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LongText Report for: 6sjl-pdb

Name Class
6sjl-pdb
HEADER    HYDROLASE                               13-AUG-19   6SJL              
TITLE     STRUCTURE OF THE TLE1 EFFECTOR BOUND TO THE VGRG SPIKE FROM THE TYPE 6
TITLE    2 SECRETION SYSTEM                                                     
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PUTATIVE TYPE VI SECRETION PROTEIN;                        
COMPND   3 CHAIN: A, B, C;                                                      
COMPND   4 SYNONYM: TYPE VI SECRETION SYSTEM TIP PROTEIN VGRG;                  
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: PUTATIVE TYPE VI SECRETION PROTEIN;                        
COMPND   8 CHAIN: D, E, F;                                                      
COMPND   9 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE   3 ORGANISM_TAXID: 562;                                                 
SOURCE   4 GENE: VGRG, DL654_23170, DM280_18435, EF082_25505, EHD42_22735,      
SOURCE   5 EIT12_22235, EIT27_22025, NCTC9044_02519;                            
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE  10 ORGANISM_TAXID: 562;                                                 
SOURCE  11 GENE: NCTC12950_00913, NCTC9044_02520;                               
SOURCE  12 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  13 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    HYDROLASE, TOXIN, LIPASE, EFFECTOR, BACTERIAL                         
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    C.RAPISARDA,R.FRONZES                                                 
REVDAT   2   11-NOV-20 6SJL    1       JRNL                                     
REVDAT   1   29-APR-20 6SJL    0                                                
JRNL        AUTH   N.FLAUGNATTI,C.RAPISARDA,M.REY,S.G.BEAUVOIS,V.A.NGUYEN,      
JRNL        AUTH 2 S.CANAAN,E.DURAND,J.CHAMOT-ROOKE,E.CASCALES,R.FRONZES,       
JRNL        AUTH 3 L.JOURNET                                                    
JRNL        TITL   STRUCTURAL BASIS FOR LOADING AND INHIBITION OF A BACTERIAL   
JRNL        TITL 2 T6SS PHOSPHOLIPASE EFFECTOR BY THE VGRG SPIKE.               
JRNL        REF    EMBO J.                       V.  39 04129 2020              
JRNL        REFN                   ESSN 1460-2075                               
JRNL        PMID   32350888                                                     
JRNL        DOI    10.15252/EMBJ.2019104129                                     
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : SERIALEM, GCTF, CRYOSPARC, CRYOSPARC,     
REMARK   3                            CRYOSPARC, CRYOSPARC                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 2.600                          
REMARK   3   NUMBER OF PARTICLES               : 468438                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6SJL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 14-AUG-19.                  
REMARK 100 THE DEPOSITION ID IS D_1292103841.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : TLE1 EFFECTOR BOUND TO THE VGRG   
REMARK 245                                    SPIKE OF THE TYPE 6 SECRETION     
REMARK 245                                    SYSTEM                            
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.60                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 53.94                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 56730 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 92370 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -262.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ASN A     2                                                      
REMARK 465     LEU A     3                                                      
REMARK 465     THR A     4                                                      
REMARK 465     ASP A     5                                                      
REMARK 465     SER A     6                                                      
REMARK 465     LEU A     7                                                      
REMARK 465     GLN A     8                                                      
REMARK 465     ASN A     9                                                      
REMARK 465     VAL A    10                                                      
REMARK 465     LEU A    11                                                      
REMARK 465     SER A    12                                                      
REMARK 465     GLY A    13                                                      
REMARK 465     VAL A    14                                                      
REMARK 465     GLY A    15                                                      
REMARK 465     THR A    16                                                      
REMARK 465     LEU A    17                                                      
REMARK 465     ASN A    18                                                      
REMARK 465     ARG A    19                                                      
REMARK 465     TYR A    20                                                      
REMARK 465     ARG A    21                                                      
REMARK 465     LEU A    22                                                      
REMARK 465     ASP A    23                                                      
REMARK 465     ILE A    24                                                      
REMARK 465     PRO A    25                                                      
REMARK 465     SER A    26                                                      
REMARK 465     CYS A    27                                                      
REMARK 465     PRO A    28                                                      
REMARK 465     SER A    29                                                      
REMARK 465     SER A    30                                                      
REMARK 465     LEU A    31                                                      
REMARK 465     ASP A    32                                                      
REMARK 465     VAL A    33                                                      
REMARK 465     GLU A    34                                                      
REMARK 465     ASP A    35                                                      
REMARK 465     PHE A    36                                                      
REMARK 465     SER A    37                                                      
REMARK 465     GLY A    38                                                      
REMARK 465     THR A    39                                                      
REMARK 465     GLU A    40                                                      
REMARK 465     GLY A    41                                                      
REMARK 465     ILE A    42                                                      
REMARK 465     SER A    43                                                      
REMARK 465     LYS A    44                                                      
REMARK 465     ILE A    45                                                      
REMARK 465     TYR A    46                                                      
REMARK 465     ARG A    47                                                      
REMARK 465     TYR A    48                                                      
REMARK 465     ASP A    49                                                      
REMARK 465     ILE A    50                                                      
REMARK 465     ILE A    51                                                      
REMARK 465     PHE A    52                                                      
REMARK 465     THR A    53                                                      
REMARK 465     SER A    54                                                      
REMARK 465     THR A    55                                                      
REMARK 465     ASP A    56                                                      
REMARK 465     ARG A    57                                                      
REMARK 465     TYR A    58                                                      
REMARK 465     PRO A    59                                                      
REMARK 465     ASP A    60                                                      
REMARK 465     ALA A    61                                                      
REMARK 465     ALA A    62                                                      
REMARK 465     TRP A    63                                                      
REMARK 465     PHE A    64                                                      
REMARK 465     LEU A    65                                                      
REMARK 465     ARG A    66                                                      
REMARK 465     LYS A    67                                                      
REMARK 465     SER A    68                                                      
REMARK 465     ALA A    69                                                      
REMARK 465     THR A    70                                                      
REMARK 465     LEU A    71                                                      
REMARK 465     ILE A    72                                                      
REMARK 465     MET A    73                                                      
REMARK 465     GLY A    74                                                      
REMARK 465     THR A    75                                                      
REMARK 465     GLY A    76                                                      
REMARK 465     LEU A    77                                                      
REMARK 465     LEU A    78                                                      
REMARK 465     GLU A    79                                                      
REMARK 465     SER A    80                                                      
REMARK 465     LEU A    81                                                      
REMARK 465     THR A    82                                                      
REMARK 465     GLU A    83                                                      
REMARK 465     GLN A    84                                                      
REMARK 465     LYS A    85                                                      
REMARK 465     LYS A    86                                                      
REMARK 465     VAL A    87                                                      
REMARK 465     HIS A    88                                                      
REMARK 465     GLY A    89                                                      
REMARK 465     VAL A    90                                                      
REMARK 465     ILE A    91                                                      
REMARK 465     THR A    92                                                      
REMARK 465     ASP A    93                                                      
REMARK 465     PHE A    94                                                      
REMARK 465     ARG A    95                                                      
REMARK 465     ARG A    96                                                      
REMARK 465     ILE A    97                                                      
REMARK 465     SER A    98                                                      
REMARK 465     GLY A    99                                                      
REMARK 465     SER A   100                                                      
REMARK 465     GLU A   101                                                      
REMARK 465     ASP A   102                                                      
REMARK 465     GLN A   103                                                      
REMARK 465     ALA A   104                                                      
REMARK 465     GLN A   105                                                      
REMARK 465     TYR A   106                                                      
REMARK 465     ARG A   107                                                      
REMARK 465     ILE A   108                                                      
REMARK 465     THR A   109                                                      
REMARK 465     LEU A   110                                                      
REMARK 465     LYS A   111                                                      
REMARK 465     PRO A   112                                                      
REMARK 465     PHE A   113                                                      
REMARK 465     ILE A   114                                                      
REMARK 465     SER A   115                                                      
REMARK 465     LEU A   116                                                      
REMARK 465     LEU A   117                                                      
REMARK 465     ASP A   118                                                      
REMARK 465     LYS A   119                                                      
REMARK 465     GLN A   120                                                      
REMARK 465     PHE A   121                                                      
REMARK 465     ARG A   122                                                      
REMARK 465     THR A   123                                                      
REMARK 465     HIS A   124                                                      
REMARK 465     ARG A   125                                                      
REMARK 465     PHE A   126                                                      
REMARK 465     PHE A   127                                                      
REMARK 465     VAL A   128                                                      
REMARK 465     ASN A   129                                                      
REMARK 465     LYS A   130                                                      
REMARK 465     SER A   131                                                      
REMARK 465     VAL A   132                                                      
REMARK 465     PRO A   133                                                      
REMARK 465     GLU A   134                                                      
REMARK 465     VAL A   135                                                      
REMARK 465     VAL A   136                                                      
REMARK 465     GLU A   137                                                      
REMARK 465     GLN A   138                                                      
REMARK 465     ILE A   139                                                      
REMARK 465     LEU A   140                                                      
REMARK 465     THR A   141                                                      
REMARK 465     GLU A   142                                                      
REMARK 465     HIS A   143                                                      
REMARK 465     GLY A   144                                                      
REMARK 465     LEU A   145                                                      
REMARK 465     LYS A   146                                                      
REMARK 465     GLY A   147                                                      
REMARK 465     TRP A   148                                                      
REMARK 465     GLU A   149                                                      
REMARK 465     TYR A   150                                                      
REMARK 465     GLU A   151                                                      
REMARK 465     PHE A   152                                                      
REMARK 465     SER A   153                                                      
REMARK 465     LEU A   154                                                      
REMARK 465     LYS A   155                                                      
REMARK 465     ARG A   156                                                      
REMARK 465     THR A   157                                                      
REMARK 465     TYR A   158                                                      
REMARK 465     PRO A   159                                                      
REMARK 465     LYS A   160                                                      
REMARK 465     ARG A   161                                                      
REMARK 465     GLU A   162                                                      
REMARK 465     GLN A   163                                                      
REMARK 465     ILE A   164                                                      
REMARK 465     ASN A   165                                                      
REMARK 465     GLN A   166                                                      
REMARK 465     TYR A   167                                                      
REMARK 465     GLN A   168                                                      
REMARK 465     GLU A   169                                                      
REMARK 465     SER A   170                                                      
REMARK 465     ASP A   171                                                      
REMARK 465     LEU A   172                                                      
REMARK 465     ARG A   173                                                      
REMARK 465     PHE A   174                                                      
REMARK 465     ILE A   175                                                      
REMARK 465     GLN A   176                                                      
REMARK 465     ARG A   177                                                      
REMARK 465     LEU A   178                                                      
REMARK 465     LEU A   179                                                      
REMARK 465     ALA A   180                                                      
REMARK 465     GLU A   181                                                      
REMARK 465     VAL A   182                                                      
REMARK 465     GLY A   183                                                      
REMARK 465     ILE A   184                                                      
REMARK 465     PHE A   185                                                      
REMARK 465     TYR A   186                                                      
REMARK 465     PHE A   187                                                      
REMARK 465     PHE A   188                                                      
REMARK 465     THR A   189                                                      
REMARK 465     LEU A   190                                                      
REMARK 465     HIS A   191                                                      
REMARK 465     PRO A   192                                                      
REMARK 465     ASP A   193                                                      
REMARK 465     ALA A   194                                                      
REMARK 465     GLN A   195                                                      
REMARK 465     THR A   196                                                      
REMARK 465     GLU A   197                                                      
REMARK 465     VAL A   198                                                      
REMARK 465     ILE A   199                                                      
REMARK 465     HIS A   200                                                      
REMARK 465     PHE A   201                                                      
REMARK 465     GLY A   202                                                      
REMARK 465     ASP A   203                                                      
REMARK 465     VAL A   204                                                      
REMARK 465     GLN A   205                                                      
REMARK 465     ALA A   206                                                      
REMARK 465     ALA A   207                                                      
REMARK 465     LEU A   208                                                      
REMARK 465     ILE A   209                                                      
REMARK 465     PHE A   210                                                      
REMARK 465     ASP A   211                                                      
REMARK 465     LYS A   212                                                      
REMARK 465     THR A   213                                                      
REMARK 465     LEU A   214                                                      
REMARK 465     PRO A   215                                                      
REMARK 465     VAL A   216                                                      
REMARK 465     ASN A   217                                                      
REMARK 465     SER A   218                                                      
REMARK 465     PRO A   219                                                      
REMARK 465     SER A   220                                                      
REMARK 465     GLY A   221                                                      
REMARK 465     MET A   222                                                      
REMARK 465     SER A   223                                                      
REMARK 465     ASP A   224                                                      
REMARK 465     SER A   225                                                      
REMARK 465     GLY A   226                                                      
REMARK 465     THR A   227                                                      
REMARK 465     ASP A   228                                                      
REMARK 465     SER A   229                                                      
REMARK 465     VAL A   230                                                      
REMARK 465     TRP A   231                                                      
REMARK 465     ALA A   232                                                      
REMARK 465     LEU A   233                                                      
REMARK 465     ASN A   234                                                      
REMARK 465     VAL A   235                                                      
REMARK 465     GLU A   236                                                      
REMARK 465     HIS A   237                                                      
REMARK 465     ARG A   238                                                      
REMARK 465     VAL A   239                                                      
REMARK 465     VAL A   240                                                      
REMARK 465     GLU A   241                                                      
REMARK 465     SER A   242                                                      
REMARK 465     ARG A   243                                                      
REMARK 465     VAL A   244                                                      
REMARK 465     ILE A   245                                                      
REMARK 465     THR A   246                                                      
REMARK 465     ASN A   247                                                      
REMARK 465     ASP A   248                                                      
REMARK 465     TYR A   249                                                      
REMARK 465     ASN A   250                                                      
REMARK 465     HIS A   251                                                      
REMARK 465     ARG A   252                                                      
REMARK 465     GLU A   253                                                      
REMARK 465     ALA A   254                                                      
REMARK 465     GLN A   255                                                      
REMARK 465     ASN A   256                                                      
REMARK 465     ILE A   257                                                      
REMARK 465     LEU A   258                                                      
REMARK 465     MET A   259                                                      
REMARK 465     SER A   260                                                      
REMARK 465     VAL A   261                                                      
REMARK 465     PRO A   262                                                      
REMARK 465     ALA A   263                                                      
REMARK 465     ASP A   264                                                      
REMARK 465     MET A   265                                                      
REMARK 465     THR A   266                                                      
REMARK 465     ARG A   267                                                      
REMARK 465     GLY A   268                                                      
REMARK 465     GLU A   269                                                      
REMARK 465     GLY A   270                                                      
REMARK 465     TYR A   271                                                      
REMARK 465     ASP A   272                                                      
REMARK 465     THR A   273                                                      
REMARK 465     SER A   274                                                      
REMARK 465     TYR A   275                                                      
REMARK 465     GLY A   276                                                      
REMARK 465     GLU A   277                                                      
REMARK 465     VAL A   278                                                      
REMARK 465     TYR A   279                                                      
REMARK 465     HIS A   280                                                      
REMARK 465     TYR A   281                                                      
REMARK 465     ARG A   282                                                      
REMARK 465     PRO A   283                                                      
REMARK 465     ARG A   284                                                      
REMARK 465     HIS A   285                                                      
REMARK 465     THR A   286                                                      
REMARK 465     GLU A   287                                                      
REMARK 465     ARG A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     ASP A   290                                                      
REMARK 465     LYS A   291                                                      
REMARK 465     ILE A   292                                                      
REMARK 465     ASP A   293                                                      
REMARK 465     PRO A   294                                                      
REMARK 465     ALA A   295                                                      
REMARK 465     PRO A   296                                                      
REMARK 465     GLU A   297                                                      
REMARK 465     THR A   298                                                      
REMARK 465     ALA A   299                                                      
REMARK 465     ASN A   300                                                      
REMARK 465     PHE A   301                                                      
REMARK 465     TRP A   302                                                      
REMARK 465     ALA A   303                                                      
REMARK 465     ARG A   304                                                      
REMARK 465     LEU A   305                                                      
REMARK 465     ASP A   306                                                      
REMARK 465     HIS A   307                                                      
REMARK 465     GLU A   308                                                      
REMARK 465     ARG A   309                                                      
REMARK 465     PHE A   310                                                      
REMARK 465     LEU A   311                                                      
REMARK 465     ALA A   312                                                      
REMARK 465     GLU A   313                                                      
REMARK 465     GLN A   314                                                      
REMARK 465     THR A   315                                                      
REMARK 465     ARG A   316                                                      
REMARK 465     ILE A   317                                                      
REMARK 465     THR A   318                                                      
REMARK 465     GLY A   319                                                      
REMARK 465     LYS A   320                                                      
REMARK 465     SER A   321                                                      
REMARK 465     THR A   322                                                      
REMARK 465     ASP A   323                                                      
REMARK 465     ALA A   324                                                      
REMARK 465     SER A   325                                                      
REMARK 465     LEU A   326                                                      
REMARK 465     LEU A   327                                                      
REMARK 465     PRO A   328                                                      
REMARK 465     ALA A   329                                                      
REMARK 465     GLN A   330                                                      
REMARK 465     VAL A   331                                                      
REMARK 465     LEU A   332                                                      
REMARK 465     THR A   333                                                      
REMARK 465     ILE A   334                                                      
REMARK 465     THR A   335                                                      
REMARK 465     ASP A   336                                                      
REMARK 465     SER A   337                                                      
REMARK 465     THR A   338                                                      
REMARK 465     PRO A   339                                                      
REMARK 465     PRO A   340                                                      
REMARK 465     VAL A   341                                                      
REMARK 465     LEU A   342                                                      
REMARK 465     PRO A   343                                                      
REMARK 465     ALA A   344                                                      
REMARK 465     PRO A   345                                                      
REMARK 465     LEU A   346                                                      
REMARK 465     GLN A   347                                                      
REMARK 465     GLU A   348                                                      
REMARK 465     PRO A   349                                                      
REMARK 465     VAL A   350                                                      
REMARK 465     LEU A   351                                                      
REMARK 465     LEU A   352                                                      
REMARK 465     THR A   353                                                      
REMARK 465     GLN A   354                                                      
REMARK 465     LEU A   355                                                      
REMARK 465     LEU A   356                                                      
REMARK 465     PHE A   357                                                      
REMARK 465     THR A   358                                                      
REMARK 465     GLY A   359                                                      
REMARK 465     SER A   360                                                      
REMARK 465     ARG A   361                                                      
REMARK 465     LYS A   362                                                      
REMARK 465     SER A   363                                                      
REMARK 465     ALA A   364                                                      
REMARK 465     LEU A   365                                                      
REMARK 465     GLN A   366                                                      
REMARK 465     VAL A   367                                                      
REMARK 465     MET A   368                                                      
REMARK 465     LEU A   369                                                      
REMARK 465     SER A   370                                                      
REMARK 465     ALA A   371                                                      
REMARK 465     VAL A   372                                                      
REMARK 465     PRO A   373                                                      
REMARK 465     TYR A   374                                                      
REMARK 465     SER A   375                                                      
REMARK 465     GLU A   376                                                      
REMARK 465     ILE A   377                                                      
REMARK 465     VAL A   378                                                      
REMARK 465     CYS A   379                                                      
REMARK 465     TRP A   380                                                      
REMARK 465     ARG A   381                                                      
REMARK 465     PRO A   382                                                      
REMARK 465     PRO A   383                                                      
REMARK 465     LEU A   384                                                      
REMARK 465     LEU A   385                                                      
REMARK 465     THR A   386                                                      
REMARK 465     ARG A   387                                                      
REMARK 465     PRO A   388                                                      
REMARK 465     LYS A   389                                                      
REMARK 465     ILE A   390                                                      
REMARK 465     THR A   391                                                      
REMARK 465     GLY A   392                                                      
REMARK 465     THR A   393                                                      
REMARK 465     MET A   394                                                      
REMARK 465     THR A   395                                                      
REMARK 465     ALA A   396                                                      
REMARK 465     ARG A   397                                                      
REMARK 465     VAL A   398                                                      
REMARK 465     THR A   399                                                      
REMARK 465     SER A   400                                                      
REMARK 465     ALA A   401                                                      
REMARK 465     LYS A   402                                                      
REMARK 465     GLU A   403                                                      
REMARK 465     GLY A   404                                                      
REMARK 465     ASP A   405                                                      
REMARK 465     ILE A   406                                                      
REMARK 465     TYR A   407                                                      
REMARK 465     ALA A   408                                                      
REMARK 465     TRP A   409                                                      
REMARK 465     GLN A   410                                                      
REMARK 465     ASP A   411                                                      
REMARK 465     ALA A   412                                                      
REMARK 465     SER A   413                                                      
REMARK 465     GLY A   414                                                      
REMARK 465     MET A   415                                                      
REMARK 465     TYR A   416                                                      
REMARK 465     ARG A   417                                                      
REMARK 465     VAL A   418                                                      
REMARK 465     LYS A   419                                                      
REMARK 465     PHE A   420                                                      
REMARK 465     ASP A   421                                                      
REMARK 465     ALA A   422                                                      
REMARK 465     ASP A   423                                                      
REMARK 465     ARG A   424                                                      
REMARK 465     ASP A   425                                                      
REMARK 465     ASP A   426                                                      
REMARK 465     LYS A   427                                                      
REMARK 465     ASN A   428                                                      
REMARK 465     PRO A   429                                                      
REMARK 465     GLY A   430                                                      
REMARK 465     GLN A   431                                                      
REMARK 465     GLU A   432                                                      
REMARK 465     SER A   433                                                      
REMARK 465     MET A   434                                                      
REMARK 465     PRO A   435                                                      
REMARK 465     VAL A   436                                                      
REMARK 465     ARG A   437                                                      
REMARK 465     LEU A   438                                                      
REMARK 465     ALA A   439                                                      
REMARK 465     LYS A   440                                                      
REMARK 465     PRO A   441                                                      
REMARK 465     TYR A   442                                                      
REMARK 465     SER A   443                                                      
REMARK 465     GLY A   444                                                      
REMARK 465     ASP A   445                                                      
REMARK 465     ALA A   446                                                      
REMARK 465     TYR A   447                                                      
REMARK 465     GLY A   448                                                      
REMARK 465     PHE A   449                                                      
REMARK 465     HIS A   450                                                      
REMARK 465     PHE A   451                                                      
REMARK 465     PRO A   452                                                      
REMARK 465     LEU A   453                                                      
REMARK 465     ILE A   454                                                      
REMARK 465     GLN A   455                                                      
REMARK 465     GLY A   456                                                      
REMARK 465     THR A   457                                                      
REMARK 465     GLU A   458                                                      
REMARK 465     VAL A   459                                                      
REMARK 465     ALA A   460                                                      
REMARK 465     ILE A   461                                                      
REMARK 465     ALA A   462                                                      
REMARK 465     PHE A   463                                                      
REMARK 465     GLU A   464                                                      
REMARK 465     GLU A   465                                                      
REMARK 465     GLY A   466                                                      
REMARK 465     ASP A   467                                                      
REMARK 465     PRO A   468                                                      
REMARK 465     ASP A   469                                                      
REMARK 465     ARG A   470                                                      
REMARK 465     PRO A   471                                                      
REMARK 465     TYR A   472                                                      
REMARK 465     ILE A   473                                                      
REMARK 465     ALA A   474                                                      
REMARK 465     HIS A   475                                                      
REMARK 465     ALA A   476                                                      
REMARK 465     LEU A   477                                                      
REMARK 465     HIS A   478                                                      
REMARK 465     ASP A   479                                                      
REMARK 465     SER A   480                                                      
REMARK 465     ARG A   481                                                      
REMARK 465     HIS A   482                                                      
REMARK 465     VAL A   483                                                      
REMARK 465     ASP A   484                                                      
REMARK 465     HIS A   485                                                      
REMARK 465     VAL A   486                                                      
REMARK 465     THR A   487                                                      
REMARK 465     ASP A   488                                                      
REMARK 465     LYS A   489                                                      
REMARK 465     ASN A   490                                                      
REMARK 465     MET A   758                                                      
REMARK 465     GLN A   759                                                      
REMARK 465     LYS A   760                                                      
REMARK 465     MET A   761                                                      
REMARK 465     GLY A   762                                                      
REMARK 465     PRO A   763                                                      
REMARK 465     THR A   764                                                      
REMARK 465     SER A   765                                                      
REMARK 465     LEU A   766                                                      
REMARK 465     ASP A   767                                                      
REMARK 465     ILE A   768                                                      
REMARK 465     ALA A   769                                                      
REMARK 465     SER A   770                                                      
REMARK 465     VAL A   771                                                      
REMARK 465     GLU A   772                                                      
REMARK 465     MET A   773                                                      
REMARK 465     PRO A   774                                                      
REMARK 465     ARG A   775                                                      
REMARK 465     GLY A   776                                                      
REMARK 465     PHE A   777                                                      
REMARK 465     LYS A   835                                                      
REMARK 465     ILE A   836                                                      
REMARK 465     HIS A   837                                                      
REMARK 465     GLY A   838                                                      
REMARK 465     GLU A   839                                                      
REMARK 465     THR A   840                                                      
REMARK 465     GLU A   841                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ASN B     2                                                      
REMARK 465     LEU B     3                                                      
REMARK 465     THR B     4                                                      
REMARK 465     ASP B     5                                                      
REMARK 465     SER B     6                                                      
REMARK 465     LEU B     7                                                      
REMARK 465     GLN B     8                                                      
REMARK 465     ASN B     9                                                      
REMARK 465     VAL B    10                                                      
REMARK 465     LEU B    11                                                      
REMARK 465     SER B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     VAL B    14                                                      
REMARK 465     GLY B    15                                                      
REMARK 465     THR B    16                                                      
REMARK 465     LEU B    17                                                      
REMARK 465     ASN B    18                                                      
REMARK 465     ARG B    19                                                      
REMARK 465     TYR B    20                                                      
REMARK 465     ARG B    21                                                      
REMARK 465     LEU B    22                                                      
REMARK 465     ASP B    23                                                      
REMARK 465     ILE B    24                                                      
REMARK 465     PRO B    25                                                      
REMARK 465     SER B    26                                                      
REMARK 465     CYS B    27                                                      
REMARK 465     PRO B    28                                                      
REMARK 465     SER B    29                                                      
REMARK 465     SER B    30                                                      
REMARK 465     LEU B    31                                                      
REMARK 465     ASP B    32                                                      
REMARK 465     VAL B    33                                                      
REMARK 465     GLU B    34                                                      
REMARK 465     ASP B    35                                                      
REMARK 465     PHE B    36                                                      
REMARK 465     SER B    37                                                      
REMARK 465     GLY B    38                                                      
REMARK 465     THR B    39                                                      
REMARK 465     GLU B    40                                                      
REMARK 465     GLY B    41                                                      
REMARK 465     ILE B    42                                                      
REMARK 465     SER B    43                                                      
REMARK 465     LYS B    44                                                      
REMARK 465     ILE B    45                                                      
REMARK 465     TYR B    46                                                      
REMARK 465     ARG B    47                                                      
REMARK 465     TYR B    48                                                      
REMARK 465     ASP B    49                                                      
REMARK 465     ILE B    50                                                      
REMARK 465     ILE B    51                                                      
REMARK 465     PHE B    52                                                      
REMARK 465     THR B    53                                                      
REMARK 465     SER B    54                                                      
REMARK 465     THR B    55                                                      
REMARK 465     ASP B    56                                                      
REMARK 465     ARG B    57                                                      
REMARK 465     TYR B    58                                                      
REMARK 465     PRO B    59                                                      
REMARK 465     ASP B    60                                                      
REMARK 465     ALA B    61                                                      
REMARK 465     ALA B    62                                                      
REMARK 465     TRP B    63                                                      
REMARK 465     PHE B    64                                                      
REMARK 465     LEU B    65                                                      
REMARK 465     ARG B    66                                                      
REMARK 465     LYS B    67                                                      
REMARK 465     SER B    68                                                      
REMARK 465     ALA B    69                                                      
REMARK 465     THR B    70                                                      
REMARK 465     LEU B    71                                                      
REMARK 465     ILE B    72                                                      
REMARK 465     MET B    73                                                      
REMARK 465     GLY B    74                                                      
REMARK 465     THR B    75                                                      
REMARK 465     GLY B    76                                                      
REMARK 465     LEU B    77                                                      
REMARK 465     LEU B    78                                                      
REMARK 465     GLU B    79                                                      
REMARK 465     SER B    80                                                      
REMARK 465     LEU B    81                                                      
REMARK 465     THR B    82                                                      
REMARK 465     GLU B    83                                                      
REMARK 465     GLN B    84                                                      
REMARK 465     LYS B    85                                                      
REMARK 465     LYS B    86                                                      
REMARK 465     VAL B    87                                                      
REMARK 465     HIS B    88                                                      
REMARK 465     GLY B    89                                                      
REMARK 465     VAL B    90                                                      
REMARK 465     ILE B    91                                                      
REMARK 465     THR B    92                                                      
REMARK 465     ASP B    93                                                      
REMARK 465     PHE B    94                                                      
REMARK 465     ARG B    95                                                      
REMARK 465     ARG B    96                                                      
REMARK 465     ILE B    97                                                      
REMARK 465     SER B    98                                                      
REMARK 465     GLY B    99                                                      
REMARK 465     SER B   100                                                      
REMARK 465     GLU B   101                                                      
REMARK 465     ASP B   102                                                      
REMARK 465     GLN B   103                                                      
REMARK 465     ALA B   104                                                      
REMARK 465     GLN B   105                                                      
REMARK 465     TYR B   106                                                      
REMARK 465     ARG B   107                                                      
REMARK 465     ILE B   108                                                      
REMARK 465     THR B   109                                                      
REMARK 465     LEU B   110                                                      
REMARK 465     LYS B   111                                                      
REMARK 465     PRO B   112                                                      
REMARK 465     PHE B   113                                                      
REMARK 465     ILE B   114                                                      
REMARK 465     SER B   115                                                      
REMARK 465     LEU B   116                                                      
REMARK 465     LEU B   117                                                      
REMARK 465     ASP B   118                                                      
REMARK 465     LYS B   119                                                      
REMARK 465     GLN B   120                                                      
REMARK 465     PHE B   121                                                      
REMARK 465     ARG B   122                                                      
REMARK 465     THR B   123                                                      
REMARK 465     HIS B   124                                                      
REMARK 465     ARG B   125                                                      
REMARK 465     PHE B   126                                                      
REMARK 465     PHE B   127                                                      
REMARK 465     VAL B   128                                                      
REMARK 465     ASN B   129                                                      
REMARK 465     LYS B   130                                                      
REMARK 465     SER B   131                                                      
REMARK 465     VAL B   132                                                      
REMARK 465     PRO B   133                                                      
REMARK 465     GLU B   134                                                      
REMARK 465     VAL B   135                                                      
REMARK 465     VAL B   136                                                      
REMARK 465     GLU B   137                                                      
REMARK 465     GLN B   138                                                      
REMARK 465     ILE B   139                                                      
REMARK 465     LEU B   140                                                      
REMARK 465     THR B   141                                                      
REMARK 465     GLU B   142                                                      
REMARK 465     HIS B   143                                                      
REMARK 465     GLY B   144                                                      
REMARK 465     LEU B   145                                                      
REMARK 465     LYS B   146                                                      
REMARK 465     GLY B   147                                                      
REMARK 465     TRP B   148                                                      
REMARK 465     GLU B   149                                                      
REMARK 465     TYR B   150                                                      
REMARK 465     GLU B   151                                                      
REMARK 465     PHE B   152                                                      
REMARK 465     SER B   153                                                      
REMARK 465     LEU B   154                                                      
REMARK 465     LYS B   155                                                      
REMARK 465     ARG B   156                                                      
REMARK 465     THR B   157                                                      
REMARK 465     TYR B   158                                                      
REMARK 465     PRO B   159                                                      
REMARK 465     LYS B   160                                                      
REMARK 465     ARG B   161                                                      
REMARK 465     GLU B   162                                                      
REMARK 465     GLN B   163                                                      
REMARK 465     ILE B   164                                                      
REMARK 465     ASN B   165                                                      
REMARK 465     GLN B   166                                                      
REMARK 465     TYR B   167                                                      
REMARK 465     GLN B   168                                                      
REMARK 465     GLU B   169                                                      
REMARK 465     SER B   170                                                      
REMARK 465     ASP B   171                                                      
REMARK 465     LEU B   172                                                      
REMARK 465     ARG B   173                                                      
REMARK 465     PHE B   174                                                      
REMARK 465     ILE B   175                                                      
REMARK 465     GLN B   176                                                      
REMARK 465     ARG B   177                                                      
REMARK 465     LEU B   178                                                      
REMARK 465     LEU B   179                                                      
REMARK 465     ALA B   180                                                      
REMARK 465     GLU B   181                                                      
REMARK 465     VAL B   182                                                      
REMARK 465     GLY B   183                                                      
REMARK 465     ILE B   184                                                      
REMARK 465     PHE B   185                                                      
REMARK 465     TYR B   186                                                      
REMARK 465     PHE B   187                                                      
REMARK 465     PHE B   188                                                      
REMARK 465     THR B   189                                                      
REMARK 465     LEU B   190                                                      
REMARK 465     HIS B   191                                                      
REMARK 465     PRO B   192                                                      
REMARK 465     ASP B   193                                                      
REMARK 465     ALA B   194                                                      
REMARK 465     GLN B   195                                                      
REMARK 465     THR B   196                                                      
REMARK 465     GLU B   197                                                      
REMARK 465     VAL B   198                                                      
REMARK 465     ILE B   199                                                      
REMARK 465     HIS B   200                                                      
REMARK 465     PHE B   201                                                      
REMARK 465     GLY B   202                                                      
REMARK 465     ASP B   203                                                      
REMARK 465     VAL B   204                                                      
REMARK 465     GLN B   205                                                      
REMARK 465     ALA B   206                                                      
REMARK 465     ALA B   207                                                      
REMARK 465     LEU B   208                                                      
REMARK 465     ILE B   209                                                      
REMARK 465     PHE B   210                                                      
REMARK 465     ASP B   211                                                      
REMARK 465     LYS B   212                                                      
REMARK 465     THR B   213                                                      
REMARK 465     LEU B   214                                                      
REMARK 465     PRO B   215                                                      
REMARK 465     VAL B   216                                                      
REMARK 465     ASN B   217                                                      
REMARK 465     SER B   218                                                      
REMARK 465     PRO B   219                                                      
REMARK 465     SER B   220                                                      
REMARK 465     GLY B   221                                                      
REMARK 465     MET B   222                                                      
REMARK 465     SER B   223                                                      
REMARK 465     ASP B   224                                                      
REMARK 465     SER B   225                                                      
REMARK 465     GLY B   226                                                      
REMARK 465     THR B   227                                                      
REMARK 465     ASP B   228                                                      
REMARK 465     SER B   229                                                      
REMARK 465     VAL B   230                                                      
REMARK 465     TRP B   231                                                      
REMARK 465     ALA B   232                                                      
REMARK 465     LEU B   233                                                      
REMARK 465     ASN B   234                                                      
REMARK 465     VAL B   235                                                      
REMARK 465     GLU B   236                                                      
REMARK 465     HIS B   237                                                      
REMARK 465     ARG B   238                                                      
REMARK 465     VAL B   239                                                      
REMARK 465     VAL B   240                                                      
REMARK 465     GLU B   241                                                      
REMARK 465     SER B   242                                                      
REMARK 465     ARG B   243                                                      
REMARK 465     VAL B   244                                                      
REMARK 465     ILE B   245                                                      
REMARK 465     THR B   246                                                      
REMARK 465     ASN B   247                                                      
REMARK 465     ASP B   248                                                      
REMARK 465     TYR B   249                                                      
REMARK 465     ASN B   250                                                      
REMARK 465     HIS B   251                                                      
REMARK 465     ARG B   252                                                      
REMARK 465     GLU B   253                                                      
REMARK 465     ALA B   254                                                      
REMARK 465     GLN B   255                                                      
REMARK 465     ASN B   256                                                      
REMARK 465     ILE B   257                                                      
REMARK 465     LEU B   258                                                      
REMARK 465     MET B   259                                                      
REMARK 465     SER B   260                                                      
REMARK 465     VAL B   261                                                      
REMARK 465     PRO B   262                                                      
REMARK 465     ALA B   263                                                      
REMARK 465     ASP B   264                                                      
REMARK 465     MET B   265                                                      
REMARK 465     THR B   266                                                      
REMARK 465     ARG B   267                                                      
REMARK 465     GLY B   268                                                      
REMARK 465     GLU B   269                                                      
REMARK 465     GLY B   270                                                      
REMARK 465     TYR B   271                                                      
REMARK 465     ASP B   272                                                      
REMARK 465     THR B   273                                                      
REMARK 465     SER B   274                                                      
REMARK 465     TYR B   275                                                      
REMARK 465     GLY B   276                                                      
REMARK 465     GLU B   277                                                      
REMARK 465     VAL B   278                                                      
REMARK 465     TYR B   279                                                      
REMARK 465     HIS B   280                                                      
REMARK 465     TYR B   281                                                      
REMARK 465     ARG B   282                                                      
REMARK 465     PRO B   283                                                      
REMARK 465     ARG B   284                                                      
REMARK 465     HIS B   285                                                      
REMARK 465     THR B   286                                                      
REMARK 465     GLU B   287                                                      
REMARK 465     ARG B   288                                                      
REMARK 465     GLY B   289                                                      
REMARK 465     ASP B   290                                                      
REMARK 465     LYS B   291                                                      
REMARK 465     ILE B   292                                                      
REMARK 465     ASP B   293                                                      
REMARK 465     PRO B   294                                                      
REMARK 465     ALA B   295                                                      
REMARK 465     PRO B   296                                                      
REMARK 465     GLU B   297                                                      
REMARK 465     THR B   298                                                      
REMARK 465     ALA B   299                                                      
REMARK 465     ASN B   300                                                      
REMARK 465     PHE B   301                                                      
REMARK 465     TRP B   302                                                      
REMARK 465     ALA B   303                                                      
REMARK 465     ARG B   304                                                      
REMARK 465     LEU B   305                                                      
REMARK 465     ASP B   306                                                      
REMARK 465     HIS B   307                                                      
REMARK 465     GLU B   308                                                      
REMARK 465     ARG B   309                                                      
REMARK 465     PHE B   310                                                      
REMARK 465     LEU B   311                                                      
REMARK 465     ALA B   312                                                      
REMARK 465     GLU B   313                                                      
REMARK 465     GLN B   314                                                      
REMARK 465     THR B   315                                                      
REMARK 465     ARG B   316                                                      
REMARK 465     ILE B   317                                                      
REMARK 465     THR B   318                                                      
REMARK 465     GLY B   319                                                      
REMARK 465     LYS B   320                                                      
REMARK 465     SER B   321                                                      
REMARK 465     THR B   322                                                      
REMARK 465     ASP B   323                                                      
REMARK 465     ALA B   324                                                      
REMARK 465     SER B   325                                                      
REMARK 465     LEU B   326                                                      
REMARK 465     LEU B   327                                                      
REMARK 465     PRO B   328                                                      
REMARK 465     ALA B   329                                                      
REMARK 465     GLN B   330                                                      
REMARK 465     VAL B   331                                                      
REMARK 465     LEU B   332                                                      
REMARK 465     THR B   333                                                      
REMARK 465     ILE B   334                                                      
REMARK 465     THR B   335                                                      
REMARK 465     ASP B   336                                                      
REMARK 465     SER B   337                                                      
REMARK 465     THR B   338                                                      
REMARK 465     PRO B   339                                                      
REMARK 465     PRO B   340                                                      
REMARK 465     VAL B   341                                                      
REMARK 465     LEU B   342                                                      
REMARK 465     PRO B   343                                                      
REMARK 465     ALA B   344                                                      
REMARK 465     PRO B   345                                                      
REMARK 465     LEU B   346                                                      
REMARK 465     GLN B   347                                                      
REMARK 465     GLU B   348                                                      
REMARK 465     PRO B   349                                                      
REMARK 465     VAL B   350                                                      
REMARK 465     LEU B   351                                                      
REMARK 465     LEU B   352                                                      
REMARK 465     THR B   353                                                      
REMARK 465     GLN B   354                                                      
REMARK 465     LEU B   355                                                      
REMARK 465     LEU B   356                                                      
REMARK 465     PHE B   357                                                      
REMARK 465     THR B   358                                                      
REMARK 465     GLY B   359                                                      
REMARK 465     SER B   360                                                      
REMARK 465     ARG B   361                                                      
REMARK 465     LYS B   362                                                      
REMARK 465     SER B   363                                                      
REMARK 465     ALA B   364                                                      
REMARK 465     LEU B   365                                                      
REMARK 465     GLN B   366                                                      
REMARK 465     VAL B   367                                                      
REMARK 465     MET B   368                                                      
REMARK 465     LEU B   369                                                      
REMARK 465     SER B   370                                                      
REMARK 465     ALA B   371                                                      
REMARK 465     VAL B   372                                                      
REMARK 465     PRO B   373                                                      
REMARK 465     TYR B   374                                                      
REMARK 465     SER B   375                                                      
REMARK 465     GLU B   376                                                      
REMARK 465     ILE B   377                                                      
REMARK 465     VAL B   378                                                      
REMARK 465     CYS B   379                                                      
REMARK 465     TRP B   380                                                      
REMARK 465     ARG B   381                                                      
REMARK 465     PRO B   382                                                      
REMARK 465     PRO B   383                                                      
REMARK 465     LEU B   384                                                      
REMARK 465     LEU B   385                                                      
REMARK 465     THR B   386                                                      
REMARK 465     ARG B   387                                                      
REMARK 465     PRO B   388                                                      
REMARK 465     LYS B   389                                                      
REMARK 465     ILE B   390                                                      
REMARK 465     THR B   391                                                      
REMARK 465     GLY B   392                                                      
REMARK 465     THR B   393                                                      
REMARK 465     MET B   394                                                      
REMARK 465     THR B   395                                                      
REMARK 465     ALA B   396                                                      
REMARK 465     ARG B   397                                                      
REMARK 465     VAL B   398                                                      
REMARK 465     THR B   399                                                      
REMARK 465     SER B   400                                                      
REMARK 465     ALA B   401                                                      
REMARK 465     LYS B   402                                                      
REMARK 465     GLU B   403                                                      
REMARK 465     GLY B   404                                                      
REMARK 465     ASP B   405                                                      
REMARK 465     ILE B   406                                                      
REMARK 465     TYR B   407                                                      
REMARK 465     ALA B   408                                                      
REMARK 465     TRP B   409                                                      
REMARK 465     GLN B   410                                                      
REMARK 465     ASP B   411                                                      
REMARK 465     ALA B   412                                                      
REMARK 465     SER B   413                                                      
REMARK 465     GLY B   414                                                      
REMARK 465     MET B   415                                                      
REMARK 465     TYR B   416                                                      
REMARK 465     ARG B   417                                                      
REMARK 465     VAL B   418                                                      
REMARK 465     LYS B   419                                                      
REMARK 465     PHE B   420                                                      
REMARK 465     ASP B   421                                                      
REMARK 465     ALA B   422                                                      
REMARK 465     ASP B   423                                                      
REMARK 465     ARG B   424                                                      
REMARK 465     ASP B   425                                                      
REMARK 465     ASP B   426                                                      
REMARK 465     LYS B   427                                                      
REMARK 465     ASN B   428                                                      
REMARK 465     PRO B   429                                                      
REMARK 465     GLY B   430                                                      
REMARK 465     GLN B   431                                                      
REMARK 465     GLU B   432                                                      
REMARK 465     SER B   433                                                      
REMARK 465     MET B   434                                                      
REMARK 465     PRO B   435                                                      
REMARK 465     VAL B   436                                                      
REMARK 465     ARG B   437                                                      
REMARK 465     LEU B   438                                                      
REMARK 465     ALA B   439                                                      
REMARK 465     LYS B   440                                                      
REMARK 465     PRO B   441                                                      
REMARK 465     TYR B   442                                                      
REMARK 465     SER B   443                                                      
REMARK 465     GLY B   444                                                      
REMARK 465     ASP B   445                                                      
REMARK 465     ALA B   446                                                      
REMARK 465     TYR B   447                                                      
REMARK 465     GLY B   448                                                      
REMARK 465     PHE B   449                                                      
REMARK 465     HIS B   450                                                      
REMARK 465     PHE B   451                                                      
REMARK 465     PRO B   452                                                      
REMARK 465     LEU B   453                                                      
REMARK 465     ILE B   454                                                      
REMARK 465     GLN B   455                                                      
REMARK 465     GLY B   456                                                      
REMARK 465     THR B   457                                                      
REMARK 465     GLU B   458                                                      
REMARK 465     VAL B   459                                                      
REMARK 465     ALA B   460                                                      
REMARK 465     ILE B   461                                                      
REMARK 465     ALA B   462                                                      
REMARK 465     PHE B   463                                                      
REMARK 465     GLU B   464                                                      
REMARK 465     GLU B   465                                                      
REMARK 465     GLY B   466                                                      
REMARK 465     ASP B   467                                                      
REMARK 465     PRO B   468                                                      
REMARK 465     ASP B   469                                                      
REMARK 465     ARG B   470                                                      
REMARK 465     PRO B   471                                                      
REMARK 465     TYR B   472                                                      
REMARK 465     ILE B   473                                                      
REMARK 465     ALA B   474                                                      
REMARK 465     HIS B   475                                                      
REMARK 465     ALA B   476                                                      
REMARK 465     LEU B   477                                                      
REMARK 465     HIS B   478                                                      
REMARK 465     ASP B   479                                                      
REMARK 465     SER B   480                                                      
REMARK 465     ARG B   481                                                      
REMARK 465     HIS B   482                                                      
REMARK 465     VAL B   483                                                      
REMARK 465     ASP B   484                                                      
REMARK 465     HIS B   485                                                      
REMARK 465     VAL B   486                                                      
REMARK 465     THR B   487                                                      
REMARK 465     ASP B   488                                                      
REMARK 465     LYS B   489                                                      
REMARK 465     ASN B   490                                                      
REMARK 465     MET B   758                                                      
REMARK 465     GLN B   759                                                      
REMARK 465     LYS B   760                                                      
REMARK 465     MET B   761                                                      
REMARK 465     GLY B   762                                                      
REMARK 465     PRO B   763                                                      
REMARK 465     THR B   764                                                      
REMARK 465     SER B   765                                                      
REMARK 465     LEU B   766                                                      
REMARK 465     ASP B   767                                                      
REMARK 465     ILE B   768                                                      
REMARK 465     ALA B   769                                                      
REMARK 465     SER B   770                                                      
REMARK 465     VAL B   771                                                      
REMARK 465     GLU B   772                                                      
REMARK 465     MET B   773                                                      
REMARK 465     PRO B   774                                                      
REMARK 465     ARG B   775                                                      
REMARK 465     GLY B   776                                                      
REMARK 465     PHE B   777                                                      
REMARK 465     LYS B   835                                                      
REMARK 465     ILE B   836                                                      
REMARK 465     HIS B   837                                                      
REMARK 465     GLY B   838                                                      
REMARK 465     GLU B   839                                                      
REMARK 465     THR B   840                                                      
REMARK 465     GLU B   841                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ASN C     2                                                      
REMARK 465     LEU C     3                                                      
REMARK 465     THR C     4                                                      
REMARK 465     ASP C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     LEU C     7                                                      
REMARK 465     GLN C     8                                                      
REMARK 465     ASN C     9                                                      
REMARK 465     VAL C    10                                                      
REMARK 465     LEU C    11                                                      
REMARK 465     SER C    12                                                      
REMARK 465     GLY C    13                                                      
REMARK 465     VAL C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     THR C    16                                                      
REMARK 465     LEU C    17                                                      
REMARK 465     ASN C    18                                                      
REMARK 465     ARG C    19                                                      
REMARK 465     TYR C    20                                                      
REMARK 465     ARG C    21                                                      
REMARK 465     LEU C    22                                                      
REMARK 465     ASP C    23                                                      
REMARK 465     ILE C    24                                                      
REMARK 465     PRO C    25                                                      
REMARK 465     SER C    26                                                      
REMARK 465     CYS C    27                                                      
REMARK 465     PRO C    28                                                      
REMARK 465     SER C    29                                                      
REMARK 465     SER C    30                                                      
REMARK 465     LEU C    31                                                      
REMARK 465     ASP C    32                                                      
REMARK 465     VAL C    33                                                      
REMARK 465     GLU C    34                                                      
REMARK 465     ASP C    35                                                      
REMARK 465     PHE C    36                                                      
REMARK 465     SER C    37                                                      
REMARK 465     GLY C    38                                                      
REMARK 465     THR C    39                                                      
REMARK 465     GLU C    40                                                      
REMARK 465     GLY C    41                                                      
REMARK 465     ILE C    42                                                      
REMARK 465     SER C    43                                                      
REMARK 465     LYS C    44                                                      
REMARK 465     ILE C    45                                                      
REMARK 465     TYR C    46                                                      
REMARK 465     ARG C    47                                                      
REMARK 465     TYR C    48                                                      
REMARK 465     ASP C    49                                                      
REMARK 465     ILE C    50                                                      
REMARK 465     ILE C    51                                                      
REMARK 465     PHE C    52                                                      
REMARK 465     THR C    53                                                      
REMARK 465     SER C    54                                                      
REMARK 465     THR C    55                                                      
REMARK 465     ASP C    56                                                      
REMARK 465     ARG C    57                                                      
REMARK 465     TYR C    58                                                      
REMARK 465     PRO C    59                                                      
REMARK 465     ASP C    60                                                      
REMARK 465     ALA C    61                                                      
REMARK 465     ALA C    62                                                      
REMARK 465     TRP C    63                                                      
REMARK 465     PHE C    64                                                      
REMARK 465     LEU C    65                                                      
REMARK 465     ARG C    66                                                      
REMARK 465     LYS C    67                                                      
REMARK 465     SER C    68                                                      
REMARK 465     ALA C    69                                                      
REMARK 465     THR C    70                                                      
REMARK 465     LEU C    71                                                      
REMARK 465     ILE C    72                                                      
REMARK 465     MET C    73                                                      
REMARK 465     GLY C    74                                                      
REMARK 465     THR C    75                                                      
REMARK 465     GLY C    76                                                      
REMARK 465     LEU C    77                                                      
REMARK 465     LEU C    78                                                      
REMARK 465     GLU C    79                                                      
REMARK 465     SER C    80                                                      
REMARK 465     LEU C    81                                                      
REMARK 465     THR C    82                                                      
REMARK 465     GLU C    83                                                      
REMARK 465     GLN C    84                                                      
REMARK 465     LYS C    85                                                      
REMARK 465     LYS C    86                                                      
REMARK 465     VAL C    87                                                      
REMARK 465     HIS C    88                                                      
REMARK 465     GLY C    89                                                      
REMARK 465     VAL C    90                                                      
REMARK 465     ILE C    91                                                      
REMARK 465     THR C    92                                                      
REMARK 465     ASP C    93                                                      
REMARK 465     PHE C    94                                                      
REMARK 465     ARG C    95                                                      
REMARK 465     ARG C    96                                                      
REMARK 465     ILE C    97                                                      
REMARK 465     SER C    98                                                      
REMARK 465     GLY C    99                                                      
REMARK 465     SER C   100                                                      
REMARK 465     GLU C   101                                                      
REMARK 465     ASP C   102                                                      
REMARK 465     GLN C   103                                                      
REMARK 465     ALA C   104                                                      
REMARK 465     GLN C   105                                                      
REMARK 465     TYR C   106                                                      
REMARK 465     ARG C   107                                                      
REMARK 465     ILE C   108                                                      
REMARK 465     THR C   109                                                      
REMARK 465     LEU C   110                                                      
REMARK 465     LYS C   111                                                      
REMARK 465     PRO C   112                                                      
REMARK 465     PHE C   113                                                      
REMARK 465     ILE C   114                                                      
REMARK 465     SER C   115                                                      
REMARK 465     LEU C   116                                                      
REMARK 465     LEU C   117                                                      
REMARK 465     ASP C   118                                                      
REMARK 465     LYS C   119                                                      
REMARK 465     GLN C   120                                                      
REMARK 465     PHE C   121                                                      
REMARK 465     ARG C   122                                                      
REMARK 465     THR C   123                                                      
REMARK 465     HIS C   124                                                      
REMARK 465     ARG C   125                                                      
REMARK 465     PHE C   126                                                      
REMARK 465     PHE C   127                                                      
REMARK 465     VAL C   128                                                      
REMARK 465     ASN C   129                                                      
REMARK 465     LYS C   130                                                      
REMARK 465     SER C   131                                                      
REMARK 465     VAL C   132                                                      
REMARK 465     PRO C   133                                                      
REMARK 465     GLU C   134                                                      
REMARK 465     VAL C   135                                                      
REMARK 465     VAL C   136                                                      
REMARK 465     GLU C   137                                                      
REMARK 465     GLN C   138                                                      
REMARK 465     ILE C   139                                                      
REMARK 465     LEU C   140                                                      
REMARK 465     THR C   141                                                      
REMARK 465     GLU C   142                                                      
REMARK 465     HIS C   143                                                      
REMARK 465     GLY C   144                                                      
REMARK 465     LEU C   145                                                      
REMARK 465     LYS C   146                                                      
REMARK 465     GLY C   147                                                      
REMARK 465     TRP C   148                                                      
REMARK 465     GLU C   149                                                      
REMARK 465     TYR C   150                                                      
REMARK 465     GLU C   151                                                      
REMARK 465     PHE C   152                                                      
REMARK 465     SER C   153                                                      
REMARK 465     LEU C   154                                                      
REMARK 465     LYS C   155                                                      
REMARK 465     ARG C   156                                                      
REMARK 465     THR C   157                                                      
REMARK 465     TYR C   158                                                      
REMARK 465     PRO C   159                                                      
REMARK 465     LYS C   160                                                      
REMARK 465     ARG C   161                                                      
REMARK 465     GLU C   162                                                      
REMARK 465     GLN C   163                                                      
REMARK 465     ILE C   164                                                      
REMARK 465     ASN C   165                                                      
REMARK 465     GLN C   166                                                      
REMARK 465     TYR C   167                                                      
REMARK 465     GLN C   168                                                      
REMARK 465     GLU C   169                                                      
REMARK 465     SER C   170                                                      
REMARK 465     ASP C   171                                                      
REMARK 465     LEU C   172                                                      
REMARK 465     ARG C   173                                                      
REMARK 465     PHE C   174                                                      
REMARK 465     ILE C   175                                                      
REMARK 465     GLN C   176                                                      
REMARK 465     ARG C   177                                                      
REMARK 465     LEU C   178                                                      
REMARK 465     LEU C   179                                                      
REMARK 465     ALA C   180                                                      
REMARK 465     GLU C   181                                                      
REMARK 465     VAL C   182                                                      
REMARK 465     GLY C   183                                                      
REMARK 465     ILE C   184                                                      
REMARK 465     PHE C   185                                                      
REMARK 465     TYR C   186                                                      
REMARK 465     PHE C   187                                                      
REMARK 465     PHE C   188                                                      
REMARK 465     THR C   189                                                      
REMARK 465     LEU C   190                                                      
REMARK 465     HIS C   191                                                      
REMARK 465     PRO C   192                                                      
REMARK 465     ASP C   193                                                      
REMARK 465     ALA C   194                                                      
REMARK 465     GLN C   195                                                      
REMARK 465     THR C   196                                                      
REMARK 465     GLU C   197                                                      
REMARK 465     VAL C   198                                                      
REMARK 465     ILE C   199                                                      
REMARK 465     HIS C   200                                                      
REMARK 465     PHE C   201                                                      
REMARK 465     GLY C   202                                                      
REMARK 465     ASP C   203                                                      
REMARK 465     VAL C   204                                                      
REMARK 465     GLN C   205                                                      
REMARK 465     ALA C   206                                                      
REMARK 465     ALA C   207                                                      
REMARK 465     LEU C   208                                                      
REMARK 465     ILE C   209                                                      
REMARK 465     PHE C   210                                                      
REMARK 465     ASP C   211                                                      
REMARK 465     LYS C   212                                                      
REMARK 465     THR C   213                                                      
REMARK 465     LEU C   214                                                      
REMARK 465     PRO C   215                                                      
REMARK 465     VAL C   216                                                      
REMARK 465     ASN C   217                                                      
REMARK 465     SER C   218                                                      
REMARK 465     PRO C   219                                                      
REMARK 465     SER C   220                                                      
REMARK 465     GLY C   221                                                      
REMARK 465     MET C   222                                                      
REMARK 465     SER C   223                                                      
REMARK 465     ASP C   224                                                      
REMARK 465     SER C   225                                                      
REMARK 465     GLY C   226                                                      
REMARK 465     THR C   227                                                      
REMARK 465     ASP C   228                                                      
REMARK 465     SER C   229                                                      
REMARK 465     VAL C   230                                                      
REMARK 465     TRP C   231                                                      
REMARK 465     ALA C   232                                                      
REMARK 465     LEU C   233                                                      
REMARK 465     ASN C   234                                                      
REMARK 465     VAL C   235                                                      
REMARK 465     GLU C   236                                                      
REMARK 465     HIS C   237                                                      
REMARK 465     ARG C   238                                                      
REMARK 465     VAL C   239                                                      
REMARK 465     VAL C   240                                                      
REMARK 465     GLU C   241                                                      
REMARK 465     SER C   242                                                      
REMARK 465     ARG C   243                                                      
REMARK 465     VAL C   244                                                      
REMARK 465     ILE C   245                                                      
REMARK 465     THR C   246                                                      
REMARK 465     ASN C   247                                                      
REMARK 465     ASP C   248                                                      
REMARK 465     TYR C   249                                                      
REMARK 465     ASN C   250                                                      
REMARK 465     HIS C   251                                                      
REMARK 465     ARG C   252                                                      
REMARK 465     GLU C   253                                                      
REMARK 465     ALA C   254                                                      
REMARK 465     GLN C   255                                                      
REMARK 465     ASN C   256                                                      
REMARK 465     ILE C   257                                                      
REMARK 465     LEU C   258                                                      
REMARK 465     MET C   259                                                      
REMARK 465     SER C   260                                                      
REMARK 465     VAL C   261                                                      
REMARK 465     PRO C   262                                                      
REMARK 465     ALA C   263                                                      
REMARK 465     ASP C   264                                                      
REMARK 465     MET C   265                                                      
REMARK 465     THR C   266                                                      
REMARK 465     ARG C   267                                                      
REMARK 465     GLY C   268                                                      
REMARK 465     GLU C   269                                                      
REMARK 465     GLY C   270                                                      
REMARK 465     TYR C   271                                                      
REMARK 465     ASP C   272                                                      
REMARK 465     THR C   273                                                      
REMARK 465     SER C   274                                                      
REMARK 465     TYR C   275                                                      
REMARK 465     GLY C   276                                                      
REMARK 465     GLU C   277                                                      
REMARK 465     VAL C   278                                                      
REMARK 465     TYR C   279                                                      
REMARK 465     HIS C   280                                                      
REMARK 465     TYR C   281                                                      
REMARK 465     ARG C   282                                                      
REMARK 465     PRO C   283                                                      
REMARK 465     ARG C   284                                                      
REMARK 465     HIS C   285                                                      
REMARK 465     THR C   286                                                      
REMARK 465     GLU C   287                                                      
REMARK 465     ARG C   288                                                      
REMARK 465     GLY C   289                                                      
REMARK 465     ASP C   290                                                      
REMARK 465     LYS C   291                                                      
REMARK 465     ILE C   292                                                      
REMARK 465     ASP C   293                                                      
REMARK 465     PRO C   294                                                      
REMARK 465     ALA C   295                                                      
REMARK 465     PRO C   296                                                      
REMARK 465     GLU C   297                                                      
REMARK 465     THR C   298                                                      
REMARK 465     ALA C   299                                                      
REMARK 465     ASN C   300                                                      
REMARK 465     PHE C   301                                                      
REMARK 465     TRP C   302                                                      
REMARK 465     ALA C   303                                                      
REMARK 465     ARG C   304                                                      
REMARK 465     LEU C   305                                                      
REMARK 465     ASP C   306                                                      
REMARK 465     HIS C   307                                                      
REMARK 465     GLU C   308                                                      
REMARK 465     ARG C   309                                                      
REMARK 465     PHE C   310                                                      
REMARK 465     LEU C   311                                                      
REMARK 465     ALA C   312                                                      
REMARK 465     GLU C   313                                                      
REMARK 465     GLN C   314                                                      
REMARK 465     THR C   315                                                      
REMARK 465     ARG C   316                                                      
REMARK 465     ILE C   317                                                      
REMARK 465     THR C   318                                                      
REMARK 465     GLY C   319                                                      
REMARK 465     LYS C   320                                                      
REMARK 465     SER C   321                                                      
REMARK 465     THR C   322                                                      
REMARK 465     ASP C   323                                                      
REMARK 465     ALA C   324                                                      
REMARK 465     SER C   325                                                      
REMARK 465     LEU C   326                                                      
REMARK 465     LEU C   327                                                      
REMARK 465     PRO C   328                                                      
REMARK 465     ALA C   329                                                      
REMARK 465     GLN C   330                                                      
REMARK 465     VAL C   331                                                      
REMARK 465     LEU C   332                                                      
REMARK 465     THR C   333                                                      
REMARK 465     ILE C   334                                                      
REMARK 465     THR C   335                                                      
REMARK 465     ASP C   336                                                      
REMARK 465     SER C   337                                                      
REMARK 465     THR C   338                                                      
REMARK 465     PRO C   339                                                      
REMARK 465     PRO C   340                                                      
REMARK 465     VAL C   341                                                      
REMARK 465     LEU C   342                                                      
REMARK 465     PRO C   343                                                      
REMARK 465     ALA C   344                                                      
REMARK 465     PRO C   345                                                      
REMARK 465     LEU C   346                                                      
REMARK 465     GLN C   347                                                      
REMARK 465     GLU C   348                                                      
REMARK 465     PRO C   349                                                      
REMARK 465     VAL C   350                                                      
REMARK 465     LEU C   351                                                      
REMARK 465     LEU C   352                                                      
REMARK 465     THR C   353                                                      
REMARK 465     GLN C   354                                                      
REMARK 465     LEU C   355                                                      
REMARK 465     LEU C   356                                                      
REMARK 465     PHE C   357                                                      
REMARK 465     THR C   358                                                      
REMARK 465     GLY C   359                                                      
REMARK 465     SER C   360                                                      
REMARK 465     ARG C   361                                                      
REMARK 465     LYS C   362                                                      
REMARK 465     SER C   363                                                      
REMARK 465     ALA C   364                                                      
REMARK 465     LEU C   365                                                      
REMARK 465     GLN C   366                                                      
REMARK 465     VAL C   367                                                      
REMARK 465     MET C   368                                                      
REMARK 465     LEU C   369                                                      
REMARK 465     SER C   370                                                      
REMARK 465     ALA C   371                                                      
REMARK 465     VAL C   372                                                      
REMARK 465     PRO C   373                                                      
REMARK 465     TYR C   374                                                      
REMARK 465     SER C   375                                                      
REMARK 465     GLU C   376                                                      
REMARK 465     ILE C   377                                                      
REMARK 465     VAL C   378                                                      
REMARK 465     CYS C   379                                                      
REMARK 465     TRP C   380                                                      
REMARK 465     ARG C   381                                                      
REMARK 465     PRO C   382                                                      
REMARK 465     PRO C   383                                                      
REMARK 465     LEU C   384                                                      
REMARK 465     LEU C   385                                                      
REMARK 465     THR C   386                                                      
REMARK 465     ARG C   387                                                      
REMARK 465     PRO C   388                                                      
REMARK 465     LYS C   389                                                      
REMARK 465     ILE C   390                                                      
REMARK 465     THR C   391                                                      
REMARK 465     GLY C   392                                                      
REMARK 465     THR C   393                                                      
REMARK 465     MET C   394                                                      
REMARK 465     THR C   395                                                      
REMARK 465     ALA C   396                                                      
REMARK 465     ARG C   397                                                      
REMARK 465     VAL C   398                                                      
REMARK 465     THR C   399                                                      
REMARK 465     SER C   400                                                      
REMARK 465     ALA C   401                                                      
REMARK 465     LYS C   402                                                      
REMARK 465     GLU C   403                                                      
REMARK 465     GLY C   404                                                      
REMARK 465     ASP C   405                                                      
REMARK 465     ILE C   406                                                      
REMARK 465     TYR C   407                                                      
REMARK 465     ALA C   408                                                      
REMARK 465     TRP C   409                                                      
REMARK 465     GLN C   410                                                      
REMARK 465     ASP C   411                                                      
REMARK 465     ALA C   412                                                      
REMARK 465     SER C   413                                                      
REMARK 465     GLY C   414                                                      
REMARK 465     MET C   415                                                      
REMARK 465     TYR C   416                                                      
REMARK 465     ARG C   417                                                      
REMARK 465     VAL C   418                                                      
REMARK 465     LYS C   419                                                      
REMARK 465     PHE C   420                                                      
REMARK 465     ASP C   421                                                      
REMARK 465     ALA C   422                                                      
REMARK 465     ASP C   423                                                      
REMARK 465     ARG C   424                                                      
REMARK 465     ASP C   425                                                      
REMARK 465     ASP C   426                                                      
REMARK 465     LYS C   427                                                      
REMARK 465     ASN C   428                                                      
REMARK 465     PRO C   429                                                      
REMARK 465     GLY C   430                                                      
REMARK 465     GLN C   431                                                      
REMARK 465     GLU C   432                                                      
REMARK 465     SER C   433                                                      
REMARK 465     MET C   434                                                      
REMARK 465     PRO C   435                                                      
REMARK 465     VAL C   436                                                      
REMARK 465     ARG C   437                                                      
REMARK 465     LEU C   438                                                      
REMARK 465     ALA C   439                                                      
REMARK 465     LYS C   440                                                      
REMARK 465     PRO C   441                                                      
REMARK 465     TYR C   442                                                      
REMARK 465     SER C   443                                                      
REMARK 465     GLY C   444                                                      
REMARK 465     ASP C   445                                                      
REMARK 465     ALA C   446                                                      
REMARK 465     TYR C   447                                                      
REMARK 465     GLY C   448                                                      
REMARK 465     PHE C   449                                                      
REMARK 465     HIS C   450                                                      
REMARK 465     PHE C   451                                                      
REMARK 465     PRO C   452                                                      
REMARK 465     LEU C   453                                                      
REMARK 465     ILE C   454                                                      
REMARK 465     GLN C   455                                                      
REMARK 465     GLY C   456                                                      
REMARK 465     THR C   457                                                      
REMARK 465     GLU C   458                                                      
REMARK 465     VAL C   459                                                      
REMARK 465     ALA C   460                                                      
REMARK 465     ILE C   461                                                      
REMARK 465     ALA C   462                                                      
REMARK 465     PHE C   463                                                      
REMARK 465     GLU C   464                                                      
REMARK 465     GLU C   465                                                      
REMARK 465     GLY C   466                                                      
REMARK 465     ASP C   467                                                      
REMARK 465     PRO C   468                                                      
REMARK 465     ASP C   469                                                      
REMARK 465     ARG C   470                                                      
REMARK 465     PRO C   471                                                      
REMARK 465     TYR C   472                                                      
REMARK 465     ILE C   473                                                      
REMARK 465     ALA C   474                                                      
REMARK 465     HIS C   475                                                      
REMARK 465     ALA C   476                                                      
REMARK 465     LEU C   477                                                      
REMARK 465     HIS C   478                                                      
REMARK 465     ASP C   479                                                      
REMARK 465     SER C   480                                                      
REMARK 465     ARG C   481                                                      
REMARK 465     HIS C   482                                                      
REMARK 465     VAL C   483                                                      
REMARK 465     ASP C   484                                                      
REMARK 465     HIS C   485                                                      
REMARK 465     VAL C   486                                                      
REMARK 465     THR C   487                                                      
REMARK 465     ASP C   488                                                      
REMARK 465     LYS C   489                                                      
REMARK 465     ASN C   490                                                      
REMARK 465     MET C   758                                                      
REMARK 465     GLN C   759                                                      
REMARK 465     LYS C   760                                                      
REMARK 465     MET C   761                                                      
REMARK 465     GLY C   762                                                      
REMARK 465     PRO C   763                                                      
REMARK 465     THR C   764                                                      
REMARK 465     SER C   765                                                      
REMARK 465     LEU C   766                                                      
REMARK 465     ASP C   767                                                      
REMARK 465     ILE C   768                                                      
REMARK 465     ALA C   769                                                      
REMARK 465     SER C   770                                                      
REMARK 465     VAL C   771                                                      
REMARK 465     GLU C   772                                                      
REMARK 465     MET C   773                                                      
REMARK 465     PRO C   774                                                      
REMARK 465     ARG C   775                                                      
REMARK 465     GLY C   776                                                      
REMARK 465     PHE C   777                                                      
REMARK 465     LYS C   835                                                      
REMARK 465     ILE C   836                                                      
REMARK 465     HIS C   837                                                      
REMARK 465     GLY C   838                                                      
REMARK 465     GLU C   839                                                      
REMARK 465     THR C   840                                                      
REMARK 465     GLU C   841                                                      
REMARK 465     MET D     1                                                      
REMARK 465     THR D     2                                                      
REMARK 465     LYS D    87                                                      
REMARK 465     ASN D    88                                                      
REMARK 465     SER D    89                                                      
REMARK 465     ILE D    90                                                      
REMARK 465     SER D    91                                                      
REMARK 465     ASN D    92                                                      
REMARK 465     GLY D    93                                                      
REMARK 465     ALA D   134                                                      
REMARK 465     ALA D   135                                                      
REMARK 465     GLY D   136                                                      
REMARK 465     GLU D   137                                                      
REMARK 465     ALA D   138                                                      
REMARK 465     ASP D   139                                                      
REMARK 465     SER D   140                                                      
REMARK 465     VAL D   141                                                      
REMARK 465     ILE D   142                                                      
REMARK 465     ASP D   540                                                      
REMARK 465     ASP D   541                                                      
REMARK 465     GLN D   542                                                      
REMARK 465     GLN D   543                                                      
REMARK 465     ARG D   544                                                      
REMARK 465     LEU D   545                                                      
REMARK 465     ASN D   546                                                      
REMARK 465     ASP D   547                                                      
REMARK 465     ASN D   548                                                      
REMARK 465     ALA D   549                                                      
REMARK 465     VAL D   550                                                      
REMARK 465     LYS D   551                                                      
REMARK 465     ASN D   552                                                      
REMARK 465     THR D   553                                                      
REMARK 465     LYS D   554                                                      
REMARK 465     VAL D   555                                                      
REMARK 465     MET D   556                                                      
REMARK 465     MET D   557                                                      
REMARK 465     SER D   558                                                      
REMARK 465     GLY D   559                                                      
REMARK 465     VAL D   560                                                      
REMARK 465     MET E     1                                                      
REMARK 465     THR E     2                                                      
REMARK 465     LYS E    87                                                      
REMARK 465     ASN E    88                                                      
REMARK 465     SER E    89                                                      
REMARK 465     ILE E    90                                                      
REMARK 465     SER E    91                                                      
REMARK 465     ASN E    92                                                      
REMARK 465     GLY E    93                                                      
REMARK 465     ALA E   134                                                      
REMARK 465     ALA E   135                                                      
REMARK 465     GLY E   136                                                      
REMARK 465     GLU E   137                                                      
REMARK 465     ALA E   138                                                      
REMARK 465     ASP E   139                                                      
REMARK 465     SER E   140                                                      
REMARK 465     VAL E   141                                                      
REMARK 465     ASP E   540                                                      
REMARK 465     ASP E   541                                                      
REMARK 465     GLN E   542                                                      
REMARK 465     GLN E   543                                                      
REMARK 465     ARG E   544                                                      
REMARK 465     LEU E   545                                                      
REMARK 465     ASN E   546                                                      
REMARK 465     ASP E   547                                                      
REMARK 465     ASN E   548                                                      
REMARK 465     ALA E   549                                                      
REMARK 465     VAL E   550                                                      
REMARK 465     LYS E   551                                                      
REMARK 465     ASN E   552                                                      
REMARK 465     THR E   553                                                      
REMARK 465     LYS E   554                                                      
REMARK 465     VAL E   555                                                      
REMARK 465     MET E   556                                                      
REMARK 465     MET E   557                                                      
REMARK 465     SER E   558                                                      
REMARK 465     GLY E   559                                                      
REMARK 465     VAL E   560                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     LYS F    87                                                      
REMARK 465     ASN F    88                                                      
REMARK 465     SER F    89                                                      
REMARK 465     ILE F    90                                                      
REMARK 465     SER F    91                                                      
REMARK 465     ASN F    92                                                      
REMARK 465     GLY F    93                                                      
REMARK 465     ALA F   134                                                      
REMARK 465     ALA F   135                                                      
REMARK 465     GLY F   136                                                      
REMARK 465     GLU F   137                                                      
REMARK 465     ALA F   138                                                      
REMARK 465     ASP F   139                                                      
REMARK 465     SER F   140                                                      
REMARK 465     VAL F   141                                                      
REMARK 465     ASP F   540                                                      
REMARK 465     ASP F   541                                                      
REMARK 465     GLN F   542                                                      
REMARK 465     GLN F   543                                                      
REMARK 465     ARG F   544                                                      
REMARK 465     LEU F   545                                                      
REMARK 465     ASN F   546                                                      
REMARK 465     ASP F   547                                                      
REMARK 465     ASN F   548                                                      
REMARK 465     ALA F   549                                                      
REMARK 465     VAL F   550                                                      
REMARK 465     LYS F   551                                                      
REMARK 465     ASN F   552                                                      
REMARK 465     THR F   553                                                      
REMARK 465     LYS F   554                                                      
REMARK 465     VAL F   555                                                      
REMARK 465     MET F   556                                                      
REMARK 465     MET F   557                                                      
REMARK 465     SER F   558                                                      
REMARK 465     GLY F   559                                                      
REMARK 465     VAL F   560                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NH2  ARG D   422     O    LEU D   445              1.99            
REMARK 500   NH2  ARG E   422     O    LEU E   445              2.05            
REMARK 500   NH2  ARG F   422     O    LEU F   445              2.05            
REMARK 500   O    ARG A   640     OG   SER B   646              2.09            
REMARK 500   O    ARG B   640     OG   SER C   646              2.11            
REMARK 500   OG   SER A   646     O    ARG C   640              2.13            
REMARK 500   O    GLN A   567     NH1  ARG B   547              2.14            
REMARK 500   OD1  ASN E   390     NH2  ARG E   393              2.14            
REMARK 500   OG   SER C   563     OD1  ASP C   565              2.16            
REMARK 500   OE2  GLU E   450     OH   TYR E   485              2.16            
REMARK 500   NH1  ARG A   547     O    GLN C   567              2.17            
REMARK 500   O    VAL D   320     NE2  GLN D   325              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP A 550     -157.24    -96.78                                   
REMARK 500    LEU A 575       42.76   -108.48                                   
REMARK 500    ASP A 620       14.51     58.75                                   
REMARK 500    PRO A 624       76.33    -65.97                                   
REMARK 500    ASP A 657     -152.79    -97.01                                   
REMARK 500    GLN A 665     -150.88   -100.50                                   
REMARK 500    SER A 699       12.79   -145.34                                   
REMARK 500    ASP A 700     -166.33   -160.75                                   
REMARK 500    GLN A 708     -157.35    -89.53                                   
REMARK 500    CYS A 731      112.01   -163.66                                   
REMARK 500    LYS A 754       74.45   -100.37                                   
REMARK 500    PRO A 790       41.17    -84.98                                   
REMARK 500    GLN A 791       75.12     32.10                                   
REMARK 500    ALA A 801       46.63    -86.37                                   
REMARK 500    GLU A 812       78.91     48.73                                   
REMARK 500    ASN A 813       12.59     88.77                                   
REMARK 500    ILE A 823       75.58   -150.43                                   
REMARK 500    ASP B 550     -157.12    -97.46                                   
REMARK 500    ALA B 564       32.01    -99.88                                   
REMARK 500    LEU B 575       40.88   -104.60                                   
REMARK 500    PRO B 624       78.28    -64.78                                   
REMARK 500    GLU B 649     -163.39   -125.69                                   
REMARK 500    ASP B 657     -154.27    -97.24                                   
REMARK 500    GLN B 665     -152.16   -101.91                                   
REMARK 500    ASN B 681      -33.34   -131.24                                   
REMARK 500    SER B 699       17.25   -145.91                                   
REMARK 500    ASP B 700     -169.09   -162.15                                   
REMARK 500    GLN B 708     -155.69    -88.82                                   
REMARK 500    CYS B 731      113.38   -161.47                                   
REMARK 500    PRO B 790       44.58    -84.66                                   
REMARK 500    GLN B 791       76.83     38.77                                   
REMARK 500    GLU B 812       70.85     51.20                                   
REMARK 500    ASN B 813        9.92     85.09                                   
REMARK 500    SER B 822      -71.60    -57.24                                   
REMARK 500    THR C 492       17.42     57.96                                   
REMARK 500    ASP C 550     -156.86    -95.49                                   
REMARK 500    ALA C 564       31.25    -93.65                                   
REMARK 500    PRO C 624       75.04    -63.71                                   
REMARK 500    GLU C 649     -160.55   -127.22                                   
REMARK 500    ASP C 657     -152.03    -96.68                                   
REMARK 500    GLN C 665      -70.42   -117.95                                   
REMARK 500    ASN C 681      -32.34   -131.62                                   
REMARK 500    SER C 699       15.23   -145.95                                   
REMARK 500    GLN C 708     -157.25    -91.28                                   
REMARK 500    GLU C 716       10.70   -142.57                                   
REMARK 500    CYS C 731      111.82   -160.31                                   
REMARK 500    PRO C 790       45.35    -83.77                                   
REMARK 500    GLN C 791       67.69     36.40                                   
REMARK 500    ALA C 801       45.36    -84.84                                   
REMARK 500    ILE C 823       61.68   -167.03                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      85 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ASP A  811     GLU A  812                  147.36                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-10218   RELATED DB: EMDB                             
REMARK 900 STRUCTURE OF THE TLE1 EFFECTOR BOUND TO THE VGRG SPIKE FROM THE      
REMARK 900 TYPE 6 SECRETION SYSTEM                                              
DBREF1 6SJL A    1   841  UNP                  A0A3W2RZ19_ECOLX                 
DBREF2 6SJL A     A0A3W2RZ19                          1         841             
DBREF1 6SJL B    1   841  UNP                  A0A3W2RZ19_ECOLX                 
DBREF2 6SJL B     A0A3W2RZ19                          1         841             
DBREF1 6SJL C    1   841  UNP                  A0A3W2RZ19_ECOLX                 
DBREF2 6SJL C     A0A3W2RZ19                          1         841             
DBREF1 6SJL D    1   560  UNP                  A0A377LA80_ECOLX                 
DBREF2 6SJL D     A0A377LA80                          1         560             
DBREF1 6SJL E    1   560  UNP                  A0A377LA80_ECOLX                 
DBREF2 6SJL E     A0A377LA80                          1         560             
DBREF1 6SJL F    1   560  UNP                  A0A377LA80_ECOLX                 
DBREF2 6SJL F     A0A377LA80                          1         560             
SEQRES   1 A  841  MET ASN LEU THR ASP SER LEU GLN ASN VAL LEU SER GLY          
SEQRES   2 A  841  VAL GLY THR LEU ASN ARG TYR ARG LEU ASP ILE PRO SER          
SEQRES   3 A  841  CYS PRO SER SER LEU ASP VAL GLU ASP PHE SER GLY THR          
SEQRES   4 A  841  GLU GLY ILE SER LYS ILE TYR ARG TYR ASP ILE ILE PHE          
SEQRES   5 A  841  THR SER THR ASP ARG TYR PRO ASP ALA ALA TRP PHE LEU          
SEQRES   6 A  841  ARG LYS SER ALA THR LEU ILE MET GLY THR GLY LEU LEU          
SEQRES   7 A  841  GLU SER LEU THR GLU GLN LYS LYS VAL HIS GLY VAL ILE          
SEQRES   8 A  841  THR ASP PHE ARG ARG ILE SER GLY SER GLU ASP GLN ALA          
SEQRES   9 A  841  GLN TYR ARG ILE THR LEU LYS PRO PHE ILE SER LEU LEU          
SEQRES  10 A  841  ASP LYS GLN PHE ARG THR HIS ARG PHE PHE VAL ASN LYS          
SEQRES  11 A  841  SER VAL PRO GLU VAL VAL GLU GLN ILE LEU THR GLU HIS          
SEQRES  12 A  841  GLY LEU LYS GLY TRP GLU TYR GLU PHE SER LEU LYS ARG          
SEQRES  13 A  841  THR TYR PRO LYS ARG GLU GLN ILE ASN GLN TYR GLN GLU          
SEQRES  14 A  841  SER ASP LEU ARG PHE ILE GLN ARG LEU LEU ALA GLU VAL          
SEQRES  15 A  841  GLY ILE PHE TYR PHE PHE THR LEU HIS PRO ASP ALA GLN          
SEQRES  16 A  841  THR GLU VAL ILE HIS PHE GLY ASP VAL GLN ALA ALA LEU          
SEQRES  17 A  841  ILE PHE ASP LYS THR LEU PRO VAL ASN SER PRO SER GLY          
SEQRES  18 A  841  MET SER ASP SER GLY THR ASP SER VAL TRP ALA LEU ASN          
SEQRES  19 A  841  VAL GLU HIS ARG VAL VAL GLU SER ARG VAL ILE THR ASN          
SEQRES  20 A  841  ASP TYR ASN HIS ARG GLU ALA GLN ASN ILE LEU MET SER          
SEQRES  21 A  841  VAL PRO ALA ASP MET THR ARG GLY GLU GLY TYR ASP THR          
SEQRES  22 A  841  SER TYR GLY GLU VAL TYR HIS TYR ARG PRO ARG HIS THR          
SEQRES  23 A  841  GLU ARG GLY ASP LYS ILE ASP PRO ALA PRO GLU THR ALA          
SEQRES  24 A  841  ASN PHE TRP ALA ARG LEU ASP HIS GLU ARG PHE LEU ALA          
SEQRES  25 A  841  GLU GLN THR ARG ILE THR GLY LYS SER THR ASP ALA SER          
SEQRES  26 A  841  LEU LEU PRO ALA GLN VAL LEU THR ILE THR ASP SER THR          
SEQRES  27 A  841  PRO PRO VAL LEU PRO ALA PRO LEU GLN GLU PRO VAL LEU          
SEQRES  28 A  841  LEU THR GLN LEU LEU PHE THR GLY SER ARG LYS SER ALA          
SEQRES  29 A  841  LEU GLN VAL MET LEU SER ALA VAL PRO TYR SER GLU ILE          
SEQRES  30 A  841  VAL CYS TRP ARG PRO PRO LEU LEU THR ARG PRO LYS ILE          
SEQRES  31 A  841  THR GLY THR MET THR ALA ARG VAL THR SER ALA LYS GLU          
SEQRES  32 A  841  GLY ASP ILE TYR ALA TRP GLN ASP ALA SER GLY MET TYR          
SEQRES  33 A  841  ARG VAL LYS PHE ASP ALA ASP ARG ASP ASP LYS ASN PRO          
SEQRES  34 A  841  GLY GLN GLU SER MET PRO VAL ARG LEU ALA LYS PRO TYR          
SEQRES  35 A  841  SER GLY ASP ALA TYR GLY PHE HIS PHE PRO LEU ILE GLN          
SEQRES  36 A  841  GLY THR GLU VAL ALA ILE ALA PHE GLU GLU GLY ASP PRO          
SEQRES  37 A  841  ASP ARG PRO TYR ILE ALA HIS ALA LEU HIS ASP SER ARG          
SEQRES  38 A  841  HIS VAL ASP HIS VAL THR ASP LYS ASN GLY THR ARG ASN          
SEQRES  39 A  841  VAL ILE ARG THR PRO ALA ASN ASN LYS LEU ARG MET GLU          
SEQRES  40 A  841  ASP LYS ARG GLY GLU GLU HIS ILE LYS LEU SER THR GLU          
SEQRES  41 A  841  TYR GLY GLY LYS THR GLN LEU ASN LEU GLY HIS ASN VAL          
SEQRES  42 A  841  ASP ALA SER ARG GLU LEU ARG GLY GLU GLY ALA GLU LEU          
SEQRES  43 A  841  ARG THR ASP ASP TRP ILE SER ILE ARG GLY GLY LYS GLY          
SEQRES  44 A  841  ILE PHE ILE SER ALA ASP MET GLN PRO GLN ALA GLN GLY          
SEQRES  45 A  841  LYS MET LEU ASP MET ASP GLU ALA ILE ARG GLN LEU GLU          
SEQRES  46 A  841  GLN ALA LEU SER LEU ALA ARG SER MET ALA LYS ALA ALA          
SEQRES  47 A  841  THR ALA ALA ASN ALA THR GLN GLY ASP ILE SER CYS GLN          
SEQRES  48 A  841  GLN ARG LEU ASN ALA SER LEU THR ASP LEU THR ALA PRO          
SEQRES  49 A  841  GLY MET LEU LEU HIS ALA PRO ASP GLY ILE GLY MET VAL          
SEQRES  50 A  841  SER ALA ARG ALA LEU ARG ILE ALA SER GLY SER GLU SER          
SEQRES  51 A  841  VAL GLY ILE MET SER GLY ASP ASN THR ASP ILE THR ALA          
SEQRES  52 A  841  GLY GLN SER PHE THR VAL VAL ALA GLU GLY ALA VAL SER          
SEQRES  53 A  841  LEU LEU SER ARG ASN GLN GLY MET GLN LEU LEU ALA ALA          
SEQRES  54 A  841  LYS GLY ARG VAL ASN ILE GLN ALA GLN SER ASP ASP LEU          
SEQRES  55 A  841  SER MET SER SER GLN GLN ASN LEU ASP ILE GLN SER SER          
SEQRES  56 A  841  GLU GLY LYS VAL THR VAL SER ALA ASN GLN GLU LEU ILE          
SEQRES  57 A  841  LEU ALA CYS GLY GLY ALA TYR ILE LYS LEU SER GLY GLY          
SEQRES  58 A  841  ASN ILE GLU LEU GLY CYS PRO GLY GLN ILE LEU LEU LYS          
SEQRES  59 A  841  SER THR ASN MET GLN LYS MET GLY PRO THR SER LEU ASP          
SEQRES  60 A  841  ILE ALA SER VAL GLU MET PRO ARG GLY PHE GLY GLY GLY          
SEQRES  61 A  841  PHE ILE LEU THR ASP GLU ALA GLY VAL PRO GLN PRO SER          
SEQRES  62 A  841  THR PRO TYR ARG LEU THR THR ALA GLU GLY ASP ILE LEU          
SEQRES  63 A  841  GLN GLY ILE THR ASP GLU ASN GLY LYS THR ALA PRO VAL          
SEQRES  64 A  841  ASN THR SER ILE PRO SER VAL VAL LYS VAL GLU PHE GLY          
SEQRES  65 A  841  LYS VAL LYS ILE HIS GLY GLU THR GLU                          
SEQRES   1 B  841  MET ASN LEU THR ASP SER LEU GLN ASN VAL LEU SER GLY          
SEQRES   2 B  841  VAL GLY THR LEU ASN ARG TYR ARG LEU ASP ILE PRO SER          
SEQRES   3 B  841  CYS PRO SER SER LEU ASP VAL GLU ASP PHE SER GLY THR          
SEQRES   4 B  841  GLU GLY ILE SER LYS ILE TYR ARG TYR ASP ILE ILE PHE          
SEQRES   5 B  841  THR SER THR ASP ARG TYR PRO ASP ALA ALA TRP PHE LEU          
SEQRES   6 B  841  ARG LYS SER ALA THR LEU ILE MET GLY THR GLY LEU LEU          
SEQRES   7 B  841  GLU SER LEU THR GLU GLN LYS LYS VAL HIS GLY VAL ILE          
SEQRES   8 B  841  THR ASP PHE ARG ARG ILE SER GLY SER GLU ASP GLN ALA          
SEQRES   9 B  841  GLN TYR ARG ILE THR LEU LYS PRO PHE ILE SER LEU LEU          
SEQRES  10 B  841  ASP LYS GLN PHE ARG THR HIS ARG PHE PHE VAL ASN LYS          
SEQRES  11 B  841  SER VAL PRO GLU VAL VAL GLU GLN ILE LEU THR GLU HIS          
SEQRES  12 B  841  GLY LEU LYS GLY TRP GLU TYR GLU PHE SER LEU LYS ARG          
SEQRES  13 B  841  THR TYR PRO LYS ARG GLU GLN ILE ASN GLN TYR GLN GLU          
SEQRES  14 B  841  SER ASP LEU ARG PHE ILE GLN ARG LEU LEU ALA GLU VAL          
SEQRES  15 B  841  GLY ILE PHE TYR PHE PHE THR LEU HIS PRO ASP ALA GLN          
SEQRES  16 B  841  THR GLU VAL ILE HIS PHE GLY ASP VAL GLN ALA ALA LEU          
SEQRES  17 B  841  ILE PHE ASP LYS THR LEU PRO VAL ASN SER PRO SER GLY          
SEQRES  18 B  841  MET SER ASP SER GLY THR ASP SER VAL TRP ALA LEU ASN          
SEQRES  19 B  841  VAL GLU HIS ARG VAL VAL GLU SER ARG VAL ILE THR ASN          
SEQRES  20 B  841  ASP TYR ASN HIS ARG GLU ALA GLN ASN ILE LEU MET SER          
SEQRES  21 B  841  VAL PRO ALA ASP MET THR ARG GLY GLU GLY TYR ASP THR          
SEQRES  22 B  841  SER TYR GLY GLU VAL TYR HIS TYR ARG PRO ARG HIS THR          
SEQRES  23 B  841  GLU ARG GLY ASP LYS ILE ASP PRO ALA PRO GLU THR ALA          
SEQRES  24 B  841  ASN PHE TRP ALA ARG LEU ASP HIS GLU ARG PHE LEU ALA          
SEQRES  25 B  841  GLU GLN THR ARG ILE THR GLY LYS SER THR ASP ALA SER          
SEQRES  26 B  841  LEU LEU PRO ALA GLN VAL LEU THR ILE THR ASP SER THR          
SEQRES  27 B  841  PRO PRO VAL LEU PRO ALA PRO LEU GLN GLU PRO VAL LEU          
SEQRES  28 B  841  LEU THR GLN LEU LEU PHE THR GLY SER ARG LYS SER ALA          
SEQRES  29 B  841  LEU GLN VAL MET LEU SER ALA VAL PRO TYR SER GLU ILE          
SEQRES  30 B  841  VAL CYS TRP ARG PRO PRO LEU LEU THR ARG PRO LYS ILE          
SEQRES  31 B  841  THR GLY THR MET THR ALA ARG VAL THR SER ALA LYS GLU          
SEQRES  32 B  841  GLY ASP ILE TYR ALA TRP GLN ASP ALA SER GLY MET TYR          
SEQRES  33 B  841  ARG VAL LYS PHE ASP ALA ASP ARG ASP ASP LYS ASN PRO          
SEQRES  34 B  841  GLY GLN GLU SER MET PRO VAL ARG LEU ALA LYS PRO TYR          
SEQRES  35 B  841  SER GLY ASP ALA TYR GLY PHE HIS PHE PRO LEU ILE GLN          
SEQRES  36 B  841  GLY THR GLU VAL ALA ILE ALA PHE GLU GLU GLY ASP PRO          
SEQRES  37 B  841  ASP ARG PRO TYR ILE ALA HIS ALA LEU HIS ASP SER ARG          
SEQRES  38 B  841  HIS VAL ASP HIS VAL THR ASP LYS ASN GLY THR ARG ASN          
SEQRES  39 B  841  VAL ILE ARG THR PRO ALA ASN ASN LYS LEU ARG MET GLU          
SEQRES  40 B  841  ASP LYS ARG GLY GLU GLU HIS ILE LYS LEU SER THR GLU          
SEQRES  41 B  841  TYR GLY GLY LYS THR GLN LEU ASN LEU GLY HIS ASN VAL          
SEQRES  42 B  841  ASP ALA SER ARG GLU LEU ARG GLY GLU GLY ALA GLU LEU          
SEQRES  43 B  841  ARG THR ASP ASP TRP ILE SER ILE ARG GLY GLY LYS GLY          
SEQRES  44 B  841  ILE PHE ILE SER ALA ASP MET GLN PRO GLN ALA GLN GLY          
SEQRES  45 B  841  LYS MET LEU ASP MET ASP GLU ALA ILE ARG GLN LEU GLU          
SEQRES  46 B  841  GLN ALA LEU SER LEU ALA ARG SER MET ALA LYS ALA ALA          
SEQRES  47 B  841  THR ALA ALA ASN ALA THR GLN GLY ASP ILE SER CYS GLN          
SEQRES  48 B  841  GLN ARG LEU ASN ALA SER LEU THR ASP LEU THR ALA PRO          
SEQRES  49 B  841  GLY MET LEU LEU HIS ALA PRO ASP GLY ILE GLY MET VAL          
SEQRES  50 B  841  SER ALA ARG ALA LEU ARG ILE ALA SER GLY SER GLU SER          
SEQRES  51 B  841  VAL GLY ILE MET SER GLY ASP ASN THR ASP ILE THR ALA          
SEQRES  52 B  841  GLY GLN SER PHE THR VAL VAL ALA GLU GLY ALA VAL SER          
SEQRES  53 B  841  LEU LEU SER ARG ASN GLN GLY MET GLN LEU LEU ALA ALA          
SEQRES  54 B  841  LYS GLY ARG VAL ASN ILE GLN ALA GLN SER ASP ASP LEU          
SEQRES  55 B  841  SER MET SER SER GLN GLN ASN LEU ASP ILE GLN SER SER          
SEQRES  56 B  841  GLU GLY LYS VAL THR VAL SER ALA ASN GLN GLU LEU ILE          
SEQRES  57 B  841  LEU ALA CYS GLY GLY ALA TYR ILE LYS LEU SER GLY GLY          
SEQRES  58 B  841  ASN ILE GLU LEU GLY CYS PRO GLY GLN ILE LEU LEU LYS          
SEQRES  59 B  841  SER THR ASN MET GLN LYS MET GLY PRO THR SER LEU ASP          
SEQRES  60 B  841  ILE ALA SER VAL GLU MET PRO ARG GLY PHE GLY GLY GLY          
SEQRES  61 B  841  PHE ILE LEU THR ASP GLU ALA GLY VAL PRO GLN PRO SER          
SEQRES  62 B  841  THR PRO TYR ARG LEU THR THR ALA GLU GLY ASP ILE LEU          
SEQRES  63 B  841  GLN GLY ILE THR ASP GLU ASN GLY LYS THR ALA PRO VAL          
SEQRES  64 B  841  ASN THR SER ILE PRO SER VAL VAL LYS VAL GLU PHE GLY          
SEQRES  65 B  841  LYS VAL LYS ILE HIS GLY GLU THR GLU                          
SEQRES   1 C  841  MET ASN LEU THR ASP SER LEU GLN ASN VAL LEU SER GLY          
SEQRES   2 C  841  VAL GLY THR LEU ASN ARG TYR ARG LEU ASP ILE PRO SER          
SEQRES   3 C  841  CYS PRO SER SER LEU ASP VAL GLU ASP PHE SER GLY THR          
SEQRES   4 C  841  GLU GLY ILE SER LYS ILE TYR ARG TYR ASP ILE ILE PHE          
SEQRES   5 C  841  THR SER THR ASP ARG TYR PRO ASP ALA ALA TRP PHE LEU          
SEQRES   6 C  841  ARG LYS SER ALA THR LEU ILE MET GLY THR GLY LEU LEU          
SEQRES   7 C  841  GLU SER LEU THR GLU GLN LYS LYS VAL HIS GLY VAL ILE          
SEQRES   8 C  841  THR ASP PHE ARG ARG ILE SER GLY SER GLU ASP GLN ALA          
SEQRES   9 C  841  GLN TYR ARG ILE THR LEU LYS PRO PHE ILE SER LEU LEU          
SEQRES  10 C  841  ASP LYS GLN PHE ARG THR HIS ARG PHE PHE VAL ASN LYS          
SEQRES  11 C  841  SER VAL PRO GLU VAL VAL GLU GLN ILE LEU THR GLU HIS          
SEQRES  12 C  841  GLY LEU LYS GLY TRP GLU TYR GLU PHE SER LEU LYS ARG          
SEQRES  13 C  841  THR TYR PRO LYS ARG GLU GLN ILE ASN GLN TYR GLN GLU          
SEQRES  14 C  841  SER ASP LEU ARG PHE ILE GLN ARG LEU LEU ALA GLU VAL          
SEQRES  15 C  841  GLY ILE PHE TYR PHE PHE THR LEU HIS PRO ASP ALA GLN          
SEQRES  16 C  841  THR GLU VAL ILE HIS PHE GLY ASP VAL GLN ALA ALA LEU          
SEQRES  17 C  841  ILE PHE ASP LYS THR LEU PRO VAL ASN SER PRO SER GLY          
SEQRES  18 C  841  MET SER ASP SER GLY THR ASP SER VAL TRP ALA LEU ASN          
SEQRES  19 C  841  VAL GLU HIS ARG VAL VAL GLU SER ARG VAL ILE THR ASN          
SEQRES  20 C  841  ASP TYR ASN HIS ARG GLU ALA GLN ASN ILE LEU MET SER          
SEQRES  21 C  841  VAL PRO ALA ASP MET THR ARG GLY GLU GLY TYR ASP THR          
SEQRES  22 C  841  SER TYR GLY GLU VAL TYR HIS TYR ARG PRO ARG HIS THR          
SEQRES  23 C  841  GLU ARG GLY ASP LYS ILE ASP PRO ALA PRO GLU THR ALA          
SEQRES  24 C  841  ASN PHE TRP ALA ARG LEU ASP HIS GLU ARG PHE LEU ALA          
SEQRES  25 C  841  GLU GLN THR ARG ILE THR GLY LYS SER THR ASP ALA SER          
SEQRES  26 C  841  LEU LEU PRO ALA GLN VAL LEU THR ILE THR ASP SER THR          
SEQRES  27 C  841  PRO PRO VAL LEU PRO ALA PRO LEU GLN GLU PRO VAL LEU          
SEQRES  28 C  841  LEU THR GLN LEU LEU PHE THR GLY SER ARG LYS SER ALA          
SEQRES  29 C  841  LEU GLN VAL MET LEU SER ALA VAL PRO TYR SER GLU ILE          
SEQRES  30 C  841  VAL CYS TRP ARG PRO PRO LEU LEU THR ARG PRO LYS ILE          
SEQRES  31 C  841  THR GLY THR MET THR ALA ARG VAL THR SER ALA LYS GLU          
SEQRES  32 C  841  GLY ASP ILE TYR ALA TRP GLN ASP ALA SER GLY MET TYR          
SEQRES  33 C  841  ARG VAL LYS PHE ASP ALA ASP ARG ASP ASP LYS ASN PRO          
SEQRES  34 C  841  GLY GLN GLU SER MET PRO VAL ARG LEU ALA LYS PRO TYR          
SEQRES  35 C  841  SER GLY ASP ALA TYR GLY PHE HIS PHE PRO LEU ILE GLN          
SEQRES  36 C  841  GLY THR GLU VAL ALA ILE ALA PHE GLU GLU GLY ASP PRO          
SEQRES  37 C  841  ASP ARG PRO TYR ILE ALA HIS ALA LEU HIS ASP SER ARG          
SEQRES  38 C  841  HIS VAL ASP HIS VAL THR ASP LYS ASN GLY THR ARG ASN          
SEQRES  39 C  841  VAL ILE ARG THR PRO ALA ASN ASN LYS LEU ARG MET GLU          
SEQRES  40 C  841  ASP LYS ARG GLY GLU GLU HIS ILE LYS LEU SER THR GLU          
SEQRES  41 C  841  TYR GLY GLY LYS THR GLN LEU ASN LEU GLY HIS ASN VAL          
SEQRES  42 C  841  ASP ALA SER ARG GLU LEU ARG GLY GLU GLY ALA GLU LEU          
SEQRES  43 C  841  ARG THR ASP ASP TRP ILE SER ILE ARG GLY GLY LYS GLY          
SEQRES  44 C  841  ILE PHE ILE SER ALA ASP MET GLN PRO GLN ALA GLN GLY          
SEQRES  45 C  841  LYS MET LEU ASP MET ASP GLU ALA ILE ARG GLN LEU GLU          
SEQRES  46 C  841  GLN ALA LEU SER LEU ALA ARG SER MET ALA LYS ALA ALA          
SEQRES  47 C  841  THR ALA ALA ASN ALA THR GLN GLY ASP ILE SER CYS GLN          
SEQRES  48 C  841  GLN ARG LEU ASN ALA SER LEU THR ASP LEU THR ALA PRO          
SEQRES  49 C  841  GLY MET LEU LEU HIS ALA PRO ASP GLY ILE GLY MET VAL          
SEQRES  50 C  841  SER ALA ARG ALA LEU ARG ILE ALA SER GLY SER GLU SER          
SEQRES  51 C  841  VAL GLY ILE MET SER GLY ASP ASN THR ASP ILE THR ALA          
SEQRES  52 C  841  GLY GLN SER PHE THR VAL VAL ALA GLU GLY ALA VAL SER          
SEQRES  53 C  841  LEU LEU SER ARG ASN GLN GLY MET GLN LEU LEU ALA ALA          
SEQRES  54 C  841  LYS GLY ARG VAL ASN ILE GLN ALA GLN SER ASP ASP LEU          
SEQRES  55 C  841  SER MET SER SER GLN GLN ASN LEU ASP ILE GLN SER SER          
SEQRES  56 C  841  GLU GLY LYS VAL THR VAL SER ALA ASN GLN GLU LEU ILE          
SEQRES  57 C  841  LEU ALA CYS GLY GLY ALA TYR ILE LYS LEU SER GLY GLY          
SEQRES  58 C  841  ASN ILE GLU LEU GLY CYS PRO GLY GLN ILE LEU LEU LYS          
SEQRES  59 C  841  SER THR ASN MET GLN LYS MET GLY PRO THR SER LEU ASP          
SEQRES  60 C  841  ILE ALA SER VAL GLU MET PRO ARG GLY PHE GLY GLY GLY          
SEQRES  61 C  841  PHE ILE LEU THR ASP GLU ALA GLY VAL PRO GLN PRO SER          
SEQRES  62 C  841  THR PRO TYR ARG LEU THR THR ALA GLU GLY ASP ILE LEU          
SEQRES  63 C  841  GLN GLY ILE THR ASP GLU ASN GLY LYS THR ALA PRO VAL          
SEQRES  64 C  841  ASN THR SER ILE PRO SER VAL VAL LYS VAL GLU PHE GLY          
SEQRES  65 C  841  LYS VAL LYS ILE HIS GLY GLU THR GLU                          
SEQRES   1 D  560  MET THR LYS TYR GLN GLY TYR ASP VAL THR ASP ALA THR          
SEQRES   2 D  560  HIS LYS THR SER ILE HIS ASN ASP TRP LYS VAL VAL VAL          
SEQRES   3 D  560  ALA LYS LYS LYS PRO ALA ARG GLY VAL THR LEU THR ILE          
SEQRES   4 D  560  GLY ILE PHE PHE ASP GLY THR GLY ASN ASN ARG GLU ASN          
SEQRES   5 D  560  THR ALA SER ARG LEU MET LYS PHE ASN GLU CYS SER ALA          
SEQRES   6 D  560  ALA ARG GLN GLY VAL ASN GLN LYS ASP ALA GLN SER CYS          
SEQRES   7 D  560  GLU ASP PHE LEU LYS GLU ILE ASN LYS ASN SER ILE SER          
SEQRES   8 D  560  ASN GLY SER TYR ARG GLY TYR TYR SER ASN ILE HIS TRP          
SEQRES   9 D  560  LEU ASN ILE LEU TYR HIS PRO ASP GLN VAL LEU LYS LYS          
SEQRES  10 D  560  ASP GLN THR SER ALA GLN ILE LYS THR TYR ILE SER GLY          
SEQRES  11 D  560  ILE GLY THR ALA ALA GLY GLU ALA ASP SER VAL ILE GLY          
SEQRES  12 D  560  MET GLY LEU GLY THR SER ILE LEU ASP ILE PHE GLU GLY          
SEQRES  13 D  560  VAL VAL THR LYS THR ASP GLU ALA MET GLU ARG ILE THR          
SEQRES  14 D  560  GLN ALA LEU SER GLU PHE MET GLY PHE ASN LEU SER PRO          
SEQRES  15 D  560  ASP PHE CYS ILE ALA LYS ILE GLN PHE ASP VAL PHE GLY          
SEQRES  16 D  560  PHE SER ARG GLY ALA ALA ALA ALA ARG HIS PHE ALA ASN          
SEQRES  17 D  560  ARG VAL MET GLU GLN ASP PRO ALA ILE ALA ARG ALA ILE          
SEQRES  18 D  560  ALA LYS GLY LEU ARG GLY ASP PHE TYR ASP GLY LYS PRO          
SEQRES  19 D  560  SER GLY GLU VAL ARG PHE LEU GLY LEU PHE ASP THR VAL          
SEQRES  20 D  560  ALA ALA ILE GLY GLY ILE SER ASN PHE PHE ASP ILE ASN          
SEQRES  21 D  560  GLY ARG SER ASN PRO GLY VAL LYS LEU GLU LEU ARG PRO          
SEQRES  22 D  560  SER VAL ALA LYS LYS VAL PHE GLN ILE THR ALA MET ASN          
SEQRES  23 D  560  GLU TYR ARG TYR ASN PHE SER LEU ASN SER ILE LYS GLY          
SEQRES  24 D  560  MET TRP PRO GLU LEU ALA LEU PRO GLY ALA HIS SER ASP          
SEQRES  25 D  560  ILE GLY GLY GLY TYR ASN PRO VAL GLY SER PRO LEU GLN          
SEQRES  26 D  560  GLU ASN GLU SER LEU PHE LEU SER CYS PRO GLU PHE GLU          
SEQRES  27 D  560  ILE VAL SER ASP ASP THR ARG GLU MET ASP THR ARG VAL          
SEQRES  28 D  560  TYR ARG LYS ALA GLU GLN VAL ARG LYS MET LEU MET THR          
SEQRES  29 D  560  LEU PRO ALA LEU LYS HIS ILE LEU PRO HIS GLY LYS LEU          
SEQRES  30 D  560  THR THR LYS ILE ARG SER ILE GLY VAL ASN ASN SER ASN          
SEQRES  31 D  560  GLN ARG ARG ALA GLY VAL ILE GLN LYS GLN VAL GLY ALA          
SEQRES  32 D  560  ALA VAL PHE PHE GLU ARG MET ALA VAL PRO ASN ASP TRP          
SEQRES  33 D  560  ALA ASN VAL CYS LEU ARG VAL MET LEU ASP ALA ALA GLN          
SEQRES  34 D  560  GLU ALA GLY VAL LEU PHE GLU PRO ILE ARG GLN THR ASN          
SEQRES  35 D  560  THR GLU LEU GLN LEU PRO SER GLU LEU ILE PHE LEU ALA          
SEQRES  36 D  560  ASP LYS ALA ILE ALA GLN GLY LYS ALA VAL ARG LEU GLY          
SEQRES  37 D  560  GLN GLU PRO GLN ALA PHE THR GLU GLU GLU LEU TYR ILE          
SEQRES  38 D  560  ILE GLY LYS TYR THR HIS CYS SER ALA ASN TRP ASN ILE          
SEQRES  39 D  560  GLU SER ASP GLY ASN LEU TRP VAL ASP PRO THR THR GLY          
SEQRES  40 D  560  GLU ILE PHE ILE HIS ARG PHE GLY PRO LYS GLY ASN LYS          
SEQRES  41 D  560  ALA PHE VAL PHE PRO ASN LYS PRO ASN ASP ARG TRP ILE          
SEQRES  42 D  560  ARG SER VAL TRP TYR MET ASP ASP GLN GLN ARG LEU ASN          
SEQRES  43 D  560  ASP ASN ALA VAL LYS ASN THR LYS VAL MET MET SER GLY          
SEQRES  44 D  560  VAL                                                          
SEQRES   1 E  560  MET THR LYS TYR GLN GLY TYR ASP VAL THR ASP ALA THR          
SEQRES   2 E  560  HIS LYS THR SER ILE HIS ASN ASP TRP LYS VAL VAL VAL          
SEQRES   3 E  560  ALA LYS LYS LYS PRO ALA ARG GLY VAL THR LEU THR ILE          
SEQRES   4 E  560  GLY ILE PHE PHE ASP GLY THR GLY ASN ASN ARG GLU ASN          
SEQRES   5 E  560  THR ALA SER ARG LEU MET LYS PHE ASN GLU CYS SER ALA          
SEQRES   6 E  560  ALA ARG GLN GLY VAL ASN GLN LYS ASP ALA GLN SER CYS          
SEQRES   7 E  560  GLU ASP PHE LEU LYS GLU ILE ASN LYS ASN SER ILE SER          
SEQRES   8 E  560  ASN GLY SER TYR ARG GLY TYR TYR SER ASN ILE HIS TRP          
SEQRES   9 E  560  LEU ASN ILE LEU TYR HIS PRO ASP GLN VAL LEU LYS LYS          
SEQRES  10 E  560  ASP GLN THR SER ALA GLN ILE LYS THR TYR ILE SER GLY          
SEQRES  11 E  560  ILE GLY THR ALA ALA GLY GLU ALA ASP SER VAL ILE GLY          
SEQRES  12 E  560  MET GLY LEU GLY THR SER ILE LEU ASP ILE PHE GLU GLY          
SEQRES  13 E  560  VAL VAL THR LYS THR ASP GLU ALA MET GLU ARG ILE THR          
SEQRES  14 E  560  GLN ALA LEU SER GLU PHE MET GLY PHE ASN LEU SER PRO          
SEQRES  15 E  560  ASP PHE CYS ILE ALA LYS ILE GLN PHE ASP VAL PHE GLY          
SEQRES  16 E  560  PHE SER ARG GLY ALA ALA ALA ALA ARG HIS PHE ALA ASN          
SEQRES  17 E  560  ARG VAL MET GLU GLN ASP PRO ALA ILE ALA ARG ALA ILE          
SEQRES  18 E  560  ALA LYS GLY LEU ARG GLY ASP PHE TYR ASP GLY LYS PRO          
SEQRES  19 E  560  SER GLY GLU VAL ARG PHE LEU GLY LEU PHE ASP THR VAL          
SEQRES  20 E  560  ALA ALA ILE GLY GLY ILE SER ASN PHE PHE ASP ILE ASN          
SEQRES  21 E  560  GLY ARG SER ASN PRO GLY VAL LYS LEU GLU LEU ARG PRO          
SEQRES  22 E  560  SER VAL ALA LYS LYS VAL PHE GLN ILE THR ALA MET ASN          
SEQRES  23 E  560  GLU TYR ARG TYR ASN PHE SER LEU ASN SER ILE LYS GLY          
SEQRES  24 E  560  MET TRP PRO GLU LEU ALA LEU PRO GLY ALA HIS SER ASP          
SEQRES  25 E  560  ILE GLY GLY GLY TYR ASN PRO VAL GLY SER PRO LEU GLN          
SEQRES  26 E  560  GLU ASN GLU SER LEU PHE LEU SER CYS PRO GLU PHE GLU          
SEQRES  27 E  560  ILE VAL SER ASP ASP THR ARG GLU MET ASP THR ARG VAL          
SEQRES  28 E  560  TYR ARG LYS ALA GLU GLN VAL ARG LYS MET LEU MET THR          
SEQRES  29 E  560  LEU PRO ALA LEU LYS HIS ILE LEU PRO HIS GLY LYS LEU          
SEQRES  30 E  560  THR THR LYS ILE ARG SER ILE GLY VAL ASN ASN SER ASN          
SEQRES  31 E  560  GLN ARG ARG ALA GLY VAL ILE GLN LYS GLN VAL GLY ALA          
SEQRES  32 E  560  ALA VAL PHE PHE GLU ARG MET ALA VAL PRO ASN ASP TRP          
SEQRES  33 E  560  ALA ASN VAL CYS LEU ARG VAL MET LEU ASP ALA ALA GLN          
SEQRES  34 E  560  GLU ALA GLY VAL LEU PHE GLU PRO ILE ARG GLN THR ASN          
SEQRES  35 E  560  THR GLU LEU GLN LEU PRO SER GLU LEU ILE PHE LEU ALA          
SEQRES  36 E  560  ASP LYS ALA ILE ALA GLN GLY LYS ALA VAL ARG LEU GLY          
SEQRES  37 E  560  GLN GLU PRO GLN ALA PHE THR GLU GLU GLU LEU TYR ILE          
SEQRES  38 E  560  ILE GLY LYS TYR THR HIS CYS SER ALA ASN TRP ASN ILE          
SEQRES  39 E  560  GLU SER ASP GLY ASN LEU TRP VAL ASP PRO THR THR GLY          
SEQRES  40 E  560  GLU ILE PHE ILE HIS ARG PHE GLY PRO LYS GLY ASN LYS          
SEQRES  41 E  560  ALA PHE VAL PHE PRO ASN LYS PRO ASN ASP ARG TRP ILE          
SEQRES  42 E  560  ARG SER VAL TRP TYR MET ASP ASP GLN GLN ARG LEU ASN          
SEQRES  43 E  560  ASP ASN ALA VAL LYS ASN THR LYS VAL MET MET SER GLY          
SEQRES  44 E  560  VAL                                                          
SEQRES   1 F  560  MET THR LYS TYR GLN GLY TYR ASP VAL THR ASP ALA THR          
SEQRES   2 F  560  HIS LYS THR SER ILE HIS ASN ASP TRP LYS VAL VAL VAL          
SEQRES   3 F  560  ALA LYS LYS LYS PRO ALA ARG GLY VAL THR LEU THR ILE          
SEQRES   4 F  560  GLY ILE PHE PHE ASP GLY THR GLY ASN ASN ARG GLU ASN          
SEQRES   5 F  560  THR ALA SER ARG LEU MET LYS PHE ASN GLU CYS SER ALA          
SEQRES   6 F  560  ALA ARG GLN GLY VAL ASN GLN LYS ASP ALA GLN SER CYS          
SEQRES   7 F  560  GLU ASP PHE LEU LYS GLU ILE ASN LYS ASN SER ILE SER          
SEQRES   8 F  560  ASN GLY SER TYR ARG GLY TYR TYR SER ASN ILE HIS TRP          
SEQRES   9 F  560  LEU ASN ILE LEU TYR HIS PRO ASP GLN VAL LEU LYS LYS          
SEQRES  10 F  560  ASP GLN THR SER ALA GLN ILE LYS THR TYR ILE SER GLY          
SEQRES  11 F  560  ILE GLY THR ALA ALA GLY GLU ALA ASP SER VAL ILE GLY          
SEQRES  12 F  560  MET GLY LEU GLY THR SER ILE LEU ASP ILE PHE GLU GLY          
SEQRES  13 F  560  VAL VAL THR LYS THR ASP GLU ALA MET GLU ARG ILE THR          
SEQRES  14 F  560  GLN ALA LEU SER GLU PHE MET GLY PHE ASN LEU SER PRO          
SEQRES  15 F  560  ASP PHE CYS ILE ALA LYS ILE GLN PHE ASP VAL PHE GLY          
SEQRES  16 F  560  PHE SER ARG GLY ALA ALA ALA ALA ARG HIS PHE ALA ASN          
SEQRES  17 F  560  ARG VAL MET GLU GLN ASP PRO ALA ILE ALA ARG ALA ILE          
SEQRES  18 F  560  ALA LYS GLY LEU ARG GLY ASP PHE TYR ASP GLY LYS PRO          
SEQRES  19 F  560  SER GLY GLU VAL ARG PHE LEU GLY LEU PHE ASP THR VAL          
SEQRES  20 F  560  ALA ALA ILE GLY GLY ILE SER ASN PHE PHE ASP ILE ASN          
SEQRES  21 F  560  GLY ARG SER ASN PRO GLY VAL LYS LEU GLU LEU ARG PRO          
SEQRES  22 F  560  SER VAL ALA LYS LYS VAL PHE GLN ILE THR ALA MET ASN          
SEQRES  23 F  560  GLU TYR ARG TYR ASN PHE SER LEU ASN SER ILE LYS GLY          
SEQRES  24 F  560  MET TRP PRO GLU LEU ALA LEU PRO GLY ALA HIS SER ASP          
SEQRES  25 F  560  ILE GLY GLY GLY TYR ASN PRO VAL GLY SER PRO LEU GLN          
SEQRES  26 F  560  GLU ASN GLU SER LEU PHE LEU SER CYS PRO GLU PHE GLU          
SEQRES  27 F  560  ILE VAL SER ASP ASP THR ARG GLU MET ASP THR ARG VAL          
SEQRES  28 F  560  TYR ARG LYS ALA GLU GLN VAL ARG LYS MET LEU MET THR          
SEQRES  29 F  560  LEU PRO ALA LEU LYS HIS ILE LEU PRO HIS GLY LYS LEU          
SEQRES  30 F  560  THR THR LYS ILE ARG SER ILE GLY VAL ASN ASN SER ASN          
SEQRES  31 F  560  GLN ARG ARG ALA GLY VAL ILE GLN LYS GLN VAL GLY ALA          
SEQRES  32 F  560  ALA VAL PHE PHE GLU ARG MET ALA VAL PRO ASN ASP TRP          
SEQRES  33 F  560  ALA ASN VAL CYS LEU ARG VAL MET LEU ASP ALA ALA GLN          
SEQRES  34 F  560  GLU ALA GLY VAL LEU PHE GLU PRO ILE ARG GLN THR ASN          
SEQRES  35 F  560  THR GLU LEU GLN LEU PRO SER GLU LEU ILE PHE LEU ALA          
SEQRES  36 F  560  ASP LYS ALA ILE ALA GLN GLY LYS ALA VAL ARG LEU GLY          
SEQRES  37 F  560  GLN GLU PRO GLN ALA PHE THR GLU GLU GLU LEU TYR ILE          
SEQRES  38 F  560  ILE GLY LYS TYR THR HIS CYS SER ALA ASN TRP ASN ILE          
SEQRES  39 F  560  GLU SER ASP GLY ASN LEU TRP VAL ASP PRO THR THR GLY          
SEQRES  40 F  560  GLU ILE PHE ILE HIS ARG PHE GLY PRO LYS GLY ASN LYS          
SEQRES  41 F  560  ALA PHE VAL PHE PRO ASN LYS PRO ASN ASP ARG TRP ILE          
SEQRES  42 F  560  ARG SER VAL TRP TYR MET ASP ASP GLN GLN ARG LEU ASN          
SEQRES  43 F  560  ASP ASN ALA VAL LYS ASN THR LYS VAL MET MET SER GLY          
SEQRES  44 F  560  VAL                                                          
HELIX    1 AA1 GLN A  567  GLN A  571  5                                   5    
HELIX    2 AA2 MET A  577  ALA A  601  1                                  25    
HELIX    3 AA3 ASP A  607  THR A  619  1                                  13    
HELIX    4 AA4 ASP A  620  THR A  622  5                                   3    
HELIX    5 AA5 GLN B  567  GLN B  571  5                                   5    
HELIX    6 AA6 MET B  577  ALA B  601  1                                  25    
HELIX    7 AA7 ASP B  607  THR B  619  1                                  13    
HELIX    8 AA8 ASP B  620  THR B  622  5                                   3    
HELIX    9 AA9 GLN C  567  GLN C  571  5                                   5    
HELIX   10 AB1 MET C  577  ALA C  601  1                                  25    
HELIX   11 AB2 ASP C  607  THR C  619  1                                  13    
HELIX   12 AB3 ASP C  620  THR C  622  5                                   3    
HELIX   13 AB4 ASN D   52  MET D   58  1                                   7    
HELIX   14 AB5 LYS D   59  ASN D   61  5                                   3    
HELIX   15 AB6 ASN D   71  GLU D   84  1                                  14    
HELIX   16 AB7 SER D  100  TYR D  109  1                                  10    
HELIX   17 AB8 GLY D  145  GLU D  155  1                                  11    
HELIX   18 AB9 GLU D  155  ASN D  179  1                                  25    
HELIX   19 AC1 ARG D  198  GLU D  212  1                                  15    
HELIX   20 AC2 ASP D  214  ARG D  226  1                                  13    
HELIX   21 AC3 ALA D  309  GLY D  315  1                                   7    
HELIX   22 AC4 ARG D  345  ASP D  348  5                                   4    
HELIX   23 AC5 THR D  349  LEU D  365  1                                  17    
HELIX   24 AC6 PRO D  366  LYS D  369  5                                   4    
HELIX   25 AC7 ILE D  371  GLY D  375  5                                   5    
HELIX   26 AC8 ASN D  388  ALA D  394  1                                   7    
HELIX   27 AC9 TRP D  416  ALA D  431  1                                  16    
HELIX   28 AD1 ASN D  442  GLN D  446  5                                   5    
HELIX   29 AD2 PRO D  448  GLU D  450  5                                   3    
HELIX   30 AD3 LEU D  451  LEU D  467  1                                  17    
HELIX   31 AD4 THR D  475  GLY D  483  1                                   9    
HELIX   32 AD5 ASN D  529  ILE D  533  5                                   5    
HELIX   33 AD6 ASN E   52  LYS E   59  1                                   8    
HELIX   34 AD7 ASN E   71  ASN E   86  1                                  16    
HELIX   35 AD8 SER E  100  TYR E  109  1                                  10    
HELIX   36 AD9 ILE E  142  MET E  144  5                                   3    
HELIX   37 AE1 GLY E  145  GLU E  155  1                                  11    
HELIX   38 AE2 GLU E  155  PHE E  178  1                                  24    
HELIX   39 AE3 ARG E  198  GLU E  212  1                                  15    
HELIX   40 AE4 ASP E  214  ARG E  226  1                                  13    
HELIX   41 AE5 ALA E  309  GLY E  315  1                                   7    
HELIX   42 AE6 ARG E  345  ASP E  348  5                                   4    
HELIX   43 AE7 THR E  349  LEU E  365  1                                  17    
HELIX   44 AE8 PRO E  366  LYS E  369  5                                   4    
HELIX   45 AE9 ILE E  371  GLY E  375  5                                   5    
HELIX   46 AF1 ASN E  388  ALA E  394  1                                   7    
HELIX   47 AF2 TRP E  416  ALA E  431  1                                  16    
HELIX   48 AF3 ASN E  442  GLN E  446  5                                   5    
HELIX   49 AF4 PRO E  448  GLU E  450  5                                   3    
HELIX   50 AF5 LEU E  451  LEU E  467  1                                  17    
HELIX   51 AF6 THR E  475  LYS E  484  1                                  10    
HELIX   52 AF7 ASN E  529  ILE E  533  5                                   5    
HELIX   53 AF8 ASN F   52  LYS F   59  1                                   8    
HELIX   54 AF9 ASN F   71  ASN F   86  1                                  16    
HELIX   55 AG1 SER F  100  TYR F  109  1                                  10    
HELIX   56 AG2 GLY F  145  GLU F  155  1                                  11    
HELIX   57 AG3 GLU F  155  ASN F  179  1                                  25    
HELIX   58 AG4 ARG F  198  GLU F  212  1                                  15    
HELIX   59 AG5 ASP F  214  ARG F  226  1                                  13    
HELIX   60 AG6 ALA F  309  GLY F  315  1                                   7    
HELIX   61 AG7 ARG F  345  ASP F  348  5                                   4    
HELIX   62 AG8 THR F  349  LEU F  365  1                                  17    
HELIX   63 AG9 PRO F  366  LYS F  369  5                                   4    
HELIX   64 AH1 ILE F  371  GLY F  375  5                                   5    
HELIX   65 AH2 ASN F  388  ALA F  394  1                                   7    
HELIX   66 AH3 TRP F  416  ALA F  431  1                                  16    
HELIX   67 AH4 ASN F  442  GLN F  446  5                                   5    
HELIX   68 AH5 PRO F  448  GLU F  450  5                                   3    
HELIX   69 AH6 LEU F  451  LEU F  467  1                                  17    
HELIX   70 AH7 THR F  475  LYS F  484  1                                  10    
HELIX   71 AH8 ASN F  529  ILE F  533  5                                   5    
SHEET    1 AA123 ARG A 493  ARG A 497  0                                        
SHEET    2 AA123 LYS A 503  GLU A 507 -1  O  MET A 506   N  ASN A 494           
SHEET    3 AA123 HIS A 514  THR A 519 -1  O  LYS A 516   N  ARG A 505           
SHEET    4 AA123 THR A 525  VAL A 533 -1  O  LEU A 529   N  ILE A 515           
SHEET    5 AA123 LEU A 539  THR A 548 -1  O  GLU A 545   N  ASN A 528           
SHEET    6 AA123 TRP B 551  GLY B 556  1  O  SER B 553   N  ALA A 544           
SHEET    7 AA123 GLY C 559  SER C 563  1  O  PHE C 561   N  ILE B 552           
SHEET    8 AA123 MET C 626  HIS C 629  1  O  LEU C 627   N  ILE C 560           
SHEET    9 AA123 ILE A 634  SER A 638  1  N  GLY A 635   O  LEU C 628           
SHEET   10 AA123 LEU B 642  SER B 646  1  O  ARG B 643   N  MET A 636           
SHEET   11 AA123 VAL C 651  SER C 655  1  O  GLY C 652   N  LEU B 642           
SHEET   12 AA123 THR A 659  ALA A 663  1  N  THR A 662   O  ILE C 653           
SHEET   13 AA123 PHE B 667  ALA B 671  1  O  THR B 668   N  ILE A 661           
SHEET   14 AA123 VAL C 675  SER C 679  1  O  LEU C 678   N  ALA B 671           
SHEET   15 AA123 MET A 684  ALA A 688  1  N  GLN A 685   O  LEU C 677           
SHEET   16 AA123 VAL B 693  ALA B 697  1  O  ASN B 694   N  MET A 684           
SHEET   17 AA123 LEU C 702  SER C 706  1  O  SER C 703   N  ILE B 695           
SHEET   18 AA123 LEU A 710  SER A 714  1  N  ASP A 711   O  MET C 704           
SHEET   19 AA123 VAL B 719  SER B 722  1  O  THR B 720   N  LEU A 710           
SHEET   20 AA123 GLU C 726  CYS C 731  1  O  ILE C 728   N  VAL B 721           
SHEET   21 AA123 ALA C 734  SER C 739 -1  O  ALA C 734   N  CYS C 731           
SHEET   22 AA123 ASN C 742  GLY C 746 -1  O  ASN C 742   N  SER C 739           
SHEET   23 AA123 ILE A 751  LYS A 754  1  N  LEU A 752   O  ILE C 743           
SHEET    1 AA223 ARG C 493  ARG C 497  0                                        
SHEET    2 AA223 LYS C 503  GLU C 507 -1  O  MET C 506   N  ASN C 494           
SHEET    3 AA223 HIS C 514  THR C 519 -1  O  LYS C 516   N  ARG C 505           
SHEET    4 AA223 THR C 525  VAL C 533 -1  O  LEU C 529   N  ILE C 515           
SHEET    5 AA223 LEU C 539  THR C 548 -1  O  ARG C 540   N  ASN C 532           
SHEET    6 AA223 TRP A 551  GLY A 556  1  N  ARG A 555   O  LEU C 546           
SHEET    7 AA223 ILE B 560  SER B 563  1  O  SER B 563   N  ILE A 554           
SHEET    8 AA223 MET B 626  HIS B 629  1  O  LEU B 627   N  ILE B 560           
SHEET    9 AA223 ILE C 634  SER C 638  1  O  GLY C 635   N  LEU B 628           
SHEET   10 AA223 LEU A 642  SER A 646  1  N  ARG A 643   O  MET C 636           
SHEET   11 AA223 VAL B 651  SER B 655  1  O  GLY B 652   N  ILE A 644           
SHEET   12 AA223 THR C 659  ALA C 663  1  O  ASP C 660   N  ILE B 653           
SHEET   13 AA223 PHE A 667  ALA A 671  1  N  THR A 668   O  THR C 659           
SHEET   14 AA223 VAL B 675  SER B 679  1  O  LEU B 678   N  VAL A 669           
SHEET   15 AA223 MET C 684  ALA C 688  1  O  GLN C 685   N  VAL B 675           
SHEET   16 AA223 VAL A 693  ALA A 697  1  N  ASN A 694   O  MET C 684           
SHEET   17 AA223 LEU B 702  SER B 706  1  O  SER B 705   N  ILE A 695           
SHEET   18 AA223 LEU C 710  SER C 714  1  O  ASP C 711   N  MET B 704           
SHEET   19 AA223 VAL A 719  SER A 722  1  N  THR A 720   O  ILE C 712           
SHEET   20 AA223 GLU B 726  CYS B 731  1  O  ILE B 728   N  VAL A 719           
SHEET   21 AA223 ALA B 734  SER B 739 -1  O  LEU B 738   N  LEU B 727           
SHEET   22 AA223 ASN B 742  GLY B 746 -1  O  GLY B 746   N  TYR B 735           
SHEET   23 AA223 ILE C 751  LYS C 754  1  O  LEU C 752   N  ILE B 743           
SHEET    1 AA323 ARG B 493  ARG B 497  0                                        
SHEET    2 AA323 LYS B 503  GLU B 507 -1  O  MET B 506   N  ASN B 494           
SHEET    3 AA323 HIS B 514  THR B 519 -1  O  LYS B 516   N  ARG B 505           
SHEET    4 AA323 THR B 525  VAL B 533 -1  O  LEU B 529   N  ILE B 515           
SHEET    5 AA323 LEU B 539  THR B 548 -1  O  ARG B 540   N  ASN B 532           
SHEET    6 AA323 TRP C 551  GLY C 556  1  O  ARG C 555   N  LEU B 546           
SHEET    7 AA323 GLY A 559  SER A 563  1  N  PHE A 561   O  ILE C 554           
SHEET    8 AA323 MET A 626  ALA A 630  1  O  HIS A 629   N  ILE A 562           
SHEET    9 AA323 ILE B 634  SER B 638  1  O  GLY B 635   N  LEU A 628           
SHEET   10 AA323 LEU C 642  SER C 646  1  O  ARG C 643   N  MET B 636           
SHEET   11 AA323 VAL A 651  SER A 655  1  N  GLY A 652   O  LEU C 642           
SHEET   12 AA323 THR B 659  ALA B 663  1  O  THR B 662   N  ILE A 653           
SHEET   13 AA323 PHE C 667  ALA C 671  1  O  THR C 668   N  ILE B 661           
SHEET   14 AA323 VAL A 675  SER A 679  1  N  SER A 676   O  PHE C 667           
SHEET   15 AA323 MET B 684  ALA B 688  1  O  GLN B 685   N  LEU A 677           
SHEET   16 AA323 VAL C 693  ALA C 697  1  O  ASN C 694   N  MET B 684           
SHEET   17 AA323 LEU A 702  SER A 706  1  N  SER A 705   O  ILE C 695           
SHEET   18 AA323 LEU B 710  SER B 714  1  O  ASP B 711   N  MET A 704           
SHEET   19 AA323 VAL C 719  ALA C 723  1  O  THR C 720   N  ILE B 712           
SHEET   20 AA323 GLU A 726  CYS A 731  1  N  ILE A 728   O  VAL C 721           
SHEET   21 AA323 ALA A 734  SER A 739 -1  O  LEU A 738   N  LEU A 727           
SHEET   22 AA323 ASN A 742  GLY A 746 -1  O  GLU A 744   N  LYS A 737           
SHEET   23 AA323 ILE B 751  LYS B 754  1  O  LEU B 752   N  LEU A 745           
SHEET    1 AA4 3 LEU A 783  THR A 784  0                                        
SHEET    2 AA4 3 VAL D  25  PHE D  43  1  O  VAL D  25   N  THR A 784           
SHEET    3 AA4 3 SER D 121  ILE D 128  1  O  ILE D 124   N  GLY D  40           
SHEET    1 AA5 6 TYR D   4  VAL D   9  0                                        
SHEET    2 AA5 6 VAL D  25  PHE D  43 -1  O  LYS D  30   N  GLY D   6           
SHEET    3 AA5 6 PHE D 184  GLY D 195  1  O  CYS D 185   N  ARG D  33           
SHEET    4 AA5 6 GLU D 237  LEU D 243  1  O  ARG D 239   N  PHE D 191           
SHEET    5 AA5 6 LYS D 278  ALA D 284  1  O  PHE D 280   N  LEU D 243           
SHEET    6 AA5 6 GLU D 303  LEU D 306  1  O  LEU D 304   N  GLN D 281           
SHEET    1 AA6 4 ILE A 805  ILE A 809  0                                        
SHEET    2 AA6 4 PRO A 795  THR A 799 -1  N  TYR A 796   O  GLY A 808           
SHEET    3 AA6 4 SER A 825  GLU A 830 -1  O  VAL A 827   N  THR A 799           
SHEET    4 AA6 4 THR D  13  LYS D  15 -1  O  HIS D  14   N  VAL A 826           
SHEET    1 AA7 3 LEU B 783  THR B 784  0                                        
SHEET    2 AA7 3 VAL E  25  PHE E  43  1  O  VAL E  25   N  THR B 784           
SHEET    3 AA7 3 SER E 121  ILE E 128  1  O  ILE E 124   N  GLY E  40           
SHEET    1 AA8 6 TYR E   4  VAL E   9  0                                        
SHEET    2 AA8 6 VAL E  25  PHE E  43 -1  O  LYS E  28   N  ASP E   8           
SHEET    3 AA8 6 PHE E 184  GLY E 195  1  O  PHE E 194   N  PHE E  43           
SHEET    4 AA8 6 GLU E 237  LEU E 243  1  O  ARG E 239   N  PHE E 191           
SHEET    5 AA8 6 LYS E 278  ALA E 284  1  O  PHE E 280   N  LEU E 243           
SHEET    6 AA8 6 GLU E 303  LEU E 306  1  O  LEU E 304   N  GLN E 281           
SHEET    1 AA9 4 ILE B 805  ILE B 809  0                                        
SHEET    2 AA9 4 PRO B 795  THR B 799 -1  N  TYR B 796   O  GLY B 808           
SHEET    3 AA9 4 SER B 825  GLU B 830 -1  O  VAL B 827   N  THR B 799           
SHEET    4 AA9 4 THR E  13  LYS E  15 -1  O  HIS E  14   N  VAL B 826           
SHEET    1 AB1 3 LEU C 783  ASP C 785  0                                        
SHEET    2 AB1 3 VAL F  25  PHE F  43  1  O  VAL F  25   N  THR C 784           
SHEET    3 AB1 3 SER F 121  ILE F 128  1  O  ILE F 124   N  GLY F  40           
SHEET    1 AB2 6 TYR F   4  VAL F   9  0                                        
SHEET    2 AB2 6 VAL F  25  PHE F  43 -1  O  LYS F  28   N  ASP F   8           
SHEET    3 AB2 6 PHE F 184  GLY F 195  1  O  CYS F 185   N  ARG F  33           
SHEET    4 AB2 6 GLU F 237  LEU F 243  1  O  ARG F 239   N  PHE F 191           
SHEET    5 AB2 6 LYS F 278  ALA F 284  1  O  LYS F 278   N  ARG F 239           
SHEET    6 AB2 6 GLU F 303  LEU F 306  1  O  LEU F 304   N  GLN F 281           
SHEET    1 AB3 2 PRO C 795  THR C 799  0                                        
SHEET    2 AB3 2 ILE C 805  ILE C 809 -1  O  GLY C 808   N  TYR C 796           
SHEET    1 AB4 2 VAL C 826  VAL C 827  0                                        
SHEET    2 AB4 2 THR F  13  HIS F  14 -1  O  HIS F  14   N  VAL C 826           
SHEET    1 AB5 2 LEU D 294  ASN D 295  0                                        
SHEET    2 AB5 2 VAL D 536  TRP D 537  1  O  TRP D 537   N  LEU D 294           
SHEET    1 AB6 3 GLU D 328  PHE D 331  0                                        
SHEET    2 AB6 3 GLN D 398  ARG D 409 -1  O  ARG D 409   N  GLU D 328           
SHEET    3 AB6 3 GLU D 336  SER D 341 -1  N  GLU D 338   O  VAL D 401           
SHEET    1 AB7 3 GLU D 328  PHE D 331  0                                        
SHEET    2 AB7 3 GLN D 398  ARG D 409 -1  O  ARG D 409   N  GLU D 328           
SHEET    3 AB7 3 LYS D 376  VAL D 386 -1  N  ARG D 382   O  GLY D 402           
SHEET    1 AB8 2 GLU D 495  ASP D 497  0                                        
SHEET    2 AB8 2 ALA D 521  VAL D 523 -1  O  VAL D 523   N  GLU D 495           
SHEET    1 AB9 2 LEU D 500  VAL D 502  0                                        
SHEET    2 AB9 2 ILE D 509  ILE D 511 -1  O  PHE D 510   N  TRP D 501           
SHEET    1 AC1 2 LEU E 294  ASN E 295  0                                        
SHEET    2 AC1 2 VAL E 536  TRP E 537  1  O  TRP E 537   N  LEU E 294           
SHEET    1 AC2 3 GLU E 328  PHE E 331  0                                        
SHEET    2 AC2 3 GLN E 398  ARG E 409 -1  O  ARG E 409   N  GLU E 328           
SHEET    3 AC2 3 GLU E 336  SER E 341 -1  N  VAL E 340   O  LYS E 399           
SHEET    1 AC3 3 GLU E 328  PHE E 331  0                                        
SHEET    2 AC3 3 GLN E 398  ARG E 409 -1  O  ARG E 409   N  GLU E 328           
SHEET    3 AC3 3 LYS E 376  VAL E 386 -1  N  THR E 378   O  PHE E 406           
SHEET    1 AC4 2 GLU E 495  ASP E 497  0                                        
SHEET    2 AC4 2 ALA E 521  VAL E 523 -1  O  VAL E 523   N  GLU E 495           
SHEET    1 AC5 2 LEU E 500  VAL E 502  0                                        
SHEET    2 AC5 2 ILE E 509  ILE E 511 -1  O  PHE E 510   N  TRP E 501           
SHEET    1 AC6 2 LEU F 294  ASN F 295  0                                        
SHEET    2 AC6 2 VAL F 536  TRP F 537  1  O  TRP F 537   N  LEU F 294           
SHEET    1 AC7 3 GLU F 328  PHE F 331  0                                        
SHEET    2 AC7 3 GLN F 398  ARG F 409 -1  O  ARG F 409   N  GLU F 328           
SHEET    3 AC7 3 GLU F 336  SER F 341 -1  N  VAL F 340   O  LYS F 399           
SHEET    1 AC8 3 GLU F 328  PHE F 331  0                                        
SHEET    2 AC8 3 GLN F 398  ARG F 409 -1  O  ARG F 409   N  GLU F 328           
SHEET    3 AC8 3 LYS F 376  VAL F 386 -1  N  ARG F 382   O  GLY F 402           
SHEET    1 AC9 2 GLU F 495  ASP F 497  0                                        
SHEET    2 AC9 2 ALA F 521  VAL F 523 -1  O  ALA F 521   N  ASP F 497           
SHEET    1 AD1 2 LEU F 500  VAL F 502  0                                        
SHEET    2 AD1 2 ILE F 509  ILE F 511 -1  O  PHE F 510   N  TRP F 501           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
TER    2377      VAL A 834                                                      
TER    4754      VAL B 834                                                      
TER    7131      VAL C 834                                                      
TER   11237      MET D 539                                                      
TER   15351      MET E 539                                                      
TER   19465      MET F 539                                                      
MASTER     1881    0    0   71  144    0    0    619459    6    0  327          
END                                                                             

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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