Structure

Tree Display

AceDB Schema

XML Display

Feedback

Structure Report for: 6S6E

Name Class
6S6ENameCrystal structure of the engineered ancestor of haloalkane dehalogenases and Renilla luciferase (AncHLD-RLuc I161_F162PinsL)
Gene_locus9zzzz-AncHLDRLuc
PaperSchenkmayerova_2020_ChemRxiv__
Schenkmayerova_2021_Nat.Commun_12_3616
PDB_file6s6e-pdb
FamilyHaloalkane_dehalogenase-HLD2
CommentSchenkmayerova, A., Damborsky, J., Marek, M. Luciferase from Renilla reniformis (RLuc) catalyzes the degradation of coelenterazine in the presence of molecular oxygen, resulting in the product coelenteramide, carbon dioxide, and the desired photon of light (EC 1.13.12.5). This enzyme belongs to the Haloalkane dehalogenase family II with a different catalytic function (EC 3.8.1.5) Reconstruction of an ancestral enzyme shows it has both hydrolase and monooxygenase activities ( Chaloupkova et al.) Preprint available of: Engineering Protein Dynamics of Ancestral Luciferase DOI: 10.26434/chemrxiv.12808295
Revelation_date27-Jan-2021
NewsJanuary-27-2021

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer