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LongText Report for: 6mlk-pdb

Name Class
6mlk-pdb
HEADER    TRANSFERASE                             27-SEP-18   6MLK              
TITLE     STRUCTURE OF THIOESTERASE FROM DEBS WITH A THIOESTERASE-SPECIFIC      
TITLE    2 ANTIBODY                                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 6-DEOXYERYTHRONOLIDE-B SYNTHASE ERYA3, MODULES 5 AND 6;    
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: DEBS 3,6-DEOXYERYTHRONOLIDE B SYNTHASE III,ERYTHRONOLIDE    
COMPND   5 SYNTHASE,ORF C;                                                      
COMPND   6 EC: 2.3.1.94;                                                        
COMPND   7 ENGINEERED: YES;                                                     
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: LIGHT CHAIN OF FAB 3A6;                                    
COMPND  10 CHAIN: L;                                                            
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: HEAVY CHAIN OF FAB 3A6;                                    
COMPND  14 CHAIN: H;                                                            
COMPND  15 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROPOLYSPORA ERYTHRAEA;                    
SOURCE   3 ORGANISM_TAXID: 1836;                                                
SOURCE   4 GENE: ERYA;                                                          
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_TAXID: 9606;                                                
SOURCE  11 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  12 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE  13 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE  14 MOL_ID: 3;                                                           
SOURCE  15 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  16 ORGANISM_TAXID: 9606;                                                
SOURCE  17 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  18 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE  19 EXPRESSION_SYSTEM_STRAIN: BL21                                       
KEYWDS    6-DEOXYERYTHRONOLIDE B SYNTHASE, THIOESTERASE, MONOCLONAL ANTIBODY,   
KEYWDS   2 TRANSFERASE                                                          
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    I.I.MATHEWS,X.LI,C.KHOSLA                                             
REVDAT   1   17-OCT-18 6MLK    0                                                
JRNL        AUTH   X.LI,N.SEVILLANO,F.LA GRECA,J.HSU,I.I.MATHEWS,T.MATSUI,      
JRNL        AUTH 2 C.S.CRAIK,C.KHOSLA                                           
JRNL        TITL   DISCOVERY AND CHARACTERIZATION OF A THIOESTERASE-SPECIFIC    
JRNL        TITL 2 MONOCLONAL ANTIBODY THAT RECOGNIZES THE 6-DEOXYERYTHRONOLIDE 
JRNL        TITL 3 B SYNTHASE.                                                  
JRNL        REF    BIOCHEMISTRY                               2018              
JRNL        REFN                   ISSN 1520-4995                               
JRNL        PMID   30289692                                                     
JRNL        DOI    10.1021/ACS.BIOCHEM.8B00886                                  
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.45 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX 1.13_2998                                     
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.45                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 38.43                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 33432                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.178                           
REMARK   3   R VALUE            (WORKING SET) : 0.175                           
REMARK   3   FREE R VALUE                     : 0.235                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1671                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 38.4306 -  5.6038    0.99     2739   144  0.1583 0.2121        
REMARK   3     2  5.6038 -  4.4500    0.99     2676   140  0.1350 0.1614        
REMARK   3     3  4.4500 -  3.8881    1.00     2642   140  0.1441 0.2238        
REMARK   3     4  3.8881 -  3.5329    1.00     2648   139  0.1698 0.2336        
REMARK   3     5  3.5329 -  3.2798    1.00     2662   140  0.1928 0.2734        
REMARK   3     6  3.2798 -  3.0865    1.00     2632   138  0.2045 0.2653        
REMARK   3     7  3.0865 -  2.9320    1.00     2641   139  0.2128 0.3138        
REMARK   3     8  2.9320 -  2.8044    1.00     2628   139  0.2343 0.2787        
REMARK   3     9  2.8044 -  2.6965    1.00     2609   137  0.2352 0.3148        
REMARK   3    10  2.6965 -  2.6035    1.00     2628   139  0.2394 0.3062        
REMARK   3    11  2.6035 -  2.5221    1.00     2641   138  0.2593 0.3456        
REMARK   3    12  2.5221 -  2.4500    1.00     2615   138  0.3142 0.3855        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : NULL                                          
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.380            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 26.280           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 63.61                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 70.58                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :   NULL           NULL                                  
REMARK   3   ANGLE     :   NULL           NULL                                  
REMARK   3   CHIRALITY :   NULL           NULL                                  
REMARK   3   PLANARITY :   NULL           NULL                                  
REMARK   3   DIHEDRAL  :   NULL           NULL                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 22                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 16 THROUGH 68 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  15.0748  17.7999 -68.0278              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9327 T22:   0.4862                                     
REMARK   3      T33:   0.5291 T12:  -0.2323                                     
REMARK   3      T13:   0.0247 T23:   0.0099                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7135 L22:   0.1186                                     
REMARK   3      L33:   0.3632 L12:  -0.2864                                     
REMARK   3      L13:   0.1541 L23:  -0.1122                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0198 S12:  -0.0560 S13:  -0.0019                       
REMARK   3      S21:   0.0162 S22:   0.0118 S23:   0.1269                       
REMARK   3      S31:   0.4343 S32:  -0.4290 S33:  -0.1134                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 69 THROUGH 135 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):  14.4088  13.2386 -54.1232              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0200 T22:   0.6024                                     
REMARK   3      T33:   0.5103 T12:  -0.1938                                     
REMARK   3      T13:   0.1208 T23:   0.0905                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1754 L22:   0.0296                                     
REMARK   3      L33:   0.1590 L12:   0.0581                                     
REMARK   3      L13:   0.1348 L23:   0.0760                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2616 S12:  -0.3149 S13:  -0.2376                       
REMARK   3      S21:  -0.0416 S22:   0.2349 S23:   0.3498                       
REMARK   3      S31:   0.4195 S32:  -0.6617 S33:  -0.0127                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 136 THROUGH 230 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  23.5766  18.6275 -59.0574              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9326 T22:   0.4339                                     
REMARK   3      T33:   0.5089 T12:  -0.0572                                     
REMARK   3      T13:   0.0158 T23:  -0.0151                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1359 L22:   0.0397                                     
REMARK   3      L33:   0.4532 L12:  -0.0841                                     
REMARK   3      L13:  -0.1024 L23:  -0.1662                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3213 S12:  -0.1422 S13:  -0.0390                       
REMARK   3      S21:   0.0366 S22:   0.1530 S23:  -0.0991                       
REMARK   3      S31:   0.2762 S32:   0.0406 S33:  -0.0005                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 231 THROUGH 250 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  38.1841  17.9498 -59.5802              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8349 T22:   0.5277                                     
REMARK   3      T33:   0.4903 T12:   0.0741                                     
REMARK   3      T13:   0.0337 T23:   0.0347                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0236 L22:   0.0651                                     
REMARK   3      L33:   0.0513 L12:   0.0672                                     
REMARK   3      L13:  -0.0271 L23:  -0.0486                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0312 S12:  -0.3171 S13:   0.0321                       
REMARK   3      S21:   0.2791 S22:  -0.1444 S23:   0.0106                       
REMARK   3      S31:   0.2711 S32:   0.4953 S33:  -0.0003                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 251 THROUGH 279 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  31.3540   6.6060 -52.5894              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4157 T22:   0.5892                                     
REMARK   3      T33:   0.7126 T12:   0.0912                                     
REMARK   3      T13:   0.0288 T23:   0.0582                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0749 L22:   0.0178                                     
REMARK   3      L33:   0.0275 L12:   0.0265                                     
REMARK   3      L13:  -0.0310 L23:  -0.0369                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3105 S12:  -0.1457 S13:  -0.3104                       
REMARK   3      S21:  -0.1723 S22:  -0.0444 S23:   0.0932                       
REMARK   3      S31:   0.1798 S32:   0.1679 S33:   0.0000                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 16 THROUGH 82 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  45.3899  11.0863 -88.8997              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3236 T22:   0.0470                                     
REMARK   3      T33:   0.6143 T12:  -0.1628                                     
REMARK   3      T13:   0.2693 T23:   0.0849                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8938 L22:   0.3749                                     
REMARK   3      L33:   0.4825 L12:  -0.2938                                     
REMARK   3      L13:  -0.3020 L23:   0.1979                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.9498 S12:   0.2060 S13:  -0.2984                       
REMARK   3      S21:  -0.0915 S22:   0.2853 S23:  -0.1650                       
REMARK   3      S31:   1.0024 S32:  -0.2772 S33:  -0.0800                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 83 THROUGH 111 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):  44.8087   9.6240 -93.5555              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4953 T22:  -0.0110                                     
REMARK   3      T33:   0.5725 T12:  -0.3041                                     
REMARK   3      T13:   0.3551 T23:  -0.0371                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8381 L22:   0.2575                                     
REMARK   3      L33:   0.0104 L12:  -0.0869                                     
REMARK   3      L13:  -0.0696 L23:   0.0966                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.9896 S12:   0.1911 S13:  -0.3684                       
REMARK   3      S21:   0.2797 S22:   0.1280 S23:   0.0166                       
REMARK   3      S31:   1.0115 S32:  -0.2568 S33:  -0.5948                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 112 THROUGH 149 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  56.7369  24.5590-104.1165              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6762 T22:   0.1936                                     
REMARK   3      T33:   0.4183 T12:  -0.0447                                     
REMARK   3      T13:   0.0183 T23:  -0.0209                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5912 L22:   0.5195                                     
REMARK   3      L33:   0.5798 L12:  -0.1833                                     
REMARK   3      L13:  -0.6667 L23:  -0.2689                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2851 S12:   0.4910 S13:   0.0295                       
REMARK   3      S21:   0.2689 S22:   0.3165 S23:   0.0071                       
REMARK   3      S31:   0.3116 S32:  -0.1876 S33:   0.0729                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 150 THROUGH 171 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  64.0693  25.0915-115.8441              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5407 T22:   0.4468                                     
REMARK   3      T33:   0.5418 T12:  -0.0332                                     
REMARK   3      T13:  -0.0251 T23:   0.0074                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0285 L22:   0.0417                                     
REMARK   3      L33:   0.1061 L12:   0.0344                                     
REMARK   3      L13:  -0.0226 L23:   0.0646                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0006 S12:   0.4037 S13:   0.2064                       
REMARK   3      S21:  -0.2208 S22:  -0.0092 S23:   0.0666                       
REMARK   3      S31:   0.5406 S32:   0.0478 S33:   0.0007                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 172 THROUGH 195 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  62.0166  24.6001-112.1746              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6529 T22:   0.5638                                     
REMARK   3      T33:   0.6739 T12:  -0.0027                                     
REMARK   3      T13:  -0.0402 T23:   0.0221                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0724 L22:   0.2417                                     
REMARK   3      L33:   0.1055 L12:  -0.1164                                     
REMARK   3      L13:   0.0111 L23:   0.0631                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4551 S12:   0.5339 S13:  -0.0882                       
REMARK   3      S21:   0.2065 S22:  -0.3232 S23:  -0.2644                       
REMARK   3      S31:   0.6161 S32:   0.0231 S33:   0.0008                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 196 THROUGH 232 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  69.5697  30.5911-121.1316              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5510 T22:   0.6338                                     
REMARK   3      T33:   0.6916 T12:  -0.0452                                     
REMARK   3      T13:   0.1487 T23:   0.0435                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0517 L22:   0.0026                                     
REMARK   3      L33:   0.1579 L12:  -0.0025                                     
REMARK   3      L13:  -0.0477 L23:  -0.0138                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0489 S12:   0.2057 S13:   0.0982                       
REMARK   3      S21:  -0.2285 S22:   0.0593 S23:  -0.1923                       
REMARK   3      S31:   0.0805 S32:   0.2028 S33:   0.0000                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 4 THROUGH 19 )                    
REMARK   3    ORIGIN FOR THE GROUP (A):  51.8323  38.4752 -85.2919              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6260 T22:   0.4287                                     
REMARK   3      T33:   0.6898 T12:   0.0452                                     
REMARK   3      T13:  -0.0966 T23:   0.0942                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7753 L22:   0.0457                                     
REMARK   3      L33:   0.3226 L12:   0.1999                                     
REMARK   3      L13:  -0.1517 L23:   0.1095                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1984 S12:  -0.4805 S13:   0.3402                       
REMARK   3      S21:   0.4080 S22:   0.2105 S23:   0.1713                       
REMARK   3      S31:  -0.2224 S32:   0.3167 S33:   0.0032                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 20 THROUGH 35 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  39.8801  32.6993 -80.0384              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6481 T22:   0.4797                                     
REMARK   3      T33:   0.6899 T12:  -0.0091                                     
REMARK   3      T13:  -0.0765 T23:   0.0623                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0184 L22:   0.0816                                     
REMARK   3      L33:   0.1017 L12:  -0.0468                                     
REMARK   3      L13:  -0.0107 L23:   0.0517                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1164 S12:   0.1097 S13:   0.4698                       
REMARK   3      S21:  -0.0423 S22:   0.1456 S23:   0.2952                       
REMARK   3      S31:   0.2190 S32:  -0.1053 S33:  -0.0001                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 36 THROUGH 47 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  52.5325  26.0936 -85.3452              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7294 T22:   0.3799                                     
REMARK   3      T33:   0.5281 T12:   0.0036                                     
REMARK   3      T13:   0.1248 T23:   0.0139                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0348 L22:   0.0053                                     
REMARK   3      L33:   0.0767 L12:   0.0473                                     
REMARK   3      L13:   0.0251 L23:   0.0461                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1614 S12:  -0.1384 S13:  -0.1832                       
REMARK   3      S21:  -0.3868 S22:  -0.0265 S23:   0.0530                       
REMARK   3      S31:   0.2126 S32:   0.0286 S33:   0.0002                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 48 THROUGH 61 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  46.4561  27.2477 -73.3593              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6573 T22:   0.4250                                     
REMARK   3      T33:   0.4581 T12:   0.0819                                     
REMARK   3      T13:   0.0314 T23:  -0.0092                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0285 L22:   0.0459                                     
REMARK   3      L33:   0.0452 L12:   0.0214                                     
REMARK   3      L13:   0.0147 L23:  -0.0368                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0846 S12:  -0.5680 S13:  -0.0445                       
REMARK   3      S21:   0.2705 S22:  -0.2489 S23:   0.1823                       
REMARK   3      S31:   0.2175 S32:  -0.1025 S33:   0.0002                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 62 THROUGH 77 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  50.0589  32.4659 -73.5847              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5984 T22:   0.4387                                     
REMARK   3      T33:   0.6465 T12:   0.0628                                     
REMARK   3      T13:  -0.0866 T23:  -0.0229                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0282 L22:   0.0381                                     
REMARK   3      L33:   0.1701 L12:   0.0369                                     
REMARK   3      L13:  -0.0560 L23:   0.0043                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2018 S12:  -0.3343 S13:   0.3244                       
REMARK   3      S21:   0.2021 S22:  -0.1480 S23:   0.4249                       
REMARK   3      S31:  -0.0368 S32:   0.2002 S33:   0.0000                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 78 THROUGH 92 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  54.4045  34.7792 -79.6314              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5461 T22:   0.5631                                     
REMARK   3      T33:   0.6012 T12:   0.0750                                     
REMARK   3      T13:   0.0194 T23:  -0.1041                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0059 L22:   0.0237                                     
REMARK   3      L33:   0.0669 L12:   0.0129                                     
REMARK   3      L13:  -0.0030 L23:  -0.0354                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0724 S12:  -0.1060 S13:   0.1144                       
REMARK   3      S21:  -0.1610 S22:  -0.0266 S23:   0.2453                       
REMARK   3      S31:   0.1947 S32:   0.3473 S33:  -0.0061                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 93 THROUGH 109 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):  41.6146  23.5282 -83.9525              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7502 T22:   0.3102                                     
REMARK   3      T33:   0.5096 T12:  -0.0069                                     
REMARK   3      T13:   0.1231 T23:   0.0575                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0456 L22:  -0.0357                                     
REMARK   3      L33:   0.0714 L12:   0.0475                                     
REMARK   3      L13:   0.0079 L23:   0.0014                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1412 S12:   0.1233 S13:  -0.2978                       
REMARK   3      S21:   0.2903 S22:   0.0674 S23:  -0.0258                       
REMARK   3      S31:   0.3848 S32:   0.1039 S33:  -0.0001                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 110 THROUGH 128 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  55.1223  36.3673 -91.5022              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5360 T22:   0.4581                                     
REMARK   3      T33:   0.5832 T12:  -0.0322                                     
REMARK   3      T13:  -0.0906 T23:   0.0323                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1258 L22:   0.0322                                     
REMARK   3      L33:   0.1738 L12:  -0.0933                                     
REMARK   3      L13:  -0.0681 L23:   0.0439                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0636 S12:   0.1359 S13:   0.1641                       
REMARK   3      S21:  -0.0521 S22:   0.0622 S23:   0.0155                       
REMARK   3      S31:   0.3840 S32:  -0.0663 S33:   0.0003                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 129 THROUGH 154 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  58.4757  39.4523-114.6218              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3745 T22:   0.4559                                     
REMARK   3      T33:   0.5150 T12:   0.0178                                     
REMARK   3      T13:  -0.0434 T23:   0.0735                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0826 L22:   0.0747                                     
REMARK   3      L33:   0.0147 L12:  -0.1078                                     
REMARK   3      L13:  -0.0334 L23:   0.0397                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1603 S12:   0.5111 S13:   0.0920                       
REMARK   3      S21:  -0.0498 S22:  -0.2094 S23:  -0.0813                       
REMARK   3      S31:  -0.0114 S32:   0.1072 S33:  -0.0002                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 155 THROUGH 203 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  53.4676  36.4563-110.4464              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4072 T22:   0.5158                                     
REMARK   3      T33:   0.5736 T12:  -0.0509                                     
REMARK   3      T13:  -0.0448 T23:   0.0907                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1409 L22:   0.4042                                     
REMARK   3      L33:   0.2045 L12:  -0.0994                                     
REMARK   3      L13:  -0.1985 L23:   0.1857                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0742 S12:   0.1620 S13:   0.0587                       
REMARK   3      S21:   0.0248 S22:  -0.2676 S23:   0.0920                       
REMARK   3      S31:   0.0678 S32:  -0.2474 S33:  -0.0002                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 204 THROUGH 222 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  52.5923  45.3176-107.0642              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3798 T22:   0.4136                                     
REMARK   3      T33:   0.4947 T12:  -0.0491                                     
REMARK   3      T13:  -0.0038 T23:   0.0920                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0017 L22:   0.0372                                     
REMARK   3      L33:   0.0045 L12:   0.0148                                     
REMARK   3      L13:  -0.0091 L23:  -0.0025                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1112 S12:   0.0948 S13:   0.0534                       
REMARK   3      S21:   0.1886 S22:   0.1031 S23:   0.1670                       
REMARK   3      S31:  -0.1280 S32:  -0.1204 S33:  -0.0004                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 6MLK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-SEP-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000236433.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 02-DEC-16                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SSRL                               
REMARK 200  BEAMLINE                       : BL12-2                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97946                            
REMARK 200  MONOCHROMATOR                  : SI(111)                            
REMARK 200  OPTICS                         : RH COATED COLLIMATING MIRRORS, K   
REMARK 200                                   -B FOCUSING MIRRORS                
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XSCALE                             
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 33435                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.450                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 38.426                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY                : 9.519                              
REMARK 200  R MERGE                    (I) : 0.09000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : 14.2300                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.45                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.51                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0                              
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.33                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.85800                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : 2.000                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: MOLREP                                                
REMARK 200 STARTING MODEL: PDB CODES: 1MN6 AND 4LRI                             
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 54.45                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.70                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG3350, 15% ETHYLENE GLYCOL, 0.2M   
REMARK 280  NA2HPO4, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 295K            
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: H 3 2                            
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z                                                
REMARK 290       3555   -X+Y,-X,Z                                               
REMARK 290       4555   Y,X,-Z                                                  
REMARK 290       5555   X-Y,-Y,-Z                                               
REMARK 290       6555   -X,-X+Y,-Z                                              
REMARK 290       7555   X+2/3,Y+1/3,Z+1/3                                       
REMARK 290       8555   -Y+2/3,X-Y+1/3,Z+1/3                                    
REMARK 290       9555   -X+Y+2/3,-X+1/3,Z+1/3                                   
REMARK 290      10555   Y+2/3,X+1/3,-Z+1/3                                      
REMARK 290      11555   X-Y+2/3,-Y+1/3,-Z+1/3                                   
REMARK 290      12555   -X+2/3,-X+Y+1/3,-Z+1/3                                  
REMARK 290      13555   X+1/3,Y+2/3,Z+2/3                                       
REMARK 290      14555   -Y+1/3,X-Y+2/3,Z+2/3                                    
REMARK 290      15555   -X+Y+1/3,-X+2/3,Z+2/3                                   
REMARK 290      16555   Y+1/3,X+2/3,-Z+2/3                                      
REMARK 290      17555   X-Y+1/3,-Y+2/3,-Z+2/3                                   
REMARK 290      18555   -X+1/3,-X+Y+2/3,-Z+2/3                                  
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   7  1.000000  0.000000  0.000000       86.29000            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       49.81955            
REMARK 290   SMTRY3   7  0.000000  0.000000  1.000000       53.01667            
REMARK 290   SMTRY1   8 -0.500000 -0.866025  0.000000       86.29000            
REMARK 290   SMTRY2   8  0.866025 -0.500000  0.000000       49.81955            
REMARK 290   SMTRY3   8  0.000000  0.000000  1.000000       53.01667            
REMARK 290   SMTRY1   9 -0.500000  0.866025  0.000000       86.29000            
REMARK 290   SMTRY2   9 -0.866025 -0.500000  0.000000       49.81955            
REMARK 290   SMTRY3   9  0.000000  0.000000  1.000000       53.01667            
REMARK 290   SMTRY1  10 -0.500000  0.866025  0.000000       86.29000            
REMARK 290   SMTRY2  10  0.866025  0.500000  0.000000       49.81955            
REMARK 290   SMTRY3  10  0.000000  0.000000 -1.000000       53.01667            
REMARK 290   SMTRY1  11  1.000000  0.000000  0.000000       86.29000            
REMARK 290   SMTRY2  11  0.000000 -1.000000  0.000000       49.81955            
REMARK 290   SMTRY3  11  0.000000  0.000000 -1.000000       53.01667            
REMARK 290   SMTRY1  12 -0.500000 -0.866025  0.000000       86.29000            
REMARK 290   SMTRY2  12 -0.866025  0.500000  0.000000       49.81955            
REMARK 290   SMTRY3  12  0.000000  0.000000 -1.000000       53.01667            
REMARK 290   SMTRY1  13  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2  13  0.000000  1.000000  0.000000       99.63911            
REMARK 290   SMTRY3  13  0.000000  0.000000  1.000000      106.03333            
REMARK 290   SMTRY1  14 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  14  0.866025 -0.500000  0.000000       99.63911            
REMARK 290   SMTRY3  14  0.000000  0.000000  1.000000      106.03333            
REMARK 290   SMTRY1  15 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  15 -0.866025 -0.500000  0.000000       99.63911            
REMARK 290   SMTRY3  15  0.000000  0.000000  1.000000      106.03333            
REMARK 290   SMTRY1  16 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  16  0.866025  0.500000  0.000000       99.63911            
REMARK 290   SMTRY3  16  0.000000  0.000000 -1.000000      106.03333            
REMARK 290   SMTRY1  17  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2  17  0.000000 -1.000000  0.000000       99.63911            
REMARK 290   SMTRY3  17  0.000000  0.000000 -1.000000      106.03333            
REMARK 290   SMTRY1  18 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2  18 -0.866025  0.500000  0.000000       99.63911            
REMARK 290   SMTRY3  18  0.000000  0.000000 -1.000000      106.03333            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5140 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 29010 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -39.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, L, H                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 375                                                                      
REMARK 375 SPECIAL POSITION                                                     
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS            
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL          
REMARK 375 POSITIONS.                                                           
REMARK 375                                                                      
REMARK 375 ATOM RES CSSEQI                                                      
REMARK 375      HOH H 419  LIES ON A SPECIAL POSITION.                          
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     SER A     3                                                      
REMARK 465     GLN A     4                                                      
REMARK 465     LEU A     5                                                      
REMARK 465     ASP A     6                                                      
REMARK 465     SER A     7                                                      
REMARK 465     GLY A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     PRO A    10                                                      
REMARK 465     ALA A    11                                                      
REMARK 465     ARG A    12                                                      
REMARK 465     GLU A    13                                                      
REMARK 465     ALA A    14                                                      
REMARK 465     SER A    15                                                      
REMARK 465     GLY A    50                                                      
REMARK 465     SER A    51                                                      
REMARK 465     ASP A    52                                                      
REMARK 465     ALA A    62                                                      
REMARK 465     ASP A    63                                                      
REMARK 465     GLY A   132                                                      
REMARK 465     ASP A   133                                                      
REMARK 465     GLY A   280                                                      
REMARK 465     GLY A   281                                                      
REMARK 465     ASN A   282                                                      
REMARK 465     SER A   283                                                      
REMARK 465     SER A   284                                                      
REMARK 465     SER A   285                                                      
REMARK 465     VAL A   286                                                      
REMARK 465     ASP A   287                                                      
REMARK 465     LYS A   288                                                      
REMARK 465     LEU A   289                                                      
REMARK 465     ALA A   290                                                      
REMARK 465     ALA A   291                                                      
REMARK 465     ALA A   292                                                      
REMARK 465     LEU A   293                                                      
REMARK 465     GLU A   294                                                      
REMARK 465     HIS A   295                                                      
REMARK 465     HIS A   296                                                      
REMARK 465     HIS A   297                                                      
REMARK 465     HIS A   298                                                      
REMARK 465     HIS A   299                                                      
REMARK 465     HIS A   300                                                      
REMARK 465     LEU L     1                                                      
REMARK 465     PHE L     2                                                      
REMARK 465     ALA L     3                                                      
REMARK 465     ILE L     4                                                      
REMARK 465     PRO L     5                                                      
REMARK 465     LEU L     6                                                      
REMARK 465     VAL L     7                                                      
REMARK 465     VAL L     8                                                      
REMARK 465     PRO L     9                                                      
REMARK 465     PHE L    10                                                      
REMARK 465     TYR L    11                                                      
REMARK 465     SER L    12                                                      
REMARK 465     HIS L    13                                                      
REMARK 465     SER L    14                                                      
REMARK 465     ALA L    15                                                      
REMARK 465     GLY L   233                                                      
REMARK 465     GLU L   234                                                      
REMARK 465     CYS L   235                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ALA H     2                                                      
REMARK 465     GLN H     3                                                      
REMARK 465     LYS H   138                                                      
REMARK 465     SER H   139                                                      
REMARK 465     THR H   140                                                      
REMARK 465     SER H   141                                                      
REMARK 465     GLY H   142                                                      
REMARK 465     GLY H   143                                                      
REMARK 465     LYS H   223                                                      
REMARK 465     SER H   224                                                      
REMARK 465     CYS H   225                                                      
REMARK 465     ALA H   226                                                      
REMARK 465     ALA H   227                                                      
REMARK 465     ALA H   228                                                      
REMARK 465     HIS H   229                                                      
REMARK 465     HIS H   230                                                      
REMARK 465     HIS H   231                                                      
REMARK 465     HIS H   232                                                      
REMARK 465     HIS H   233                                                      
REMARK 465     HIS H   234                                                      
REMARK 465     GLY H   235                                                      
REMARK 465     ALA H   236                                                      
REMARK 465     ALA H   237                                                      
REMARK 465     GLU H   238                                                      
REMARK 465     GLN H   239                                                      
REMARK 465     LYS H   240                                                      
REMARK 465     LEU H   241                                                      
REMARK 465     ILE H   242                                                      
REMARK 465     SER H   243                                                      
REMARK 465     GLU H   244                                                      
REMARK 465     GLU H   245                                                      
REMARK 465     ASP H   246                                                      
REMARK 465     LEU H   247                                                      
REMARK 465     ASN H   248                                                      
REMARK 465     GLY H   249                                                      
REMARK 465     ALA H   250                                                      
REMARK 465     ALA H   251                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD1  ASP A   239     OG   SER A   241              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A 130       27.01   -146.16                                   
REMARK 500    SER A 142     -127.12     59.10                                   
REMARK 500    GLU A 194       94.28    -63.33                                   
REMARK 500    MET A 198       92.44    -69.25                                   
REMARK 500    SER A 241        1.88    -66.39                                   
REMARK 500    GLN A 264      -82.66   -116.09                                   
REMARK 500    SER L  48      -39.45    -36.37                                   
REMARK 500    ASN L 159       70.53     47.48                                   
REMARK 500    SER H  17      -12.28     74.68                                   
REMARK 500    ASP H 153       54.34     72.72                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CL H 301                  
DBREF  6MLK A    4   283  UNP    Q03133   ERYA3_SACER   2893   3172             
DBREF  6MLK L    1   235  PDB    6MLK     6MLK             1    235             
DBREF  6MLK H    1   251  PDB    6MLK     6MLK             1    251             
SEQADV 6MLK MET A    1  UNP  Q03133              INITIATING METHIONINE          
SEQADV 6MLK ALA A    2  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK SER A    3  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK SER A  284  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK SER A  285  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK VAL A  286  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK ASP A  287  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK LYS A  288  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK LEU A  289  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK ALA A  290  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK ALA A  291  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK ALA A  292  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK LEU A  293  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK GLU A  294  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK HIS A  295  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK HIS A  296  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK HIS A  297  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK HIS A  298  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK HIS A  299  UNP  Q03133              EXPRESSION TAG                 
SEQADV 6MLK HIS A  300  UNP  Q03133              EXPRESSION TAG                 
SEQRES   1 A  300  MET ALA SER GLN LEU ASP SER GLY THR PRO ALA ARG GLU          
SEQRES   2 A  300  ALA SER SER ALA LEU ARG ASP GLY TYR ARG GLN ALA GLY          
SEQRES   3 A  300  VAL SER GLY ARG VAL ARG SER TYR LEU ASP LEU LEU ALA          
SEQRES   4 A  300  GLY LEU SER ASP PHE ARG GLU HIS PHE ASP GLY SER ASP          
SEQRES   5 A  300  GLY PHE SER LEU ASP LEU VAL ASP MET ALA ASP GLY PRO          
SEQRES   6 A  300  GLY GLU VAL THR VAL ILE CYS CYS ALA GLY THR ALA ALA          
SEQRES   7 A  300  ILE SER GLY PRO HIS GLU PHE THR ARG LEU ALA GLY ALA          
SEQRES   8 A  300  LEU ARG GLY ILE ALA PRO VAL ARG ALA VAL PRO GLN PRO          
SEQRES   9 A  300  GLY TYR GLU GLU GLY GLU PRO LEU PRO SER SER MET ALA          
SEQRES  10 A  300  ALA VAL ALA ALA VAL GLN ALA ASP ALA VAL ILE ARG THR          
SEQRES  11 A  300  GLN GLY ASP LYS PRO PHE VAL VAL ALA GLY HIS SER ALA          
SEQRES  12 A  300  GLY ALA LEU MET ALA TYR ALA LEU ALA THR GLU LEU LEU          
SEQRES  13 A  300  ASP ARG GLY HIS PRO PRO ARG GLY VAL VAL LEU ILE ASP          
SEQRES  14 A  300  VAL TYR PRO PRO GLY HIS GLN ASP ALA MET ASN ALA TRP          
SEQRES  15 A  300  LEU GLU GLU LEU THR ALA THR LEU PHE ASP ARG GLU THR          
SEQRES  16 A  300  VAL ARG MET ASP ASP THR ARG LEU THR ALA LEU GLY ALA          
SEQRES  17 A  300  TYR ASP ARG LEU THR GLY GLN TRP ARG PRO ARG GLU THR          
SEQRES  18 A  300  GLY LEU PRO THR LEU LEU VAL SER ALA GLY GLU PRO MET          
SEQRES  19 A  300  GLY PRO TRP PRO ASP ASP SER TRP LYS PRO THR TRP PRO          
SEQRES  20 A  300  PHE GLU HIS ASP THR VAL ALA VAL PRO GLY ASP HIS PHE          
SEQRES  21 A  300  THR MET VAL GLN GLU HIS ALA ASP ALA ILE ALA ARG HIS          
SEQRES  22 A  300  ILE ASP ALA TRP LEU GLY GLY GLY ASN SER SER SER VAL          
SEQRES  23 A  300  ASP LYS LEU ALA ALA ALA LEU GLU HIS HIS HIS HIS HIS          
SEQRES  24 A  300  HIS                                                          
SEQRES   1 L  235  LEU PHE ALA ILE PRO LEU VAL VAL PRO PHE TYR SER HIS          
SEQRES   2 L  235  SER ALA LEU ASP VAL VAL MET THR GLN SER PRO LEU SER          
SEQRES   3 L  235  LEU PRO VAL THR PRO GLY GLU PRO ALA SER ILE SER CYS          
SEQRES   4 L  235  ARG SER SER GLN SER LEU LEU HIS SER ASN GLY TYR ASN          
SEQRES   5 L  235  TYR LEU ASP TRP TYR LEU GLN LYS PRO GLY GLN SER PRO          
SEQRES   6 L  235  GLN LEU LEU ILE TYR LEU GLY SER ASN ARG ALA SER GLY          
SEQRES   7 L  235  VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY THR ASP          
SEQRES   8 L  235  PHE THR LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL          
SEQRES   9 L  235  GLY VAL TYR TYR CYS MET GLN GLY THR HIS TRP PRO ARG          
SEQRES  10 L  235  THR PHE GLY GLN GLY THR LYS VAL GLU ILE LYS ARG THR          
SEQRES  11 L  235  VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP          
SEQRES  12 L  235  GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU          
SEQRES  13 L  235  LEU ASN ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP          
SEQRES  14 L  235  LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU          
SEQRES  15 L  235  SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SER          
SEQRES  16 L  235  LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR GLU          
SEQRES  17 L  235  LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY          
SEQRES  18 L  235  LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU          
SEQRES  19 L  235  CYS                                                          
SEQRES   1 H  251  MET ALA GLN VAL GLN LEU GLN GLN TRP GLY ALA GLY LEU          
SEQRES   2 H  251  LEU LYS PRO SER GLU THR LEU SER LEU THR CYS ALA VAL          
SEQRES   3 H  251  TYR GLY GLY SER PHE SER GLY TYR TYR TRP SER TRP ILE          
SEQRES   4 H  251  ARG GLN PRO PRO GLY LYS GLY LEU GLU TRP ILE GLY GLU          
SEQRES   5 H  251  ILE ASN HIS SER GLY SER THR ASN TYR ASN PRO SER LEU          
SEQRES   6 H  251  LYS SER ARG VAL THR ILE SER VAL ASP THR SER LYS ASN          
SEQRES   7 H  251  GLN PHE SER LEU LYS LEU SER SER VAL THR ALA ALA ASP          
SEQRES   8 H  251  THR ALA VAL TYR TYR CYS ALA ARG GLY LEU GLY TYR SER          
SEQRES   9 H  251  GLY SER TYR TYR ALA PRO ASN TRP GLY GLN GLY THR LEU          
SEQRES  10 H  251  VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER VAL          
SEQRES  11 H  251  PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY GLY          
SEQRES  12 H  251  THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO          
SEQRES  13 H  251  GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU THR          
SEQRES  14 H  251  SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER          
SEQRES  15 H  251  GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SER          
SEQRES  16 H  251  SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN          
SEQRES  17 H  251  HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU          
SEQRES  18 H  251  PRO LYS SER CYS ALA ALA ALA HIS HIS HIS HIS HIS HIS          
SEQRES  19 H  251  GLY ALA ALA GLU GLN LYS LEU ILE SER GLU GLU ASP LEU          
SEQRES  20 H  251  ASN GLY ALA ALA                                              
HET     CL  H 301       1                                                       
HETNAM      CL CHLORIDE ION                                                     
FORMUL   4   CL    CL 1-                                                        
FORMUL   5  HOH   *65(H2 O)                                                     
HELIX    1 AA1 SER A   16  SER A   28  1                                  13    
HELIX    2 AA2 ARG A   30  ASP A   43  1                                  14    
HELIX    3 AA3 GLY A   81  GLU A   84  5                                   4    
HELIX    4 AA4 PHE A   85  ARG A   93  1                                   9    
HELIX    5 AA5 SER A  115  ARG A  129  1                                  15    
HELIX    6 AA6 SER A  142  GLY A  159  1                                  18    
HELIX    7 AA7 GLN A  176  TRP A  182  1                                   7    
HELIX    8 AA8 TRP A  182  ARG A  193  1                                  12    
HELIX    9 AA9 ASP A  199  TRP A  216  1                                  18    
HELIX   10 AB1 ASP A  239  LYS A  243  5                                   5    
HELIX   11 AB2 PHE A  260  GLN A  264  5                                   5    
HELIX   12 AB3 HIS A  266  GLY A  279  1                                  14    
HELIX   13 AB4 GLU L  100  VAL L  104  5                                   5    
HELIX   14 AB5 SER L  142  LYS L  147  1                                   6    
HELIX   15 AB6 LYS L  204  GLU L  208  1                                   5    
HELIX   16 AB7 THR H   75  LYS H   77  5                                   3    
HELIX   17 AB8 THR H   88  THR H   92  5                                   5    
HELIX   18 AB9 SER H  165  ALA H  167  5                                   3    
HELIX   19 AC1 PRO H  194  GLY H  199  5                                   6    
HELIX   20 AC2 LYS H  210  ASN H  213  5                                   4    
SHEET    1 AA1 2 HIS A  47  PHE A  48  0                                        
SHEET    2 AA1 2 LEU A 112  PRO A 113  1  O  LEU A 112   N  PHE A  48           
SHEET    1 AA2 7 VAL A  59  MET A  61  0                                        
SHEET    2 AA2 7 VAL A  98  VAL A 101 -1  O  VAL A  98   N  MET A  61           
SHEET    3 AA2 7 THR A  69  CYS A  73  1  N  CYS A  72   O  VAL A 101           
SHEET    4 AA2 7 PHE A 136  HIS A 141  1  O  ALA A 139   N  CYS A  73           
SHEET    5 AA2 7 VAL A 165  ILE A 168  1  O  VAL A 166   N  VAL A 138           
SHEET    6 AA2 7 THR A 225  ALA A 230  1  O  VAL A 228   N  LEU A 167           
SHEET    7 AA2 7 ASP A 251  VAL A 255  1  O  ASP A 251   N  LEU A 227           
SHEET    1 AA3 4 MET L  20  SER L  23  0                                        
SHEET    2 AA3 4 ALA L  35  SER L  41 -1  O  SER L  38   N  SER L  23           
SHEET    3 AA3 4 ASP L  91  ILE L  96 -1  O  LEU L  94   N  ILE L  37           
SHEET    4 AA3 4 PHE L  83  SER L  88 -1  N  SER L  86   O  THR L  93           
SHEET    1 AA4 6 SER L  26  VAL L  29  0                                        
SHEET    2 AA4 6 THR L 123  ILE L 127  1  O  LYS L 124   N  LEU L  27           
SHEET    3 AA4 6 GLY L 105  GLN L 111 -1  N  TYR L 107   O  THR L 123           
SHEET    4 AA4 6 LEU L  54  GLN L  59 -1  N  ASP L  55   O  MET L 110           
SHEET    5 AA4 6 GLN L  66  TYR L  70 -1  O  ILE L  69   N  TRP L  56           
SHEET    6 AA4 6 ASN L  74  ARG L  75 -1  O  ASN L  74   N  TYR L  70           
SHEET    1 AA5 4 SER L  26  VAL L  29  0                                        
SHEET    2 AA5 4 THR L 123  ILE L 127  1  O  LYS L 124   N  LEU L  27           
SHEET    3 AA5 4 GLY L 105  GLN L 111 -1  N  TYR L 107   O  THR L 123           
SHEET    4 AA5 4 THR L 118  PHE L 119 -1  O  THR L 118   N  GLN L 111           
SHEET    1 AA6 4 SER L 135  PHE L 139  0                                        
SHEET    2 AA6 4 THR L 150  PHE L 160 -1  O  LEU L 156   N  PHE L 137           
SHEET    3 AA6 4 TYR L 194  SER L 203 -1  O  LEU L 196   N  LEU L 157           
SHEET    4 AA6 4 SER L 180  VAL L 184 -1  N  SER L 183   O  SER L 197           
SHEET    1 AA7 4 ALA L 174  LEU L 175  0                                        
SHEET    2 AA7 4 ALA L 165  VAL L 171 -1  N  VAL L 171   O  ALA L 174           
SHEET    3 AA7 4 VAL L 212  HIS L 219 -1  O  ALA L 214   N  LYS L 170           
SHEET    4 AA7 4 VAL L 226  ASN L 231 -1  O  VAL L 226   N  VAL L 217           
SHEET    1 AA8 4 GLN H   5  GLY H  10  0                                        
SHEET    2 AA8 4 LEU H  20  TYR H  27 -1  O  TYR H  27   N  GLN H   5           
SHEET    3 AA8 4 GLN H  79  LEU H  84 -1  O  PHE H  80   N  CYS H  24           
SHEET    4 AA8 4 VAL H  69  ASP H  74 -1  N  ASP H  74   O  GLN H  79           
SHEET    1 AA9 6 LEU H  13  LEU H  14  0                                        
SHEET    2 AA9 6 THR H 116  VAL H 120  1  O  THR H 119   N  LEU H  14           
SHEET    3 AA9 6 ALA H  93  ARG H  99 -1  N  ALA H  93   O  VAL H 118           
SHEET    4 AA9 6 TRP H  36  GLN H  41 -1  N  ILE H  39   O  TYR H  96           
SHEET    5 AA9 6 GLU H  48  ILE H  53 -1  O  ILE H  53   N  TRP H  36           
SHEET    6 AA9 6 THR H  59  TYR H  61 -1  O  ASN H  60   N  GLU H  52           
SHEET    1 AB1 4 SER H 129  LEU H 133  0                                        
SHEET    2 AB1 4 ALA H 145  TYR H 154 -1  O  LEU H 150   N  PHE H 131           
SHEET    3 AB1 4 TYR H 185  VAL H 193 -1  O  VAL H 193   N  ALA H 145           
SHEET    4 AB1 4 VAL H 172  THR H 174 -1  N  HIS H 173   O  VAL H 190           
SHEET    1 AB2 4 SER H 129  LEU H 133  0                                        
SHEET    2 AB2 4 ALA H 145  TYR H 154 -1  O  LEU H 150   N  PHE H 131           
SHEET    3 AB2 4 TYR H 185  VAL H 193 -1  O  VAL H 193   N  ALA H 145           
SHEET    4 AB2 4 VAL H 178  LEU H 179 -1  N  VAL H 178   O  SER H 186           
SHEET    1 AB3 3 THR H 160  TRP H 163  0                                        
SHEET    2 AB3 3 TYR H 203  HIS H 209 -1  O  ASN H 206   N  SER H 162           
SHEET    3 AB3 3 THR H 214  VAL H 220 -1  O  VAL H 216   N  VAL H 207           
SSBOND   1 CYS L  155    CYS L  215                          1555   1555  2.07  
SSBOND   2 CYS H   24    CYS H   97                          1555   1555  2.12  
SSBOND   3 CYS H  149    CYS H  205                          1555   1555  2.05  
CISPEP   1 SER L   23    PRO L   24          0        -7.20                     
CISPEP   2 TRP L  115    PRO L  116          0        -8.03                     
CISPEP   3 TYR L  161    PRO L  162          0         1.37                     
CISPEP   4 PHE H  155    PRO H  156          0       -12.40                     
CISPEP   5 GLU H  157    PRO H  158          0         3.91                     
SITE     1 AC1  3 TYR H 107  TYR H 108  SER L  77                               
CRYST1  172.580  172.580  159.050  90.00  90.00 120.00 H 3 2        18          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005794  0.003345  0.000000        0.00000                         
SCALE2      0.000000  0.006691  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.006287        0.00000                         
TER    1961      GLY A 279                                                      
TER    3638      ARG L 232                                                      
TER    5234      PRO H 222                                                      
MASTER      746    0    1   20   52    0    1    6 5291    3    6   63          
END                                                                             

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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