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Structure Report for: 6S97

Name Class
6S97NameFragment transplantation onto a hyperstable ancestor of haloalkane dehalogenases and Renilla luciferase (Anc-FT) AncFT
Gene_locus9zzzz-AncHLDRLuc2
PaperSchenkmayerova_2020_ChemRxiv__
Schenkmayerova_2021_Nat.Commun_12_3616
PDB_file6S97-pdb
FamilyHaloalkane_dehalogenase-HLD2
CommentSchenkmayerova, A., Damborsky, J., Marek, M.
Luciferase from Renilla reniformis (RLuc) catalyzes the degradation of coelenterazine in the presence of molecular oxygen, resulting in the product coelenteramide, carbon dioxide, and the desired photon of light (EC 1.13.12.5). This enzyme belongs to the Haloalkane dehalogenase family II with a different catalytic function (EC 3.8.1.5) Reconstruction of an ancestral enzyme shows it has both hydrolase and monooxygenase activities ( Chaloupkova et al.) Preprint available of: Engineering Protein Dynamics of Ancestral Luciferase DOI: 10.26434/chemrxiv.12808295
Revelation_date26-Aug-2020
NewsAUGUST-26-2020

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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