| 6sjl-pdb | HEADER HYDROLASE 13-AUG-19 6SJL
TITLE STRUCTURE OF THE TLE1 EFFECTOR BOUND TO THE VGRG SPIKE FROM THE TYPE 6
TITLE 2 SECRETION SYSTEM
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: PUTATIVE TYPE VI SECRETION PROTEIN;
COMPND 3 CHAIN: A, B, C;
COMPND 4 SYNONYM: TYPE VI SECRETION SYSTEM TIP PROTEIN VGRG;
COMPND 5 ENGINEERED: YES;
COMPND 6 MOL_ID: 2;
COMPND 7 MOLECULE: PUTATIVE TYPE VI SECRETION PROTEIN;
COMPND 8 CHAIN: D, E, F;
COMPND 9 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;
SOURCE 3 ORGANISM_TAXID: 562;
SOURCE 4 GENE: VGRG, DL654_23170, DM280_18435, EF082_25505, EHD42_22735,
SOURCE 5 EIT12_22235, EIT27_22025, NCTC9044_02519;
SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;
SOURCE 10 ORGANISM_TAXID: 562;
SOURCE 11 GENE: NCTC12950_00913, NCTC9044_02520;
SOURCE 12 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 13 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS HYDROLASE, TOXIN, LIPASE, EFFECTOR, BACTERIAL
EXPDTA ELECTRON MICROSCOPY
AUTHOR C.RAPISARDA,R.FRONZES
REVDAT 2 11-NOV-20 6SJL 1 JRNL
REVDAT 1 29-APR-20 6SJL 0
JRNL AUTH N.FLAUGNATTI,C.RAPISARDA,M.REY,S.G.BEAUVOIS,V.A.NGUYEN,
JRNL AUTH 2 S.CANAAN,E.DURAND,J.CHAMOT-ROOKE,E.CASCALES,R.FRONZES,
JRNL AUTH 3 L.JOURNET
JRNL TITL STRUCTURAL BASIS FOR LOADING AND INHIBITION OF A BACTERIAL
JRNL TITL 2 T6SS PHOSPHOLIPASE EFFECTOR BY THE VGRG SPIKE.
JRNL REF EMBO J. V. 39 04129 2020
JRNL REFN ESSN 1460-2075
JRNL PMID 32350888
JRNL DOI 10.15252/EMBJ.2019104129
REMARK 2
REMARK 2 RESOLUTION. 2.60 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : SERIALEM, GCTF, CRYOSPARC, CRYOSPARC,
REMARK 3 CRYOSPARC, CRYOSPARC
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.600
REMARK 3 NUMBER OF PARTICLES : 468438
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6SJL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 14-AUG-19.
REMARK 100 THE DEPOSITION ID IS D_1292103841.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : TLE1 EFFECTOR BOUND TO THE VGRG
REMARK 245 SPIKE OF THE TYPE 6 SECRETION
REMARK 245 SYSTEM
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.60
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 53.94
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 56730 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 92370 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -262.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 ASN A 2
REMARK 465 LEU A 3
REMARK 465 THR A 4
REMARK 465 ASP A 5
REMARK 465 SER A 6
REMARK 465 LEU A 7
REMARK 465 GLN A 8
REMARK 465 ASN A 9
REMARK 465 VAL A 10
REMARK 465 LEU A 11
REMARK 465 SER A 12
REMARK 465 GLY A 13
REMARK 465 VAL A 14
REMARK 465 GLY A 15
REMARK 465 THR A 16
REMARK 465 LEU A 17
REMARK 465 ASN A 18
REMARK 465 ARG A 19
REMARK 465 TYR A 20
REMARK 465 ARG A 21
REMARK 465 LEU A 22
REMARK 465 ASP A 23
REMARK 465 ILE A 24
REMARK 465 PRO A 25
REMARK 465 SER A 26
REMARK 465 CYS A 27
REMARK 465 PRO A 28
REMARK 465 SER A 29
REMARK 465 SER A 30
REMARK 465 LEU A 31
REMARK 465 ASP A 32
REMARK 465 VAL A 33
REMARK 465 GLU A 34
REMARK 465 ASP A 35
REMARK 465 PHE A 36
REMARK 465 SER A 37
REMARK 465 GLY A 38
REMARK 465 THR A 39
REMARK 465 GLU A 40
REMARK 465 GLY A 41
REMARK 465 ILE A 42
REMARK 465 SER A 43
REMARK 465 LYS A 44
REMARK 465 ILE A 45
REMARK 465 TYR A 46
REMARK 465 ARG A 47
REMARK 465 TYR A 48
REMARK 465 ASP A 49
REMARK 465 ILE A 50
REMARK 465 ILE A 51
REMARK 465 PHE A 52
REMARK 465 THR A 53
REMARK 465 SER A 54
REMARK 465 THR A 55
REMARK 465 ASP A 56
REMARK 465 ARG A 57
REMARK 465 TYR A 58
REMARK 465 PRO A 59
REMARK 465 ASP A 60
REMARK 465 ALA A 61
REMARK 465 ALA A 62
REMARK 465 TRP A 63
REMARK 465 PHE A 64
REMARK 465 LEU A 65
REMARK 465 ARG A 66
REMARK 465 LYS A 67
REMARK 465 SER A 68
REMARK 465 ALA A 69
REMARK 465 THR A 70
REMARK 465 LEU A 71
REMARK 465 ILE A 72
REMARK 465 MET A 73
REMARK 465 GLY A 74
REMARK 465 THR A 75
REMARK 465 GLY A 76
REMARK 465 LEU A 77
REMARK 465 LEU A 78
REMARK 465 GLU A 79
REMARK 465 SER A 80
REMARK 465 LEU A 81
REMARK 465 THR A 82
REMARK 465 GLU A 83
REMARK 465 GLN A 84
REMARK 465 LYS A 85
REMARK 465 LYS A 86
REMARK 465 VAL A 87
REMARK 465 HIS A 88
REMARK 465 GLY A 89
REMARK 465 VAL A 90
REMARK 465 ILE A 91
REMARK 465 THR A 92
REMARK 465 ASP A 93
REMARK 465 PHE A 94
REMARK 465 ARG A 95
REMARK 465 ARG A 96
REMARK 465 ILE A 97
REMARK 465 SER A 98
REMARK 465 GLY A 99
REMARK 465 SER A 100
REMARK 465 GLU A 101
REMARK 465 ASP A 102
REMARK 465 GLN A 103
REMARK 465 ALA A 104
REMARK 465 GLN A 105
REMARK 465 TYR A 106
REMARK 465 ARG A 107
REMARK 465 ILE A 108
REMARK 465 THR A 109
REMARK 465 LEU A 110
REMARK 465 LYS A 111
REMARK 465 PRO A 112
REMARK 465 PHE A 113
REMARK 465 ILE A 114
REMARK 465 SER A 115
REMARK 465 LEU A 116
REMARK 465 LEU A 117
REMARK 465 ASP A 118
REMARK 465 LYS A 119
REMARK 465 GLN A 120
REMARK 465 PHE A 121
REMARK 465 ARG A 122
REMARK 465 THR A 123
REMARK 465 HIS A 124
REMARK 465 ARG A 125
REMARK 465 PHE A 126
REMARK 465 PHE A 127
REMARK 465 VAL A 128
REMARK 465 ASN A 129
REMARK 465 LYS A 130
REMARK 465 SER A 131
REMARK 465 VAL A 132
REMARK 465 PRO A 133
REMARK 465 GLU A 134
REMARK 465 VAL A 135
REMARK 465 VAL A 136
REMARK 465 GLU A 137
REMARK 465 GLN A 138
REMARK 465 ILE A 139
REMARK 465 LEU A 140
REMARK 465 THR A 141
REMARK 465 GLU A 142
REMARK 465 HIS A 143
REMARK 465 GLY A 144
REMARK 465 LEU A 145
REMARK 465 LYS A 146
REMARK 465 GLY A 147
REMARK 465 TRP A 148
REMARK 465 GLU A 149
REMARK 465 TYR A 150
REMARK 465 GLU A 151
REMARK 465 PHE A 152
REMARK 465 SER A 153
REMARK 465 LEU A 154
REMARK 465 LYS A 155
REMARK 465 ARG A 156
REMARK 465 THR A 157
REMARK 465 TYR A 158
REMARK 465 PRO A 159
REMARK 465 LYS A 160
REMARK 465 ARG A 161
REMARK 465 GLU A 162
REMARK 465 GLN A 163
REMARK 465 ILE A 164
REMARK 465 ASN A 165
REMARK 465 GLN A 166
REMARK 465 TYR A 167
REMARK 465 GLN A 168
REMARK 465 GLU A 169
REMARK 465 SER A 170
REMARK 465 ASP A 171
REMARK 465 LEU A 172
REMARK 465 ARG A 173
REMARK 465 PHE A 174
REMARK 465 ILE A 175
REMARK 465 GLN A 176
REMARK 465 ARG A 177
REMARK 465 LEU A 178
REMARK 465 LEU A 179
REMARK 465 ALA A 180
REMARK 465 GLU A 181
REMARK 465 VAL A 182
REMARK 465 GLY A 183
REMARK 465 ILE A 184
REMARK 465 PHE A 185
REMARK 465 TYR A 186
REMARK 465 PHE A 187
REMARK 465 PHE A 188
REMARK 465 THR A 189
REMARK 465 LEU A 190
REMARK 465 HIS A 191
REMARK 465 PRO A 192
REMARK 465 ASP A 193
REMARK 465 ALA A 194
REMARK 465 GLN A 195
REMARK 465 THR A 196
REMARK 465 GLU A 197
REMARK 465 VAL A 198
REMARK 465 ILE A 199
REMARK 465 HIS A 200
REMARK 465 PHE A 201
REMARK 465 GLY A 202
REMARK 465 ASP A 203
REMARK 465 VAL A 204
REMARK 465 GLN A 205
REMARK 465 ALA A 206
REMARK 465 ALA A 207
REMARK 465 LEU A 208
REMARK 465 ILE A 209
REMARK 465 PHE A 210
REMARK 465 ASP A 211
REMARK 465 LYS A 212
REMARK 465 THR A 213
REMARK 465 LEU A 214
REMARK 465 PRO A 215
REMARK 465 VAL A 216
REMARK 465 ASN A 217
REMARK 465 SER A 218
REMARK 465 PRO A 219
REMARK 465 SER A 220
REMARK 465 GLY A 221
REMARK 465 MET A 222
REMARK 465 SER A 223
REMARK 465 ASP A 224
REMARK 465 SER A 225
REMARK 465 GLY A 226
REMARK 465 THR A 227
REMARK 465 ASP A 228
REMARK 465 SER A 229
REMARK 465 VAL A 230
REMARK 465 TRP A 231
REMARK 465 ALA A 232
REMARK 465 LEU A 233
REMARK 465 ASN A 234
REMARK 465 VAL A 235
REMARK 465 GLU A 236
REMARK 465 HIS A 237
REMARK 465 ARG A 238
REMARK 465 VAL A 239
REMARK 465 VAL A 240
REMARK 465 GLU A 241
REMARK 465 SER A 242
REMARK 465 ARG A 243
REMARK 465 VAL A 244
REMARK 465 ILE A 245
REMARK 465 THR A 246
REMARK 465 ASN A 247
REMARK 465 ASP A 248
REMARK 465 TYR A 249
REMARK 465 ASN A 250
REMARK 465 HIS A 251
REMARK 465 ARG A 252
REMARK 465 GLU A 253
REMARK 465 ALA A 254
REMARK 465 GLN A 255
REMARK 465 ASN A 256
REMARK 465 ILE A 257
REMARK 465 LEU A 258
REMARK 465 MET A 259
REMARK 465 SER A 260
REMARK 465 VAL A 261
REMARK 465 PRO A 262
REMARK 465 ALA A 263
REMARK 465 ASP A 264
REMARK 465 MET A 265
REMARK 465 THR A 266
REMARK 465 ARG A 267
REMARK 465 GLY A 268
REMARK 465 GLU A 269
REMARK 465 GLY A 270
REMARK 465 TYR A 271
REMARK 465 ASP A 272
REMARK 465 THR A 273
REMARK 465 SER A 274
REMARK 465 TYR A 275
REMARK 465 GLY A 276
REMARK 465 GLU A 277
REMARK 465 VAL A 278
REMARK 465 TYR A 279
REMARK 465 HIS A 280
REMARK 465 TYR A 281
REMARK 465 ARG A 282
REMARK 465 PRO A 283
REMARK 465 ARG A 284
REMARK 465 HIS A 285
REMARK 465 THR A 286
REMARK 465 GLU A 287
REMARK 465 ARG A 288
REMARK 465 GLY A 289
REMARK 465 ASP A 290
REMARK 465 LYS A 291
REMARK 465 ILE A 292
REMARK 465 ASP A 293
REMARK 465 PRO A 294
REMARK 465 ALA A 295
REMARK 465 PRO A 296
REMARK 465 GLU A 297
REMARK 465 THR A 298
REMARK 465 ALA A 299
REMARK 465 ASN A 300
REMARK 465 PHE A 301
REMARK 465 TRP A 302
REMARK 465 ALA A 303
REMARK 465 ARG A 304
REMARK 465 LEU A 305
REMARK 465 ASP A 306
REMARK 465 HIS A 307
REMARK 465 GLU A 308
REMARK 465 ARG A 309
REMARK 465 PHE A 310
REMARK 465 LEU A 311
REMARK 465 ALA A 312
REMARK 465 GLU A 313
REMARK 465 GLN A 314
REMARK 465 THR A 315
REMARK 465 ARG A 316
REMARK 465 ILE A 317
REMARK 465 THR A 318
REMARK 465 GLY A 319
REMARK 465 LYS A 320
REMARK 465 SER A 321
REMARK 465 THR A 322
REMARK 465 ASP A 323
REMARK 465 ALA A 324
REMARK 465 SER A 325
REMARK 465 LEU A 326
REMARK 465 LEU A 327
REMARK 465 PRO A 328
REMARK 465 ALA A 329
REMARK 465 GLN A 330
REMARK 465 VAL A 331
REMARK 465 LEU A 332
REMARK 465 THR A 333
REMARK 465 ILE A 334
REMARK 465 THR A 335
REMARK 465 ASP A 336
REMARK 465 SER A 337
REMARK 465 THR A 338
REMARK 465 PRO A 339
REMARK 465 PRO A 340
REMARK 465 VAL A 341
REMARK 465 LEU A 342
REMARK 465 PRO A 343
REMARK 465 ALA A 344
REMARK 465 PRO A 345
REMARK 465 LEU A 346
REMARK 465 GLN A 347
REMARK 465 GLU A 348
REMARK 465 PRO A 349
REMARK 465 VAL A 350
REMARK 465 LEU A 351
REMARK 465 LEU A 352
REMARK 465 THR A 353
REMARK 465 GLN A 354
REMARK 465 LEU A 355
REMARK 465 LEU A 356
REMARK 465 PHE A 357
REMARK 465 THR A 358
REMARK 465 GLY A 359
REMARK 465 SER A 360
REMARK 465 ARG A 361
REMARK 465 LYS A 362
REMARK 465 SER A 363
REMARK 465 ALA A 364
REMARK 465 LEU A 365
REMARK 465 GLN A 366
REMARK 465 VAL A 367
REMARK 465 MET A 368
REMARK 465 LEU A 369
REMARK 465 SER A 370
REMARK 465 ALA A 371
REMARK 465 VAL A 372
REMARK 465 PRO A 373
REMARK 465 TYR A 374
REMARK 465 SER A 375
REMARK 465 GLU A 376
REMARK 465 ILE A 377
REMARK 465 VAL A 378
REMARK 465 CYS A 379
REMARK 465 TRP A 380
REMARK 465 ARG A 381
REMARK 465 PRO A 382
REMARK 465 PRO A 383
REMARK 465 LEU A 384
REMARK 465 LEU A 385
REMARK 465 THR A 386
REMARK 465 ARG A 387
REMARK 465 PRO A 388
REMARK 465 LYS A 389
REMARK 465 ILE A 390
REMARK 465 THR A 391
REMARK 465 GLY A 392
REMARK 465 THR A 393
REMARK 465 MET A 394
REMARK 465 THR A 395
REMARK 465 ALA A 396
REMARK 465 ARG A 397
REMARK 465 VAL A 398
REMARK 465 THR A 399
REMARK 465 SER A 400
REMARK 465 ALA A 401
REMARK 465 LYS A 402
REMARK 465 GLU A 403
REMARK 465 GLY A 404
REMARK 465 ASP A 405
REMARK 465 ILE A 406
REMARK 465 TYR A 407
REMARK 465 ALA A 408
REMARK 465 TRP A 409
REMARK 465 GLN A 410
REMARK 465 ASP A 411
REMARK 465 ALA A 412
REMARK 465 SER A 413
REMARK 465 GLY A 414
REMARK 465 MET A 415
REMARK 465 TYR A 416
REMARK 465 ARG A 417
REMARK 465 VAL A 418
REMARK 465 LYS A 419
REMARK 465 PHE A 420
REMARK 465 ASP A 421
REMARK 465 ALA A 422
REMARK 465 ASP A 423
REMARK 465 ARG A 424
REMARK 465 ASP A 425
REMARK 465 ASP A 426
REMARK 465 LYS A 427
REMARK 465 ASN A 428
REMARK 465 PRO A 429
REMARK 465 GLY A 430
REMARK 465 GLN A 431
REMARK 465 GLU A 432
REMARK 465 SER A 433
REMARK 465 MET A 434
REMARK 465 PRO A 435
REMARK 465 VAL A 436
REMARK 465 ARG A 437
REMARK 465 LEU A 438
REMARK 465 ALA A 439
REMARK 465 LYS A 440
REMARK 465 PRO A 441
REMARK 465 TYR A 442
REMARK 465 SER A 443
REMARK 465 GLY A 444
REMARK 465 ASP A 445
REMARK 465 ALA A 446
REMARK 465 TYR A 447
REMARK 465 GLY A 448
REMARK 465 PHE A 449
REMARK 465 HIS A 450
REMARK 465 PHE A 451
REMARK 465 PRO A 452
REMARK 465 LEU A 453
REMARK 465 ILE A 454
REMARK 465 GLN A 455
REMARK 465 GLY A 456
REMARK 465 THR A 457
REMARK 465 GLU A 458
REMARK 465 VAL A 459
REMARK 465 ALA A 460
REMARK 465 ILE A 461
REMARK 465 ALA A 462
REMARK 465 PHE A 463
REMARK 465 GLU A 464
REMARK 465 GLU A 465
REMARK 465 GLY A 466
REMARK 465 ASP A 467
REMARK 465 PRO A 468
REMARK 465 ASP A 469
REMARK 465 ARG A 470
REMARK 465 PRO A 471
REMARK 465 TYR A 472
REMARK 465 ILE A 473
REMARK 465 ALA A 474
REMARK 465 HIS A 475
REMARK 465 ALA A 476
REMARK 465 LEU A 477
REMARK 465 HIS A 478
REMARK 465 ASP A 479
REMARK 465 SER A 480
REMARK 465 ARG A 481
REMARK 465 HIS A 482
REMARK 465 VAL A 483
REMARK 465 ASP A 484
REMARK 465 HIS A 485
REMARK 465 VAL A 486
REMARK 465 THR A 487
REMARK 465 ASP A 488
REMARK 465 LYS A 489
REMARK 465 ASN A 490
REMARK 465 MET A 758
REMARK 465 GLN A 759
REMARK 465 LYS A 760
REMARK 465 MET A 761
REMARK 465 GLY A 762
REMARK 465 PRO A 763
REMARK 465 THR A 764
REMARK 465 SER A 765
REMARK 465 LEU A 766
REMARK 465 ASP A 767
REMARK 465 ILE A 768
REMARK 465 ALA A 769
REMARK 465 SER A 770
REMARK 465 VAL A 771
REMARK 465 GLU A 772
REMARK 465 MET A 773
REMARK 465 PRO A 774
REMARK 465 ARG A 775
REMARK 465 GLY A 776
REMARK 465 PHE A 777
REMARK 465 LYS A 835
REMARK 465 ILE A 836
REMARK 465 HIS A 837
REMARK 465 GLY A 838
REMARK 465 GLU A 839
REMARK 465 THR A 840
REMARK 465 GLU A 841
REMARK 465 MET B 1
REMARK 465 ASN B 2
REMARK 465 LEU B 3
REMARK 465 THR B 4
REMARK 465 ASP B 5
REMARK 465 SER B 6
REMARK 465 LEU B 7
REMARK 465 GLN B 8
REMARK 465 ASN B 9
REMARK 465 VAL B 10
REMARK 465 LEU B 11
REMARK 465 SER B 12
REMARK 465 GLY B 13
REMARK 465 VAL B 14
REMARK 465 GLY B 15
REMARK 465 THR B 16
REMARK 465 LEU B 17
REMARK 465 ASN B 18
REMARK 465 ARG B 19
REMARK 465 TYR B 20
REMARK 465 ARG B 21
REMARK 465 LEU B 22
REMARK 465 ASP B 23
REMARK 465 ILE B 24
REMARK 465 PRO B 25
REMARK 465 SER B 26
REMARK 465 CYS B 27
REMARK 465 PRO B 28
REMARK 465 SER B 29
REMARK 465 SER B 30
REMARK 465 LEU B 31
REMARK 465 ASP B 32
REMARK 465 VAL B 33
REMARK 465 GLU B 34
REMARK 465 ASP B 35
REMARK 465 PHE B 36
REMARK 465 SER B 37
REMARK 465 GLY B 38
REMARK 465 THR B 39
REMARK 465 GLU B 40
REMARK 465 GLY B 41
REMARK 465 ILE B 42
REMARK 465 SER B 43
REMARK 465 LYS B 44
REMARK 465 ILE B 45
REMARK 465 TYR B 46
REMARK 465 ARG B 47
REMARK 465 TYR B 48
REMARK 465 ASP B 49
REMARK 465 ILE B 50
REMARK 465 ILE B 51
REMARK 465 PHE B 52
REMARK 465 THR B 53
REMARK 465 SER B 54
REMARK 465 THR B 55
REMARK 465 ASP B 56
REMARK 465 ARG B 57
REMARK 465 TYR B 58
REMARK 465 PRO B 59
REMARK 465 ASP B 60
REMARK 465 ALA B 61
REMARK 465 ALA B 62
REMARK 465 TRP B 63
REMARK 465 PHE B 64
REMARK 465 LEU B 65
REMARK 465 ARG B 66
REMARK 465 LYS B 67
REMARK 465 SER B 68
REMARK 465 ALA B 69
REMARK 465 THR B 70
REMARK 465 LEU B 71
REMARK 465 ILE B 72
REMARK 465 MET B 73
REMARK 465 GLY B 74
REMARK 465 THR B 75
REMARK 465 GLY B 76
REMARK 465 LEU B 77
REMARK 465 LEU B 78
REMARK 465 GLU B 79
REMARK 465 SER B 80
REMARK 465 LEU B 81
REMARK 465 THR B 82
REMARK 465 GLU B 83
REMARK 465 GLN B 84
REMARK 465 LYS B 85
REMARK 465 LYS B 86
REMARK 465 VAL B 87
REMARK 465 HIS B 88
REMARK 465 GLY B 89
REMARK 465 VAL B 90
REMARK 465 ILE B 91
REMARK 465 THR B 92
REMARK 465 ASP B 93
REMARK 465 PHE B 94
REMARK 465 ARG B 95
REMARK 465 ARG B 96
REMARK 465 ILE B 97
REMARK 465 SER B 98
REMARK 465 GLY B 99
REMARK 465 SER B 100
REMARK 465 GLU B 101
REMARK 465 ASP B 102
REMARK 465 GLN B 103
REMARK 465 ALA B 104
REMARK 465 GLN B 105
REMARK 465 TYR B 106
REMARK 465 ARG B 107
REMARK 465 ILE B 108
REMARK 465 THR B 109
REMARK 465 LEU B 110
REMARK 465 LYS B 111
REMARK 465 PRO B 112
REMARK 465 PHE B 113
REMARK 465 ILE B 114
REMARK 465 SER B 115
REMARK 465 LEU B 116
REMARK 465 LEU B 117
REMARK 465 ASP B 118
REMARK 465 LYS B 119
REMARK 465 GLN B 120
REMARK 465 PHE B 121
REMARK 465 ARG B 122
REMARK 465 THR B 123
REMARK 465 HIS B 124
REMARK 465 ARG B 125
REMARK 465 PHE B 126
REMARK 465 PHE B 127
REMARK 465 VAL B 128
REMARK 465 ASN B 129
REMARK 465 LYS B 130
REMARK 465 SER B 131
REMARK 465 VAL B 132
REMARK 465 PRO B 133
REMARK 465 GLU B 134
REMARK 465 VAL B 135
REMARK 465 VAL B 136
REMARK 465 GLU B 137
REMARK 465 GLN B 138
REMARK 465 ILE B 139
REMARK 465 LEU B 140
REMARK 465 THR B 141
REMARK 465 GLU B 142
REMARK 465 HIS B 143
REMARK 465 GLY B 144
REMARK 465 LEU B 145
REMARK 465 LYS B 146
REMARK 465 GLY B 147
REMARK 465 TRP B 148
REMARK 465 GLU B 149
REMARK 465 TYR B 150
REMARK 465 GLU B 151
REMARK 465 PHE B 152
REMARK 465 SER B 153
REMARK 465 LEU B 154
REMARK 465 LYS B 155
REMARK 465 ARG B 156
REMARK 465 THR B 157
REMARK 465 TYR B 158
REMARK 465 PRO B 159
REMARK 465 LYS B 160
REMARK 465 ARG B 161
REMARK 465 GLU B 162
REMARK 465 GLN B 163
REMARK 465 ILE B 164
REMARK 465 ASN B 165
REMARK 465 GLN B 166
REMARK 465 TYR B 167
REMARK 465 GLN B 168
REMARK 465 GLU B 169
REMARK 465 SER B 170
REMARK 465 ASP B 171
REMARK 465 LEU B 172
REMARK 465 ARG B 173
REMARK 465 PHE B 174
REMARK 465 ILE B 175
REMARK 465 GLN B 176
REMARK 465 ARG B 177
REMARK 465 LEU B 178
REMARK 465 LEU B 179
REMARK 465 ALA B 180
REMARK 465 GLU B 181
REMARK 465 VAL B 182
REMARK 465 GLY B 183
REMARK 465 ILE B 184
REMARK 465 PHE B 185
REMARK 465 TYR B 186
REMARK 465 PHE B 187
REMARK 465 PHE B 188
REMARK 465 THR B 189
REMARK 465 LEU B 190
REMARK 465 HIS B 191
REMARK 465 PRO B 192
REMARK 465 ASP B 193
REMARK 465 ALA B 194
REMARK 465 GLN B 195
REMARK 465 THR B 196
REMARK 465 GLU B 197
REMARK 465 VAL B 198
REMARK 465 ILE B 199
REMARK 465 HIS B 200
REMARK 465 PHE B 201
REMARK 465 GLY B 202
REMARK 465 ASP B 203
REMARK 465 VAL B 204
REMARK 465 GLN B 205
REMARK 465 ALA B 206
REMARK 465 ALA B 207
REMARK 465 LEU B 208
REMARK 465 ILE B 209
REMARK 465 PHE B 210
REMARK 465 ASP B 211
REMARK 465 LYS B 212
REMARK 465 THR B 213
REMARK 465 LEU B 214
REMARK 465 PRO B 215
REMARK 465 VAL B 216
REMARK 465 ASN B 217
REMARK 465 SER B 218
REMARK 465 PRO B 219
REMARK 465 SER B 220
REMARK 465 GLY B 221
REMARK 465 MET B 222
REMARK 465 SER B 223
REMARK 465 ASP B 224
REMARK 465 SER B 225
REMARK 465 GLY B 226
REMARK 465 THR B 227
REMARK 465 ASP B 228
REMARK 465 SER B 229
REMARK 465 VAL B 230
REMARK 465 TRP B 231
REMARK 465 ALA B 232
REMARK 465 LEU B 233
REMARK 465 ASN B 234
REMARK 465 VAL B 235
REMARK 465 GLU B 236
REMARK 465 HIS B 237
REMARK 465 ARG B 238
REMARK 465 VAL B 239
REMARK 465 VAL B 240
REMARK 465 GLU B 241
REMARK 465 SER B 242
REMARK 465 ARG B 243
REMARK 465 VAL B 244
REMARK 465 ILE B 245
REMARK 465 THR B 246
REMARK 465 ASN B 247
REMARK 465 ASP B 248
REMARK 465 TYR B 249
REMARK 465 ASN B 250
REMARK 465 HIS B 251
REMARK 465 ARG B 252
REMARK 465 GLU B 253
REMARK 465 ALA B 254
REMARK 465 GLN B 255
REMARK 465 ASN B 256
REMARK 465 ILE B 257
REMARK 465 LEU B 258
REMARK 465 MET B 259
REMARK 465 SER B 260
REMARK 465 VAL B 261
REMARK 465 PRO B 262
REMARK 465 ALA B 263
REMARK 465 ASP B 264
REMARK 465 MET B 265
REMARK 465 THR B 266
REMARK 465 ARG B 267
REMARK 465 GLY B 268
REMARK 465 GLU B 269
REMARK 465 GLY B 270
REMARK 465 TYR B 271
REMARK 465 ASP B 272
REMARK 465 THR B 273
REMARK 465 SER B 274
REMARK 465 TYR B 275
REMARK 465 GLY B 276
REMARK 465 GLU B 277
REMARK 465 VAL B 278
REMARK 465 TYR B 279
REMARK 465 HIS B 280
REMARK 465 TYR B 281
REMARK 465 ARG B 282
REMARK 465 PRO B 283
REMARK 465 ARG B 284
REMARK 465 HIS B 285
REMARK 465 THR B 286
REMARK 465 GLU B 287
REMARK 465 ARG B 288
REMARK 465 GLY B 289
REMARK 465 ASP B 290
REMARK 465 LYS B 291
REMARK 465 ILE B 292
REMARK 465 ASP B 293
REMARK 465 PRO B 294
REMARK 465 ALA B 295
REMARK 465 PRO B 296
REMARK 465 GLU B 297
REMARK 465 THR B 298
REMARK 465 ALA B 299
REMARK 465 ASN B 300
REMARK 465 PHE B 301
REMARK 465 TRP B 302
REMARK 465 ALA B 303
REMARK 465 ARG B 304
REMARK 465 LEU B 305
REMARK 465 ASP B 306
REMARK 465 HIS B 307
REMARK 465 GLU B 308
REMARK 465 ARG B 309
REMARK 465 PHE B 310
REMARK 465 LEU B 311
REMARK 465 ALA B 312
REMARK 465 GLU B 313
REMARK 465 GLN B 314
REMARK 465 THR B 315
REMARK 465 ARG B 316
REMARK 465 ILE B 317
REMARK 465 THR B 318
REMARK 465 GLY B 319
REMARK 465 LYS B 320
REMARK 465 SER B 321
REMARK 465 THR B 322
REMARK 465 ASP B 323
REMARK 465 ALA B 324
REMARK 465 SER B 325
REMARK 465 LEU B 326
REMARK 465 LEU B 327
REMARK 465 PRO B 328
REMARK 465 ALA B 329
REMARK 465 GLN B 330
REMARK 465 VAL B 331
REMARK 465 LEU B 332
REMARK 465 THR B 333
REMARK 465 ILE B 334
REMARK 465 THR B 335
REMARK 465 ASP B 336
REMARK 465 SER B 337
REMARK 465 THR B 338
REMARK 465 PRO B 339
REMARK 465 PRO B 340
REMARK 465 VAL B 341
REMARK 465 LEU B 342
REMARK 465 PRO B 343
REMARK 465 ALA B 344
REMARK 465 PRO B 345
REMARK 465 LEU B 346
REMARK 465 GLN B 347
REMARK 465 GLU B 348
REMARK 465 PRO B 349
REMARK 465 VAL B 350
REMARK 465 LEU B 351
REMARK 465 LEU B 352
REMARK 465 THR B 353
REMARK 465 GLN B 354
REMARK 465 LEU B 355
REMARK 465 LEU B 356
REMARK 465 PHE B 357
REMARK 465 THR B 358
REMARK 465 GLY B 359
REMARK 465 SER B 360
REMARK 465 ARG B 361
REMARK 465 LYS B 362
REMARK 465 SER B 363
REMARK 465 ALA B 364
REMARK 465 LEU B 365
REMARK 465 GLN B 366
REMARK 465 VAL B 367
REMARK 465 MET B 368
REMARK 465 LEU B 369
REMARK 465 SER B 370
REMARK 465 ALA B 371
REMARK 465 VAL B 372
REMARK 465 PRO B 373
REMARK 465 TYR B 374
REMARK 465 SER B 375
REMARK 465 GLU B 376
REMARK 465 ILE B 377
REMARK 465 VAL B 378
REMARK 465 CYS B 379
REMARK 465 TRP B 380
REMARK 465 ARG B 381
REMARK 465 PRO B 382
REMARK 465 PRO B 383
REMARK 465 LEU B 384
REMARK 465 LEU B 385
REMARK 465 THR B 386
REMARK 465 ARG B 387
REMARK 465 PRO B 388
REMARK 465 LYS B 389
REMARK 465 ILE B 390
REMARK 465 THR B 391
REMARK 465 GLY B 392
REMARK 465 THR B 393
REMARK 465 MET B 394
REMARK 465 THR B 395
REMARK 465 ALA B 396
REMARK 465 ARG B 397
REMARK 465 VAL B 398
REMARK 465 THR B 399
REMARK 465 SER B 400
REMARK 465 ALA B 401
REMARK 465 LYS B 402
REMARK 465 GLU B 403
REMARK 465 GLY B 404
REMARK 465 ASP B 405
REMARK 465 ILE B 406
REMARK 465 TYR B 407
REMARK 465 ALA B 408
REMARK 465 TRP B 409
REMARK 465 GLN B 410
REMARK 465 ASP B 411
REMARK 465 ALA B 412
REMARK 465 SER B 413
REMARK 465 GLY B 414
REMARK 465 MET B 415
REMARK 465 TYR B 416
REMARK 465 ARG B 417
REMARK 465 VAL B 418
REMARK 465 LYS B 419
REMARK 465 PHE B 420
REMARK 465 ASP B 421
REMARK 465 ALA B 422
REMARK 465 ASP B 423
REMARK 465 ARG B 424
REMARK 465 ASP B 425
REMARK 465 ASP B 426
REMARK 465 LYS B 427
REMARK 465 ASN B 428
REMARK 465 PRO B 429
REMARK 465 GLY B 430
REMARK 465 GLN B 431
REMARK 465 GLU B 432
REMARK 465 SER B 433
REMARK 465 MET B 434
REMARK 465 PRO B 435
REMARK 465 VAL B 436
REMARK 465 ARG B 437
REMARK 465 LEU B 438
REMARK 465 ALA B 439
REMARK 465 LYS B 440
REMARK 465 PRO B 441
REMARK 465 TYR B 442
REMARK 465 SER B 443
REMARK 465 GLY B 444
REMARK 465 ASP B 445
REMARK 465 ALA B 446
REMARK 465 TYR B 447
REMARK 465 GLY B 448
REMARK 465 PHE B 449
REMARK 465 HIS B 450
REMARK 465 PHE B 451
REMARK 465 PRO B 452
REMARK 465 LEU B 453
REMARK 465 ILE B 454
REMARK 465 GLN B 455
REMARK 465 GLY B 456
REMARK 465 THR B 457
REMARK 465 GLU B 458
REMARK 465 VAL B 459
REMARK 465 ALA B 460
REMARK 465 ILE B 461
REMARK 465 ALA B 462
REMARK 465 PHE B 463
REMARK 465 GLU B 464
REMARK 465 GLU B 465
REMARK 465 GLY B 466
REMARK 465 ASP B 467
REMARK 465 PRO B 468
REMARK 465 ASP B 469
REMARK 465 ARG B 470
REMARK 465 PRO B 471
REMARK 465 TYR B 472
REMARK 465 ILE B 473
REMARK 465 ALA B 474
REMARK 465 HIS B 475
REMARK 465 ALA B 476
REMARK 465 LEU B 477
REMARK 465 HIS B 478
REMARK 465 ASP B 479
REMARK 465 SER B 480
REMARK 465 ARG B 481
REMARK 465 HIS B 482
REMARK 465 VAL B 483
REMARK 465 ASP B 484
REMARK 465 HIS B 485
REMARK 465 VAL B 486
REMARK 465 THR B 487
REMARK 465 ASP B 488
REMARK 465 LYS B 489
REMARK 465 ASN B 490
REMARK 465 MET B 758
REMARK 465 GLN B 759
REMARK 465 LYS B 760
REMARK 465 MET B 761
REMARK 465 GLY B 762
REMARK 465 PRO B 763
REMARK 465 THR B 764
REMARK 465 SER B 765
REMARK 465 LEU B 766
REMARK 465 ASP B 767
REMARK 465 ILE B 768
REMARK 465 ALA B 769
REMARK 465 SER B 770
REMARK 465 VAL B 771
REMARK 465 GLU B 772
REMARK 465 MET B 773
REMARK 465 PRO B 774
REMARK 465 ARG B 775
REMARK 465 GLY B 776
REMARK 465 PHE B 777
REMARK 465 LYS B 835
REMARK 465 ILE B 836
REMARK 465 HIS B 837
REMARK 465 GLY B 838
REMARK 465 GLU B 839
REMARK 465 THR B 840
REMARK 465 GLU B 841
REMARK 465 MET C 1
REMARK 465 ASN C 2
REMARK 465 LEU C 3
REMARK 465 THR C 4
REMARK 465 ASP C 5
REMARK 465 SER C 6
REMARK 465 LEU C 7
REMARK 465 GLN C 8
REMARK 465 ASN C 9
REMARK 465 VAL C 10
REMARK 465 LEU C 11
REMARK 465 SER C 12
REMARK 465 GLY C 13
REMARK 465 VAL C 14
REMARK 465 GLY C 15
REMARK 465 THR C 16
REMARK 465 LEU C 17
REMARK 465 ASN C 18
REMARK 465 ARG C 19
REMARK 465 TYR C 20
REMARK 465 ARG C 21
REMARK 465 LEU C 22
REMARK 465 ASP C 23
REMARK 465 ILE C 24
REMARK 465 PRO C 25
REMARK 465 SER C 26
REMARK 465 CYS C 27
REMARK 465 PRO C 28
REMARK 465 SER C 29
REMARK 465 SER C 30
REMARK 465 LEU C 31
REMARK 465 ASP C 32
REMARK 465 VAL C 33
REMARK 465 GLU C 34
REMARK 465 ASP C 35
REMARK 465 PHE C 36
REMARK 465 SER C 37
REMARK 465 GLY C 38
REMARK 465 THR C 39
REMARK 465 GLU C 40
REMARK 465 GLY C 41
REMARK 465 ILE C 42
REMARK 465 SER C 43
REMARK 465 LYS C 44
REMARK 465 ILE C 45
REMARK 465 TYR C 46
REMARK 465 ARG C 47
REMARK 465 TYR C 48
REMARK 465 ASP C 49
REMARK 465 ILE C 50
REMARK 465 ILE C 51
REMARK 465 PHE C 52
REMARK 465 THR C 53
REMARK 465 SER C 54
REMARK 465 THR C 55
REMARK 465 ASP C 56
REMARK 465 ARG C 57
REMARK 465 TYR C 58
REMARK 465 PRO C 59
REMARK 465 ASP C 60
REMARK 465 ALA C 61
REMARK 465 ALA C 62
REMARK 465 TRP C 63
REMARK 465 PHE C 64
REMARK 465 LEU C 65
REMARK 465 ARG C 66
REMARK 465 LYS C 67
REMARK 465 SER C 68
REMARK 465 ALA C 69
REMARK 465 THR C 70
REMARK 465 LEU C 71
REMARK 465 ILE C 72
REMARK 465 MET C 73
REMARK 465 GLY C 74
REMARK 465 THR C 75
REMARK 465 GLY C 76
REMARK 465 LEU C 77
REMARK 465 LEU C 78
REMARK 465 GLU C 79
REMARK 465 SER C 80
REMARK 465 LEU C 81
REMARK 465 THR C 82
REMARK 465 GLU C 83
REMARK 465 GLN C 84
REMARK 465 LYS C 85
REMARK 465 LYS C 86
REMARK 465 VAL C 87
REMARK 465 HIS C 88
REMARK 465 GLY C 89
REMARK 465 VAL C 90
REMARK 465 ILE C 91
REMARK 465 THR C 92
REMARK 465 ASP C 93
REMARK 465 PHE C 94
REMARK 465 ARG C 95
REMARK 465 ARG C 96
REMARK 465 ILE C 97
REMARK 465 SER C 98
REMARK 465 GLY C 99
REMARK 465 SER C 100
REMARK 465 GLU C 101
REMARK 465 ASP C 102
REMARK 465 GLN C 103
REMARK 465 ALA C 104
REMARK 465 GLN C 105
REMARK 465 TYR C 106
REMARK 465 ARG C 107
REMARK 465 ILE C 108
REMARK 465 THR C 109
REMARK 465 LEU C 110
REMARK 465 LYS C 111
REMARK 465 PRO C 112
REMARK 465 PHE C 113
REMARK 465 ILE C 114
REMARK 465 SER C 115
REMARK 465 LEU C 116
REMARK 465 LEU C 117
REMARK 465 ASP C 118
REMARK 465 LYS C 119
REMARK 465 GLN C 120
REMARK 465 PHE C 121
REMARK 465 ARG C 122
REMARK 465 THR C 123
REMARK 465 HIS C 124
REMARK 465 ARG C 125
REMARK 465 PHE C 126
REMARK 465 PHE C 127
REMARK 465 VAL C 128
REMARK 465 ASN C 129
REMARK 465 LYS C 130
REMARK 465 SER C 131
REMARK 465 VAL C 132
REMARK 465 PRO C 133
REMARK 465 GLU C 134
REMARK 465 VAL C 135
REMARK 465 VAL C 136
REMARK 465 GLU C 137
REMARK 465 GLN C 138
REMARK 465 ILE C 139
REMARK 465 LEU C 140
REMARK 465 THR C 141
REMARK 465 GLU C 142
REMARK 465 HIS C 143
REMARK 465 GLY C 144
REMARK 465 LEU C 145
REMARK 465 LYS C 146
REMARK 465 GLY C 147
REMARK 465 TRP C 148
REMARK 465 GLU C 149
REMARK 465 TYR C 150
REMARK 465 GLU C 151
REMARK 465 PHE C 152
REMARK 465 SER C 153
REMARK 465 LEU C 154
REMARK 465 LYS C 155
REMARK 465 ARG C 156
REMARK 465 THR C 157
REMARK 465 TYR C 158
REMARK 465 PRO C 159
REMARK 465 LYS C 160
REMARK 465 ARG C 161
REMARK 465 GLU C 162
REMARK 465 GLN C 163
REMARK 465 ILE C 164
REMARK 465 ASN C 165
REMARK 465 GLN C 166
REMARK 465 TYR C 167
REMARK 465 GLN C 168
REMARK 465 GLU C 169
REMARK 465 SER C 170
REMARK 465 ASP C 171
REMARK 465 LEU C 172
REMARK 465 ARG C 173
REMARK 465 PHE C 174
REMARK 465 ILE C 175
REMARK 465 GLN C 176
REMARK 465 ARG C 177
REMARK 465 LEU C 178
REMARK 465 LEU C 179
REMARK 465 ALA C 180
REMARK 465 GLU C 181
REMARK 465 VAL C 182
REMARK 465 GLY C 183
REMARK 465 ILE C 184
REMARK 465 PHE C 185
REMARK 465 TYR C 186
REMARK 465 PHE C 187
REMARK 465 PHE C 188
REMARK 465 THR C 189
REMARK 465 LEU C 190
REMARK 465 HIS C 191
REMARK 465 PRO C 192
REMARK 465 ASP C 193
REMARK 465 ALA C 194
REMARK 465 GLN C 195
REMARK 465 THR C 196
REMARK 465 GLU C 197
REMARK 465 VAL C 198
REMARK 465 ILE C 199
REMARK 465 HIS C 200
REMARK 465 PHE C 201
REMARK 465 GLY C 202
REMARK 465 ASP C 203
REMARK 465 VAL C 204
REMARK 465 GLN C 205
REMARK 465 ALA C 206
REMARK 465 ALA C 207
REMARK 465 LEU C 208
REMARK 465 ILE C 209
REMARK 465 PHE C 210
REMARK 465 ASP C 211
REMARK 465 LYS C 212
REMARK 465 THR C 213
REMARK 465 LEU C 214
REMARK 465 PRO C 215
REMARK 465 VAL C 216
REMARK 465 ASN C 217
REMARK 465 SER C 218
REMARK 465 PRO C 219
REMARK 465 SER C 220
REMARK 465 GLY C 221
REMARK 465 MET C 222
REMARK 465 SER C 223
REMARK 465 ASP C 224
REMARK 465 SER C 225
REMARK 465 GLY C 226
REMARK 465 THR C 227
REMARK 465 ASP C 228
REMARK 465 SER C 229
REMARK 465 VAL C 230
REMARK 465 TRP C 231
REMARK 465 ALA C 232
REMARK 465 LEU C 233
REMARK 465 ASN C 234
REMARK 465 VAL C 235
REMARK 465 GLU C 236
REMARK 465 HIS C 237
REMARK 465 ARG C 238
REMARK 465 VAL C 239
REMARK 465 VAL C 240
REMARK 465 GLU C 241
REMARK 465 SER C 242
REMARK 465 ARG C 243
REMARK 465 VAL C 244
REMARK 465 ILE C 245
REMARK 465 THR C 246
REMARK 465 ASN C 247
REMARK 465 ASP C 248
REMARK 465 TYR C 249
REMARK 465 ASN C 250
REMARK 465 HIS C 251
REMARK 465 ARG C 252
REMARK 465 GLU C 253
REMARK 465 ALA C 254
REMARK 465 GLN C 255
REMARK 465 ASN C 256
REMARK 465 ILE C 257
REMARK 465 LEU C 258
REMARK 465 MET C 259
REMARK 465 SER C 260
REMARK 465 VAL C 261
REMARK 465 PRO C 262
REMARK 465 ALA C 263
REMARK 465 ASP C 264
REMARK 465 MET C 265
REMARK 465 THR C 266
REMARK 465 ARG C 267
REMARK 465 GLY C 268
REMARK 465 GLU C 269
REMARK 465 GLY C 270
REMARK 465 TYR C 271
REMARK 465 ASP C 272
REMARK 465 THR C 273
REMARK 465 SER C 274
REMARK 465 TYR C 275
REMARK 465 GLY C 276
REMARK 465 GLU C 277
REMARK 465 VAL C 278
REMARK 465 TYR C 279
REMARK 465 HIS C 280
REMARK 465 TYR C 281
REMARK 465 ARG C 282
REMARK 465 PRO C 283
REMARK 465 ARG C 284
REMARK 465 HIS C 285
REMARK 465 THR C 286
REMARK 465 GLU C 287
REMARK 465 ARG C 288
REMARK 465 GLY C 289
REMARK 465 ASP C 290
REMARK 465 LYS C 291
REMARK 465 ILE C 292
REMARK 465 ASP C 293
REMARK 465 PRO C 294
REMARK 465 ALA C 295
REMARK 465 PRO C 296
REMARK 465 GLU C 297
REMARK 465 THR C 298
REMARK 465 ALA C 299
REMARK 465 ASN C 300
REMARK 465 PHE C 301
REMARK 465 TRP C 302
REMARK 465 ALA C 303
REMARK 465 ARG C 304
REMARK 465 LEU C 305
REMARK 465 ASP C 306
REMARK 465 HIS C 307
REMARK 465 GLU C 308
REMARK 465 ARG C 309
REMARK 465 PHE C 310
REMARK 465 LEU C 311
REMARK 465 ALA C 312
REMARK 465 GLU C 313
REMARK 465 GLN C 314
REMARK 465 THR C 315
REMARK 465 ARG C 316
REMARK 465 ILE C 317
REMARK 465 THR C 318
REMARK 465 GLY C 319
REMARK 465 LYS C 320
REMARK 465 SER C 321
REMARK 465 THR C 322
REMARK 465 ASP C 323
REMARK 465 ALA C 324
REMARK 465 SER C 325
REMARK 465 LEU C 326
REMARK 465 LEU C 327
REMARK 465 PRO C 328
REMARK 465 ALA C 329
REMARK 465 GLN C 330
REMARK 465 VAL C 331
REMARK 465 LEU C 332
REMARK 465 THR C 333
REMARK 465 ILE C 334
REMARK 465 THR C 335
REMARK 465 ASP C 336
REMARK 465 SER C 337
REMARK 465 THR C 338
REMARK 465 PRO C 339
REMARK 465 PRO C 340
REMARK 465 VAL C 341
REMARK 465 LEU C 342
REMARK 465 PRO C 343
REMARK 465 ALA C 344
REMARK 465 PRO C 345
REMARK 465 LEU C 346
REMARK 465 GLN C 347
REMARK 465 GLU C 348
REMARK 465 PRO C 349
REMARK 465 VAL C 350
REMARK 465 LEU C 351
REMARK 465 LEU C 352
REMARK 465 THR C 353
REMARK 465 GLN C 354
REMARK 465 LEU C 355
REMARK 465 LEU C 356
REMARK 465 PHE C 357
REMARK 465 THR C 358
REMARK 465 GLY C 359
REMARK 465 SER C 360
REMARK 465 ARG C 361
REMARK 465 LYS C 362
REMARK 465 SER C 363
REMARK 465 ALA C 364
REMARK 465 LEU C 365
REMARK 465 GLN C 366
REMARK 465 VAL C 367
REMARK 465 MET C 368
REMARK 465 LEU C 369
REMARK 465 SER C 370
REMARK 465 ALA C 371
REMARK 465 VAL C 372
REMARK 465 PRO C 373
REMARK 465 TYR C 374
REMARK 465 SER C 375
REMARK 465 GLU C 376
REMARK 465 ILE C 377
REMARK 465 VAL C 378
REMARK 465 CYS C 379
REMARK 465 TRP C 380
REMARK 465 ARG C 381
REMARK 465 PRO C 382
REMARK 465 PRO C 383
REMARK 465 LEU C 384
REMARK 465 LEU C 385
REMARK 465 THR C 386
REMARK 465 ARG C 387
REMARK 465 PRO C 388
REMARK 465 LYS C 389
REMARK 465 ILE C 390
REMARK 465 THR C 391
REMARK 465 GLY C 392
REMARK 465 THR C 393
REMARK 465 MET C 394
REMARK 465 THR C 395
REMARK 465 ALA C 396
REMARK 465 ARG C 397
REMARK 465 VAL C 398
REMARK 465 THR C 399
REMARK 465 SER C 400
REMARK 465 ALA C 401
REMARK 465 LYS C 402
REMARK 465 GLU C 403
REMARK 465 GLY C 404
REMARK 465 ASP C 405
REMARK 465 ILE C 406
REMARK 465 TYR C 407
REMARK 465 ALA C 408
REMARK 465 TRP C 409
REMARK 465 GLN C 410
REMARK 465 ASP C 411
REMARK 465 ALA C 412
REMARK 465 SER C 413
REMARK 465 GLY C 414
REMARK 465 MET C 415
REMARK 465 TYR C 416
REMARK 465 ARG C 417
REMARK 465 VAL C 418
REMARK 465 LYS C 419
REMARK 465 PHE C 420
REMARK 465 ASP C 421
REMARK 465 ALA C 422
REMARK 465 ASP C 423
REMARK 465 ARG C 424
REMARK 465 ASP C 425
REMARK 465 ASP C 426
REMARK 465 LYS C 427
REMARK 465 ASN C 428
REMARK 465 PRO C 429
REMARK 465 GLY C 430
REMARK 465 GLN C 431
REMARK 465 GLU C 432
REMARK 465 SER C 433
REMARK 465 MET C 434
REMARK 465 PRO C 435
REMARK 465 VAL C 436
REMARK 465 ARG C 437
REMARK 465 LEU C 438
REMARK 465 ALA C 439
REMARK 465 LYS C 440
REMARK 465 PRO C 441
REMARK 465 TYR C 442
REMARK 465 SER C 443
REMARK 465 GLY C 444
REMARK 465 ASP C 445
REMARK 465 ALA C 446
REMARK 465 TYR C 447
REMARK 465 GLY C 448
REMARK 465 PHE C 449
REMARK 465 HIS C 450
REMARK 465 PHE C 451
REMARK 465 PRO C 452
REMARK 465 LEU C 453
REMARK 465 ILE C 454
REMARK 465 GLN C 455
REMARK 465 GLY C 456
REMARK 465 THR C 457
REMARK 465 GLU C 458
REMARK 465 VAL C 459
REMARK 465 ALA C 460
REMARK 465 ILE C 461
REMARK 465 ALA C 462
REMARK 465 PHE C 463
REMARK 465 GLU C 464
REMARK 465 GLU C 465
REMARK 465 GLY C 466
REMARK 465 ASP C 467
REMARK 465 PRO C 468
REMARK 465 ASP C 469
REMARK 465 ARG C 470
REMARK 465 PRO C 471
REMARK 465 TYR C 472
REMARK 465 ILE C 473
REMARK 465 ALA C 474
REMARK 465 HIS C 475
REMARK 465 ALA C 476
REMARK 465 LEU C 477
REMARK 465 HIS C 478
REMARK 465 ASP C 479
REMARK 465 SER C 480
REMARK 465 ARG C 481
REMARK 465 HIS C 482
REMARK 465 VAL C 483
REMARK 465 ASP C 484
REMARK 465 HIS C 485
REMARK 465 VAL C 486
REMARK 465 THR C 487
REMARK 465 ASP C 488
REMARK 465 LYS C 489
REMARK 465 ASN C 490
REMARK 465 MET C 758
REMARK 465 GLN C 759
REMARK 465 LYS C 760
REMARK 465 MET C 761
REMARK 465 GLY C 762
REMARK 465 PRO C 763
REMARK 465 THR C 764
REMARK 465 SER C 765
REMARK 465 LEU C 766
REMARK 465 ASP C 767
REMARK 465 ILE C 768
REMARK 465 ALA C 769
REMARK 465 SER C 770
REMARK 465 VAL C 771
REMARK 465 GLU C 772
REMARK 465 MET C 773
REMARK 465 PRO C 774
REMARK 465 ARG C 775
REMARK 465 GLY C 776
REMARK 465 PHE C 777
REMARK 465 LYS C 835
REMARK 465 ILE C 836
REMARK 465 HIS C 837
REMARK 465 GLY C 838
REMARK 465 GLU C 839
REMARK 465 THR C 840
REMARK 465 GLU C 841
REMARK 465 MET D 1
REMARK 465 THR D 2
REMARK 465 LYS D 87
REMARK 465 ASN D 88
REMARK 465 SER D 89
REMARK 465 ILE D 90
REMARK 465 SER D 91
REMARK 465 ASN D 92
REMARK 465 GLY D 93
REMARK 465 ALA D 134
REMARK 465 ALA D 135
REMARK 465 GLY D 136
REMARK 465 GLU D 137
REMARK 465 ALA D 138
REMARK 465 ASP D 139
REMARK 465 SER D 140
REMARK 465 VAL D 141
REMARK 465 ILE D 142
REMARK 465 ASP D 540
REMARK 465 ASP D 541
REMARK 465 GLN D 542
REMARK 465 GLN D 543
REMARK 465 ARG D 544
REMARK 465 LEU D 545
REMARK 465 ASN D 546
REMARK 465 ASP D 547
REMARK 465 ASN D 548
REMARK 465 ALA D 549
REMARK 465 VAL D 550
REMARK 465 LYS D 551
REMARK 465 ASN D 552
REMARK 465 THR D 553
REMARK 465 LYS D 554
REMARK 465 VAL D 555
REMARK 465 MET D 556
REMARK 465 MET D 557
REMARK 465 SER D 558
REMARK 465 GLY D 559
REMARK 465 VAL D 560
REMARK 465 MET E 1
REMARK 465 THR E 2
REMARK 465 LYS E 87
REMARK 465 ASN E 88
REMARK 465 SER E 89
REMARK 465 ILE E 90
REMARK 465 SER E 91
REMARK 465 ASN E 92
REMARK 465 GLY E 93
REMARK 465 ALA E 134
REMARK 465 ALA E 135
REMARK 465 GLY E 136
REMARK 465 GLU E 137
REMARK 465 ALA E 138
REMARK 465 ASP E 139
REMARK 465 SER E 140
REMARK 465 VAL E 141
REMARK 465 ASP E 540
REMARK 465 ASP E 541
REMARK 465 GLN E 542
REMARK 465 GLN E 543
REMARK 465 ARG E 544
REMARK 465 LEU E 545
REMARK 465 ASN E 546
REMARK 465 ASP E 547
REMARK 465 ASN E 548
REMARK 465 ALA E 549
REMARK 465 VAL E 550
REMARK 465 LYS E 551
REMARK 465 ASN E 552
REMARK 465 THR E 553
REMARK 465 LYS E 554
REMARK 465 VAL E 555
REMARK 465 MET E 556
REMARK 465 MET E 557
REMARK 465 SER E 558
REMARK 465 GLY E 559
REMARK 465 VAL E 560
REMARK 465 MET F 1
REMARK 465 THR F 2
REMARK 465 LYS F 87
REMARK 465 ASN F 88
REMARK 465 SER F 89
REMARK 465 ILE F 90
REMARK 465 SER F 91
REMARK 465 ASN F 92
REMARK 465 GLY F 93
REMARK 465 ALA F 134
REMARK 465 ALA F 135
REMARK 465 GLY F 136
REMARK 465 GLU F 137
REMARK 465 ALA F 138
REMARK 465 ASP F 139
REMARK 465 SER F 140
REMARK 465 VAL F 141
REMARK 465 ASP F 540
REMARK 465 ASP F 541
REMARK 465 GLN F 542
REMARK 465 GLN F 543
REMARK 465 ARG F 544
REMARK 465 LEU F 545
REMARK 465 ASN F 546
REMARK 465 ASP F 547
REMARK 465 ASN F 548
REMARK 465 ALA F 549
REMARK 465 VAL F 550
REMARK 465 LYS F 551
REMARK 465 ASN F 552
REMARK 465 THR F 553
REMARK 465 LYS F 554
REMARK 465 VAL F 555
REMARK 465 MET F 556
REMARK 465 MET F 557
REMARK 465 SER F 558
REMARK 465 GLY F 559
REMARK 465 VAL F 560
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 NH2 ARG D 422 O LEU D 445 1.99
REMARK 500 NH2 ARG E 422 O LEU E 445 2.05
REMARK 500 NH2 ARG F 422 O LEU F 445 2.05
REMARK 500 O ARG A 640 OG SER B 646 2.09
REMARK 500 O ARG B 640 OG SER C 646 2.11
REMARK 500 OG SER A 646 O ARG C 640 2.13
REMARK 500 O GLN A 567 NH1 ARG B 547 2.14
REMARK 500 OD1 ASN E 390 NH2 ARG E 393 2.14
REMARK 500 OG SER C 563 OD1 ASP C 565 2.16
REMARK 500 OE2 GLU E 450 OH TYR E 485 2.16
REMARK 500 NH1 ARG A 547 O GLN C 567 2.17
REMARK 500 O VAL D 320 NE2 GLN D 325 2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 ASP A 550 -157.24 -96.78
REMARK 500 LEU A 575 42.76 -108.48
REMARK 500 ASP A 620 14.51 58.75
REMARK 500 PRO A 624 76.33 -65.97
REMARK 500 ASP A 657 -152.79 -97.01
REMARK 500 GLN A 665 -150.88 -100.50
REMARK 500 SER A 699 12.79 -145.34
REMARK 500 ASP A 700 -166.33 -160.75
REMARK 500 GLN A 708 -157.35 -89.53
REMARK 500 CYS A 731 112.01 -163.66
REMARK 500 LYS A 754 74.45 -100.37
REMARK 500 PRO A 790 41.17 -84.98
REMARK 500 GLN A 791 75.12 32.10
REMARK 500 ALA A 801 46.63 -86.37
REMARK 500 GLU A 812 78.91 48.73
REMARK 500 ASN A 813 12.59 88.77
REMARK 500 ILE A 823 75.58 -150.43
REMARK 500 ASP B 550 -157.12 -97.46
REMARK 500 ALA B 564 32.01 -99.88
REMARK 500 LEU B 575 40.88 -104.60
REMARK 500 PRO B 624 78.28 -64.78
REMARK 500 GLU B 649 -163.39 -125.69
REMARK 500 ASP B 657 -154.27 -97.24
REMARK 500 GLN B 665 -152.16 -101.91
REMARK 500 ASN B 681 -33.34 -131.24
REMARK 500 SER B 699 17.25 -145.91
REMARK 500 ASP B 700 -169.09 -162.15
REMARK 500 GLN B 708 -155.69 -88.82
REMARK 500 CYS B 731 113.38 -161.47
REMARK 500 PRO B 790 44.58 -84.66
REMARK 500 GLN B 791 76.83 38.77
REMARK 500 GLU B 812 70.85 51.20
REMARK 500 ASN B 813 9.92 85.09
REMARK 500 SER B 822 -71.60 -57.24
REMARK 500 THR C 492 17.42 57.96
REMARK 500 ASP C 550 -156.86 -95.49
REMARK 500 ALA C 564 31.25 -93.65
REMARK 500 PRO C 624 75.04 -63.71
REMARK 500 GLU C 649 -160.55 -127.22
REMARK 500 ASP C 657 -152.03 -96.68
REMARK 500 GLN C 665 -70.42 -117.95
REMARK 500 ASN C 681 -32.34 -131.62
REMARK 500 SER C 699 15.23 -145.95
REMARK 500 GLN C 708 -157.25 -91.28
REMARK 500 GLU C 716 10.70 -142.57
REMARK 500 CYS C 731 111.82 -160.31
REMARK 500 PRO C 790 45.35 -83.77
REMARK 500 GLN C 791 67.69 36.40
REMARK 500 ALA C 801 45.36 -84.84
REMARK 500 ILE C 823 61.68 -167.03
REMARK 500
REMARK 500 THIS ENTRY HAS 85 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 ASP A 811 GLU A 812 147.36
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-10218 RELATED DB: EMDB
REMARK 900 STRUCTURE OF THE TLE1 EFFECTOR BOUND TO THE VGRG SPIKE FROM THE
REMARK 900 TYPE 6 SECRETION SYSTEM
DBREF1 6SJL A 1 841 UNP A0A3W2RZ19_ECOLX
DBREF2 6SJL A A0A3W2RZ19 1 841
DBREF1 6SJL B 1 841 UNP A0A3W2RZ19_ECOLX
DBREF2 6SJL B A0A3W2RZ19 1 841
DBREF1 6SJL C 1 841 UNP A0A3W2RZ19_ECOLX
DBREF2 6SJL C A0A3W2RZ19 1 841
DBREF1 6SJL D 1 560 UNP A0A377LA80_ECOLX
DBREF2 6SJL D A0A377LA80 1 560
DBREF1 6SJL E 1 560 UNP A0A377LA80_ECOLX
DBREF2 6SJL E A0A377LA80 1 560
DBREF1 6SJL F 1 560 UNP A0A377LA80_ECOLX
DBREF2 6SJL F A0A377LA80 1 560
SEQRES 1 A 841 MET ASN LEU THR ASP SER LEU GLN ASN VAL LEU SER GLY
SEQRES 2 A 841 VAL GLY THR LEU ASN ARG TYR ARG LEU ASP ILE PRO SER
SEQRES 3 A 841 CYS PRO SER SER LEU ASP VAL GLU ASP PHE SER GLY THR
SEQRES 4 A 841 GLU GLY ILE SER LYS ILE TYR ARG TYR ASP ILE ILE PHE
SEQRES 5 A 841 THR SER THR ASP ARG TYR PRO ASP ALA ALA TRP PHE LEU
SEQRES 6 A 841 ARG LYS SER ALA THR LEU ILE MET GLY THR GLY LEU LEU
SEQRES 7 A 841 GLU SER LEU THR GLU GLN LYS LYS VAL HIS GLY VAL ILE
SEQRES 8 A 841 THR ASP PHE ARG ARG ILE SER GLY SER GLU ASP GLN ALA
SEQRES 9 A 841 GLN TYR ARG ILE THR LEU LYS PRO PHE ILE SER LEU LEU
SEQRES 10 A 841 ASP LYS GLN PHE ARG THR HIS ARG PHE PHE VAL ASN LYS
SEQRES 11 A 841 SER VAL PRO GLU VAL VAL GLU GLN ILE LEU THR GLU HIS
SEQRES 12 A 841 GLY LEU LYS GLY TRP GLU TYR GLU PHE SER LEU LYS ARG
SEQRES 13 A 841 THR TYR PRO LYS ARG GLU GLN ILE ASN GLN TYR GLN GLU
SEQRES 14 A 841 SER ASP LEU ARG PHE ILE GLN ARG LEU LEU ALA GLU VAL
SEQRES 15 A 841 GLY ILE PHE TYR PHE PHE THR LEU HIS PRO ASP ALA GLN
SEQRES 16 A 841 THR GLU VAL ILE HIS PHE GLY ASP VAL GLN ALA ALA LEU
SEQRES 17 A 841 ILE PHE ASP LYS THR LEU PRO VAL ASN SER PRO SER GLY
SEQRES 18 A 841 MET SER ASP SER GLY THR ASP SER VAL TRP ALA LEU ASN
SEQRES 19 A 841 VAL GLU HIS ARG VAL VAL GLU SER ARG VAL ILE THR ASN
SEQRES 20 A 841 ASP TYR ASN HIS ARG GLU ALA GLN ASN ILE LEU MET SER
SEQRES 21 A 841 VAL PRO ALA ASP MET THR ARG GLY GLU GLY TYR ASP THR
SEQRES 22 A 841 SER TYR GLY GLU VAL TYR HIS TYR ARG PRO ARG HIS THR
SEQRES 23 A 841 GLU ARG GLY ASP LYS ILE ASP PRO ALA PRO GLU THR ALA
SEQRES 24 A 841 ASN PHE TRP ALA ARG LEU ASP HIS GLU ARG PHE LEU ALA
SEQRES 25 A 841 GLU GLN THR ARG ILE THR GLY LYS SER THR ASP ALA SER
SEQRES 26 A 841 LEU LEU PRO ALA GLN VAL LEU THR ILE THR ASP SER THR
SEQRES 27 A 841 PRO PRO VAL LEU PRO ALA PRO LEU GLN GLU PRO VAL LEU
SEQRES 28 A 841 LEU THR GLN LEU LEU PHE THR GLY SER ARG LYS SER ALA
SEQRES 29 A 841 LEU GLN VAL MET LEU SER ALA VAL PRO TYR SER GLU ILE
SEQRES 30 A 841 VAL CYS TRP ARG PRO PRO LEU LEU THR ARG PRO LYS ILE
SEQRES 31 A 841 THR GLY THR MET THR ALA ARG VAL THR SER ALA LYS GLU
SEQRES 32 A 841 GLY ASP ILE TYR ALA TRP GLN ASP ALA SER GLY MET TYR
SEQRES 33 A 841 ARG VAL LYS PHE ASP ALA ASP ARG ASP ASP LYS ASN PRO
SEQRES 34 A 841 GLY GLN GLU SER MET PRO VAL ARG LEU ALA LYS PRO TYR
SEQRES 35 A 841 SER GLY ASP ALA TYR GLY PHE HIS PHE PRO LEU ILE GLN
SEQRES 36 A 841 GLY THR GLU VAL ALA ILE ALA PHE GLU GLU GLY ASP PRO
SEQRES 37 A 841 ASP ARG PRO TYR ILE ALA HIS ALA LEU HIS ASP SER ARG
SEQRES 38 A 841 HIS VAL ASP HIS VAL THR ASP LYS ASN GLY THR ARG ASN
SEQRES 39 A 841 VAL ILE ARG THR PRO ALA ASN ASN LYS LEU ARG MET GLU
SEQRES 40 A 841 ASP LYS ARG GLY GLU GLU HIS ILE LYS LEU SER THR GLU
SEQRES 41 A 841 TYR GLY GLY LYS THR GLN LEU ASN LEU GLY HIS ASN VAL
SEQRES 42 A 841 ASP ALA SER ARG GLU LEU ARG GLY GLU GLY ALA GLU LEU
SEQRES 43 A 841 ARG THR ASP ASP TRP ILE SER ILE ARG GLY GLY LYS GLY
SEQRES 44 A 841 ILE PHE ILE SER ALA ASP MET GLN PRO GLN ALA GLN GLY
SEQRES 45 A 841 LYS MET LEU ASP MET ASP GLU ALA ILE ARG GLN LEU GLU
SEQRES 46 A 841 GLN ALA LEU SER LEU ALA ARG SER MET ALA LYS ALA ALA
SEQRES 47 A 841 THR ALA ALA ASN ALA THR GLN GLY ASP ILE SER CYS GLN
SEQRES 48 A 841 GLN ARG LEU ASN ALA SER LEU THR ASP LEU THR ALA PRO
SEQRES 49 A 841 GLY MET LEU LEU HIS ALA PRO ASP GLY ILE GLY MET VAL
SEQRES 50 A 841 SER ALA ARG ALA LEU ARG ILE ALA SER GLY SER GLU SER
SEQRES 51 A 841 VAL GLY ILE MET SER GLY ASP ASN THR ASP ILE THR ALA
SEQRES 52 A 841 GLY GLN SER PHE THR VAL VAL ALA GLU GLY ALA VAL SER
SEQRES 53 A 841 LEU LEU SER ARG ASN GLN GLY MET GLN LEU LEU ALA ALA
SEQRES 54 A 841 LYS GLY ARG VAL ASN ILE GLN ALA GLN SER ASP ASP LEU
SEQRES 55 A 841 SER MET SER SER GLN GLN ASN LEU ASP ILE GLN SER SER
SEQRES 56 A 841 GLU GLY LYS VAL THR VAL SER ALA ASN GLN GLU LEU ILE
SEQRES 57 A 841 LEU ALA CYS GLY GLY ALA TYR ILE LYS LEU SER GLY GLY
SEQRES 58 A 841 ASN ILE GLU LEU GLY CYS PRO GLY GLN ILE LEU LEU LYS
SEQRES 59 A 841 SER THR ASN MET GLN LYS MET GLY PRO THR SER LEU ASP
SEQRES 60 A 841 ILE ALA SER VAL GLU MET PRO ARG GLY PHE GLY GLY GLY
SEQRES 61 A 841 PHE ILE LEU THR ASP GLU ALA GLY VAL PRO GLN PRO SER
SEQRES 62 A 841 THR PRO TYR ARG LEU THR THR ALA GLU GLY ASP ILE LEU
SEQRES 63 A 841 GLN GLY ILE THR ASP GLU ASN GLY LYS THR ALA PRO VAL
SEQRES 64 A 841 ASN THR SER ILE PRO SER VAL VAL LYS VAL GLU PHE GLY
SEQRES 65 A 841 LYS VAL LYS ILE HIS GLY GLU THR GLU
SEQRES 1 B 841 MET ASN LEU THR ASP SER LEU GLN ASN VAL LEU SER GLY
SEQRES 2 B 841 VAL GLY THR LEU ASN ARG TYR ARG LEU ASP ILE PRO SER
SEQRES 3 B 841 CYS PRO SER SER LEU ASP VAL GLU ASP PHE SER GLY THR
SEQRES 4 B 841 GLU GLY ILE SER LYS ILE TYR ARG TYR ASP ILE ILE PHE
SEQRES 5 B 841 THR SER THR ASP ARG TYR PRO ASP ALA ALA TRP PHE LEU
SEQRES 6 B 841 ARG LYS SER ALA THR LEU ILE MET GLY THR GLY LEU LEU
SEQRES 7 B 841 GLU SER LEU THR GLU GLN LYS LYS VAL HIS GLY VAL ILE
SEQRES 8 B 841 THR ASP PHE ARG ARG ILE SER GLY SER GLU ASP GLN ALA
SEQRES 9 B 841 GLN TYR ARG ILE THR LEU LYS PRO PHE ILE SER LEU LEU
SEQRES 10 B 841 ASP LYS GLN PHE ARG THR HIS ARG PHE PHE VAL ASN LYS
SEQRES 11 B 841 SER VAL PRO GLU VAL VAL GLU GLN ILE LEU THR GLU HIS
SEQRES 12 B 841 GLY LEU LYS GLY TRP GLU TYR GLU PHE SER LEU LYS ARG
SEQRES 13 B 841 THR TYR PRO LYS ARG GLU GLN ILE ASN GLN TYR GLN GLU
SEQRES 14 B 841 SER ASP LEU ARG PHE ILE GLN ARG LEU LEU ALA GLU VAL
SEQRES 15 B 841 GLY ILE PHE TYR PHE PHE THR LEU HIS PRO ASP ALA GLN
SEQRES 16 B 841 THR GLU VAL ILE HIS PHE GLY ASP VAL GLN ALA ALA LEU
SEQRES 17 B 841 ILE PHE ASP LYS THR LEU PRO VAL ASN SER PRO SER GLY
SEQRES 18 B 841 MET SER ASP SER GLY THR ASP SER VAL TRP ALA LEU ASN
SEQRES 19 B 841 VAL GLU HIS ARG VAL VAL GLU SER ARG VAL ILE THR ASN
SEQRES 20 B 841 ASP TYR ASN HIS ARG GLU ALA GLN ASN ILE LEU MET SER
SEQRES 21 B 841 VAL PRO ALA ASP MET THR ARG GLY GLU GLY TYR ASP THR
SEQRES 22 B 841 SER TYR GLY GLU VAL TYR HIS TYR ARG PRO ARG HIS THR
SEQRES 23 B 841 GLU ARG GLY ASP LYS ILE ASP PRO ALA PRO GLU THR ALA
SEQRES 24 B 841 ASN PHE TRP ALA ARG LEU ASP HIS GLU ARG PHE LEU ALA
SEQRES 25 B 841 GLU GLN THR ARG ILE THR GLY LYS SER THR ASP ALA SER
SEQRES 26 B 841 LEU LEU PRO ALA GLN VAL LEU THR ILE THR ASP SER THR
SEQRES 27 B 841 PRO PRO VAL LEU PRO ALA PRO LEU GLN GLU PRO VAL LEU
SEQRES 28 B 841 LEU THR GLN LEU LEU PHE THR GLY SER ARG LYS SER ALA
SEQRES 29 B 841 LEU GLN VAL MET LEU SER ALA VAL PRO TYR SER GLU ILE
SEQRES 30 B 841 VAL CYS TRP ARG PRO PRO LEU LEU THR ARG PRO LYS ILE
SEQRES 31 B 841 THR GLY THR MET THR ALA ARG VAL THR SER ALA LYS GLU
SEQRES 32 B 841 GLY ASP ILE TYR ALA TRP GLN ASP ALA SER GLY MET TYR
SEQRES 33 B 841 ARG VAL LYS PHE ASP ALA ASP ARG ASP ASP LYS ASN PRO
SEQRES 34 B 841 GLY GLN GLU SER MET PRO VAL ARG LEU ALA LYS PRO TYR
SEQRES 35 B 841 SER GLY ASP ALA TYR GLY PHE HIS PHE PRO LEU ILE GLN
SEQRES 36 B 841 GLY THR GLU VAL ALA ILE ALA PHE GLU GLU GLY ASP PRO
SEQRES 37 B 841 ASP ARG PRO TYR ILE ALA HIS ALA LEU HIS ASP SER ARG
SEQRES 38 B 841 HIS VAL ASP HIS VAL THR ASP LYS ASN GLY THR ARG ASN
SEQRES 39 B 841 VAL ILE ARG THR PRO ALA ASN ASN LYS LEU ARG MET GLU
SEQRES 40 B 841 ASP LYS ARG GLY GLU GLU HIS ILE LYS LEU SER THR GLU
SEQRES 41 B 841 TYR GLY GLY LYS THR GLN LEU ASN LEU GLY HIS ASN VAL
SEQRES 42 B 841 ASP ALA SER ARG GLU LEU ARG GLY GLU GLY ALA GLU LEU
SEQRES 43 B 841 ARG THR ASP ASP TRP ILE SER ILE ARG GLY GLY LYS GLY
SEQRES 44 B 841 ILE PHE ILE SER ALA ASP MET GLN PRO GLN ALA GLN GLY
SEQRES 45 B 841 LYS MET LEU ASP MET ASP GLU ALA ILE ARG GLN LEU GLU
SEQRES 46 B 841 GLN ALA LEU SER LEU ALA ARG SER MET ALA LYS ALA ALA
SEQRES 47 B 841 THR ALA ALA ASN ALA THR GLN GLY ASP ILE SER CYS GLN
SEQRES 48 B 841 GLN ARG LEU ASN ALA SER LEU THR ASP LEU THR ALA PRO
SEQRES 49 B 841 GLY MET LEU LEU HIS ALA PRO ASP GLY ILE GLY MET VAL
SEQRES 50 B 841 SER ALA ARG ALA LEU ARG ILE ALA SER GLY SER GLU SER
SEQRES 51 B 841 VAL GLY ILE MET SER GLY ASP ASN THR ASP ILE THR ALA
SEQRES 52 B 841 GLY GLN SER PHE THR VAL VAL ALA GLU GLY ALA VAL SER
SEQRES 53 B 841 LEU LEU SER ARG ASN GLN GLY MET GLN LEU LEU ALA ALA
SEQRES 54 B 841 LYS GLY ARG VAL ASN ILE GLN ALA GLN SER ASP ASP LEU
SEQRES 55 B 841 SER MET SER SER GLN GLN ASN LEU ASP ILE GLN SER SER
SEQRES 56 B 841 GLU GLY LYS VAL THR VAL SER ALA ASN GLN GLU LEU ILE
SEQRES 57 B 841 LEU ALA CYS GLY GLY ALA TYR ILE LYS LEU SER GLY GLY
SEQRES 58 B 841 ASN ILE GLU LEU GLY CYS PRO GLY GLN ILE LEU LEU LYS
SEQRES 59 B 841 SER THR ASN MET GLN LYS MET GLY PRO THR SER LEU ASP
SEQRES 60 B 841 ILE ALA SER VAL GLU MET PRO ARG GLY PHE GLY GLY GLY
SEQRES 61 B 841 PHE ILE LEU THR ASP GLU ALA GLY VAL PRO GLN PRO SER
SEQRES 62 B 841 THR PRO TYR ARG LEU THR THR ALA GLU GLY ASP ILE LEU
SEQRES 63 B 841 GLN GLY ILE THR ASP GLU ASN GLY LYS THR ALA PRO VAL
SEQRES 64 B 841 ASN THR SER ILE PRO SER VAL VAL LYS VAL GLU PHE GLY
SEQRES 65 B 841 LYS VAL LYS ILE HIS GLY GLU THR GLU
SEQRES 1 C 841 MET ASN LEU THR ASP SER LEU GLN ASN VAL LEU SER GLY
SEQRES 2 C 841 VAL GLY THR LEU ASN ARG TYR ARG LEU ASP ILE PRO SER
SEQRES 3 C 841 CYS PRO SER SER LEU ASP VAL GLU ASP PHE SER GLY THR
SEQRES 4 C 841 GLU GLY ILE SER LYS ILE TYR ARG TYR ASP ILE ILE PHE
SEQRES 5 C 841 THR SER THR ASP ARG TYR PRO ASP ALA ALA TRP PHE LEU
SEQRES 6 C 841 ARG LYS SER ALA THR LEU ILE MET GLY THR GLY LEU LEU
SEQRES 7 C 841 GLU SER LEU THR GLU GLN LYS LYS VAL HIS GLY VAL ILE
SEQRES 8 C 841 THR ASP PHE ARG ARG ILE SER GLY SER GLU ASP GLN ALA
SEQRES 9 C 841 GLN TYR ARG ILE THR LEU LYS PRO PHE ILE SER LEU LEU
SEQRES 10 C 841 ASP LYS GLN PHE ARG THR HIS ARG PHE PHE VAL ASN LYS
SEQRES 11 C 841 SER VAL PRO GLU VAL VAL GLU GLN ILE LEU THR GLU HIS
SEQRES 12 C 841 GLY LEU LYS GLY TRP GLU TYR GLU PHE SER LEU LYS ARG
SEQRES 13 C 841 THR TYR PRO LYS ARG GLU GLN ILE ASN GLN TYR GLN GLU
SEQRES 14 C 841 SER ASP LEU ARG PHE ILE GLN ARG LEU LEU ALA GLU VAL
SEQRES 15 C 841 GLY ILE PHE TYR PHE PHE THR LEU HIS PRO ASP ALA GLN
SEQRES 16 C 841 THR GLU VAL ILE HIS PHE GLY ASP VAL GLN ALA ALA LEU
SEQRES 17 C 841 ILE PHE ASP LYS THR LEU PRO VAL ASN SER PRO SER GLY
SEQRES 18 C 841 MET SER ASP SER GLY THR ASP SER VAL TRP ALA LEU ASN
SEQRES 19 C 841 VAL GLU HIS ARG VAL VAL GLU SER ARG VAL ILE THR ASN
SEQRES 20 C 841 ASP TYR ASN HIS ARG GLU ALA GLN ASN ILE LEU MET SER
SEQRES 21 C 841 VAL PRO ALA ASP MET THR ARG GLY GLU GLY TYR ASP THR
SEQRES 22 C 841 SER TYR GLY GLU VAL TYR HIS TYR ARG PRO ARG HIS THR
SEQRES 23 C 841 GLU ARG GLY ASP LYS ILE ASP PRO ALA PRO GLU THR ALA
SEQRES 24 C 841 ASN PHE TRP ALA ARG LEU ASP HIS GLU ARG PHE LEU ALA
SEQRES 25 C 841 GLU GLN THR ARG ILE THR GLY LYS SER THR ASP ALA SER
SEQRES 26 C 841 LEU LEU PRO ALA GLN VAL LEU THR ILE THR ASP SER THR
SEQRES 27 C 841 PRO PRO VAL LEU PRO ALA PRO LEU GLN GLU PRO VAL LEU
SEQRES 28 C 841 LEU THR GLN LEU LEU PHE THR GLY SER ARG LYS SER ALA
SEQRES 29 C 841 LEU GLN VAL MET LEU SER ALA VAL PRO TYR SER GLU ILE
SEQRES 30 C 841 VAL CYS TRP ARG PRO PRO LEU LEU THR ARG PRO LYS ILE
SEQRES 31 C 841 THR GLY THR MET THR ALA ARG VAL THR SER ALA LYS GLU
SEQRES 32 C 841 GLY ASP ILE TYR ALA TRP GLN ASP ALA SER GLY MET TYR
SEQRES 33 C 841 ARG VAL LYS PHE ASP ALA ASP ARG ASP ASP LYS ASN PRO
SEQRES 34 C 841 GLY GLN GLU SER MET PRO VAL ARG LEU ALA LYS PRO TYR
SEQRES 35 C 841 SER GLY ASP ALA TYR GLY PHE HIS PHE PRO LEU ILE GLN
SEQRES 36 C 841 GLY THR GLU VAL ALA ILE ALA PHE GLU GLU GLY ASP PRO
SEQRES 37 C 841 ASP ARG PRO TYR ILE ALA HIS ALA LEU HIS ASP SER ARG
SEQRES 38 C 841 HIS VAL ASP HIS VAL THR ASP LYS ASN GLY THR ARG ASN
SEQRES 39 C 841 VAL ILE ARG THR PRO ALA ASN ASN LYS LEU ARG MET GLU
SEQRES 40 C 841 ASP LYS ARG GLY GLU GLU HIS ILE LYS LEU SER THR GLU
SEQRES 41 C 841 TYR GLY GLY LYS THR GLN LEU ASN LEU GLY HIS ASN VAL
SEQRES 42 C 841 ASP ALA SER ARG GLU LEU ARG GLY GLU GLY ALA GLU LEU
SEQRES 43 C 841 ARG THR ASP ASP TRP ILE SER ILE ARG GLY GLY LYS GLY
SEQRES 44 C 841 ILE PHE ILE SER ALA ASP MET GLN PRO GLN ALA GLN GLY
SEQRES 45 C 841 LYS MET LEU ASP MET ASP GLU ALA ILE ARG GLN LEU GLU
SEQRES 46 C 841 GLN ALA LEU SER LEU ALA ARG SER MET ALA LYS ALA ALA
SEQRES 47 C 841 THR ALA ALA ASN ALA THR GLN GLY ASP ILE SER CYS GLN
SEQRES 48 C 841 GLN ARG LEU ASN ALA SER LEU THR ASP LEU THR ALA PRO
SEQRES 49 C 841 GLY MET LEU LEU HIS ALA PRO ASP GLY ILE GLY MET VAL
SEQRES 50 C 841 SER ALA ARG ALA LEU ARG ILE ALA SER GLY SER GLU SER
SEQRES 51 C 841 VAL GLY ILE MET SER GLY ASP ASN THR ASP ILE THR ALA
SEQRES 52 C 841 GLY GLN SER PHE THR VAL VAL ALA GLU GLY ALA VAL SER
SEQRES 53 C 841 LEU LEU SER ARG ASN GLN GLY MET GLN LEU LEU ALA ALA
SEQRES 54 C 841 LYS GLY ARG VAL ASN ILE GLN ALA GLN SER ASP ASP LEU
SEQRES 55 C 841 SER MET SER SER GLN GLN ASN LEU ASP ILE GLN SER SER
SEQRES 56 C 841 GLU GLY LYS VAL THR VAL SER ALA ASN GLN GLU LEU ILE
SEQRES 57 C 841 LEU ALA CYS GLY GLY ALA TYR ILE LYS LEU SER GLY GLY
SEQRES 58 C 841 ASN ILE GLU LEU GLY CYS PRO GLY GLN ILE LEU LEU LYS
SEQRES 59 C 841 SER THR ASN MET GLN LYS MET GLY PRO THR SER LEU ASP
SEQRES 60 C 841 ILE ALA SER VAL GLU MET PRO ARG GLY PHE GLY GLY GLY
SEQRES 61 C 841 PHE ILE LEU THR ASP GLU ALA GLY VAL PRO GLN PRO SER
SEQRES 62 C 841 THR PRO TYR ARG LEU THR THR ALA GLU GLY ASP ILE LEU
SEQRES 63 C 841 GLN GLY ILE THR ASP GLU ASN GLY LYS THR ALA PRO VAL
SEQRES 64 C 841 ASN THR SER ILE PRO SER VAL VAL LYS VAL GLU PHE GLY
SEQRES 65 C 841 LYS VAL LYS ILE HIS GLY GLU THR GLU
SEQRES 1 D 560 MET THR LYS TYR GLN GLY TYR ASP VAL THR ASP ALA THR
SEQRES 2 D 560 HIS LYS THR SER ILE HIS ASN ASP TRP LYS VAL VAL VAL
SEQRES 3 D 560 ALA LYS LYS LYS PRO ALA ARG GLY VAL THR LEU THR ILE
SEQRES 4 D 560 GLY ILE PHE PHE ASP GLY THR GLY ASN ASN ARG GLU ASN
SEQRES 5 D 560 THR ALA SER ARG LEU MET LYS PHE ASN GLU CYS SER ALA
SEQRES 6 D 560 ALA ARG GLN GLY VAL ASN GLN LYS ASP ALA GLN SER CYS
SEQRES 7 D 560 GLU ASP PHE LEU LYS GLU ILE ASN LYS ASN SER ILE SER
SEQRES 8 D 560 ASN GLY SER TYR ARG GLY TYR TYR SER ASN ILE HIS TRP
SEQRES 9 D 560 LEU ASN ILE LEU TYR HIS PRO ASP GLN VAL LEU LYS LYS
SEQRES 10 D 560 ASP GLN THR SER ALA GLN ILE LYS THR TYR ILE SER GLY
SEQRES 11 D 560 ILE GLY THR ALA ALA GLY GLU ALA ASP SER VAL ILE GLY
SEQRES 12 D 560 MET GLY LEU GLY THR SER ILE LEU ASP ILE PHE GLU GLY
SEQRES 13 D 560 VAL VAL THR LYS THR ASP GLU ALA MET GLU ARG ILE THR
SEQRES 14 D 560 GLN ALA LEU SER GLU PHE MET GLY PHE ASN LEU SER PRO
SEQRES 15 D 560 ASP PHE CYS ILE ALA LYS ILE GLN PHE ASP VAL PHE GLY
SEQRES 16 D 560 PHE SER ARG GLY ALA ALA ALA ALA ARG HIS PHE ALA ASN
SEQRES 17 D 560 ARG VAL MET GLU GLN ASP PRO ALA ILE ALA ARG ALA ILE
SEQRES 18 D 560 ALA LYS GLY LEU ARG GLY ASP PHE TYR ASP GLY LYS PRO
SEQRES 19 D 560 SER GLY GLU VAL ARG PHE LEU GLY LEU PHE ASP THR VAL
SEQRES 20 D 560 ALA ALA ILE GLY GLY ILE SER ASN PHE PHE ASP ILE ASN
SEQRES 21 D 560 GLY ARG SER ASN PRO GLY VAL LYS LEU GLU LEU ARG PRO
SEQRES 22 D 560 SER VAL ALA LYS LYS VAL PHE GLN ILE THR ALA MET ASN
SEQRES 23 D 560 GLU TYR ARG TYR ASN PHE SER LEU ASN SER ILE LYS GLY
SEQRES 24 D 560 MET TRP PRO GLU LEU ALA LEU PRO GLY ALA HIS SER ASP
SEQRES 25 D 560 ILE GLY GLY GLY TYR ASN PRO VAL GLY SER PRO LEU GLN
SEQRES 26 D 560 GLU ASN GLU SER LEU PHE LEU SER CYS PRO GLU PHE GLU
SEQRES 27 D 560 ILE VAL SER ASP ASP THR ARG GLU MET ASP THR ARG VAL
SEQRES 28 D 560 TYR ARG LYS ALA GLU GLN VAL ARG LYS MET LEU MET THR
SEQRES 29 D 560 LEU PRO ALA LEU LYS HIS ILE LEU PRO HIS GLY LYS LEU
SEQRES 30 D 560 THR THR LYS ILE ARG SER ILE GLY VAL ASN ASN SER ASN
SEQRES 31 D 560 GLN ARG ARG ALA GLY VAL ILE GLN LYS GLN VAL GLY ALA
SEQRES 32 D 560 ALA VAL PHE PHE GLU ARG MET ALA VAL PRO ASN ASP TRP
SEQRES 33 D 560 ALA ASN VAL CYS LEU ARG VAL MET LEU ASP ALA ALA GLN
SEQRES 34 D 560 GLU ALA GLY VAL LEU PHE GLU PRO ILE ARG GLN THR ASN
SEQRES 35 D 560 THR GLU LEU GLN LEU PRO SER GLU LEU ILE PHE LEU ALA
SEQRES 36 D 560 ASP LYS ALA ILE ALA GLN GLY LYS ALA VAL ARG LEU GLY
SEQRES 37 D 560 GLN GLU PRO GLN ALA PHE THR GLU GLU GLU LEU TYR ILE
SEQRES 38 D 560 ILE GLY LYS TYR THR HIS CYS SER ALA ASN TRP ASN ILE
SEQRES 39 D 560 GLU SER ASP GLY ASN LEU TRP VAL ASP PRO THR THR GLY
SEQRES 40 D 560 GLU ILE PHE ILE HIS ARG PHE GLY PRO LYS GLY ASN LYS
SEQRES 41 D 560 ALA PHE VAL PHE PRO ASN LYS PRO ASN ASP ARG TRP ILE
SEQRES 42 D 560 ARG SER VAL TRP TYR MET ASP ASP GLN GLN ARG LEU ASN
SEQRES 43 D 560 ASP ASN ALA VAL LYS ASN THR LYS VAL MET MET SER GLY
SEQRES 44 D 560 VAL
SEQRES 1 E 560 MET THR LYS TYR GLN GLY TYR ASP VAL THR ASP ALA THR
SEQRES 2 E 560 HIS LYS THR SER ILE HIS ASN ASP TRP LYS VAL VAL VAL
SEQRES 3 E 560 ALA LYS LYS LYS PRO ALA ARG GLY VAL THR LEU THR ILE
SEQRES 4 E 560 GLY ILE PHE PHE ASP GLY THR GLY ASN ASN ARG GLU ASN
SEQRES 5 E 560 THR ALA SER ARG LEU MET LYS PHE ASN GLU CYS SER ALA
SEQRES 6 E 560 ALA ARG GLN GLY VAL ASN GLN LYS ASP ALA GLN SER CYS
SEQRES 7 E 560 GLU ASP PHE LEU LYS GLU ILE ASN LYS ASN SER ILE SER
SEQRES 8 E 560 ASN GLY SER TYR ARG GLY TYR TYR SER ASN ILE HIS TRP
SEQRES 9 E 560 LEU ASN ILE LEU TYR HIS PRO ASP GLN VAL LEU LYS LYS
SEQRES 10 E 560 ASP GLN THR SER ALA GLN ILE LYS THR TYR ILE SER GLY
SEQRES 11 E 560 ILE GLY THR ALA ALA GLY GLU ALA ASP SER VAL ILE GLY
SEQRES 12 E 560 MET GLY LEU GLY THR SER ILE LEU ASP ILE PHE GLU GLY
SEQRES 13 E 560 VAL VAL THR LYS THR ASP GLU ALA MET GLU ARG ILE THR
SEQRES 14 E 560 GLN ALA LEU SER GLU PHE MET GLY PHE ASN LEU SER PRO
SEQRES 15 E 560 ASP PHE CYS ILE ALA LYS ILE GLN PHE ASP VAL PHE GLY
SEQRES 16 E 560 PHE SER ARG GLY ALA ALA ALA ALA ARG HIS PHE ALA ASN
SEQRES 17 E 560 ARG VAL MET GLU GLN ASP PRO ALA ILE ALA ARG ALA ILE
SEQRES 18 E 560 ALA LYS GLY LEU ARG GLY ASP PHE TYR ASP GLY LYS PRO
SEQRES 19 E 560 SER GLY GLU VAL ARG PHE LEU GLY LEU PHE ASP THR VAL
SEQRES 20 E 560 ALA ALA ILE GLY GLY ILE SER ASN PHE PHE ASP ILE ASN
SEQRES 21 E 560 GLY ARG SER ASN PRO GLY VAL LYS LEU GLU LEU ARG PRO
SEQRES 22 E 560 SER VAL ALA LYS LYS VAL PHE GLN ILE THR ALA MET ASN
SEQRES 23 E 560 GLU TYR ARG TYR ASN PHE SER LEU ASN SER ILE LYS GLY
SEQRES 24 E 560 MET TRP PRO GLU LEU ALA LEU PRO GLY ALA HIS SER ASP
SEQRES 25 E 560 ILE GLY GLY GLY TYR ASN PRO VAL GLY SER PRO LEU GLN
SEQRES 26 E 560 GLU ASN GLU SER LEU PHE LEU SER CYS PRO GLU PHE GLU
SEQRES 27 E 560 ILE VAL SER ASP ASP THR ARG GLU MET ASP THR ARG VAL
SEQRES 28 E 560 TYR ARG LYS ALA GLU GLN VAL ARG LYS MET LEU MET THR
SEQRES 29 E 560 LEU PRO ALA LEU LYS HIS ILE LEU PRO HIS GLY LYS LEU
SEQRES 30 E 560 THR THR LYS ILE ARG SER ILE GLY VAL ASN ASN SER ASN
SEQRES 31 E 560 GLN ARG ARG ALA GLY VAL ILE GLN LYS GLN VAL GLY ALA
SEQRES 32 E 560 ALA VAL PHE PHE GLU ARG MET ALA VAL PRO ASN ASP TRP
SEQRES 33 E 560 ALA ASN VAL CYS LEU ARG VAL MET LEU ASP ALA ALA GLN
SEQRES 34 E 560 GLU ALA GLY VAL LEU PHE GLU PRO ILE ARG GLN THR ASN
SEQRES 35 E 560 THR GLU LEU GLN LEU PRO SER GLU LEU ILE PHE LEU ALA
SEQRES 36 E 560 ASP LYS ALA ILE ALA GLN GLY LYS ALA VAL ARG LEU GLY
SEQRES 37 E 560 GLN GLU PRO GLN ALA PHE THR GLU GLU GLU LEU TYR ILE
SEQRES 38 E 560 ILE GLY LYS TYR THR HIS CYS SER ALA ASN TRP ASN ILE
SEQRES 39 E 560 GLU SER ASP GLY ASN LEU TRP VAL ASP PRO THR THR GLY
SEQRES 40 E 560 GLU ILE PHE ILE HIS ARG PHE GLY PRO LYS GLY ASN LYS
SEQRES 41 E 560 ALA PHE VAL PHE PRO ASN LYS PRO ASN ASP ARG TRP ILE
SEQRES 42 E 560 ARG SER VAL TRP TYR MET ASP ASP GLN GLN ARG LEU ASN
SEQRES 43 E 560 ASP ASN ALA VAL LYS ASN THR LYS VAL MET MET SER GLY
SEQRES 44 E 560 VAL
SEQRES 1 F 560 MET THR LYS TYR GLN GLY TYR ASP VAL THR ASP ALA THR
SEQRES 2 F 560 HIS LYS THR SER ILE HIS ASN ASP TRP LYS VAL VAL VAL
SEQRES 3 F 560 ALA LYS LYS LYS PRO ALA ARG GLY VAL THR LEU THR ILE
SEQRES 4 F 560 GLY ILE PHE PHE ASP GLY THR GLY ASN ASN ARG GLU ASN
SEQRES 5 F 560 THR ALA SER ARG LEU MET LYS PHE ASN GLU CYS SER ALA
SEQRES 6 F 560 ALA ARG GLN GLY VAL ASN GLN LYS ASP ALA GLN SER CYS
SEQRES 7 F 560 GLU ASP PHE LEU LYS GLU ILE ASN LYS ASN SER ILE SER
SEQRES 8 F 560 ASN GLY SER TYR ARG GLY TYR TYR SER ASN ILE HIS TRP
SEQRES 9 F 560 LEU ASN ILE LEU TYR HIS PRO ASP GLN VAL LEU LYS LYS
SEQRES 10 F 560 ASP GLN THR SER ALA GLN ILE LYS THR TYR ILE SER GLY
SEQRES 11 F 560 ILE GLY THR ALA ALA GLY GLU ALA ASP SER VAL ILE GLY
SEQRES 12 F 560 MET GLY LEU GLY THR SER ILE LEU ASP ILE PHE GLU GLY
SEQRES 13 F 560 VAL VAL THR LYS THR ASP GLU ALA MET GLU ARG ILE THR
SEQRES 14 F 560 GLN ALA LEU SER GLU PHE MET GLY PHE ASN LEU SER PRO
SEQRES 15 F 560 ASP PHE CYS ILE ALA LYS ILE GLN PHE ASP VAL PHE GLY
SEQRES 16 F 560 PHE SER ARG GLY ALA ALA ALA ALA ARG HIS PHE ALA ASN
SEQRES 17 F 560 ARG VAL MET GLU GLN ASP PRO ALA ILE ALA ARG ALA ILE
SEQRES 18 F 560 ALA LYS GLY LEU ARG GLY ASP PHE TYR ASP GLY LYS PRO
SEQRES 19 F 560 SER GLY GLU VAL ARG PHE LEU GLY LEU PHE ASP THR VAL
SEQRES 20 F 560 ALA ALA ILE GLY GLY ILE SER ASN PHE PHE ASP ILE ASN
SEQRES 21 F 560 GLY ARG SER ASN PRO GLY VAL LYS LEU GLU LEU ARG PRO
SEQRES 22 F 560 SER VAL ALA LYS LYS VAL PHE GLN ILE THR ALA MET ASN
SEQRES 23 F 560 GLU TYR ARG TYR ASN PHE SER LEU ASN SER ILE LYS GLY
SEQRES 24 F 560 MET TRP PRO GLU LEU ALA LEU PRO GLY ALA HIS SER ASP
SEQRES 25 F 560 ILE GLY GLY GLY TYR ASN PRO VAL GLY SER PRO LEU GLN
SEQRES 26 F 560 GLU ASN GLU SER LEU PHE LEU SER CYS PRO GLU PHE GLU
SEQRES 27 F 560 ILE VAL SER ASP ASP THR ARG GLU MET ASP THR ARG VAL
SEQRES 28 F 560 TYR ARG LYS ALA GLU GLN VAL ARG LYS MET LEU MET THR
SEQRES 29 F 560 LEU PRO ALA LEU LYS HIS ILE LEU PRO HIS GLY LYS LEU
SEQRES 30 F 560 THR THR LYS ILE ARG SER ILE GLY VAL ASN ASN SER ASN
SEQRES 31 F 560 GLN ARG ARG ALA GLY VAL ILE GLN LYS GLN VAL GLY ALA
SEQRES 32 F 560 ALA VAL PHE PHE GLU ARG MET ALA VAL PRO ASN ASP TRP
SEQRES 33 F 560 ALA ASN VAL CYS LEU ARG VAL MET LEU ASP ALA ALA GLN
SEQRES 34 F 560 GLU ALA GLY VAL LEU PHE GLU PRO ILE ARG GLN THR ASN
SEQRES 35 F 560 THR GLU LEU GLN LEU PRO SER GLU LEU ILE PHE LEU ALA
SEQRES 36 F 560 ASP LYS ALA ILE ALA GLN GLY LYS ALA VAL ARG LEU GLY
SEQRES 37 F 560 GLN GLU PRO GLN ALA PHE THR GLU GLU GLU LEU TYR ILE
SEQRES 38 F 560 ILE GLY LYS TYR THR HIS CYS SER ALA ASN TRP ASN ILE
SEQRES 39 F 560 GLU SER ASP GLY ASN LEU TRP VAL ASP PRO THR THR GLY
SEQRES 40 F 560 GLU ILE PHE ILE HIS ARG PHE GLY PRO LYS GLY ASN LYS
SEQRES 41 F 560 ALA PHE VAL PHE PRO ASN LYS PRO ASN ASP ARG TRP ILE
SEQRES 42 F 560 ARG SER VAL TRP TYR MET ASP ASP GLN GLN ARG LEU ASN
SEQRES 43 F 560 ASP ASN ALA VAL LYS ASN THR LYS VAL MET MET SER GLY
SEQRES 44 F 560 VAL
HELIX 1 AA1 GLN A 567 GLN A 571 5 5
HELIX 2 AA2 MET A 577 ALA A 601 1 25
HELIX 3 AA3 ASP A 607 THR A 619 1 13
HELIX 4 AA4 ASP A 620 THR A 622 5 3
HELIX 5 AA5 GLN B 567 GLN B 571 5 5
HELIX 6 AA6 MET B 577 ALA B 601 1 25
HELIX 7 AA7 ASP B 607 THR B 619 1 13
HELIX 8 AA8 ASP B 620 THR B 622 5 3
HELIX 9 AA9 GLN C 567 GLN C 571 5 5
HELIX 10 AB1 MET C 577 ALA C 601 1 25
HELIX 11 AB2 ASP C 607 THR C 619 1 13
HELIX 12 AB3 ASP C 620 THR C 622 5 3
HELIX 13 AB4 ASN D 52 MET D 58 1 7
HELIX 14 AB5 LYS D 59 ASN D 61 5 3
HELIX 15 AB6 ASN D 71 GLU D 84 1 14
HELIX 16 AB7 SER D 100 TYR D 109 1 10
HELIX 17 AB8 GLY D 145 GLU D 155 1 11
HELIX 18 AB9 GLU D 155 ASN D 179 1 25
HELIX 19 AC1 ARG D 198 GLU D 212 1 15
HELIX 20 AC2 ASP D 214 ARG D 226 1 13
HELIX 21 AC3 ALA D 309 GLY D 315 1 7
HELIX 22 AC4 ARG D 345 ASP D 348 5 4
HELIX 23 AC5 THR D 349 LEU D 365 1 17
HELIX 24 AC6 PRO D 366 LYS D 369 5 4
HELIX 25 AC7 ILE D 371 GLY D 375 5 5
HELIX 26 AC8 ASN D 388 ALA D 394 1 7
HELIX 27 AC9 TRP D 416 ALA D 431 1 16
HELIX 28 AD1 ASN D 442 GLN D 446 5 5
HELIX 29 AD2 PRO D 448 GLU D 450 5 3
HELIX 30 AD3 LEU D 451 LEU D 467 1 17
HELIX 31 AD4 THR D 475 GLY D 483 1 9
HELIX 32 AD5 ASN D 529 ILE D 533 5 5
HELIX 33 AD6 ASN E 52 LYS E 59 1 8
HELIX 34 AD7 ASN E 71 ASN E 86 1 16
HELIX 35 AD8 SER E 100 TYR E 109 1 10
HELIX 36 AD9 ILE E 142 MET E 144 5 3
HELIX 37 AE1 GLY E 145 GLU E 155 1 11
HELIX 38 AE2 GLU E 155 PHE E 178 1 24
HELIX 39 AE3 ARG E 198 GLU E 212 1 15
HELIX 40 AE4 ASP E 214 ARG E 226 1 13
HELIX 41 AE5 ALA E 309 GLY E 315 1 7
HELIX 42 AE6 ARG E 345 ASP E 348 5 4
HELIX 43 AE7 THR E 349 LEU E 365 1 17
HELIX 44 AE8 PRO E 366 LYS E 369 5 4
HELIX 45 AE9 ILE E 371 GLY E 375 5 5
HELIX 46 AF1 ASN E 388 ALA E 394 1 7
HELIX 47 AF2 TRP E 416 ALA E 431 1 16
HELIX 48 AF3 ASN E 442 GLN E 446 5 5
HELIX 49 AF4 PRO E 448 GLU E 450 5 3
HELIX 50 AF5 LEU E 451 LEU E 467 1 17
HELIX 51 AF6 THR E 475 LYS E 484 1 10
HELIX 52 AF7 ASN E 529 ILE E 533 5 5
HELIX 53 AF8 ASN F 52 LYS F 59 1 8
HELIX 54 AF9 ASN F 71 ASN F 86 1 16
HELIX 55 AG1 SER F 100 TYR F 109 1 10
HELIX 56 AG2 GLY F 145 GLU F 155 1 11
HELIX 57 AG3 GLU F 155 ASN F 179 1 25
HELIX 58 AG4 ARG F 198 GLU F 212 1 15
HELIX 59 AG5 ASP F 214 ARG F 226 1 13
HELIX 60 AG6 ALA F 309 GLY F 315 1 7
HELIX 61 AG7 ARG F 345 ASP F 348 5 4
HELIX 62 AG8 THR F 349 LEU F 365 1 17
HELIX 63 AG9 PRO F 366 LYS F 369 5 4
HELIX 64 AH1 ILE F 371 GLY F 375 5 5
HELIX 65 AH2 ASN F 388 ALA F 394 1 7
HELIX 66 AH3 TRP F 416 ALA F 431 1 16
HELIX 67 AH4 ASN F 442 GLN F 446 5 5
HELIX 68 AH5 PRO F 448 GLU F 450 5 3
HELIX 69 AH6 LEU F 451 LEU F 467 1 17
HELIX 70 AH7 THR F 475 LYS F 484 1 10
HELIX 71 AH8 ASN F 529 ILE F 533 5 5
SHEET 1 AA123 ARG A 493 ARG A 497 0
SHEET 2 AA123 LYS A 503 GLU A 507 -1 O MET A 506 N ASN A 494
SHEET 3 AA123 HIS A 514 THR A 519 -1 O LYS A 516 N ARG A 505
SHEET 4 AA123 THR A 525 VAL A 533 -1 O LEU A 529 N ILE A 515
SHEET 5 AA123 LEU A 539 THR A 548 -1 O GLU A 545 N ASN A 528
SHEET 6 AA123 TRP B 551 GLY B 556 1 O SER B 553 N ALA A 544
SHEET 7 AA123 GLY C 559 SER C 563 1 O PHE C 561 N ILE B 552
SHEET 8 AA123 MET C 626 HIS C 629 1 O LEU C 627 N ILE C 560
SHEET 9 AA123 ILE A 634 SER A 638 1 N GLY A 635 O LEU C 628
SHEET 10 AA123 LEU B 642 SER B 646 1 O ARG B 643 N MET A 636
SHEET 11 AA123 VAL C 651 SER C 655 1 O GLY C 652 N LEU B 642
SHEET 12 AA123 THR A 659 ALA A 663 1 N THR A 662 O ILE C 653
SHEET 13 AA123 PHE B 667 ALA B 671 1 O THR B 668 N ILE A 661
SHEET 14 AA123 VAL C 675 SER C 679 1 O LEU C 678 N ALA B 671
SHEET 15 AA123 MET A 684 ALA A 688 1 N GLN A 685 O LEU C 677
SHEET 16 AA123 VAL B 693 ALA B 697 1 O ASN B 694 N MET A 684
SHEET 17 AA123 LEU C 702 SER C 706 1 O SER C 703 N ILE B 695
SHEET 18 AA123 LEU A 710 SER A 714 1 N ASP A 711 O MET C 704
SHEET 19 AA123 VAL B 719 SER B 722 1 O THR B 720 N LEU A 710
SHEET 20 AA123 GLU C 726 CYS C 731 1 O ILE C 728 N VAL B 721
SHEET 21 AA123 ALA C 734 SER C 739 -1 O ALA C 734 N CYS C 731
SHEET 22 AA123 ASN C 742 GLY C 746 -1 O ASN C 742 N SER C 739
SHEET 23 AA123 ILE A 751 LYS A 754 1 N LEU A 752 O ILE C 743
SHEET 1 AA223 ARG C 493 ARG C 497 0
SHEET 2 AA223 LYS C 503 GLU C 507 -1 O MET C 506 N ASN C 494
SHEET 3 AA223 HIS C 514 THR C 519 -1 O LYS C 516 N ARG C 505
SHEET 4 AA223 THR C 525 VAL C 533 -1 O LEU C 529 N ILE C 515
SHEET 5 AA223 LEU C 539 THR C 548 -1 O ARG C 540 N ASN C 532
SHEET 6 AA223 TRP A 551 GLY A 556 1 N ARG A 555 O LEU C 546
SHEET 7 AA223 ILE B 560 SER B 563 1 O SER B 563 N ILE A 554
SHEET 8 AA223 MET B 626 HIS B 629 1 O LEU B 627 N ILE B 560
SHEET 9 AA223 ILE C 634 SER C 638 1 O GLY C 635 N LEU B 628
SHEET 10 AA223 LEU A 642 SER A 646 1 N ARG A 643 O MET C 636
SHEET 11 AA223 VAL B 651 SER B 655 1 O GLY B 652 N ILE A 644
SHEET 12 AA223 THR C 659 ALA C 663 1 O ASP C 660 N ILE B 653
SHEET 13 AA223 PHE A 667 ALA A 671 1 N THR A 668 O THR C 659
SHEET 14 AA223 VAL B 675 SER B 679 1 O LEU B 678 N VAL A 669
SHEET 15 AA223 MET C 684 ALA C 688 1 O GLN C 685 N VAL B 675
SHEET 16 AA223 VAL A 693 ALA A 697 1 N ASN A 694 O MET C 684
SHEET 17 AA223 LEU B 702 SER B 706 1 O SER B 705 N ILE A 695
SHEET 18 AA223 LEU C 710 SER C 714 1 O ASP C 711 N MET B 704
SHEET 19 AA223 VAL A 719 SER A 722 1 N THR A 720 O ILE C 712
SHEET 20 AA223 GLU B 726 CYS B 731 1 O ILE B 728 N VAL A 719
SHEET 21 AA223 ALA B 734 SER B 739 -1 O LEU B 738 N LEU B 727
SHEET 22 AA223 ASN B 742 GLY B 746 -1 O GLY B 746 N TYR B 735
SHEET 23 AA223 ILE C 751 LYS C 754 1 O LEU C 752 N ILE B 743
SHEET 1 AA323 ARG B 493 ARG B 497 0
SHEET 2 AA323 LYS B 503 GLU B 507 -1 O MET B 506 N ASN B 494
SHEET 3 AA323 HIS B 514 THR B 519 -1 O LYS B 516 N ARG B 505
SHEET 4 AA323 THR B 525 VAL B 533 -1 O LEU B 529 N ILE B 515
SHEET 5 AA323 LEU B 539 THR B 548 -1 O ARG B 540 N ASN B 532
SHEET 6 AA323 TRP C 551 GLY C 556 1 O ARG C 555 N LEU B 546
SHEET 7 AA323 GLY A 559 SER A 563 1 N PHE A 561 O ILE C 554
SHEET 8 AA323 MET A 626 ALA A 630 1 O HIS A 629 N ILE A 562
SHEET 9 AA323 ILE B 634 SER B 638 1 O GLY B 635 N LEU A 628
SHEET 10 AA323 LEU C 642 SER C 646 1 O ARG C 643 N MET B 636
SHEET 11 AA323 VAL A 651 SER A 655 1 N GLY A 652 O LEU C 642
SHEET 12 AA323 THR B 659 ALA B 663 1 O THR B 662 N ILE A 653
SHEET 13 AA323 PHE C 667 ALA C 671 1 O THR C 668 N ILE B 661
SHEET 14 AA323 VAL A 675 SER A 679 1 N SER A 676 O PHE C 667
SHEET 15 AA323 MET B 684 ALA B 688 1 O GLN B 685 N LEU A 677
SHEET 16 AA323 VAL C 693 ALA C 697 1 O ASN C 694 N MET B 684
SHEET 17 AA323 LEU A 702 SER A 706 1 N SER A 705 O ILE C 695
SHEET 18 AA323 LEU B 710 SER B 714 1 O ASP B 711 N MET A 704
SHEET 19 AA323 VAL C 719 ALA C 723 1 O THR C 720 N ILE B 712
SHEET 20 AA323 GLU A 726 CYS A 731 1 N ILE A 728 O VAL C 721
SHEET 21 AA323 ALA A 734 SER A 739 -1 O LEU A 738 N LEU A 727
SHEET 22 AA323 ASN A 742 GLY A 746 -1 O GLU A 744 N LYS A 737
SHEET 23 AA323 ILE B 751 LYS B 754 1 O LEU B 752 N LEU A 745
SHEET 1 AA4 3 LEU A 783 THR A 784 0
SHEET 2 AA4 3 VAL D 25 PHE D 43 1 O VAL D 25 N THR A 784
SHEET 3 AA4 3 SER D 121 ILE D 128 1 O ILE D 124 N GLY D 40
SHEET 1 AA5 6 TYR D 4 VAL D 9 0
SHEET 2 AA5 6 VAL D 25 PHE D 43 -1 O LYS D 30 N GLY D 6
SHEET 3 AA5 6 PHE D 184 GLY D 195 1 O CYS D 185 N ARG D 33
SHEET 4 AA5 6 GLU D 237 LEU D 243 1 O ARG D 239 N PHE D 191
SHEET 5 AA5 6 LYS D 278 ALA D 284 1 O PHE D 280 N LEU D 243
SHEET 6 AA5 6 GLU D 303 LEU D 306 1 O LEU D 304 N GLN D 281
SHEET 1 AA6 4 ILE A 805 ILE A 809 0
SHEET 2 AA6 4 PRO A 795 THR A 799 -1 N TYR A 796 O GLY A 808
SHEET 3 AA6 4 SER A 825 GLU A 830 -1 O VAL A 827 N THR A 799
SHEET 4 AA6 4 THR D 13 LYS D 15 -1 O HIS D 14 N VAL A 826
SHEET 1 AA7 3 LEU B 783 THR B 784 0
SHEET 2 AA7 3 VAL E 25 PHE E 43 1 O VAL E 25 N THR B 784
SHEET 3 AA7 3 SER E 121 ILE E 128 1 O ILE E 124 N GLY E 40
SHEET 1 AA8 6 TYR E 4 VAL E 9 0
SHEET 2 AA8 6 VAL E 25 PHE E 43 -1 O LYS E 28 N ASP E 8
SHEET 3 AA8 6 PHE E 184 GLY E 195 1 O PHE E 194 N PHE E 43
SHEET 4 AA8 6 GLU E 237 LEU E 243 1 O ARG E 239 N PHE E 191
SHEET 5 AA8 6 LYS E 278 ALA E 284 1 O PHE E 280 N LEU E 243
SHEET 6 AA8 6 GLU E 303 LEU E 306 1 O LEU E 304 N GLN E 281
SHEET 1 AA9 4 ILE B 805 ILE B 809 0
SHEET 2 AA9 4 PRO B 795 THR B 799 -1 N TYR B 796 O GLY B 808
SHEET 3 AA9 4 SER B 825 GLU B 830 -1 O VAL B 827 N THR B 799
SHEET 4 AA9 4 THR E 13 LYS E 15 -1 O HIS E 14 N VAL B 826
SHEET 1 AB1 3 LEU C 783 ASP C 785 0
SHEET 2 AB1 3 VAL F 25 PHE F 43 1 O VAL F 25 N THR C 784
SHEET 3 AB1 3 SER F 121 ILE F 128 1 O ILE F 124 N GLY F 40
SHEET 1 AB2 6 TYR F 4 VAL F 9 0
SHEET 2 AB2 6 VAL F 25 PHE F 43 -1 O LYS F 28 N ASP F 8
SHEET 3 AB2 6 PHE F 184 GLY F 195 1 O CYS F 185 N ARG F 33
SHEET 4 AB2 6 GLU F 237 LEU F 243 1 O ARG F 239 N PHE F 191
SHEET 5 AB2 6 LYS F 278 ALA F 284 1 O LYS F 278 N ARG F 239
SHEET 6 AB2 6 GLU F 303 LEU F 306 1 O LEU F 304 N GLN F 281
SHEET 1 AB3 2 PRO C 795 THR C 799 0
SHEET 2 AB3 2 ILE C 805 ILE C 809 -1 O GLY C 808 N TYR C 796
SHEET 1 AB4 2 VAL C 826 VAL C 827 0
SHEET 2 AB4 2 THR F 13 HIS F 14 -1 O HIS F 14 N VAL C 826
SHEET 1 AB5 2 LEU D 294 ASN D 295 0
SHEET 2 AB5 2 VAL D 536 TRP D 537 1 O TRP D 537 N LEU D 294
SHEET 1 AB6 3 GLU D 328 PHE D 331 0
SHEET 2 AB6 3 GLN D 398 ARG D 409 -1 O ARG D 409 N GLU D 328
SHEET 3 AB6 3 GLU D 336 SER D 341 -1 N GLU D 338 O VAL D 401
SHEET 1 AB7 3 GLU D 328 PHE D 331 0
SHEET 2 AB7 3 GLN D 398 ARG D 409 -1 O ARG D 409 N GLU D 328
SHEET 3 AB7 3 LYS D 376 VAL D 386 -1 N ARG D 382 O GLY D 402
SHEET 1 AB8 2 GLU D 495 ASP D 497 0
SHEET 2 AB8 2 ALA D 521 VAL D 523 -1 O VAL D 523 N GLU D 495
SHEET 1 AB9 2 LEU D 500 VAL D 502 0
SHEET 2 AB9 2 ILE D 509 ILE D 511 -1 O PHE D 510 N TRP D 501
SHEET 1 AC1 2 LEU E 294 ASN E 295 0
SHEET 2 AC1 2 VAL E 536 TRP E 537 1 O TRP E 537 N LEU E 294
SHEET 1 AC2 3 GLU E 328 PHE E 331 0
SHEET 2 AC2 3 GLN E 398 ARG E 409 -1 O ARG E 409 N GLU E 328
SHEET 3 AC2 3 GLU E 336 SER E 341 -1 N VAL E 340 O LYS E 399
SHEET 1 AC3 3 GLU E 328 PHE E 331 0
SHEET 2 AC3 3 GLN E 398 ARG E 409 -1 O ARG E 409 N GLU E 328
SHEET 3 AC3 3 LYS E 376 VAL E 386 -1 N THR E 378 O PHE E 406
SHEET 1 AC4 2 GLU E 495 ASP E 497 0
SHEET 2 AC4 2 ALA E 521 VAL E 523 -1 O VAL E 523 N GLU E 495
SHEET 1 AC5 2 LEU E 500 VAL E 502 0
SHEET 2 AC5 2 ILE E 509 ILE E 511 -1 O PHE E 510 N TRP E 501
SHEET 1 AC6 2 LEU F 294 ASN F 295 0
SHEET 2 AC6 2 VAL F 536 TRP F 537 1 O TRP F 537 N LEU F 294
SHEET 1 AC7 3 GLU F 328 PHE F 331 0
SHEET 2 AC7 3 GLN F 398 ARG F 409 -1 O ARG F 409 N GLU F 328
SHEET 3 AC7 3 GLU F 336 SER F 341 -1 N VAL F 340 O LYS F 399
SHEET 1 AC8 3 GLU F 328 PHE F 331 0
SHEET 2 AC8 3 GLN F 398 ARG F 409 -1 O ARG F 409 N GLU F 328
SHEET 3 AC8 3 LYS F 376 VAL F 386 -1 N ARG F 382 O GLY F 402
SHEET 1 AC9 2 GLU F 495 ASP F 497 0
SHEET 2 AC9 2 ALA F 521 VAL F 523 -1 O ALA F 521 N ASP F 497
SHEET 1 AD1 2 LEU F 500 VAL F 502 0
SHEET 2 AD1 2 ILE F 509 ILE F 511 -1 O PHE F 510 N TRP F 501
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 2377 VAL A 834
TER 4754 VAL B 834
TER 7131 VAL C 834
TER 11237 MET D 539
TER 15351 MET E 539
TER 19465 MET F 539
MASTER 1881 0 0 71 144 0 0 619459 6 0 327
END
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