU PHE SER ILE PRO TYR VAL ASP HIS HIS ARG VAL          
SEQRES  23 E  435  GLY LEU ILE GLY PHE ARG PHE GLY GLY ASN ALA MET VAL          
SEQRES  24 E  435  ARG LEU SER PHE LEU GLU GLN GLU LYS ILE LYS ALA CYS          
SEQRES  25 E  435  VAL ILE LEU GLY ALA PRO ILE HIS ASP ILE PHE ALA SER          
SEQRES  26 E  435  PRO GLN LYS LEU GLN GLN MET PRO LYS MET TYR LEU ASP          
SEQRES  27 E  435  VAL LEU ALA SER ARG LEU GLY LYS SER VAL VAL ASP ILE          
SEQRES  28 E  435  TYR SER LEU SER GLY GLN MET ALA ALA TRP SER LEU LYS          
SEQRES  29 E  435  VAL GLN GLY PHE LEU SER SER ARG LYS THR LYS VAL PRO          
SEQRES  30 E  435  ILE LEU ALA MET SER LEU GLU GLY ASP PRO VAL SER PRO          
SEQRES  31 E  435  TYR SER ASP ASN GLN MET VAL ALA PHE PHE SER THR TYR          
SEQRES  32 E  435  GLY LYS ALA LYS LYS ILE SER SER LYS THR ILE THR GLN          
SEQRES  33 E  435  GLY TYR GLU GLN SER LEU ASP LEU ALA ILE LYS TRP LEU          
SEQRES  34 E  435  GLU ASP GLU LEU LEU ARG                                      
SEQRES   1 F  183  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ASP          
SEQRES   2 F  183  THR MET GLY LEU PHE ASP LYS LEU LYS LYS LEU VAL SER          
SEQRES   3 F  183  ASP ASP SER ALA SER ALA GLY ALA ILE GLU ILE ILE ALA          
SEQRES   4 F  183  PRO LEU SER GLY GLU ILE VAL ASN ILE GLU ASP VAL PRO          
SEQRES   5 F  183  ASP VAL VAL PHE ALA GLU LYS ILE VAL GLY ASP GLY ILE          
SEQRES   6 F  183  ALA ILE LYS PRO THR GLY ASN LYS MET VAL ALA PRO VAL          
SEQRES   7 F  183  ASN GLY THR ILE GLY LYS ILE PHE GLU THR ASN HIS ALA          
SEQRES   8 F  183  PHE SER ILE GLU SER ASP ASP GLY VAL GLU LEU PHE VAL          
SEQRES   9 F  183  HIS PHE GLY ILE ASP THR VAL GLU LEU LYS GLY GLU GLY          
SEQRES  10 F  183  PHE THR ARG ILE ALA GLU GLU GLY GLN THR VAL LYS ALA          
SEQRES  11 F  183  GLY ASP THR VAL ILE GLU PHE ASP LEU ALA LEU LEU GLU          
SEQRES  12 F  183  GLU LYS ALA LYS SER THR LEU THR PRO VAL VAL ILE SER          
SEQRES  13 F  183  ASN MET ASP GLU ILE LYS GLU LEU ASN LYS LEU SER GLY          
SEQRES  14 F  183  SER VAL VAL VAL GLY GLU THR PRO VAL LEU ARG VAL THR          
SEQRES  15 F  183  LYS                                                          
SEQRES   1 G  435  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ALA          
SEQRES   2 G  435  CYS GLU LEU GLY THR PRO ASN MET SER GLU GLU VAL SER          
SEQRES   3 G  435  LYS ASN LEU SER GLU THR LEU PHE VAL LYS HIS LYS GLN          
SEQRES   4 G  435  ALA LYS GLU THR SER ALA LEU THR GLN TYR MET PRO THR          
SEQRES   5 G  435  SER GLN SER LEU LEU ASP GLU ILE LYS GLU LYS ASN GLY          
SEQRES   6 G  435  PHE SER TRP TYR ARG ASN LEU ARG ARG LEU GLN TRP VAL          
SEQRES   7 G  435  TRP GLN GLY VAL ASP PRO ILE GLU GLN GLU GLN VAL LEU          
SEQRES   8 G  435  ALA ARG ILE ALA SER SER LYS HIS SER ARG THR ASP GLU          
SEQRES   9 G  435  GLN TRP LEU ASP THR VAL MET GLY TYR HIS SER GLY ASN          
SEQRES  10 G  435  TRP ALA TYR GLU TRP THR ARG LEU GLY MET GLU HIS GLN          
SEQRES  11 G  435  LYS ARG ALA GLY GLU MET THR ASN GLU ALA ALA SER GLU          
SEQRES  12 G  435  ALA LEU PHE SER ALA SER LEU CYS TYR SER ILE ALA GLY          
SEQRES  13 G  435  TYR PRO HIS LEU LYS SER ASP ASN LEU ALA ILE GLN ALA          
SEQRES  14 G  435  GLN VAL LEU ALA ASN SER ALA TYR LEU GLU ALA ALA LYS          
SEQRES  15 G  435  LYS SER LYS TYR ILE ILE LYS GLN LEU GLU ILE PRO PHE          
SEQRES  16 G  435  GLU LYS GLY LYS ILE THR ALA HIS LEU HIS LEU THR ASN          
SEQRES  17 G  435  THR ASP LYS PRO HIS PRO VAL VAL ILE VAL SER ALA GLY          
SEQRES  18 G  435  LEU ASP SER LEU GLN THR ASP MET TRP ARG LEU PHE ARG          
SEQRES  19 G  435  ASP HIS LEU ALA LYS HIS ASP ILE ALA MET LEU THR VAL          
SEQRES  20 G  435  ASP MET PRO SER VAL GLY TYR SER SER LYS TYR PRO LEU          
SEQRES  21 G  435  THR GLU ASP TYR SER ARG LEU HIS GLN ALA VAL LEU ASN          
SEQRES  22 G  435  GLU LEU PHE SER ILE PRO TYR VAL ASP HIS HIS ARG VAL          
SEQRES  23 G  435  GLY LEU ILE GLY PHE ARG PHE GLY GLY ASN ALA MET VAL          
SEQRES  24 G  435  ARG LEU SER PHE LEU GLU GLN GLU LYS ILE LYS ALA CYS          
SEQRES  25 G  435  VAL ILE LEU GLY ALA PRO ILE HIS ASP ILE PHE ALA SER          
SEQRES  26 G  435  PRO GLN LYS LEU GLN GLN MET PRO LYS MET TYR LEU ASP          
SEQRES  27 G  435  VAL LEU ALA SER ARG LEU GLY LYS SER VAL VAL ASP ILE          
SEQRES  28 G  435  TYR SER LEU SER GLY GLN MET ALA ALA TRP SER LEU LYS          
SEQRES  29 G  435  VAL GLN GLY PHE LEU SER SER ARG LYS THR LYS VAL PRO          
SEQRES  30 G  435  ILE LEU ALA MET SER LEU GLU GLY ASP PRO VAL SER PRO          
SEQRES  31 G  435  TYR SER ASP ASN GLN MET VAL ALA PHE PHE SER THR TYR          
SEQRES  32 G  435  GLY LYS ALA LYS LYS ILE SER SER LYS THR ILE THR GLN          
SEQRES  33 G  435  GLY TYR GLU GLN SER LEU ASP LEU ALA ILE LYS TRP LEU          
SEQRES  34 G  435  GLU ASP GLU LEU LEU ARG                                      
SEQRES   1 H  183  MET ARG GLY SER HIS HIS HIS HIS HIS HIS GLY SER ASP          
SEQRES   2 H  183  THR MET GLY LEU PHE ASP LYS LEU LYS LYS LEU VAL SER          
SEQRES   3 H  183  ASP ASP SER ALA SER ALA GLY ALA ILE GLU ILE ILE ALA          
SEQRES   4 H  183  PRO LEU SER GLY GLU ILE VAL ASN ILE GLU ASP VAL PRO          
SEQRES   5 H  183  ASP VAL VAL PHE ALA GLU LYS ILE VAL GLY ASP GLY ILE          
SEQRES   6 H  183  ALA ILE LYS PRO THR GLY ASN LYS MET VAL ALA PRO VAL          
SEQRES   7 H  183  ASN GLY THR ILE GLY LYS ILE PHE GLU THR ASN HIS ALA          
SEQRES   8 H  183  PHE SER ILE GLU SER ASP ASP GLY VAL GLU LEU PHE VAL          
SEQRES   9 H  183  HIS PHE GLY ILE ASP THR VAL GLU LEU LYS GLY GLU GLY          
SEQRES  10 H  183  PHE THR ARG ILE ALA GLU GLU GLY GLN THR VAL LYS ALA          
SEQRES  11 H  183  GLY ASP THR VAL ILE GLU PHE ASP LEU ALA LEU LEU GLU          
SEQRES  12 H  183  GLU LYS ALA LYS SER THR LEU THR PRO VAL VAL ILE SER          
SEQRES  13 H  183  ASN MET ASP GLU ILE LYS GLU LEU ASN LYS LEU SER GLY          
SEQRES  14 H  183  SER VAL VAL VAL GLY GLU THR PRO VAL LEU ARG VAL THR          
SEQRES  15 H  183  LYS                                                          
FORMUL   9  HOH   *927(H2 O)                                                    
HELIX    1   1 GLU A   22  LEU A   26  5                                   5    
HELIX    2   2 MET A   30  GLY A   45  1                                  16    
HELIX    3   3 ARG A   53  GLN A   60  1                                   8    
HELIX    4   4 ASP A   63  SER A   77  1                                  15    
HELIX    5   5 ASN A   97  ARG A  112  1                                  16    
HELIX    6   6 ALA A  113  MET A  116  5                                   4    
HELIX    7   7 THR A  117  TYR A  137  1                                  21    
HELIX    8   8 ASP A  143  LYS A  163  1                                  21    
HELIX    9   9 LEU A  205  ASP A  208  5                                   4    
HELIX   10  10 MET A  209  ASP A  215  1                                   7    
HELIX   11  11 LEU A  217  ASP A  221  5                                   5    
HELIX   12  12 VAL A  232  SER A  236  5                                   5    
HELIX   13  13 SER A  245  LEU A  255  1                                  11    
HELIX   14  14 PHE A  256  ILE A  258  5                                   3    
HELIX   15  15 ARG A  272  GLU A  285  1                                  14    
HELIX   16  16 GLN A  286  ILE A  289  5                                   4    
HELIX   17  17 HIS A  300  ALA A  304  5                                   5    
HELIX   18  18 SER A  305  GLN A  310  1                                   6    
HELIX   19  19 PRO A  313  LEU A  324  1                                  12    
HELIX   20  20 ASP A  330  MET A  338  1                                   9    
HELIX   21  21 ALA A  339  SER A  342  5                                   4    
HELIX   22  22 SER A  372  PHE A  380  1                                   9    
HELIX   23  23 THR A  395  LEU A  413  1                                  19    
HELIX   24  24 GLU B   35  VAL B   37  5                                   3    
HELIX   25  25 ASP B   39  GLU B   44  1                                   6    
HELIX   26  26 ASP B   95  LYS B  100  5                                   6    
HELIX   27  27 ASP B  124  ALA B  132  1                                   9    
HELIX   28  28 ASN B  143  ILE B  147  5                                   5    
HELIX   29  29 GLU C   22  LEU C   26  5                                   5    
HELIX   30  30 MET C   30  LYS C   41  1                                  12    
HELIX   31  31 ARG C   53  GLY C   61  1                                   9    
HELIX   32  32 ASP C   63  SER C   77  1                                  15    
HELIX   33  33 TRP C   86  VAL C   90  5                                   5    
HELIX   34  34 ASN C   97  GLY C  114  1                                  18    
HELIX   35  35 THR C  117  TYR C  137  1                                  21    
HELIX   36  36 ASP C  143  SER C  164  1                                  22    
HELIX   37  37 LEU C  205  ASP C  208  5                                   4    
HELIX   38  38 MET C  209  HIS C  216  1                                   8    
HELIX   39  39 VAL C  232  SER C  236  5                                   5    
HELIX   40  40 SER C  245  ASN C  253  1                                   9    
HELIX   41  41 GLU C  254  ILE C  258  5                                   5    
HELIX   42  42 ARG C  272  GLU C  285  1                                  14    
HELIX   43  43 HIS C  300  ALA C  304  5                                   5    
HELIX   44  44 SER C  305  MET C  312  1                                   8    
HELIX   45  45 PRO C  313  GLY C  325  1                                  13    
HELIX   46  46 ASP C  330  GLN C  337  1                                   8    
HELIX   47  47 MET C  338  SER C  342  5                                   5    
HELIX   48  48 PRO C  370  PHE C  380  1                                  11    
HELIX   49  49 THR C  393  LEU C  413  1                                  21    
HELIX   50  50 GLU D   35  VAL D   37  5                                   3    
HELIX   51  51 ASP D   39  GLU D   44  1                                   6    
HELIX   52  52 ASP D   95  LYS D  100  5                                   6    
HELIX   53  53 ASP D  124  ALA D  132  1                                   9    
HELIX   54  54 ASN D  143  ILE D  147  5                                   5    
HELIX   55  55 GLU E   22  LEU E   26  5                                   5    
HELIX   56  56 MET E   30  GLY E   45  1                                  16    
HELIX   57  57 ARG E   53  GLN E   60  1                                   8    
HELIX   58  58 ASP E   63  SER E   77  1                                  15    
HELIX   59  59 ASN E   97  GLY E  114  1                                  18    
HELIX   60  60 THR E  117  TYR E  137  1                                  21    
HELIX   61  61 ASP E  143  SER E  164  1                                  22    
HELIX   62  62 LEU E  205  ASP E  208  5                                   4    
HELIX   63  63 MET E  209  ASP E  215  1                                   7    
HELIX   64  64 HIS E  216  ASP E  221  5                                   6    
HELIX   65  65 VAL E  232  SER E  236  5                                   5    
HELIX   66  66 SER E  245  ASN E  253  1                                   9    
HELIX   67  67 GLU E  254  ILE E  258  5                                   5    
HELIX   68  68 ARG E  272  GLU E  285  1                                  14    
HELIX   69  69 ASP E  301  ALA E  304  5                                   4    
HELIX   70  70 SER E  305  GLN E  310  1                                   6    
HELIX   71  71 PRO E  313  GLY E  325  1                                  13    
HELIX   72  72 ASP E  330  MET E  338  1                                   9    
HELIX   73  73 ALA E  339  SER E  342  5                                   4    
HELIX   74  74 PRO E  370  PHE E  380  1                                  11    
HELIX   75  75 THR E  393  LEU E  413  1                                  21    
HELIX   76  76 GLU F   35  VAL F   37  5                                   3    
HELIX   77  77 ASP F   39  GLU F   44  1                                   6    
HELIX   78  78 ASP F   95  LYS F  100  5                                   6    
HELIX   79  79 ASP F  124  ALA F  132  1                                   9    
HELIX   80  80 ASN F  143  ILE F  147  5                                   5    
HELIX   81  81 GLU G   22  LEU G   26  5                                   5    
HELIX   82  82 MET G   30  GLY G   45  1                                  16    
HELIX   83  83 ARG G   53  GLY G   61  1                                   9    
HELIX   84  84 ASP G   63  SER G   77  1                                  15    
HELIX   85  85 ASN G   97  GLY G  114  1                                  18    
HELIX   86  86 THR G  117  TYR G  137  1                                  21    
HELIX   87  87 ASP G  143  SER G  164  1                                  22    
HELIX   88  88 LEU G  205  ASP G  208  5                                   4    
HELIX   89  89 MET G  209  HIS G  216  1                                   8    
HELIX   90  90 LEU G  217  ASP G  221  5                                   5    
HELIX   91  91 VAL G  232  SER G  236  5                                   5    
HELIX   92  92 SER G  245  ASN G  253  1                                   9    
HELIX   93  93 GLU G  254  ILE G  258  5                                   5    
HELIX   94  94 ARG G  272  GLU G  285  1                                  14    
HELIX   95  95 SER G  305  GLN G  310  1                                   6    
HELIX   96  96 PRO G  313  GLY G  325  1                                  13    
HELIX   97  97 ASP G  330  ALA G  339  1                                  10    
HELIX   98  98 ALA G  340  SER G  342  5                                   3    
HELIX   99  99 PRO G  370  PHE G  380  1                                  11    
HELIX  100 100 THR G  393  LEU G  414  1                                  22    
HELIX  101 101 GLU H   35  VAL H   37  5                                   3    
HELIX  102 102 ASP H   39  GLU H   44  1                                   6    
HELIX  103 103 ASP H   95  LYS H  100  5                                   6    
HELIX  104 104 ASP H  124  ALA H  132  1                                   9    
HELIX  105 105 ASN H  143  ILE H  147  5                                   5    
SHEET    1   A 7 ILE A 167  PRO A 174  0                                        
SHEET    2   A 7 LYS A 179  LEU A 186 -1  O  LEU A 186   N  ILE A 167           
SHEET    3   A 7 ALA A 223  VAL A 227 -1  O  MET A 224   N  HIS A 185           
SHEET    4   A 7 HIS A 193  SER A 199  1  N  VAL A 196   O  LEU A 225           
SHEET    5   A 7 VAL A 261  PHE A 271  1  O  GLY A 267   N  VAL A 195           
SHEET    6   A 7 ALA A 291  LEU A 295  1  O  VAL A 293   N  LEU A 268           
SHEET    7   A 7 ILE A 358  MET A 361  1  O  LEU A 359   N  CYS A 292           
SHEET    1   B 3 ILE B  21  ILE B  24  0                                        
SHEET    2   B 3 PRO B 163  THR B 168 -1  O  VAL B 164   N  ILE B  23           
SHEET    3   B 3 GLU B 149  LYS B 152 -1  N  ASN B 151   O  ARG B 166           
SHEET    1   C 8 THR B 113  VAL B 114  0                                        
SHEET    2   C 8 GLY B  66  ILE B  71 -1  N  GLY B  66   O  VAL B 114           
SHEET    3   C 8 ALA B  77  SER B  82 -1  O  GLU B  81   N  THR B  67           
SHEET    4   C 8 GLU B  87  HIS B  91 -1  O  LEU B  88   N  ILE B  80           
SHEET    5   C 8 THR B 137  ILE B 141 -1  O  PRO B 138   N  HIS B  91           
SHEET    6   C 8 ASP B  49  PRO B  55 -1  N  ASP B  49   O  ILE B 141           
SHEET    7   C 8 GLY B  29  ASN B  33 -1  N  GLU B  30   O  LYS B  54           
SHEET    8   C 8 SER B 156  VAL B 157 -1  O  VAL B 157   N  GLY B  29           
SHEET    1   D 3 LYS B  59  VAL B  61  0                                        
SHEET    2   D 3 THR B 119  PHE B 123 -1  O  ILE B 121   N  MET B  60           
SHEET    3   D 3 PHE B 104  ARG B 106 -1  N  THR B 105   O  GLU B 122           
SHEET    1   E 8 ILE C 167  PRO C 174  0                                        
SHEET    2   E 8 LYS C 179  LEU C 186 -1  O  ALA C 182   N  LEU C 171           
SHEET    3   E 8 ALA C 223  VAL C 227 -1  O  THR C 226   N  HIS C 183           
SHEET    4   E 8 HIS C 193  SER C 199  1  N  VAL C 198   O  LEU C 225           
SHEET    5   E 8 VAL C 261  PHE C 271  1  O  GLY C 267   N  VAL C 195           
SHEET    6   E 8 ALA C 291  LEU C 295  1  O  VAL C 293   N  LEU C 268           
SHEET    7   E 8 ILE C 358  LEU C 363  1  O  LEU C 359   N  CYS C 292           
SHEET    8   E 8 LYS C 385  ILE C 389  1  O  LYS C 385   N  ALA C 360           
SHEET    1   F 3 ILE D  21  ILE D  24  0                                        
SHEET    2   F 3 PRO D 163  THR D 168 -1  O  LEU D 165   N  ILE D  23           
SHEET    3   F 3 GLU D 149  LYS D 152 -1  N  ASN D 151   O  ARG D 166           
SHEET    1   G 8 THR D 113  VAL D 114  0                                        
SHEET    2   G 8 GLY D  66  ILE D  71 -1  N  GLY D  66   O  VAL D 114           
SHEET    3   G 8 ALA D  77  SER D  82 -1  O  SER D  79   N  LYS D  70           
SHEET    4   G 8 GLU D  87  HIS D  91 -1  O  LEU D  88   N  ILE D  80           
SHEET    5   G 8 THR D 137  ILE D 141 -1  O  VAL D 140   N  PHE D  89           
SHEET    6   G 8 ASP D  49  PRO D  55 -1  N  ILE D  51   O  VAL D 139           
SHEET    7   G 8 GLY D  29  ASN D  33 -1  N  VAL D  32   O  ALA D  52           
SHEET    8   G 8 SER D 156  VAL D 157 -1  O  VAL D 157   N  GLY D  29           
SHEET    1   H 3 LYS D  59  VAL D  61  0                                        
SHEET    2   H 3 THR D 119  PHE D 123 -1  O  ILE D 121   N  MET D  60           
SHEET    3   H 3 PHE D 104  ARG D 106 -1  N  THR D 105   O  GLU D 122           
SHEET    1   I 2 GLN E  28  TYR E  29  0                                        
SHEET    2   I 2 VAL E 328  VAL E 329  1  O  VAL E 329   N  GLN E  28           
SHEET    1   J 8 ILE E 167  PHE E 175  0                                        
SHEET    2   J 8 GLY E 178  LEU E 186 -1  O  ILE E 180   N  ILE E 173           
SHEET    3   J 8 ALA E 223  VAL E 227 -1  O  MET E 224   N  HIS E 185           
SHEET    4   J 8 HIS E 193  SER E 199  1  N  VAL E 198   O  LEU E 225           
SHEET    5   J 8 VAL E 261  PHE E 271  1  O  GLY E 267   N  VAL E 195           
SHEET    6   J 8 ALA E 291  LEU E 295  1  O  LEU E 295   N  GLY E 270           
SHEET    7   J 8 ILE E 358  LEU E 363  1  O  LEU E 359   N  CYS E 292           
SHEET    8   J 8 LYS E 385  ILE E 389  1  O  LYS E 385   N  ALA E 360           
SHEET    1   K 3 ILE F  21  ILE F  24  0                                        
SHEET    2   K 3 PRO F 163  THR F 168 -1  O  VAL F 167   N  ILE F  21           
SHEET    3   K 3 GLU F 149  LYS F 152 -1  N  ASN F 151   O  ARG F 166           
SHEET    1   L 8 THR F 113  VAL F 114  0                                        
SHEET    2   L 8 GLY F  66  ILE F  71 -1  N  GLY F  66   O  VAL F 114           
SHEET    3   L 8 ALA F  77  SER F  82 -1  O  SER F  79   N  GLY F  69           
SHEET    4   L 8 GLU F  87  HIS F  91 -1  O  LEU F  88   N  ILE F  80           
SHEET    5   L 8 THR F 137  ILE F 141 -1  O  VAL F 140   N  PHE F  89           
SHEET    6   L 8 ASP F  49  PRO F  55 -1  N  ILE F  51   O  VAL F 139           
SHEET    7   L 8 GLY F  29  ASN F  33 -1  N  VAL F  32   O  ALA F  52           
SHEET    8   L 8 SER F 156  VAL F 157 -1  O  VAL F 157   N  GLY F  29           
SHEET    1   M 3 LYS F  59  VAL F  61  0                                        
SHEET    2   M 3 THR F 119  PHE F 123 -1  O  ILE F 121   N  MET F  60           
SHEET    3   M 3 PHE F 104  ARG F 106 -1  N  THR F 105   O  GLU F 122           
SHEET    1   N 2 GLN G  28  TYR G  29  0                                        
SHEET    2   N 2 VAL G 328  VAL G 329  1  O  VAL G 329   N  GLN G  28           
SHEET    1   O 8 ILE G 167  PHE G 175  0                                        
SHEET    2   O 8 GLY G 178  LEU G 186 -1  O  LEU G 186   N  ILE G 167           
SHEET    3   O 8 ALA G 223  VAL G 227 -1  O  MET G 224   N  HIS G 185           
SHEET    4   O 8 HIS G 193  SER G 199  1  N  VAL G 196   O  LEU G 225           
SHEET    5   O 8 VAL G 261  PHE G 271  1  O  GLY G 267   N  VAL G 195           
SHEET    6   O 8 ALA G 291  LEU G 295  1  O  VAL G 293   N  LEU G 268           
SHEET    7   O 8 ILE G 358  LEU G 363  1  O  LEU G 359   N  CYS G 292           
SHEET    8   O 8 LYS G 385  ILE G 389  1  O  ILE G 389   N  SER G 362           
SHEET    1   P 3 ILE H  21  ILE H  24  0                                        
SHEET    2   P 3 PRO H 163  THR H 168 -1  O  LEU H 165   N  ILE H  23           
SHEET    3   P 3 GLU H 149  LYS H 152 -1  N  ASN H 151   O  ARG H 166           
SHEET    1   Q 8 THR H 113  VAL H 114  0                                        
SHEET    2   Q 8 GLY H  66  ILE H  71 -1  N  GLY H  66   O  VAL H 114           
SHEET    3   Q 8 ALA H  77  SER H  82 -1  O  SER H  79   N  GLY H  69           
SHEET    4   Q 8 GLU H  87  HIS H  91 -1  O  LEU H  88   N  ILE H  80           
SHEET    5   Q 8 THR H 137  ILE H 141 -1  O  VAL H 140   N  PHE H  89           
SHEET    6   Q 8 ASP H  49  PRO H  55 -1  N  ILE H  51   O  VAL H 139           
SHEET    7   Q 8 GLY H  29  ASN H  33 -1  N  VAL H  32   O  ALA H  52           
SHEET    8   Q 8 SER H 156  VAL H 157 -1  O  VAL H 157   N  GLY H  29           
SHEET    1   R 3 LYS H  59  VAL H  61  0                                        
SHEET    2   R 3 THR H 119  PHE H 123 -1  O  VAL H 120   N  MET H  60           
SHEET    3   R 3 PHE H 104  ARG H 106 -1  N  THR H 105   O  GLU H 122           
CISPEP   1 TYR A  137    PRO A  138          0         0.28                     
CISPEP   2 TYR C  137    PRO C  138          0         0.13                     
CISPEP   3 TYR E  137    PRO E  138          0         0.40                     
CISPEP   4 TYR G  137    PRO G  138          0         0.28                     
CRYST1  322.866   62.067  126.362  90.00 110.80  90.00 C 1 2 1      16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.003097  0.000000  0.001177        0.00000                         
SCALE2      0.000000  0.016112  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.008466        0.00000                         
TER    3019      LEU A 414                                                      
TER    4141      LYS B 169                                                      
TER    7221      LEU C 413                                                      
TER    8339      LYS D 169                                                      
TER   11388      LEU E 414                                                      
TER   12510      LYS F 169                                                      
TER   15609      ARG G 415                                                      
TER   16731      LYS H 169                                                      
MASTER      807    0    0  105   91    0    0    617650    8    0  196          
END                                                                             

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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