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LongText Report for: 6qzv-pdb

Name Class
6qzv-pdb
HEADER    HYDROLASE                               12-MAR-19   6QZV              
TITLE     DPP9 BOUND TO A DIPEPTIDE (MP) FROM THE N-TERMINUS OF BRCA2           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DIPEPTIDYL PEPTIDASE 9;                                    
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 SYNONYM: DP9,DIPEPTIDYL PEPTIDASE IV-RELATED PROTEIN 2,DPRP-2,       
COMPND   5 DIPEPTIDYL PEPTIDASE IX,DPP IX,DIPEPTIDYL PEPTIDASE-LIKE PROTEIN 9,  
COMPND   6 DPLP9;                                                               
COMPND   7 EC: 3.4.14.5;                                                        
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 2;                                                           
COMPND  10 MOLECULE: MET-PRO;                                                   
COMPND  11 CHAIN: E, F, G, H;                                                   
COMPND  12 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: DPP9, DPRP2;                                                   
SOURCE   6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE   7 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 SYNTHETIC: YES;                                                      
SOURCE  11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  12 ORGANISM_COMMON: HUMAN;                                              
SOURCE  13 ORGANISM_TAXID: 9606                                                 
KEYWDS    DPP8, DPP9, BRCA2, DIPEPTIDE, HYDROLASE                               
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    B.ROSS,R.GEISS-FRIEDLANDER,R.HUBER                                    
REVDAT   1   30-SEP-20 6QZV    0                                                
JRNL        AUTH   B.H.ROSS,R.HUBER                                             
JRNL        TITL   DIPEPTIDYL PEPTIDASE 9 ACTIVITY PROMOTES THE REPAIR OF       
JRNL        TITL 2 MITOMYCIN-C INDUCED DNA DAMAGE BY CLAVING THE N-TERMINUS OF  
JRNL        TITL 3 BRCA2                                                        
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.8.0232                                      
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,              
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN                             
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 43.47                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 88.1                           
REMARK   3   NUMBER OF REFLECTIONS             : 72706                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.289                           
REMARK   3   R VALUE            (WORKING SET) : 0.286                           
REMARK   3   FREE R VALUE                     : 0.345                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3827                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.00                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.08                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 5385                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 89.11                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3350                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 283                          
REMARK   3   BIN FREE R VALUE                    : 0.4150                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 26312                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 4                                       
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 25.56                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -2.81000                                             
REMARK   3    B22 (A**2) : 3.79000                                              
REMARK   3    B33 (A**2) : -0.73000                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : -0.23000                                             
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.662         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.533         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 29.275        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.888                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.828                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 27089 ; 0.004 ; 0.013       
REMARK   3   BOND LENGTHS OTHERS               (A): 24371 ; 0.002 ; 0.017       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 36728 ; 1.120 ; 1.644       
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 56654 ; 0.348 ; 1.571       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  3200 ; 7.218 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  1496 ;33.113 ;22.092       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  4425 ;18.554 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   160 ;18.169 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  3305 ; 0.046 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 30132 ; 0.004 ; 0.020       
REMARK   3   GENERAL PLANES OTHERS             (A):  5996 ; 0.001 ; 0.020       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2): 12923 ; 1.136 ; 2.741       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2): 12922 ; 1.136 ; 2.741       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 16082 ; 2.036 ; 4.099       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2): 16083 ; 2.036 ; 4.099       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2): 14166 ; 0.839 ; 2.803       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2): 14166 ; 0.838 ; 2.803       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2): 20646 ; 1.526 ; 4.166       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 29418 ; 3.670 ;30.200       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 29419 ; 3.670 ;30.201       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING   
REMARK   3  POSITIONS                                                           
REMARK   4                                                                      
REMARK   4 6QZV COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 12-MAR-19.                  
REMARK 100 THE DEPOSITION ID IS D_1292101210.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 13-DEC-18                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.25                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SLS                                
REMARK 200  BEAMLINE                       : X10SA                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00002                            
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M-F               
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 76534                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 43.470                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 87.8                               
REMARK 200  DATA REDUNDANCY                : 2.650                              
REMARK 200  R MERGE                    (I) : 0.13000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : 5.9000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.00                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.19                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 88.8                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.30000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : 3.000                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 6EOQ                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 54.06                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.68                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 20 MG/ML OF PROTEIN, 10% PEG 8000, 25%   
REMARK 280  GLYCEROL, 0.16 M CALCIUM ACETATE, 0.08 M CACODILATE PH 6.25.        
REMARK 280  DROPS ARE SET IN A 1:1 RATIO., VAPOR DIFFUSION, HANGING DROP,       
REMARK 280  TEMPERATURE 293K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       58.60950            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5370 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 63390 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -25.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, E, F                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5420 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 63020 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -23.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D, G, H                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -28                                                      
REMARK 465     ARG A   -27                                                      
REMARK 465     LYS A   -26                                                      
REMARK 465     VAL A   -25                                                      
REMARK 465     LYS A   -24                                                      
REMARK 465     LYS A   -23                                                      
REMARK 465     LEU A   -22                                                      
REMARK 465     ARG A   -21                                                      
REMARK 465     LEU A   -20                                                      
REMARK 465     ASP A   -19                                                      
REMARK 465     LYS A   -18                                                      
REMARK 465     GLU A   -17                                                      
REMARK 465     ASN A   -16                                                      
REMARK 465     THR A   -15                                                      
REMARK 465     GLY A   -14                                                      
REMARK 465     SER A   -13                                                      
REMARK 465     TRP A   -12                                                      
REMARK 465     ARG A   -11                                                      
REMARK 465     SER A   -10                                                      
REMARK 465     PHE A    -9                                                      
REMARK 465     SER A    -8                                                      
REMARK 465     LEU A    -7                                                      
REMARK 465     ASN A    -6                                                      
REMARK 465     SER A    -5                                                      
REMARK 465     GLU A    -4                                                      
REMARK 465     GLY A    -3                                                      
REMARK 465     ALA A    -2                                                      
REMARK 465     GLU A    -1                                                      
REMARK 465     ARG A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     THR A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     THR A     8                                                      
REMARK 465     ALA A     9                                                      
REMARK 465     ASP A    10                                                      
REMARK 465     ARG A    11                                                      
REMARK 465     GLY A    12                                                      
REMARK 465     ASP A    13                                                      
REMARK 465     ALA A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     ALA A    16                                                      
REMARK 465     THR A    17                                                      
REMARK 465     ASP A    18                                                      
REMARK 465     ASP A    19                                                      
REMARK 465     PRO A    20                                                      
REMARK 465     TYR A    44                                                      
REMARK 465     SER A    45                                                      
REMARK 465     GLY A    46                                                      
REMARK 465     LEU A    47                                                      
REMARK 465     ILE A    48                                                      
REMARK 465     VAL A    49                                                      
REMARK 465     ASN A    50                                                      
REMARK 465     LYS A    51                                                      
REMARK 465     THR A    62                                                      
REMARK 465     ASP A    63                                                      
REMARK 465     GLU A    64                                                      
REMARK 465     GLY A    80                                                      
REMARK 465     SER A    81                                                      
REMARK 465     LYS A    94                                                      
REMARK 465     VAL A    95                                                      
REMARK 465     ARG A    96                                                      
REMARK 465     LYS A    97                                                      
REMARK 465     GLU A    98                                                      
REMARK 465     ALA A    99                                                      
REMARK 465     LEU A   100                                                      
REMARK 465     GLY A   228                                                      
REMARK 465     LEU A   229                                                      
REMARK 465     SER A   230                                                      
REMARK 465     SER A   267                                                      
REMARK 465     GLU A   268                                                      
REMARK 465     GLY A   269                                                      
REMARK 465     SER A   433                                                      
REMARK 465     GLU A   434                                                      
REMARK 465     GLY A   435                                                      
REMARK 465     GLU A   436                                                      
REMARK 465     ASP A   437                                                      
REMARK 465     GLU A   438                                                      
REMARK 465     ALA A   599                                                      
REMARK 465     SER A   600                                                      
REMARK 465     CYS A   601                                                      
REMARK 465     PRO A   602                                                      
REMARK 465     PRO A   603                                                      
REMARK 465     HIS A   866                                                      
REMARK 465     HIS A   867                                                      
REMARK 465     HIS A   868                                                      
REMARK 465     HIS A   869                                                      
REMARK 465     MET B   -28                                                      
REMARK 465     ARG B   -27                                                      
REMARK 465     LYS B   -26                                                      
REMARK 465     VAL B   -25                                                      
REMARK 465     LYS B   -24                                                      
REMARK 465     LYS B   -23                                                      
REMARK 465     LEU B   -22                                                      
REMARK 465     ARG B   -21                                                      
REMARK 465     LEU B   -20                                                      
REMARK 465     ASP B   -19                                                      
REMARK 465     LYS B   -18                                                      
REMARK 465     GLU B   -17                                                      
REMARK 465     ASN B   -16                                                      
REMARK 465     THR B   -15                                                      
REMARK 465     GLY B   -14                                                      
REMARK 465     SER B   -13                                                      
REMARK 465     TRP B   -12                                                      
REMARK 465     ARG B   -11                                                      
REMARK 465     SER B   -10                                                      
REMARK 465     PHE B    -9                                                      
REMARK 465     SER B    -8                                                      
REMARK 465     LEU B    -7                                                      
REMARK 465     ASN B    -6                                                      
REMARK 465     SER B    -5                                                      
REMARK 465     GLU B    -4                                                      
REMARK 465     GLY B    -3                                                      
REMARK 465     ALA B    -2                                                      
REMARK 465     GLU B    -1                                                      
REMARK 465     ARG B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     THR B     3                                                      
REMARK 465     THR B     4                                                      
REMARK 465     GLY B     5                                                      
REMARK 465     THR B     6                                                      
REMARK 465     PRO B     7                                                      
REMARK 465     THR B     8                                                      
REMARK 465     ALA B     9                                                      
REMARK 465     ASP B    10                                                      
REMARK 465     ARG B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     ASP B    13                                                      
REMARK 465     ALA B    14                                                      
REMARK 465     ALA B    15                                                      
REMARK 465     ALA B    16                                                      
REMARK 465     THR B    17                                                      
REMARK 465     ASP B    18                                                      
REMARK 465     ASP B    19                                                      
REMARK 465     TYR B    44                                                      
REMARK 465     SER B    45                                                      
REMARK 465     GLY B    46                                                      
REMARK 465     LEU B    47                                                      
REMARK 465     ILE B    48                                                      
REMARK 465     VAL B    49                                                      
REMARK 465     ASN B    50                                                      
REMARK 465     TYR B    79                                                      
REMARK 465     GLY B    80                                                      
REMARK 465     SER B    81                                                      
REMARK 465     VAL B    95                                                      
REMARK 465     ARG B    96                                                      
REMARK 465     LYS B    97                                                      
REMARK 465     GLU B    98                                                      
REMARK 465     ALA B    99                                                      
REMARK 465     LEU B   100                                                      
REMARK 465     GLY B   165                                                      
REMARK 465     GLY B   166                                                      
REMARK 465     LYS B   167                                                      
REMARK 465     ASN B   168                                                      
REMARK 465     GLY B   228                                                      
REMARK 465     LEU B   229                                                      
REMARK 465     SER B   230                                                      
REMARK 465     ASN B   231                                                      
REMARK 465     GLU B   265                                                      
REMARK 465     GLY B   266                                                      
REMARK 465     SER B   267                                                      
REMARK 465     GLU B   268                                                      
REMARK 465     GLY B   269                                                      
REMARK 465     GLY B   435                                                      
REMARK 465     GLU B   436                                                      
REMARK 465     GLU B   476                                                      
REMARK 465     ASP B   477                                                      
REMARK 465     GLU B   478                                                      
REMARK 465     ALA B   599                                                      
REMARK 465     SER B   600                                                      
REMARK 465     CYS B   601                                                      
REMARK 465     PRO B   602                                                      
REMARK 465     PRO B   603                                                      
REMARK 465     HIS B   864                                                      
REMARK 465     HIS B   865                                                      
REMARK 465     HIS B   866                                                      
REMARK 465     HIS B   867                                                      
REMARK 465     HIS B   868                                                      
REMARK 465     HIS B   869                                                      
REMARK 465     MET C   -28                                                      
REMARK 465     ARG C   -27                                                      
REMARK 465     LYS C   -26                                                      
REMARK 465     VAL C   -25                                                      
REMARK 465     LYS C   -24                                                      
REMARK 465     LYS C   -23                                                      
REMARK 465     LEU C   -22                                                      
REMARK 465     ARG C   -21                                                      
REMARK 465     LEU C   -20                                                      
REMARK 465     ASP C   -19                                                      
REMARK 465     LYS C   -18                                                      
REMARK 465     GLU C   -17                                                      
REMARK 465     ASN C   -16                                                      
REMARK 465     THR C   -15                                                      
REMARK 465     GLY C   -14                                                      
REMARK 465     SER C   -13                                                      
REMARK 465     TRP C   -12                                                      
REMARK 465     ARG C   -11                                                      
REMARK 465     SER C   -10                                                      
REMARK 465     PHE C    -9                                                      
REMARK 465     SER C    -8                                                      
REMARK 465     LEU C    -7                                                      
REMARK 465     ASN C    -6                                                      
REMARK 465     SER C    -5                                                      
REMARK 465     GLU C    -4                                                      
REMARK 465     GLY C    -3                                                      
REMARK 465     ALA C    -2                                                      
REMARK 465     GLU C    -1                                                      
REMARK 465     ARG C     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     THR C     3                                                      
REMARK 465     THR C     4                                                      
REMARK 465     GLY C     5                                                      
REMARK 465     THR C     6                                                      
REMARK 465     PRO C     7                                                      
REMARK 465     THR C     8                                                      
REMARK 465     ALA C     9                                                      
REMARK 465     ASP C    10                                                      
REMARK 465     ARG C    11                                                      
REMARK 465     GLY C    12                                                      
REMARK 465     ASP C    13                                                      
REMARK 465     ALA C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     ALA C    16                                                      
REMARK 465     THR C    17                                                      
REMARK 465     ASP C    18                                                      
REMARK 465     ASP C    19                                                      
REMARK 465     TYR C    44                                                      
REMARK 465     SER C    45                                                      
REMARK 465     GLY C    46                                                      
REMARK 465     LEU C    47                                                      
REMARK 465     ILE C    48                                                      
REMARK 465     VAL C    49                                                      
REMARK 465     ASN C    50                                                      
REMARK 465     LYS C    51                                                      
REMARK 465     TYR C    79                                                      
REMARK 465     GLY C    80                                                      
REMARK 465     SER C    81                                                      
REMARK 465     VAL C    95                                                      
REMARK 465     ARG C    96                                                      
REMARK 465     LYS C    97                                                      
REMARK 465     GLU C    98                                                      
REMARK 465     ALA C    99                                                      
REMARK 465     LEU C   100                                                      
REMARK 465     GLY C   166                                                      
REMARK 465     LYS C   167                                                      
REMARK 465     GLY C   228                                                      
REMARK 465     LEU C   229                                                      
REMARK 465     SER C   230                                                      
REMARK 465     ASN C   231                                                      
REMARK 465     GLU C   265                                                      
REMARK 465     GLY C   266                                                      
REMARK 465     SER C   267                                                      
REMARK 465     GLU C   268                                                      
REMARK 465     GLY C   269                                                      
REMARK 465     GLU C   434                                                      
REMARK 465     GLY C   435                                                      
REMARK 465     GLU C   436                                                      
REMARK 465     ALA C   599                                                      
REMARK 465     SER C   600                                                      
REMARK 465     CYS C   601                                                      
REMARK 465     PRO C   602                                                      
REMARK 465     PRO C   603                                                      
REMARK 465     HIS C   864                                                      
REMARK 465     HIS C   865                                                      
REMARK 465     HIS C   866                                                      
REMARK 465     HIS C   867                                                      
REMARK 465     HIS C   868                                                      
REMARK 465     HIS C   869                                                      
REMARK 465     MET D   -28                                                      
REMARK 465     ARG D   -27                                                      
REMARK 465     LYS D   -26                                                      
REMARK 465     VAL D   -25                                                      
REMARK 465     LYS D   -24                                                      
REMARK 465     LYS D   -23                                                      
REMARK 465     LEU D   -22                                                      
REMARK 465     ARG D   -21                                                      
REMARK 465     LEU D   -20                                                      
REMARK 465     ASP D   -19                                                      
REMARK 465     LYS D   -18                                                      
REMARK 465     GLU D   -17                                                      
REMARK 465     ASN D   -16                                                      
REMARK 465     THR D   -15                                                      
REMARK 465     GLY D   -14                                                      
REMARK 465     SER D   -13                                                      
REMARK 465     TRP D   -12                                                      
REMARK 465     ARG D   -11                                                      
REMARK 465     SER D   -10                                                      
REMARK 465     PHE D    -9                                                      
REMARK 465     SER D    -8                                                      
REMARK 465     LEU D    -7                                                      
REMARK 465     ASN D    -6                                                      
REMARK 465     SER D    -5                                                      
REMARK 465     GLU D    -4                                                      
REMARK 465     GLY D    -3                                                      
REMARK 465     ALA D    -2                                                      
REMARK 465     GLU D    -1                                                      
REMARK 465     ARG D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ALA D     2                                                      
REMARK 465     THR D     3                                                      
REMARK 465     THR D     4                                                      
REMARK 465     GLY D     5                                                      
REMARK 465     THR D     6                                                      
REMARK 465     PRO D     7                                                      
REMARK 465     THR D     8                                                      
REMARK 465     ALA D     9                                                      
REMARK 465     ASP D    10                                                      
REMARK 465     ARG D    11                                                      
REMARK 465     GLY D    12                                                      
REMARK 465     ASP D    13                                                      
REMARK 465     ALA D    14                                                      
REMARK 465     ALA D    15                                                      
REMARK 465     ALA D    16                                                      
REMARK 465     THR D    17                                                      
REMARK 465     ASP D    18                                                      
REMARK 465     ASP D    19                                                      
REMARK 465     TYR D    44                                                      
REMARK 465     SER D    45                                                      
REMARK 465     GLY D    46                                                      
REMARK 465     LEU D    47                                                      
REMARK 465     ILE D    48                                                      
REMARK 465     VAL D    49                                                      
REMARK 465     ASN D    50                                                      
REMARK 465     LYS D    51                                                      
REMARK 465     SER D    65                                                      
REMARK 465     TYR D    79                                                      
REMARK 465     GLY D    80                                                      
REMARK 465     SER D    81                                                      
REMARK 465     LYS D    94                                                      
REMARK 465     VAL D    95                                                      
REMARK 465     ARG D    96                                                      
REMARK 465     LYS D    97                                                      
REMARK 465     GLU D    98                                                      
REMARK 465     ALA D    99                                                      
REMARK 465     LEU D   100                                                      
REMARK 465     GLY D   228                                                      
REMARK 465     LEU D   229                                                      
REMARK 465     SER D   230                                                      
REMARK 465     ASN D   231                                                      
REMARK 465     SER D   267                                                      
REMARK 465     GLU D   268                                                      
REMARK 465     GLY D   269                                                      
REMARK 465     GLU D   434                                                      
REMARK 465     GLY D   435                                                      
REMARK 465     SER D   600                                                      
REMARK 465     CYS D   601                                                      
REMARK 465     PRO D   602                                                      
REMARK 465     PRO D   603                                                      
REMARK 465     HIS D   864                                                      
REMARK 465     HIS D   865                                                      
REMARK 465     HIS D   866                                                      
REMARK 465     HIS D   867                                                      
REMARK 465     HIS D   868                                                      
REMARK 465     HIS D   869                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    HIS A 118     -114.57     47.48                                   
REMARK 500    SER A 156     -109.41     42.10                                   
REMARK 500    SER A 158     -161.07   -102.08                                   
REMARK 500    ASP A 190       64.80     64.05                                   
REMARK 500    VAL A 232     -111.59    -76.14                                   
REMARK 500    PRO A 313      124.11    -39.43                                   
REMARK 500    ALA A 316      149.65   -174.93                                   
REMARK 500    ASP A 325     -150.83   -101.17                                   
REMARK 500    VAL A 331      -83.38    -98.74                                   
REMARK 500    LYS A 348       -3.22     79.77                                   
REMARK 500    GLN A 373       51.27     71.25                                   
REMARK 500    VAL A 419      -76.00    -98.84                                   
REMARK 500    TRP A 420      150.43    176.36                                   
REMARK 500    PHE A 427       86.25   -156.24                                   
REMARK 500    GLU A 486       85.46   -158.68                                   
REMARK 500    GLU A 493       43.64    -85.23                                   
REMARK 500    LYS A 511       31.16     70.61                                   
REMARK 500    HIS A 586       42.92    -98.49                                   
REMARK 500    ASP A 618       33.56     74.38                                   
REMARK 500    TYR A 644      -75.41   -122.15                                   
REMARK 500    TYR A 661       56.93   -109.68                                   
REMARK 500    GLN A 696       33.83   -160.09                                   
REMARK 500    SER A 730     -117.59     60.29                                   
REMARK 500    LYS A 743       57.20   -142.90                                   
REMARK 500    ALA A 754       60.63     37.75                                   
REMARK 500    ASP A 772     -167.17     78.48                                   
REMARK 500    ASN A 777       59.79   -146.18                                   
REMARK 500    ASN A 798        4.92     83.73                                   
REMARK 500    ARG A 839     -123.25    -91.63                                   
REMARK 500    LEU A 863       94.56    -67.36                                   
REMARK 500    ARG B  42       57.95    -96.98                                   
REMARK 500    ASP B  55       73.60     60.54                                   
REMARK 500    ASP B 110       84.97    -65.85                                   
REMARK 500    HIS B 111     -101.83     53.89                                   
REMARK 500    PHE B 112      160.65     63.69                                   
REMARK 500    SER B 156     -132.11     41.07                                   
REMARK 500    ASN B 157       50.42   -116.77                                   
REMARK 500    SER B 158     -159.53   -161.40                                   
REMARK 500    VAL B 172      -50.05   -121.01                                   
REMARK 500    LEU B 233      -48.44     73.28                                   
REMARK 500    GLU B 282       32.37    -99.56                                   
REMARK 500    ALA B 294       78.57    -69.89                                   
REMARK 500    LYS B 348       -9.13     82.23                                   
REMARK 500    PRO B 372        8.11    -63.14                                   
REMARK 500    PRO B 383       -8.19    -55.06                                   
REMARK 500    VAL B 419      -85.72   -103.08                                   
REMARK 500    SER B 433      -77.39   -114.53                                   
REMARK 500    LEU B 461       73.50   -112.77                                   
REMARK 500    GLU B 486       84.57   -159.04                                   
REMARK 500    ALA B 498       27.76   -144.50                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     131 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  6QZV A  -28   863  UNP    Q86TI2   DPP9_HUMAN       1    892             
DBREF  6QZV B  -28   863  UNP    Q86TI2   DPP9_HUMAN       1    892             
DBREF  6QZV C  -28   863  UNP    Q86TI2   DPP9_HUMAN       1    892             
DBREF  6QZV D  -28   863  UNP    Q86TI2   DPP9_HUMAN       1    892             
DBREF  6QZV E  232   233  PDB    6QZV     6QZV           232    233             
DBREF  6QZV F  232   233  PDB    6QZV     6QZV           232    233             
DBREF  6QZV G  232   233  PDB    6QZV     6QZV           232    233             
DBREF  6QZV H  232   233  PDB    6QZV     6QZV           232    233             
SEQADV 6QZV HIS A  864  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS A  865  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS A  866  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS A  867  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS A  868  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS A  869  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS B  864  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS B  865  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS B  866  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS B  867  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS B  868  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS B  869  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS C  864  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS C  865  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS C  866  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS C  867  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS C  868  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS C  869  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS D  864  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS D  865  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS D  866  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS D  867  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS D  868  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6QZV HIS D  869  UNP  Q86TI2              EXPRESSION TAG                 
SEQRES   1 A  898  MET ARG LYS VAL LYS LYS LEU ARG LEU ASP LYS GLU ASN          
SEQRES   2 A  898  THR GLY SER TRP ARG SER PHE SER LEU ASN SER GLU GLY          
SEQRES   3 A  898  ALA GLU ARG MET ALA THR THR GLY THR PRO THR ALA ASP          
SEQRES   4 A  898  ARG GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG          
SEQRES   5 A  898  PHE GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER          
SEQRES   6 A  898  ILE ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL          
SEQRES   7 A  898  ASN LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR          
SEQRES   8 A  898  ASP GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU          
SEQRES   9 A  898  GLY MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR          
SEQRES  10 A  898  SER GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU          
SEQRES  11 A  898  LEU LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA          
SEQRES  12 A  898  THR PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU          
SEQRES  13 A  898  LEU ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR          
SEQRES  14 A  898  SER TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE          
SEQRES  15 A  898  GLN ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY          
SEQRES  16 A  898  LYS ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU          
SEQRES  17 A  898  ILE LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS          
SEQRES  18 A  898  ILE CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN          
SEQRES  19 A  898  ASN SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU          
SEQRES  20 A  898  GLU ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN          
SEQRES  21 A  898  VAL LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE          
SEQRES  22 A  898  VAL ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP          
SEQRES  23 A  898  TRP CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU          
SEQRES  24 A  898  LYS THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER          
SEQRES  25 A  898  GLU VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU          
SEQRES  26 A  898  GLU ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY          
SEQRES  27 A  898  SER LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE          
SEQRES  28 A  898  GLN THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU          
SEQRES  29 A  898  LYS GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS          
SEQRES  30 A  898  VAL GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY          
SEQRES  31 A  898  LYS TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN          
SEQRES  32 A  898  TRP LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE          
SEQRES  33 A  898  PRO SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA          
SEQRES  34 A  898  ARG ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR          
SEQRES  35 A  898  GLU GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE          
SEQRES  36 A  898  PHE TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU          
SEQRES  37 A  898  CYS PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS          
SEQRES  38 A  898  HIS LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY          
SEQRES  39 A  898  TYR ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU          
SEQRES  40 A  898  PHE LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER          
SEQRES  41 A  898  GLY GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE          
SEQRES  42 A  898  TRP VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY          
SEQRES  43 A  898  THR LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL          
SEQRES  44 A  898  SER TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR          
SEQRES  45 A  898  PRO GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE          
SEQRES  46 A  898  ASP MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO          
SEQRES  47 A  898  PRO CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP          
SEQRES  48 A  898  ASP PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET          
SEQRES  49 A  898  MET GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO          
SEQRES  50 A  898  GLU ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU          
SEQRES  51 A  898  TYR GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY          
SEQRES  52 A  898  LYS LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO          
SEQRES  53 A  898  GLN VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS          
SEQRES  54 A  898  TYR LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA          
SEQRES  55 A  898  VAL VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY          
SEQRES  56 A  898  LEU ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN          
SEQRES  57 A  898  VAL GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL          
SEQRES  58 A  898  ALA GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA          
SEQRES  59 A  898  ILE HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET          
SEQRES  60 A  898  GLY LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE          
SEQRES  61 A  898  ALA GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR          
SEQRES  62 A  898  GLY TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN          
SEQRES  63 A  898  GLN HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL          
SEQRES  64 A  898  GLU LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU          
SEQRES  65 A  898  HIS GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR          
SEQRES  66 A  898  ASN PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO          
SEQRES  67 A  898  TYR GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE          
SEQRES  68 A  898  ARG CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU          
SEQRES  69 A  898  LEU HIS PHE LEU GLN GLU TYR LEU HIS HIS HIS HIS HIS          
SEQRES  70 A  898  HIS                                                          
SEQRES   1 B  898  MET ARG LYS VAL LYS LYS LEU ARG LEU ASP LYS GLU ASN          
SEQRES   2 B  898  THR GLY SER TRP ARG SER PHE SER LEU ASN SER GLU GLY          
SEQRES   3 B  898  ALA GLU ARG MET ALA THR THR GLY THR PRO THR ALA ASP          
SEQRES   4 B  898  ARG GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG          
SEQRES   5 B  898  PHE GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER          
SEQRES   6 B  898  ILE ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL          
SEQRES   7 B  898  ASN LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR          
SEQRES   8 B  898  ASP GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU          
SEQRES   9 B  898  GLY MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR          
SEQRES  10 B  898  SER GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU          
SEQRES  11 B  898  LEU LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA          
SEQRES  12 B  898  THR PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU          
SEQRES  13 B  898  LEU ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR          
SEQRES  14 B  898  SER TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE          
SEQRES  15 B  898  GLN ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY          
SEQRES  16 B  898  LYS ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU          
SEQRES  17 B  898  ILE LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS          
SEQRES  18 B  898  ILE CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN          
SEQRES  19 B  898  ASN SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU          
SEQRES  20 B  898  GLU ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN          
SEQRES  21 B  898  VAL LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE          
SEQRES  22 B  898  VAL ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP          
SEQRES  23 B  898  TRP CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU          
SEQRES  24 B  898  LYS THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER          
SEQRES  25 B  898  GLU VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU          
SEQRES  26 B  898  GLU ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY          
SEQRES  27 B  898  SER LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE          
SEQRES  28 B  898  GLN THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU          
SEQRES  29 B  898  LYS GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS          
SEQRES  30 B  898  VAL GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY          
SEQRES  31 B  898  LYS TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN          
SEQRES  32 B  898  TRP LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE          
SEQRES  33 B  898  PRO SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA          
SEQRES  34 B  898  ARG ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR          
SEQRES  35 B  898  GLU GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE          
SEQRES  36 B  898  PHE TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU          
SEQRES  37 B  898  CYS PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS          
SEQRES  38 B  898  HIS LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY          
SEQRES  39 B  898  TYR ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU          
SEQRES  40 B  898  PHE LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER          
SEQRES  41 B  898  GLY GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE          
SEQRES  42 B  898  TRP VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY          
SEQRES  43 B  898  THR LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL          
SEQRES  44 B  898  SER TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR          
SEQRES  45 B  898  PRO GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE          
SEQRES  46 B  898  ASP MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO          
SEQRES  47 B  898  PRO CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP          
SEQRES  48 B  898  ASP PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET          
SEQRES  49 B  898  MET GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO          
SEQRES  50 B  898  GLU ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU          
SEQRES  51 B  898  TYR GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY          
SEQRES  52 B  898  LYS LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO          
SEQRES  53 B  898  GLN VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS          
SEQRES  54 B  898  TYR LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA          
SEQRES  55 B  898  VAL VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY          
SEQRES  56 B  898  LEU ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN          
SEQRES  57 B  898  VAL GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL          
SEQRES  58 B  898  ALA GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA          
SEQRES  59 B  898  ILE HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET          
SEQRES  60 B  898  GLY LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE          
SEQRES  61 B  898  ALA GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR          
SEQRES  62 B  898  GLY TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN          
SEQRES  63 B  898  GLN HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL          
SEQRES  64 B  898  GLU LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU          
SEQRES  65 B  898  HIS GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR          
SEQRES  66 B  898  ASN PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO          
SEQRES  67 B  898  TYR GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE          
SEQRES  68 B  898  ARG CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU          
SEQRES  69 B  898  LEU HIS PHE LEU GLN GLU TYR LEU HIS HIS HIS HIS HIS          
SEQRES  70 B  898  HIS                                                          
SEQRES   1 C  898  MET ARG LYS VAL LYS LYS LEU ARG LEU ASP LYS GLU ASN          
SEQRES   2 C  898  THR GLY SER TRP ARG SER PHE SER LEU ASN SER GLU GLY          
SEQRES   3 C  898  ALA GLU ARG MET ALA THR THR GLY THR PRO THR ALA ASP          
SEQRES   4 C  898  ARG GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG          
SEQRES   5 C  898  PHE GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER          
SEQRES   6 C  898  ILE ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL          
SEQRES   7 C  898  ASN LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR          
SEQRES   8 C  898  ASP GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU          
SEQRES   9 C  898  GLY MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR          
SEQRES  10 C  898  SER GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU          
SEQRES  11 C  898  LEU LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA          
SEQRES  12 C  898  THR PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU          
SEQRES  13 C  898  LEU ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR          
SEQRES  14 C  898  SER TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE          
SEQRES  15 C  898  GLN ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY          
SEQRES  16 C  898  LYS ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU          
SEQRES  17 C  898  ILE LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS          
SEQRES  18 C  898  ILE CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN          
SEQRES  19 C  898  ASN SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU          
SEQRES  20 C  898  GLU ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN          
SEQRES  21 C  898  VAL LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE          
SEQRES  22 C  898  VAL ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP          
SEQRES  23 C  898  TRP CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU          
SEQRES  24 C  898  LYS THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER          
SEQRES  25 C  898  GLU VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU          
SEQRES  26 C  898  GLU ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY          
SEQRES  27 C  898  SER LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE          
SEQRES  28 C  898  GLN THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU          
SEQRES  29 C  898  LYS GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS          
SEQRES  30 C  898  VAL GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY          
SEQRES  31 C  898  LYS TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN          
SEQRES  32 C  898  TRP LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE          
SEQRES  33 C  898  PRO SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA          
SEQRES  34 C  898  ARG ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR          
SEQRES  35 C  898  GLU GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE          
SEQRES  36 C  898  PHE TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU          
SEQRES  37 C  898  CYS PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS          
SEQRES  38 C  898  HIS LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY          
SEQRES  39 C  898  TYR ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU          
SEQRES  40 C  898  PHE LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER          
SEQRES  41 C  898  GLY GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE          
SEQRES  42 C  898  TRP VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY          
SEQRES  43 C  898  THR LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL          
SEQRES  44 C  898  SER TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR          
SEQRES  45 C  898  PRO GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE          
SEQRES  46 C  898  ASP MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO          
SEQRES  47 C  898  PRO CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP          
SEQRES  48 C  898  ASP PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET          
SEQRES  49 C  898  MET GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO          
SEQRES  50 C  898  GLU ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU          
SEQRES  51 C  898  TYR GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY          
SEQRES  52 C  898  LYS LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO          
SEQRES  53 C  898  GLN VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS          
SEQRES  54 C  898  TYR LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA          
SEQRES  55 C  898  VAL VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY          
SEQRES  56 C  898  LEU ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN          
SEQRES  57 C  898  VAL GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL          
SEQRES  58 C  898  ALA GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA          
SEQRES  59 C  898  ILE HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET          
SEQRES  60 C  898  GLY LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE          
SEQRES  61 C  898  ALA GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR          
SEQRES  62 C  898  GLY TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN          
SEQRES  63 C  898  GLN HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL          
SEQRES  64 C  898  GLU LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU          
SEQRES  65 C  898  HIS GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR          
SEQRES  66 C  898  ASN PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO          
SEQRES  67 C  898  TYR GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE          
SEQRES  68 C  898  ARG CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU          
SEQRES  69 C  898  LEU HIS PHE LEU GLN GLU TYR LEU HIS HIS HIS HIS HIS          
SEQRES  70 C  898  HIS                                                          
SEQRES   1 D  898  MET ARG LYS VAL LYS LYS LEU ARG LEU ASP LYS GLU ASN          
SEQRES   2 D  898  THR GLY SER TRP ARG SER PHE SER LEU ASN SER GLU GLY          
SEQRES   3 D  898  ALA GLU ARG MET ALA THR THR GLY THR PRO THR ALA ASP          
SEQRES   4 D  898  ARG GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG          
SEQRES   5 D  898  PHE GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER          
SEQRES   6 D  898  ILE ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL          
SEQRES   7 D  898  ASN LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR          
SEQRES   8 D  898  ASP GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU          
SEQRES   9 D  898  GLY MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR          
SEQRES  10 D  898  SER GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU          
SEQRES  11 D  898  LEU LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA          
SEQRES  12 D  898  THR PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU          
SEQRES  13 D  898  LEU ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR          
SEQRES  14 D  898  SER TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE          
SEQRES  15 D  898  GLN ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY          
SEQRES  16 D  898  LYS ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU          
SEQRES  17 D  898  ILE LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS          
SEQRES  18 D  898  ILE CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN          
SEQRES  19 D  898  ASN SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU          
SEQRES  20 D  898  GLU ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN          
SEQRES  21 D  898  VAL LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE          
SEQRES  22 D  898  VAL ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP          
SEQRES  23 D  898  TRP CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU          
SEQRES  24 D  898  LYS THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER          
SEQRES  25 D  898  GLU VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU          
SEQRES  26 D  898  GLU ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY          
SEQRES  27 D  898  SER LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE          
SEQRES  28 D  898  GLN THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU          
SEQRES  29 D  898  LYS GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS          
SEQRES  30 D  898  VAL GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY          
SEQRES  31 D  898  LYS TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN          
SEQRES  32 D  898  TRP LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE          
SEQRES  33 D  898  PRO SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA          
SEQRES  34 D  898  ARG ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR          
SEQRES  35 D  898  GLU GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE          
SEQRES  36 D  898  PHE TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU          
SEQRES  37 D  898  CYS PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS          
SEQRES  38 D  898  HIS LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY          
SEQRES  39 D  898  TYR ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU          
SEQRES  40 D  898  PHE LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER          
SEQRES  41 D  898  GLY GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE          
SEQRES  42 D  898  TRP VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY          
SEQRES  43 D  898  THR LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL          
SEQRES  44 D  898  SER TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR          
SEQRES  45 D  898  PRO GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE          
SEQRES  46 D  898  ASP MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO          
SEQRES  47 D  898  PRO CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP          
SEQRES  48 D  898  ASP PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET          
SEQRES  49 D  898  MET GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO          
SEQRES  50 D  898  GLU ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU          
SEQRES  51 D  898  TYR GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY          
SEQRES  52 D  898  LYS LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO          
SEQRES  53 D  898  GLN VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS          
SEQRES  54 D  898  TYR LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA          
SEQRES  55 D  898  VAL VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY          
SEQRES  56 D  898  LEU ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN          
SEQRES  57 D  898  VAL GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL          
SEQRES  58 D  898  ALA GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA          
SEQRES  59 D  898  ILE HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET          
SEQRES  60 D  898  GLY LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE          
SEQRES  61 D  898  ALA GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR          
SEQRES  62 D  898  GLY TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN          
SEQRES  63 D  898  GLN HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL          
SEQRES  64 D  898  GLU LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU          
SEQRES  65 D  898  HIS GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR          
SEQRES  66 D  898  ASN PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO          
SEQRES  67 D  898  TYR GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE          
SEQRES  68 D  898  ARG CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU          
SEQRES  69 D  898  LEU HIS PHE LEU GLN GLU TYR LEU HIS HIS HIS HIS HIS          
SEQRES  70 D  898  HIS                                                          
SEQRES   1 E    2  MET PRO                                                      
SEQRES   1 F    2  MET PRO                                                      
SEQRES   1 G    2  MET PRO                                                      
SEQRES   1 H    2  MET PRO                                                      
FORMUL   9  HOH   *4(H2 O)                                                      
HELIX    1 AA1 SER A   30  ARG A   42  1                                  13    
HELIX    2 AA2 SER A  122  LYS A  132  1                                  11    
HELIX    3 AA3 THR A  243  ASP A  251  1                                   9    
HELIX    4 AA4 SER A  283  VAL A  285  5                                   3    
HELIX    5 AA5 PRO A  341  PHE A  346  1                                   6    
HELIX    6 AA6 PRO A  382  ALA A  384  5                                   3    
HELIX    7 AA7 ASN A  392  ALA A  402  1                                  11    
HELIX    8 AA8 LEU A  662  GLY A  671  1                                  10    
HELIX    9 AA9 GLY A  686  GLY A  691  1                                   6    
HELIX   10 AB1 ALA A  692  LYS A  694  5                                   3    
HELIX   11 AB2 VAL A  700  GLY A  717  1                                  18    
HELIX   12 AB3 SER A  730  LYS A  743  1                                  14    
HELIX   13 AB4 VAL A  758  TYR A  762  5                                   5    
HELIX   14 AB5 ASP A  763  ASP A  772  1                                  10    
HELIX   15 AB6 VAL A  773  ASN A  776  5                                   4    
HELIX   16 AB7 ASN A  777  GLY A  784  1                                   8    
HELIX   17 AB8 SER A  785  LEU A  793  5                                   9    
HELIX   18 AB9 PHE A  813  ALA A  826  1                                  14    
HELIX   19 AC1 CYS A  844  LEU A  863  1                                  20    
HELIX   20 AC2 SER B   30  ARG B   42  1                                  13    
HELIX   21 AC3 PRO B  116  VAL B  120  5                                   5    
HELIX   22 AC4 SER B  122  LYS B  132  1                                  11    
HELIX   23 AC5 THR B  243  ASP B  251  1                                   9    
HELIX   24 AC6 ALA B  294  ARG B  298  5                                   5    
HELIX   25 AC7 PRO B  341  PHE B  346  1                                   6    
HELIX   26 AC8 ASN B  392  VAL B  403  1                                  12    
HELIX   27 AC9 ASP B  583  LYS B  587  5                                   5    
HELIX   28 AD1 TYR B  661  LEU B  670  1                                  10    
HELIX   29 AD2 GLY B  686  GLY B  691  1                                   6    
HELIX   30 AD3 VAL B  700  TYR B  716  1                                  17    
HELIX   31 AD4 SER B  730  LYS B  743  1                                  14    
HELIX   32 AD5 ASP B  763  ASP B  772  1                                  10    
HELIX   33 AD6 VAL B  773  ASN B  776  5                                   4    
HELIX   34 AD7 ASN B  777  GLY B  784  1                                   8    
HELIX   35 AD8 HIS B  789  LEU B  793  5                                   5    
HELIX   36 AD9 PHE B  813  ALA B  826  1                                  14    
HELIX   37 AE1 CYS B  844  LEU B  863  1                                  20    
HELIX   38 AE2 SER C   30  ARG C   42  1                                  13    
HELIX   39 AE3 SER C  122  LYS C  132  1                                  11    
HELIX   40 AE4 THR C  243  ASP C  251  1                                   9    
HELIX   41 AE5 ALA C  294  ARG C  298  5                                   5    
HELIX   42 AE6 PRO C  341  PHE C  346  1                                   6    
HELIX   43 AE7 PRO C  382  ALA C  384  5                                   3    
HELIX   44 AE8 ASN C  392  VAL C  403  1                                  12    
HELIX   45 AE9 TYR C  661  LEU C  670  1                                  10    
HELIX   46 AF1 GLY C  686  GLY C  691  1                                   6    
HELIX   47 AF2 VAL C  700  TYR C  716  1                                  17    
HELIX   48 AF3 SER C  730  LYS C  743  1                                  14    
HELIX   49 AF4 ASP C  763  ASP C  772  1                                  10    
HELIX   50 AF5 ASN C  777  GLY C  784  1                                   8    
HELIX   51 AF6 HIS C  789  LEU C  793  5                                   5    
HELIX   52 AF7 PHE C  813  ALA C  826  1                                  14    
HELIX   53 AF8 CYS C  844  LEU C  863  1                                  20    
HELIX   54 AF9 SER D   30  ARG D   42  1                                  13    
HELIX   55 AG1 PRO D  116  VAL D  120  5                                   5    
HELIX   56 AG2 SER D  122  LYS D  132  1                                  11    
HELIX   57 AG3 THR D  243  PHE D  250  1                                   8    
HELIX   58 AG4 SER D  283  VAL D  285  5                                   3    
HELIX   59 AG5 ALA D  294  ARG D  298  5                                   5    
HELIX   60 AG6 PRO D  341  PHE D  346  1                                   6    
HELIX   61 AG7 PRO D  382  ALA D  384  5                                   3    
HELIX   62 AG8 ASN D  392  ALA D  402  1                                  11    
HELIX   63 AG9 GLU D  446  GLY D  450  1                                   5    
HELIX   64 AH1 ASP D  583  LYS D  587  5                                   5    
HELIX   65 AH2 TYR D  661  LEU D  670  1                                  10    
HELIX   66 AH3 GLY D  686  GLY D  691  1                                   6    
HELIX   67 AH4 ALA D  692  LYS D  694  5                                   3    
HELIX   68 AH5 VAL D  700  GLY D  717  1                                  18    
HELIX   69 AH6 SER D  730  LYS D  743  1                                  14    
HELIX   70 AH7 VAL D  758  TYR D  762  5                                   5    
HELIX   71 AH8 ASP D  763  ASP D  772  1                                  10    
HELIX   72 AH9 ASN D  777  GLY D  784  1                                   8    
HELIX   73 AI1 SER D  785  LEU D  793  5                                   9    
HELIX   74 AI2 PHE D  813  GLY D  827  1                                  15    
HELIX   75 AI3 CYS D  844  LEU D  863  1                                  20    
SHEET    1 AA1 4 HIS A  54  GLN A  60  0                                        
SHEET    2 AA1 4 HIS A  70  GLY A  76 -1  O  LEU A  75   N  HIS A  54           
SHEET    3 AA1 4 SER A  85  SER A  89 -1  O  LEU A  87   N  TYR A  74           
SHEET    4 AA1 4 LYS A 106  GLN A 107 -1  O  LYS A 106   N  TYR A  88           
SHEET    1 AA2 4 TYR A 142  HIS A 145  0                                        
SHEET    2 AA2 4 LEU A 150  GLN A 154 -1  O  LEU A 152   N  ASP A 143           
SHEET    3 AA2 4 LEU A 159  ARG A 163 -1  O  PHE A 160   N  PHE A 153           
SHEET    4 AA2 4 LEU A 178  ILE A 180 -1  O  LEU A 178   N  HIS A 161           
SHEET    1 AA3 4 MET A 189  ILE A 193  0                                        
SHEET    2 AA3 4 PHE A 200  ILE A 204 -1  O  SER A 202   N  LYS A 192           
SHEET    3 AA3 4 LEU A 209  ASN A 213 -1  O  TRP A 210   N  PHE A 203           
SHEET    4 AA3 4 GLU A 219  ARG A 221 -1  O  ARG A 220   N  VAL A 211           
SHEET    1 AA4 3 LYS A 237  ALA A 239  0                                        
SHEET    2 AA4 3 LYS A 271  ASP A 281 -1  O  VAL A 280   N  SER A 238           
SHEET    3 AA4 3 SER A 263  TRP A 264 -1  N  SER A 263   O  THR A 272           
SHEET    1 AA5 5 TYR A 256  TRP A 258  0                                        
SHEET    2 AA5 5 LYS A 271  ASP A 281 -1  O  LEU A 276   N  TRP A 257           
SHEET    3 AA5 5 LEU A 317  THR A 324 -1  O  LYS A 318   N  TYR A 277           
SHEET    4 AA5 5 ILE A 330  LEU A 338 -1  O  VAL A 331   N  GLN A 323           
SHEET    5 AA5 5 PHE A 386  PRO A 388 -1  O  ILE A 387   N  GLU A 337           
SHEET    1 AA6 2 VAL A 287  PRO A 291  0                                        
SHEET    2 AA6 2 THR A 300  ARG A 304 -1  O  ASP A 301   N  VAL A 290           
SHEET    1 AA7 4 TYR A 351  TRP A 357  0                                        
SHEET    2 AA7 4 ALA A 364  LEU A 369 -1  O  MET A 367   N  ARG A 354           
SHEET    3 AA7 4 TRP A 375  LEU A 381 -1  O  LEU A 381   N  ALA A 364           
SHEET    4 AA7 4 TYR A 410  VAL A 416 -1  O  GLU A 415   N  LEU A 376           
SHEET    1 AA8 4 PHE A 427  PRO A 429  0                                        
SHEET    2 AA8 4 CYS A 440  ASN A 445 -1  O  LEU A 442   N  TYR A 428           
SHEET    3 AA8 4 HIS A 453  ALA A 459 -1  O  VAL A 457   N  PHE A 441           
SHEET    4 AA8 4 ILE A 483  ALA A 488 -1  O  ILE A 487   N  LYS A 456           
SHEET    1 AA9 4 TRP A 505  ASN A 507  0                                        
SHEET    2 AA9 4 LEU A 512  THR A 521 -1  O  TYR A 514   N  TRP A 505           
SHEET    3 AA9 4 GLU A 524  SER A 531 -1  O  TYR A 528   N  PHE A 515           
SHEET    4 AA9 4 VAL A 539  ARG A 540 -1  O  VAL A 539   N  VAL A 529           
SHEET    1 AB1 4 SER A 547  MET A 552  0                                        
SHEET    2 AB1 4 MET A 558  SER A 564 -1  O  HIS A 562   N  SER A 549           
SHEET    3 AB1 4 CYS A 571  SER A 578 -1  O  TYR A 575   N  PHE A 559           
SHEET    4 AB1 4 GLN A 588  MET A 596 -1  O  ARG A 590   N  LYS A 576           
SHEET    1 AB2 8 GLU A 609  HIS A 614  0                                        
SHEET    2 AB2 8 ARG A 620  TYR A 626 -1  O  LEU A 621   N  PHE A 613           
SHEET    3 AB2 8 ALA A 673  ILE A 677 -1  O  VAL A 674   N  TYR A 626           
SHEET    4 AB2 8 HIS A 637  PHE A 642  1  N  PRO A 638   O  ALA A 673           
SHEET    5 AB2 8 ILE A 719  GLY A 728  1  O  ALA A 725   N  THR A 639           
SHEET    6 AB2 8 VAL A 749  GLY A 753  1  O  GLY A 753   N  GLY A 728           
SHEET    7 AB2 8 LEU A 800  GLY A 805  1  O  LEU A 801   N  ALA A 750           
SHEET    8 AB2 8 GLN A 831  TYR A 835  1  O  GLN A 833   N  HIS A 804           
SHEET    1 AB3 4 HIS B  54  GLN B  60  0                                        
SHEET    2 AB3 4 HIS B  68  GLY B  76 -1  O  TYR B  73   N  GLN B  57           
SHEET    3 AB3 4 SER B  85  PRO B  92 -1  O  LEU B  87   N  TYR B  74           
SHEET    4 AB3 4 LYS B 106  GLN B 107 -1  O  LYS B 106   N  TYR B  88           
SHEET    1 AB4 4 ASP B 143  HIS B 145  0                                        
SHEET    2 AB4 4 LEU B 150  ALA B 155 -1  O  LEU B 152   N  ASP B 143           
SHEET    3 AB4 4 SER B 158  ARG B 163 -1  O  SER B 158   N  ALA B 155           
SHEET    4 AB4 4 LEU B 178  GLU B 179 -1  O  LEU B 178   N  HIS B 161           
SHEET    1 AB5 4 MET B 189  ILE B 193  0                                        
SHEET    2 AB5 4 PHE B 200  ILE B 204 -1  O  ILE B 204   N  MET B 189           
SHEET    3 AB5 4 LEU B 209  ASN B 213 -1  O  TRP B 210   N  PHE B 203           
SHEET    4 AB5 4 GLU B 219  ARG B 221 -1  O  ARG B 220   N  VAL B 211           
SHEET    1 AB6 4 LYS B 237  ALA B 239  0                                        
SHEET    2 AB6 4 ILE B 275  ASP B 281 -1  O  VAL B 280   N  SER B 238           
SHEET    3 AB6 4 LYS B 314  THR B 324 -1  O  ALA B 316   N  GLU B 279           
SHEET    4 AB6 4 LYS B 271  LEU B 273 -1  N  LEU B 273   O  PHE B 322           
SHEET    1 AB7 5 TYR B 256  TRP B 258  0                                        
SHEET    2 AB7 5 ILE B 275  ASP B 281 -1  O  LEU B 276   N  TRP B 257           
SHEET    3 AB7 5 LYS B 314  THR B 324 -1  O  ALA B 316   N  GLU B 279           
SHEET    4 AB7 5 ILE B 330  LEU B 338 -1  O  LYS B 336   N  LEU B 319           
SHEET    5 AB7 5 PHE B 386  PRO B 388 -1  O  ILE B 387   N  GLU B 337           
SHEET    1 AB8 2 VAL B 287  PRO B 291  0                                        
SHEET    2 AB8 2 THR B 300  ARG B 304 -1  O  TYR B 303   N  ILE B 288           
SHEET    1 AB9 4 VAL B 349  TRP B 357  0                                        
SHEET    2 AB9 4 ALA B 364  ASP B 370 -1  O  LEU B 369   N  GLU B 350           
SHEET    3 AB9 4 TRP B 375  LEU B 381 -1  O  LEU B 381   N  ALA B 364           
SHEET    4 AB9 4 TYR B 410  VAL B 416 -1  O  GLU B 415   N  LEU B 376           
SHEET    1 AC1 4 PHE B 427  PRO B 429  0                                        
SHEET    2 AC1 4 CYS B 440  ALA B 444 -1  O  LEU B 442   N  TYR B 428           
SHEET    3 AC1 4 LEU B 454  ALA B 459 -1  O  VAL B 457   N  PHE B 441           
SHEET    4 AC1 4 ILE B 483  ALA B 488 -1  O  LYS B 484   N  THR B 458           
SHEET    1 AC2 4 TRP B 505  ASN B 507  0                                        
SHEET    2 AC2 4 LEU B 512  THR B 521 -1  O  TYR B 514   N  TRP B 505           
SHEET    3 AC2 4 GLU B 524  SER B 531 -1  O  TYR B 528   N  PHE B 515           
SHEET    4 AC2 4 VAL B 539  ARG B 540 -1  O  VAL B 539   N  VAL B 529           
SHEET    1 AC3 4 SER B 547  MET B 552  0                                        
SHEET    2 AC3 4 MET B 558  SER B 565 -1  O  HIS B 562   N  SER B 549           
SHEET    3 AC3 4 THR B 568  SER B 578 -1  O  CYS B 571   N  TYR B 563           
SHEET    4 AC3 4 GLN B 588  MET B 596 -1  O  ALA B 593   N  VAL B 574           
SHEET    1 AC4 8 GLU B 609  PHE B 613  0                                        
SHEET    2 AC4 8 LEU B 621  TYR B 626 -1  O  LEU B 621   N  PHE B 613           
SHEET    3 AC4 8 ALA B 673  ILE B 677 -1  O  VAL B 676   N  MET B 624           
SHEET    4 AC4 8 HIS B 637  PHE B 642  1  N  VAL B 640   O  ALA B 673           
SHEET    5 AC4 8 ILE B 719  GLY B 728  1  O  ALA B 725   N  LEU B 641           
SHEET    6 AC4 8 VAL B 749  GLY B 753  1  O  GLY B 753   N  GLY B 728           
SHEET    7 AC4 8 LEU B 800  HIS B 804  1  O  LEU B 801   N  ALA B 750           
SHEET    8 AC4 8 GLN B 831  ILE B 834  1  O  GLN B 833   N  ILE B 802           
SHEET    1 AC5 4 HIS C  54  GLN C  60  0                                        
SHEET    2 AC5 4 HIS C  68  GLY C  76 -1  O  LEU C  75   N  HIS C  54           
SHEET    3 AC5 4 SER C  85  PRO C  92 -1  O  LEU C  87   N  TYR C  74           
SHEET    4 AC5 4 LYS C 106  GLN C 107 -1  O  LYS C 106   N  TYR C  88           
SHEET    1 AC6 4 ASP C 143  HIS C 145  0                                        
SHEET    2 AC6 4 LEU C 150  ALA C 155 -1  O  LEU C 152   N  ASP C 143           
SHEET    3 AC6 4 SER C 158  ARG C 163 -1  O  SER C 158   N  ALA C 155           
SHEET    4 AC6 4 LEU C 178  GLU C 179 -1  O  LEU C 178   N  HIS C 161           
SHEET    1 AC7 4 MET C 189  ILE C 193  0                                        
SHEET    2 AC7 4 PHE C 200  ILE C 204 -1  O  ILE C 204   N  MET C 189           
SHEET    3 AC7 4 LEU C 209  ASN C 213 -1  O  TRP C 210   N  PHE C 203           
SHEET    4 AC7 4 GLU C 219  ARG C 221 -1  O  ARG C 220   N  VAL C 211           
SHEET    1 AC8 4 LYS C 237  ALA C 239  0                                        
SHEET    2 AC8 4 LYS C 271  ASP C 281 -1  O  VAL C 280   N  SER C 238           
SHEET    3 AC8 4 LYS C 314  THR C 324 -1  O  THR C 324   N  LYS C 271           
SHEET    4 AC8 4 ILE C 330  THR C 333 -1  O  SER C 332   N  GLN C 323           
SHEET    1 AC9 5 TYR C 256  TRP C 258  0                                        
SHEET    2 AC9 5 LYS C 271  ASP C 281 -1  O  LEU C 276   N  TRP C 257           
SHEET    3 AC9 5 LYS C 314  THR C 324 -1  O  THR C 324   N  LYS C 271           
SHEET    4 AC9 5 LYS C 336  LEU C 338 -1  O  LYS C 336   N  LEU C 319           
SHEET    5 AC9 5 PHE C 386  PRO C 388 -1  O  ILE C 387   N  GLU C 337           
SHEET    1 AD1 2 VAL C 287  PRO C 291  0                                        
SHEET    2 AD1 2 THR C 300  ARG C 304 -1  O  ASP C 301   N  VAL C 290           
SHEET    1 AD2 4 TYR C 351  TRP C 357  0                                        
SHEET    2 AD2 4 ALA C 364  LEU C 369 -1  O  TRP C 365   N  GLY C 356           
SHEET    3 AD2 4 TRP C 375  LEU C 381 -1  O  LEU C 381   N  ALA C 364           
SHEET    4 AD2 4 TYR C 410  VAL C 416 -1  O  GLU C 415   N  LEU C 376           
SHEET    1 AD3 4 PHE C 427  PRO C 429  0                                        
SHEET    2 AD3 4 GLU C 438  ASN C 445 -1  O  LEU C 442   N  TYR C 428           
SHEET    3 AD3 4 HIS C 453  VAL C 460 -1  O  VAL C 457   N  PHE C 441           
SHEET    4 AD3 4 ILE C 483  ALA C 488 -1  O  ILE C 487   N  LYS C 456           
SHEET    1 AD4 4 TRP C 505  ASN C 507  0                                        
SHEET    2 AD4 4 LEU C 512  THR C 521 -1  O  LEU C 512   N  ASN C 507           
SHEET    3 AD4 4 GLU C 524  SER C 531 -1  O  VAL C 530   N  VAL C 513           
SHEET    4 AD4 4 VAL C 539  ARG C 540 -1  O  VAL C 539   N  VAL C 529           
SHEET    1 AD5 4 SER C 547  MET C 552  0                                        
SHEET    2 AD5 4 MET C 558  SER C 565 -1  O  HIS C 562   N  SER C 549           
SHEET    3 AD5 4 THR C 568  SER C 578 -1  O  TYR C 575   N  PHE C 559           
SHEET    4 AD5 4 GLN C 588  MET C 596 -1  O  ALA C 593   N  VAL C 574           
SHEET    1 AD6 8 GLU C 609  HIS C 614  0                                        
SHEET    2 AD6 8 ARG C 620  TYR C 626 -1  O  GLY C 623   N  PHE C 611           
SHEET    3 AD6 8 ALA C 673  ILE C 677 -1  O  VAL C 676   N  MET C 624           
SHEET    4 AD6 8 HIS C 637  PHE C 642  1  N  VAL C 640   O  ALA C 673           
SHEET    5 AD6 8 ILE C 719  TRP C 729  1  O  ALA C 725   N  LEU C 641           
SHEET    6 AD6 8 VAL C 749  GLY C 753  1  O  ILE C 751   N  ILE C 726           
SHEET    7 AD6 8 LEU C 800  GLY C 805  1  O  LEU C 801   N  ALA C 750           
SHEET    8 AD6 8 GLN C 831  TYR C 835  1  O  GLN C 833   N  ILE C 802           
SHEET    1 AD7 4 HIS D  54  GLN D  60  0                                        
SHEET    2 AD7 4 HIS D  68  GLY D  76 -1  O  LEU D  75   N  HIS D  54           
SHEET    3 AD7 4 SER D  85  PRO D  92 -1  O  SER D  85   N  GLY D  76           
SHEET    4 AD7 4 LYS D 106  GLN D 107 -1  O  LYS D 106   N  TYR D  88           
SHEET    1 AD8 4 TYR D 142  HIS D 145  0                                        
SHEET    2 AD8 4 LEU D 150  ALA D 155 -1  O  LEU D 152   N  ASP D 143           
SHEET    3 AD8 4 SER D 158  ARG D 163 -1  O  SER D 158   N  ALA D 155           
SHEET    4 AD8 4 LEU D 178  ILE D 180 -1  O  LEU D 178   N  HIS D 161           
SHEET    1 AD9 4 MET D 189  ILE D 193  0                                        
SHEET    2 AD9 4 PHE D 200  ILE D 204 -1  O  ILE D 204   N  MET D 189           
SHEET    3 AD9 4 LEU D 209  ASN D 213 -1  O  TRP D 210   N  PHE D 203           
SHEET    4 AD9 4 GLU D 219  ARG D 221 -1  O  ARG D 220   N  VAL D 211           
SHEET    1 AE1 3 LYS D 237  ALA D 239  0                                        
SHEET    2 AE1 3 LYS D 271  ASP D 281 -1  O  VAL D 280   N  SER D 238           
SHEET    3 AE1 3 TYR D 256  TRP D 258 -1  N  TRP D 257   O  LEU D 276           
SHEET    1 AE2 5 LYS D 237  ALA D 239  0                                        
SHEET    2 AE2 5 LYS D 271  ASP D 281 -1  O  VAL D 280   N  SER D 238           
SHEET    3 AE2 5 LYS D 314  THR D 324 -1  O  THR D 324   N  LYS D 271           
SHEET    4 AE2 5 ILE D 330  LEU D 338 -1  O  VAL D 331   N  GLN D 323           
SHEET    5 AE2 5 PHE D 386  PRO D 388 -1  O  ILE D 387   N  GLU D 337           
SHEET    1 AE3 2 VAL D 287  PRO D 291  0                                        
SHEET    2 AE3 2 THR D 300  ARG D 304 -1  O  ASP D 301   N  VAL D 290           
SHEET    1 AE4 4 TYR D 351  TRP D 357  0                                        
SHEET    2 AE4 4 ALA D 364  LEU D 369 -1  O  TRP D 365   N  GLY D 356           
SHEET    3 AE4 4 TRP D 375  LEU D 381 -1  O  LEU D 381   N  ALA D 364           
SHEET    4 AE4 4 TYR D 410  VAL D 416 -1  O  VAL D 412   N  LEU D 378           
SHEET    1 AE5 4 PHE D 427  PRO D 429  0                                        
SHEET    2 AE5 4 LEU D 439  ASN D 445 -1  O  LEU D 442   N  TYR D 428           
SHEET    3 AE5 4 HIS D 453  ALA D 459 -1  O  ALA D 459   N  LEU D 439           
SHEET    4 AE5 4 ILE D 483  ALA D 488 -1  O  LYS D 484   N  THR D 458           
SHEET    1 AE6 4 TRP D 505  ASN D 507  0                                        
SHEET    2 AE6 4 LEU D 512  THR D 521 -1  O  TYR D 514   N  TRP D 505           
SHEET    3 AE6 4 GLU D 524  SER D 531 -1  O  VAL D 530   N  VAL D 513           
SHEET    4 AE6 4 VAL D 539  ARG D 540 -1  O  VAL D 539   N  VAL D 529           
SHEET    1 AE7 4 SER D 547  MET D 552  0                                        
SHEET    2 AE7 4 MET D 558  SER D 564 -1  O  HIS D 562   N  SER D 549           
SHEET    3 AE7 4 CYS D 571  SER D 578 -1  O  TYR D 575   N  PHE D 559           
SHEET    4 AE7 4 GLN D 588  MET D 596 -1  O  ALA D 593   N  VAL D 574           
SHEET    1 AE8 8 GLU D 609  HIS D 614  0                                        
SHEET    2 AE8 8 ARG D 620  TYR D 626 -1  O  LEU D 621   N  PHE D 613           
SHEET    3 AE8 8 ALA D 673  ILE D 677 -1  O  VAL D 676   N  MET D 624           
SHEET    4 AE8 8 HIS D 637  PHE D 642  1  N  VAL D 640   O  ALA D 673           
SHEET    5 AE8 8 ILE D 719  GLY D 728  1  O  ALA D 725   N  THR D 639           
SHEET    6 AE8 8 PHE D 747  GLY D 753  1  O  GLY D 753   N  GLY D 728           
SHEET    7 AE8 8 LEU D 800  GLY D 805  1  O  LEU D 801   N  ALA D 750           
SHEET    8 AE8 8 GLN D 831  TYR D 835  1  O  GLN D 833   N  ILE D 802           
CRYST1  119.516  117.219  163.401  90.00 105.72  90.00 P 1 21 1      8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.008367  0.000000  0.002354        0.00000                         
SCALE2      0.000000  0.008531  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.006358        0.00000                         
TER    6564      HIS A 865                                                      
TER   13105      LEU B 863                                                      
TER   19666      LEU C 863                                                      
TER   26252      LEU D 863                                                      
TER   26269      PRO E 233                                                      
TER   26286      PRO F 233                                                      
TER   26303      PRO G 233                                                      
TER   26320      PRO H 233                                                      
MASTER      680    0    0   75  186    0    0    626316    8    0  284          
END                                                                             

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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