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LongText Report for: 6x6c-pdb

Name Class
6x6c-pdb
HEADER    IMMUNE SYSTEM                           27-MAY-20   6X6C              
TITLE     CRYO-EM STRUCTURE OF NLRP1-DPP9-VBP COMPLEX                           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DIPEPTIDYL PEPTIDASE 9;                                    
COMPND   3 CHAIN: A, D;                                                         
COMPND   4 SYNONYM: DP9,DIPEPTIDYL PEPTIDASE IV-RELATED PROTEIN 2,DPRP-2,       
COMPND   5 DIPEPTIDYL PEPTIDASE IX,DPP IX,DIPEPTIDYL PEPTIDASE-LIKE PROTEIN 9,  
COMPND   6 DPLP9;                                                               
COMPND   7 EC: 3.4.14.5;                                                        
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 2;                                                           
COMPND  10 MOLECULE: NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1;           
COMPND  11 CHAIN: E, F;                                                         
COMPND  12 SYNONYM: CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 7,DEATH       
COMPND  13 EFFECTOR FILAMENT-FORMING CED-4-LIKE APOPTOSIS PROTEIN,NUCLEOTIDE-   
COMPND  14 BINDING DOMAIN AND CASPASE RECRUITMENT DOMAIN;                       
COMPND  15 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: DPP9, DPRP2;                                                   
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 EXPRESSION_SYSTEM_CELL_LINE: HEK293T;                                
SOURCE  10 MOL_ID: 2;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  12 ORGANISM_COMMON: HUMAN;                                              
SOURCE  13 ORGANISM_TAXID: 9606;                                                
SOURCE  14 GENE: NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1;                    
SOURCE  15 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  17 EXPRESSION_SYSTEM_CELL_LINE: HEK293T                                 
KEYWDS    NLRP1, DPP9, INFLAMMASOME, VAL-BOROPRO (VBP), TALABOSTAT, INNATE      
KEYWDS   2 IMMUNITY, IMMUNE SYSTEM                                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    L.R.HOLLINGSWORTH,H.SHARIF                                            
REVDAT   1   10-MAR-21 6X6C    0                                                
JRNL        AUTH   L.R.HOLLINGSWORTH,H.SHARIF                                   
JRNL        TITL   IMMUNE SYSTEM                                                
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : SERIALEM, CTFFIND, RELION, RELION,        
REMARK   3                            RELION, RELION                            
REMARK   3   RECONSTRUCTION SCHEMA  : FOURIER SPACE                             
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 2.900                          
REMARK   3   NUMBER OF PARTICLES               : 205538                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6X6C COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-JUN-20.                  
REMARK 100 THE DEPOSITION ID IS D_1000249676.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : DPP9-NLRP1 COMPLEX                
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.50                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 1954                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K3 BIOQUANTUM (6K X      
REMARK 245                                       4K)                            
REMARK 245   MINIMUM DEFOCUS (NM)              : -800.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 2200.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : OTHER                          
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 65.00                          
REMARK 245   ILLUMINATION MODE                 : SPOT SCAN                      
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : 10500                          
REMARK 245   SOURCE                            : OTHER                          
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, D, E, F                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -27                                                      
REMARK 465     SER A   -26                                                      
REMARK 465     TYR A   -25                                                      
REMARK 465     TYR A   -24                                                      
REMARK 465     HIS A   -23                                                      
REMARK 465     HIS A   -22                                                      
REMARK 465     HIS A   -21                                                      
REMARK 465     HIS A   -20                                                      
REMARK 465     HIS A   -19                                                      
REMARK 465     HIS A   -18                                                      
REMARK 465     ASP A   -17                                                      
REMARK 465     TYR A   -16                                                      
REMARK 465     ASP A   -15                                                      
REMARK 465     ILE A   -14                                                      
REMARK 465     PRO A   -13                                                      
REMARK 465     THR A   -12                                                      
REMARK 465     THR A   -11                                                      
REMARK 465     GLU A   -10                                                      
REMARK 465     ASN A    -9                                                      
REMARK 465     LEU A    -8                                                      
REMARK 465     TYR A    -7                                                      
REMARK 465     PHE A    -6                                                      
REMARK 465     GLN A    -5                                                      
REMARK 465     GLY A    -4                                                      
REMARK 465     ALA A    -3                                                      
REMARK 465     MET A    -2                                                      
REMARK 465     GLY A    -1                                                      
REMARK 465     SER A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     THR A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     THR A     8                                                      
REMARK 465     ALA A     9                                                      
REMARK 465     ASP A    10                                                      
REMARK 465     ARG A    11                                                      
REMARK 465     GLY A    12                                                      
REMARK 465     ASP A    13                                                      
REMARK 465     ALA A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     ALA A    16                                                      
REMARK 465     THR A    17                                                      
REMARK 465     MET D   -27                                                      
REMARK 465     SER D   -26                                                      
REMARK 465     TYR D   -25                                                      
REMARK 465     TYR D   -24                                                      
REMARK 465     HIS D   -23                                                      
REMARK 465     HIS D   -22                                                      
REMARK 465     HIS D   -21                                                      
REMARK 465     HIS D   -20                                                      
REMARK 465     HIS D   -19                                                      
REMARK 465     HIS D   -18                                                      
REMARK 465     ASP D   -17                                                      
REMARK 465     TYR D   -16                                                      
REMARK 465     ASP D   -15                                                      
REMARK 465     ILE D   -14                                                      
REMARK 465     PRO D   -13                                                      
REMARK 465     THR D   -12                                                      
REMARK 465     THR D   -11                                                      
REMARK 465     GLU D   -10                                                      
REMARK 465     ASN D    -9                                                      
REMARK 465     LEU D    -8                                                      
REMARK 465     TYR D    -7                                                      
REMARK 465     PHE D    -6                                                      
REMARK 465     GLN D    -5                                                      
REMARK 465     GLY D    -4                                                      
REMARK 465     ALA D    -3                                                      
REMARK 465     MET D    -2                                                      
REMARK 465     GLY D    -1                                                      
REMARK 465     SER D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ALA D     2                                                      
REMARK 465     THR D     3                                                      
REMARK 465     THR D     4                                                      
REMARK 465     GLY D     5                                                      
REMARK 465     THR D     6                                                      
REMARK 465     PRO D     7                                                      
REMARK 465     THR D     8                                                      
REMARK 465     ALA D     9                                                      
REMARK 465     ASP D    10                                                      
REMARK 465     ARG D    11                                                      
REMARK 465     GLY D    12                                                      
REMARK 465     ASP D    13                                                      
REMARK 465     ALA D    14                                                      
REMARK 465     ALA D    15                                                      
REMARK 465     ALA D    16                                                      
REMARK 465     THR D    17                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     GLY E     3                                                      
REMARK 465     GLY E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     TRP E     6                                                      
REMARK 465     GLY E     7                                                      
REMARK 465     ARG E     8                                                      
REMARK 465     LEU E     9                                                      
REMARK 465     ALA E    10                                                      
REMARK 465     CYS E    11                                                      
REMARK 465     TYR E    12                                                      
REMARK 465     LEU E    13                                                      
REMARK 465     GLU E    14                                                      
REMARK 465     PHE E    15                                                      
REMARK 465     LEU E    16                                                      
REMARK 465     LYS E    17                                                      
REMARK 465     LYS E    18                                                      
REMARK 465     GLU E    19                                                      
REMARK 465     GLU E    20                                                      
REMARK 465     LEU E    21                                                      
REMARK 465     LYS E    22                                                      
REMARK 465     GLU E    23                                                      
REMARK 465     PHE E    24                                                      
REMARK 465     GLN E    25                                                      
REMARK 465     LEU E    26                                                      
REMARK 465     LEU E    27                                                      
REMARK 465     LEU E    28                                                      
REMARK 465     ALA E    29                                                      
REMARK 465     ASN E    30                                                      
REMARK 465     LYS E    31                                                      
REMARK 465     ALA E    32                                                      
REMARK 465     HIS E    33                                                      
REMARK 465     SER E    34                                                      
REMARK 465     ARG E    35                                                      
REMARK 465     SER E    36                                                      
REMARK 465     SER E    37                                                      
REMARK 465     SER E    38                                                      
REMARK 465     GLY E    39                                                      
REMARK 465     GLU E    40                                                      
REMARK 465     THR E    41                                                      
REMARK 465     PRO E    42                                                      
REMARK 465     ALA E    43                                                      
REMARK 465     GLN E    44                                                      
REMARK 465     PRO E    45                                                      
REMARK 465     GLU E    46                                                      
REMARK 465     LYS E    47                                                      
REMARK 465     THR E    48                                                      
REMARK 465     SER E    49                                                      
REMARK 465     GLY E    50                                                      
REMARK 465     MET E    51                                                      
REMARK 465     GLU E    52                                                      
REMARK 465     VAL E    53                                                      
REMARK 465     ALA E    54                                                      
REMARK 465     SER E    55                                                      
REMARK 465     TYR E    56                                                      
REMARK 465     LEU E    57                                                      
REMARK 465     VAL E    58                                                      
REMARK 465     ALA E    59                                                      
REMARK 465     GLN E    60                                                      
REMARK 465     TYR E    61                                                      
REMARK 465     GLY E    62                                                      
REMARK 465     GLU E    63                                                      
REMARK 465     GLN E    64                                                      
REMARK 465     ARG E    65                                                      
REMARK 465     ALA E    66                                                      
REMARK 465     TRP E    67                                                      
REMARK 465     ASP E    68                                                      
REMARK 465     LEU E    69                                                      
REMARK 465     ALA E    70                                                      
REMARK 465     LEU E    71                                                      
REMARK 465     HIS E    72                                                      
REMARK 465     THR E    73                                                      
REMARK 465     TRP E    74                                                      
REMARK 465     GLU E    75                                                      
REMARK 465     GLN E    76                                                      
REMARK 465     MET E    77                                                      
REMARK 465     GLY E    78                                                      
REMARK 465     LEU E    79                                                      
REMARK 465     ARG E    80                                                      
REMARK 465     SER E    81                                                      
REMARK 465     LEU E    82                                                      
REMARK 465     CYS E    83                                                      
REMARK 465     ALA E    84                                                      
REMARK 465     GLN E    85                                                      
REMARK 465     ALA E    86                                                      
REMARK 465     GLN E    87                                                      
REMARK 465     GLU E    88                                                      
REMARK 465     GLY E    89                                                      
REMARK 465     ALA E    90                                                      
REMARK 465     GLY E    91                                                      
REMARK 465     HIS E    92                                                      
REMARK 465     SER E    93                                                      
REMARK 465     PRO E    94                                                      
REMARK 465     SER E    95                                                      
REMARK 465     PHE E    96                                                      
REMARK 465     PRO E    97                                                      
REMARK 465     TYR E    98                                                      
REMARK 465     SER E    99                                                      
REMARK 465     PRO E   100                                                      
REMARK 465     SER E   101                                                      
REMARK 465     GLU E   102                                                      
REMARK 465     PRO E   103                                                      
REMARK 465     HIS E   104                                                      
REMARK 465     LEU E   105                                                      
REMARK 465     GLY E   106                                                      
REMARK 465     SER E   107                                                      
REMARK 465     PRO E   108                                                      
REMARK 465     SER E   109                                                      
REMARK 465     GLN E   110                                                      
REMARK 465     PRO E   111                                                      
REMARK 465     THR E   112                                                      
REMARK 465     SER E   113                                                      
REMARK 465     THR E   114                                                      
REMARK 465     ALA E   115                                                      
REMARK 465     VAL E   116                                                      
REMARK 465     LEU E   117                                                      
REMARK 465     MET E   118                                                      
REMARK 465     PRO E   119                                                      
REMARK 465     TRP E   120                                                      
REMARK 465     ILE E   121                                                      
REMARK 465     HIS E   122                                                      
REMARK 465     GLU E   123                                                      
REMARK 465     LEU E   124                                                      
REMARK 465     PRO E   125                                                      
REMARK 465     ALA E   126                                                      
REMARK 465     GLY E   127                                                      
REMARK 465     CYS E   128                                                      
REMARK 465     THR E   129                                                      
REMARK 465     GLN E   130                                                      
REMARK 465     GLY E   131                                                      
REMARK 465     SER E   132                                                      
REMARK 465     GLU E   133                                                      
REMARK 465     ARG E   134                                                      
REMARK 465     ARG E   135                                                      
REMARK 465     VAL E   136                                                      
REMARK 465     LEU E   137                                                      
REMARK 465     ARG E   138                                                      
REMARK 465     GLN E   139                                                      
REMARK 465     LEU E   140                                                      
REMARK 465     PRO E   141                                                      
REMARK 465     ASP E   142                                                      
REMARK 465     THR E   143                                                      
REMARK 465     SER E   144                                                      
REMARK 465     GLY E   145                                                      
REMARK 465     ARG E   146                                                      
REMARK 465     ARG E   147                                                      
REMARK 465     TRP E   148                                                      
REMARK 465     ARG E   149                                                      
REMARK 465     GLU E   150                                                      
REMARK 465     ILE E   151                                                      
REMARK 465     SER E   152                                                      
REMARK 465     ALA E   153                                                      
REMARK 465     SER E   154                                                      
REMARK 465     LEU E   155                                                      
REMARK 465     LEU E   156                                                      
REMARK 465     TYR E   157                                                      
REMARK 465     GLN E   158                                                      
REMARK 465     ALA E   159                                                      
REMARK 465     LEU E   160                                                      
REMARK 465     PRO E   161                                                      
REMARK 465     SER E   162                                                      
REMARK 465     SER E   163                                                      
REMARK 465     PRO E   164                                                      
REMARK 465     ASP E   165                                                      
REMARK 465     HIS E   166                                                      
REMARK 465     GLU E   167                                                      
REMARK 465     SER E   168                                                      
REMARK 465     PRO E   169                                                      
REMARK 465     SER E   170                                                      
REMARK 465     GLN E   171                                                      
REMARK 465     GLU E   172                                                      
REMARK 465     SER E   173                                                      
REMARK 465     PRO E   174                                                      
REMARK 465     ASN E   175                                                      
REMARK 465     ALA E   176                                                      
REMARK 465     PRO E   177                                                      
REMARK 465     THR E   178                                                      
REMARK 465     SER E   179                                                      
REMARK 465     THR E   180                                                      
REMARK 465     ALA E   181                                                      
REMARK 465     VAL E   182                                                      
REMARK 465     LEU E   183                                                      
REMARK 465     GLY E   184                                                      
REMARK 465     SER E   185                                                      
REMARK 465     TRP E   186                                                      
REMARK 465     GLY E   187                                                      
REMARK 465     SER E   188                                                      
REMARK 465     PRO E   189                                                      
REMARK 465     PRO E   190                                                      
REMARK 465     GLN E   191                                                      
REMARK 465     PRO E   192                                                      
REMARK 465     SER E   193                                                      
REMARK 465     LEU E   194                                                      
REMARK 465     ALA E   195                                                      
REMARK 465     PRO E   196                                                      
REMARK 465     ARG E   197                                                      
REMARK 465     GLU E   198                                                      
REMARK 465     GLN E   199                                                      
REMARK 465     GLU E   200                                                      
REMARK 465     ALA E   201                                                      
REMARK 465     PRO E   202                                                      
REMARK 465     GLY E   203                                                      
REMARK 465     THR E   204                                                      
REMARK 465     GLN E   205                                                      
REMARK 465     TRP E   206                                                      
REMARK 465     PRO E   207                                                      
REMARK 465     LEU E   208                                                      
REMARK 465     ASP E   209                                                      
REMARK 465     GLU E   210                                                      
REMARK 465     THR E   211                                                      
REMARK 465     SER E   212                                                      
REMARK 465     GLY E   213                                                      
REMARK 465     ILE E   214                                                      
REMARK 465     TYR E   215                                                      
REMARK 465     TYR E   216                                                      
REMARK 465     THR E   217                                                      
REMARK 465     GLU E   218                                                      
REMARK 465     ILE E   219                                                      
REMARK 465     ARG E   220                                                      
REMARK 465     GLU E   221                                                      
REMARK 465     ARG E   222                                                      
REMARK 465     GLU E   223                                                      
REMARK 465     ARG E   224                                                      
REMARK 465     GLU E   225                                                      
REMARK 465     LYS E   226                                                      
REMARK 465     SER E   227                                                      
REMARK 465     GLU E   228                                                      
REMARK 465     LYS E   229                                                      
REMARK 465     GLY E   230                                                      
REMARK 465     ARG E   231                                                      
REMARK 465     PRO E   232                                                      
REMARK 465     PRO E   233                                                      
REMARK 465     TRP E   234                                                      
REMARK 465     ALA E   235                                                      
REMARK 465     ALA E   236                                                      
REMARK 465     VAL E   237                                                      
REMARK 465     VAL E   238                                                      
REMARK 465     GLY E   239                                                      
REMARK 465     THR E   240                                                      
REMARK 465     PRO E   241                                                      
REMARK 465     PRO E   242                                                      
REMARK 465     GLN E   243                                                      
REMARK 465     ALA E   244                                                      
REMARK 465     HIS E   245                                                      
REMARK 465     THR E   246                                                      
REMARK 465     SER E   247                                                      
REMARK 465     LEU E   248                                                      
REMARK 465     GLN E   249                                                      
REMARK 465     PRO E   250                                                      
REMARK 465     HIS E   251                                                      
REMARK 465     HIS E   252                                                      
REMARK 465     HIS E   253                                                      
REMARK 465     PRO E   254                                                      
REMARK 465     TRP E   255                                                      
REMARK 465     GLU E   256                                                      
REMARK 465     PRO E   257                                                      
REMARK 465     SER E   258                                                      
REMARK 465     VAL E   259                                                      
REMARK 465     ARG E   260                                                      
REMARK 465     GLU E   261                                                      
REMARK 465     SER E   262                                                      
REMARK 465     LEU E   263                                                      
REMARK 465     CYS E   264                                                      
REMARK 465     SER E   265                                                      
REMARK 465     THR E   266                                                      
REMARK 465     TRP E   267                                                      
REMARK 465     PRO E   268                                                      
REMARK 465     TRP E   269                                                      
REMARK 465     LYS E   270                                                      
REMARK 465     ASN E   271                                                      
REMARK 465     GLU E   272                                                      
REMARK 465     ASP E   273                                                      
REMARK 465     PHE E   274                                                      
REMARK 465     ASN E   275                                                      
REMARK 465     GLN E   276                                                      
REMARK 465     LYS E   277                                                      
REMARK 465     PHE E   278                                                      
REMARK 465     THR E   279                                                      
REMARK 465     GLN E   280                                                      
REMARK 465     LEU E   281                                                      
REMARK 465     LEU E   282                                                      
REMARK 465     LEU E   283                                                      
REMARK 465     LEU E   284                                                      
REMARK 465     GLN E   285                                                      
REMARK 465     ARG E   286                                                      
REMARK 465     PRO E   287                                                      
REMARK 465     HIS E   288                                                      
REMARK 465     PRO E   289                                                      
REMARK 465     ARG E   290                                                      
REMARK 465     SER E   291                                                      
REMARK 465     GLN E   292                                                      
REMARK 465     ASP E   293                                                      
REMARK 465     PRO E   294                                                      
REMARK 465     LEU E   295                                                      
REMARK 465     VAL E   296                                                      
REMARK 465     LYS E   297                                                      
REMARK 465     ARG E   298                                                      
REMARK 465     SER E   299                                                      
REMARK 465     TRP E   300                                                      
REMARK 465     PRO E   301                                                      
REMARK 465     ASP E   302                                                      
REMARK 465     TYR E   303                                                      
REMARK 465     VAL E   304                                                      
REMARK 465     GLU E   305                                                      
REMARK 465     GLU E   306                                                      
REMARK 465     ASN E   307                                                      
REMARK 465     ARG E   308                                                      
REMARK 465     GLY E   309                                                      
REMARK 465     HIS E   310                                                      
REMARK 465     LEU E   311                                                      
REMARK 465     ILE E   312                                                      
REMARK 465     GLU E   313                                                      
REMARK 465     ILE E   314                                                      
REMARK 465     ARG E   315                                                      
REMARK 465     ASP E   316                                                      
REMARK 465     LEU E   317                                                      
REMARK 465     PHE E   318                                                      
REMARK 465     GLY E   319                                                      
REMARK 465     PRO E   320                                                      
REMARK 465     GLY E   321                                                      
REMARK 465     LEU E   322                                                      
REMARK 465     ASP E   323                                                      
REMARK 465     THR E   324                                                      
REMARK 465     GLN E   325                                                      
REMARK 465     GLU E   326                                                      
REMARK 465     PRO E   327                                                      
REMARK 465     ARG E   328                                                      
REMARK 465     ILE E   329                                                      
REMARK 465     VAL E   330                                                      
REMARK 465     ILE E   331                                                      
REMARK 465     LEU E   332                                                      
REMARK 465     GLN E   333                                                      
REMARK 465     GLY E   334                                                      
REMARK 465     ALA E   335                                                      
REMARK 465     ALA E   336                                                      
REMARK 465     GLY E   337                                                      
REMARK 465     ILE E   338                                                      
REMARK 465     GLY E   339                                                      
REMARK 465     LYS E   340                                                      
REMARK 465     SER E   341                                                      
REMARK 465     THR E   342                                                      
REMARK 465     LEU E   343                                                      
REMARK 465     ALA E   344                                                      
REMARK 465     ARG E   345                                                      
REMARK 465     GLN E   346                                                      
REMARK 465     VAL E   347                                                      
REMARK 465     LYS E   348                                                      
REMARK 465     GLU E   349                                                      
REMARK 465     ALA E   350                                                      
REMARK 465     TRP E   351                                                      
REMARK 465     GLY E   352                                                      
REMARK 465     ARG E   353                                                      
REMARK 465     GLY E   354                                                      
REMARK 465     GLN E   355                                                      
REMARK 465     LEU E   356                                                      
REMARK 465     TYR E   357                                                      
REMARK 465     GLY E   358                                                      
REMARK 465     ASP E   359                                                      
REMARK 465     ARG E   360                                                      
REMARK 465     PHE E   361                                                      
REMARK 465     GLN E   362                                                      
REMARK 465     HIS E   363                                                      
REMARK 465     VAL E   364                                                      
REMARK 465     PHE E   365                                                      
REMARK 465     TYR E   366                                                      
REMARK 465     PHE E   367                                                      
REMARK 465     SER E   368                                                      
REMARK 465     CYS E   369                                                      
REMARK 465     ARG E   370                                                      
REMARK 465     GLU E   371                                                      
REMARK 465     LEU E   372                                                      
REMARK 465     ALA E   373                                                      
REMARK 465     GLN E   374                                                      
REMARK 465     SER E   375                                                      
REMARK 465     LYS E   376                                                      
REMARK 465     VAL E   377                                                      
REMARK 465     VAL E   378                                                      
REMARK 465     SER E   379                                                      
REMARK 465     LEU E   380                                                      
REMARK 465     ALA E   381                                                      
REMARK 465     GLU E   382                                                      
REMARK 465     LEU E   383                                                      
REMARK 465     ILE E   384                                                      
REMARK 465     GLY E   385                                                      
REMARK 465     LYS E   386                                                      
REMARK 465     ASP E   387                                                      
REMARK 465     GLY E   388                                                      
REMARK 465     THR E   389                                                      
REMARK 465     ALA E   390                                                      
REMARK 465     THR E   391                                                      
REMARK 465     PRO E   392                                                      
REMARK 465     ALA E   393                                                      
REMARK 465     PRO E   394                                                      
REMARK 465     ILE E   395                                                      
REMARK 465     ARG E   396                                                      
REMARK 465     GLN E   397                                                      
REMARK 465     ILE E   398                                                      
REMARK 465     LEU E   399                                                      
REMARK 465     SER E   400                                                      
REMARK 465     ARG E   401                                                      
REMARK 465     PRO E   402                                                      
REMARK 465     GLU E   403                                                      
REMARK 465     ARG E   404                                                      
REMARK 465     LEU E   405                                                      
REMARK 465     LEU E   406                                                      
REMARK 465     PHE E   407                                                      
REMARK 465     ILE E   408                                                      
REMARK 465     LEU E   409                                                      
REMARK 465     ASP E   410                                                      
REMARK 465     GLY E   411                                                      
REMARK 465     VAL E   412                                                      
REMARK 465     ASP E   413                                                      
REMARK 465     GLU E   414                                                      
REMARK 465     PRO E   415                                                      
REMARK 465     GLY E   416                                                      
REMARK 465     TRP E   417                                                      
REMARK 465     VAL E   418                                                      
REMARK 465     LEU E   419                                                      
REMARK 465     GLN E   420                                                      
REMARK 465     GLU E   421                                                      
REMARK 465     PRO E   422                                                      
REMARK 465     SER E   423                                                      
REMARK 465     SER E   424                                                      
REMARK 465     GLU E   425                                                      
REMARK 465     LEU E   426                                                      
REMARK 465     CYS E   427                                                      
REMARK 465     LEU E   428                                                      
REMARK 465     HIS E   429                                                      
REMARK 465     TRP E   430                                                      
REMARK 465     SER E   431                                                      
REMARK 465     GLN E   432                                                      
REMARK 465     PRO E   433                                                      
REMARK 465     GLN E   434                                                      
REMARK 465     PRO E   435                                                      
REMARK 465     ALA E   436                                                      
REMARK 465     ASP E   437                                                      
REMARK 465     ALA E   438                                                      
REMARK 465     LEU E   439                                                      
REMARK 465     LEU E   440                                                      
REMARK 465     GLY E   441                                                      
REMARK 465     SER E   442                                                      
REMARK 465     LEU E   443                                                      
REMARK 465     LEU E   444                                                      
REMARK 465     GLY E   445                                                      
REMARK 465     LYS E   446                                                      
REMARK 465     THR E   447                                                      
REMARK 465     ILE E   448                                                      
REMARK 465     LEU E   449                                                      
REMARK 465     PRO E   450                                                      
REMARK 465     GLU E   451                                                      
REMARK 465     ALA E   452                                                      
REMARK 465     SER E   453                                                      
REMARK 465     PHE E   454                                                      
REMARK 465     LEU E   455                                                      
REMARK 465     ILE E   456                                                      
REMARK 465     THR E   457                                                      
REMARK 465     ALA E   458                                                      
REMARK 465     ARG E   459                                                      
REMARK 465     THR E   460                                                      
REMARK 465     THR E   461                                                      
REMARK 465     ALA E   462                                                      
REMARK 465     LEU E   463                                                      
REMARK 465     GLN E   464                                                      
REMARK 465     ASN E   465                                                      
REMARK 465     LEU E   466                                                      
REMARK 465     ILE E   467                                                      
REMARK 465     PRO E   468                                                      
REMARK 465     SER E   469                                                      
REMARK 465     LEU E   470                                                      
REMARK 465     GLU E   471                                                      
REMARK 465     GLN E   472                                                      
REMARK 465     ALA E   473                                                      
REMARK 465     ARG E   474                                                      
REMARK 465     TRP E   475                                                      
REMARK 465     VAL E   476                                                      
REMARK 465     GLU E   477                                                      
REMARK 465     VAL E   478                                                      
REMARK 465     LEU E   479                                                      
REMARK 465     GLY E   480                                                      
REMARK 465     PHE E   481                                                      
REMARK 465     SER E   482                                                      
REMARK 465     GLU E   483                                                      
REMARK 465     SER E   484                                                      
REMARK 465     SER E   485                                                      
REMARK 465     ARG E   486                                                      
REMARK 465     LYS E   487                                                      
REMARK 465     GLU E   488                                                      
REMARK 465     TYR E   489                                                      
REMARK 465     PHE E   490                                                      
REMARK 465     TYR E   491                                                      
REMARK 465     ARG E   492                                                      
REMARK 465     TYR E   493                                                      
REMARK 465     PHE E   494                                                      
REMARK 465     THR E   495                                                      
REMARK 465     ASP E   496                                                      
REMARK 465     GLU E   497                                                      
REMARK 465     ARG E   498                                                      
REMARK 465     GLN E   499                                                      
REMARK 465     ALA E   500                                                      
REMARK 465     ILE E   501                                                      
REMARK 465     ARG E   502                                                      
REMARK 465     ALA E   503                                                      
REMARK 465     PHE E   504                                                      
REMARK 465     ARG E   505                                                      
REMARK 465     LEU E   506                                                      
REMARK 465     VAL E   507                                                      
REMARK 465     LYS E   508                                                      
REMARK 465     SER E   509                                                      
REMARK 465     ASN E   510                                                      
REMARK 465     LYS E   511                                                      
REMARK 465     GLU E   512                                                      
REMARK 465     LEU E   513                                                      
REMARK 465     TRP E   514                                                      
REMARK 465     ALA E   515                                                      
REMARK 465     LEU E   516                                                      
REMARK 465     CYS E   517                                                      
REMARK 465     LEU E   518                                                      
REMARK 465     VAL E   519                                                      
REMARK 465     PRO E   520                                                      
REMARK 465     TRP E   521                                                      
REMARK 465     VAL E   522                                                      
REMARK 465     SER E   523                                                      
REMARK 465     TRP E   524                                                      
REMARK 465     LEU E   525                                                      
REMARK 465     ALA E   526                                                      
REMARK 465     CYS E   527                                                      
REMARK 465     THR E   528                                                      
REMARK 465     CYS E   529                                                      
REMARK 465     LEU E   530                                                      
REMARK 465     MET E   531                                                      
REMARK 465     GLN E   532                                                      
REMARK 465     GLN E   533                                                      
REMARK 465     MET E   534                                                      
REMARK 465     LYS E   535                                                      
REMARK 465     ARG E   536                                                      
REMARK 465     LYS E   537                                                      
REMARK 465     GLU E   538                                                      
REMARK 465     LYS E   539                                                      
REMARK 465     LEU E   540                                                      
REMARK 465     THR E   541                                                      
REMARK 465     LEU E   542                                                      
REMARK 465     THR E   543                                                      
REMARK 465     SER E   544                                                      
REMARK 465     LYS E   545                                                      
REMARK 465     THR E   546                                                      
REMARK 465     THR E   547                                                      
REMARK 465     THR E   548                                                      
REMARK 465     THR E   549                                                      
REMARK 465     LEU E   550                                                      
REMARK 465     CYS E   551                                                      
REMARK 465     LEU E   552                                                      
REMARK 465     HIS E   553                                                      
REMARK 465     TYR E   554                                                      
REMARK 465     LEU E   555                                                      
REMARK 465     ALA E   556                                                      
REMARK 465     GLN E   557                                                      
REMARK 465     ALA E   558                                                      
REMARK 465     LEU E   559                                                      
REMARK 465     GLN E   560                                                      
REMARK 465     ALA E   561                                                      
REMARK 465     GLN E   562                                                      
REMARK 465     PRO E   563                                                      
REMARK 465     LEU E   564                                                      
REMARK 465     GLY E   565                                                      
REMARK 465     PRO E   566                                                      
REMARK 465     GLN E   567                                                      
REMARK 465     LEU E   568                                                      
REMARK 465     ARG E   569                                                      
REMARK 465     ASP E   570                                                      
REMARK 465     LEU E   571                                                      
REMARK 465     CYS E   572                                                      
REMARK 465     SER E   573                                                      
REMARK 465     LEU E   574                                                      
REMARK 465     ALA E   575                                                      
REMARK 465     ALA E   576                                                      
REMARK 465     GLU E   577                                                      
REMARK 465     GLY E   578                                                      
REMARK 465     ILE E   579                                                      
REMARK 465     TRP E   580                                                      
REMARK 465     GLN E   581                                                      
REMARK 465     LYS E   582                                                      
REMARK 465     LYS E   583                                                      
REMARK 465     THR E   584                                                      
REMARK 465     LEU E   585                                                      
REMARK 465     PHE E   586                                                      
REMARK 465     SER E   587                                                      
REMARK 465     PRO E   588                                                      
REMARK 465     ASP E   589                                                      
REMARK 465     ASP E   590                                                      
REMARK 465     LEU E   591                                                      
REMARK 465     ARG E   592                                                      
REMARK 465     LYS E   593                                                      
REMARK 465     HIS E   594                                                      
REMARK 465     GLY E   595                                                      
REMARK 465     LEU E   596                                                      
REMARK 465     ASP E   597                                                      
REMARK 465     GLY E   598                                                      
REMARK 465     ALA E   599                                                      
REMARK 465     ILE E   600                                                      
REMARK 465     ILE E   601                                                      
REMARK 465     SER E   602                                                      
REMARK 465     THR E   603                                                      
REMARK 465     PHE E   604                                                      
REMARK 465     LEU E   605                                                      
REMARK 465     LYS E   606                                                      
REMARK 465     MET E   607                                                      
REMARK 465     GLY E   608                                                      
REMARK 465     ILE E   609                                                      
REMARK 465     LEU E   610                                                      
REMARK 465     GLN E   611                                                      
REMARK 465     GLU E   612                                                      
REMARK 465     HIS E   613                                                      
REMARK 465     PRO E   614                                                      
REMARK 465     ILE E   615                                                      
REMARK 465     PRO E   616                                                      
REMARK 465     LEU E   617                                                      
REMARK 465     SER E   618                                                      
REMARK 465     TYR E   619                                                      
REMARK 465     SER E   620                                                      
REMARK 465     PHE E   621                                                      
REMARK 465     ILE E   622                                                      
REMARK 465     HIS E   623                                                      
REMARK 465     LEU E   624                                                      
REMARK 465     CYS E   625                                                      
REMARK 465     PHE E   626                                                      
REMARK 465     GLN E   627                                                      
REMARK 465     GLU E   628                                                      
REMARK 465     PHE E   629                                                      
REMARK 465     PHE E   630                                                      
REMARK 465     ALA E   631                                                      
REMARK 465     ALA E   632                                                      
REMARK 465     MET E   633                                                      
REMARK 465     SER E   634                                                      
REMARK 465     TYR E   635                                                      
REMARK 465     VAL E   636                                                      
REMARK 465     LEU E   637                                                      
REMARK 465     GLU E   638                                                      
REMARK 465     ASP E   639                                                      
REMARK 465     GLU E   640                                                      
REMARK 465     LYS E   641                                                      
REMARK 465     GLY E   642                                                      
REMARK 465     ARG E   643                                                      
REMARK 465     GLY E   644                                                      
REMARK 465     LYS E   645                                                      
REMARK 465     HIS E   646                                                      
REMARK 465     SER E   647                                                      
REMARK 465     ASN E   648                                                      
REMARK 465     CYS E   649                                                      
REMARK 465     ILE E   650                                                      
REMARK 465     ILE E   651                                                      
REMARK 465     ASP E   652                                                      
REMARK 465     LEU E   653                                                      
REMARK 465     GLU E   654                                                      
REMARK 465     LYS E   655                                                      
REMARK 465     THR E   656                                                      
REMARK 465     LEU E   657                                                      
REMARK 465     GLU E   658                                                      
REMARK 465     ALA E   659                                                      
REMARK 465     TYR E   660                                                      
REMARK 465     GLY E   661                                                      
REMARK 465     ILE E   662                                                      
REMARK 465     HIS E   663                                                      
REMARK 465     GLY E   664                                                      
REMARK 465     LEU E   665                                                      
REMARK 465     PHE E   666                                                      
REMARK 465     GLY E   667                                                      
REMARK 465     ALA E   668                                                      
REMARK 465     SER E   669                                                      
REMARK 465     THR E   670                                                      
REMARK 465     THR E   671                                                      
REMARK 465     ARG E   672                                                      
REMARK 465     PHE E   673                                                      
REMARK 465     LEU E   674                                                      
REMARK 465     LEU E   675                                                      
REMARK 465     GLY E   676                                                      
REMARK 465     LEU E   677                                                      
REMARK 465     LEU E   678                                                      
REMARK 465     SER E   679                                                      
REMARK 465     ASP E   680                                                      
REMARK 465     GLU E   681                                                      
REMARK 465     GLY E   682                                                      
REMARK 465     GLU E   683                                                      
REMARK 465     ARG E   684                                                      
REMARK 465     GLU E   685                                                      
REMARK 465     MET E   686                                                      
REMARK 465     GLU E   687                                                      
REMARK 465     ASN E   688                                                      
REMARK 465     ILE E   689                                                      
REMARK 465     PHE E   690                                                      
REMARK 465     HIS E   691                                                      
REMARK 465     CYS E   692                                                      
REMARK 465     ARG E   693                                                      
REMARK 465     LEU E   694                                                      
REMARK 465     SER E   695                                                      
REMARK 465     GLN E   696                                                      
REMARK 465     GLY E   697                                                      
REMARK 465     ARG E   698                                                      
REMARK 465     ASN E   699                                                      
REMARK 465     LEU E   700                                                      
REMARK 465     MET E   701                                                      
REMARK 465     GLN E   702                                                      
REMARK 465     TRP E   703                                                      
REMARK 465     VAL E   704                                                      
REMARK 465     PRO E   705                                                      
REMARK 465     SER E   706                                                      
REMARK 465     LEU E   707                                                      
REMARK 465     GLN E   708                                                      
REMARK 465     LEU E   709                                                      
REMARK 465     LEU E   710                                                      
REMARK 465     LEU E   711                                                      
REMARK 465     GLN E   712                                                      
REMARK 465     PRO E   713                                                      
REMARK 465     HIS E   714                                                      
REMARK 465     SER E   715                                                      
REMARK 465     LEU E   716                                                      
REMARK 465     GLU E   717                                                      
REMARK 465     SER E   718                                                      
REMARK 465     LEU E   719                                                      
REMARK 465     HIS E   720                                                      
REMARK 465     CYS E   721                                                      
REMARK 465     LEU E   722                                                      
REMARK 465     TYR E   723                                                      
REMARK 465     GLU E   724                                                      
REMARK 465     THR E   725                                                      
REMARK 465     ARG E   726                                                      
REMARK 465     ASN E   727                                                      
REMARK 465     LYS E   728                                                      
REMARK 465     THR E   729                                                      
REMARK 465     PHE E   730                                                      
REMARK 465     LEU E   731                                                      
REMARK 465     THR E   732                                                      
REMARK 465     GLN E   733                                                      
REMARK 465     VAL E   734                                                      
REMARK 465     MET E   735                                                      
REMARK 465     ALA E   736                                                      
REMARK 465     HIS E   737                                                      
REMARK 465     PHE E   738                                                      
REMARK 465     GLU E   739                                                      
REMARK 465     GLU E   740                                                      
REMARK 465     MET E   741                                                      
REMARK 465     GLY E   742                                                      
REMARK 465     MET E   743                                                      
REMARK 465     CYS E   744                                                      
REMARK 465     VAL E   745                                                      
REMARK 465     GLU E   746                                                      
REMARK 465     THR E   747                                                      
REMARK 465     ASP E   748                                                      
REMARK 465     MET E   749                                                      
REMARK 465     GLU E   750                                                      
REMARK 465     LEU E   751                                                      
REMARK 465     LEU E   752                                                      
REMARK 465     VAL E   753                                                      
REMARK 465     CYS E   754                                                      
REMARK 465     THR E   755                                                      
REMARK 465     PHE E   756                                                      
REMARK 465     CYS E   757                                                      
REMARK 465     ILE E   758                                                      
REMARK 465     LYS E   759                                                      
REMARK 465     PHE E   760                                                      
REMARK 465     SER E   761                                                      
REMARK 465     ARG E   762                                                      
REMARK 465     HIS E   763                                                      
REMARK 465     VAL E   764                                                      
REMARK 465     LYS E   765                                                      
REMARK 465     LYS E   766                                                      
REMARK 465     LEU E   767                                                      
REMARK 465     GLN E   768                                                      
REMARK 465     LEU E   769                                                      
REMARK 465     ILE E   770                                                      
REMARK 465     GLU E   771                                                      
REMARK 465     GLY E   772                                                      
REMARK 465     ARG E   773                                                      
REMARK 465     GLN E   774                                                      
REMARK 465     HIS E   775                                                      
REMARK 465     ARG E   776                                                      
REMARK 465     SER E   777                                                      
REMARK 465     THR E   778                                                      
REMARK 465     TRP E   779                                                      
REMARK 465     SER E   780                                                      
REMARK 465     PRO E   781                                                      
REMARK 465     THR E   782                                                      
REMARK 465     MET E   783                                                      
REMARK 465     VAL E   784                                                      
REMARK 465     VAL E   785                                                      
REMARK 465     LEU E   786                                                      
REMARK 465     PHE E   787                                                      
REMARK 465     ARG E   788                                                      
REMARK 465     TRP E   789                                                      
REMARK 465     VAL E   790                                                      
REMARK 465     PRO E   791                                                      
REMARK 465     VAL E   792                                                      
REMARK 465     THR E   793                                                      
REMARK 465     ASP E   794                                                      
REMARK 465     ALA E   795                                                      
REMARK 465     TYR E   796                                                      
REMARK 465     TRP E   797                                                      
REMARK 465     GLN E   798                                                      
REMARK 465     ILE E   799                                                      
REMARK 465     LEU E   800                                                      
REMARK 465     PHE E   801                                                      
REMARK 465     SER E   802                                                      
REMARK 465     VAL E   803                                                      
REMARK 465     LEU E   804                                                      
REMARK 465     LYS E   805                                                      
REMARK 465     VAL E   806                                                      
REMARK 465     THR E   807                                                      
REMARK 465     ARG E   808                                                      
REMARK 465     ASN E   809                                                      
REMARK 465     LEU E   810                                                      
REMARK 465     LYS E   811                                                      
REMARK 465     GLU E   812                                                      
REMARK 465     LEU E   813                                                      
REMARK 465     ASP E   814                                                      
REMARK 465     LEU E   815                                                      
REMARK 465     SER E   816                                                      
REMARK 465     GLY E   817                                                      
REMARK 465     ASN E   818                                                      
REMARK 465     SER E   819                                                      
REMARK 465     LEU E   820                                                      
REMARK 465     SER E   821                                                      
REMARK 465     HIS E   822                                                      
REMARK 465     SER E   823                                                      
REMARK 465     ALA E   824                                                      
REMARK 465     VAL E   825                                                      
REMARK 465     LYS E   826                                                      
REMARK 465     SER E   827                                                      
REMARK 465     LEU E   828                                                      
REMARK 465     CYS E   829                                                      
REMARK 465     LYS E   830                                                      
REMARK 465     THR E   831                                                      
REMARK 465     LEU E   832                                                      
REMARK 465     ARG E   833                                                      
REMARK 465     ARG E   834                                                      
REMARK 465     PRO E   835                                                      
REMARK 465     ARG E   836                                                      
REMARK 465     CYS E   837                                                      
REMARK 465     LEU E   838                                                      
REMARK 465     LEU E   839                                                      
REMARK 465     GLU E   840                                                      
REMARK 465     THR E   841                                                      
REMARK 465     LEU E   842                                                      
REMARK 465     ARG E   843                                                      
REMARK 465     LEU E   844                                                      
REMARK 465     ALA E   845                                                      
REMARK 465     GLY E   846                                                      
REMARK 465     CYS E   847                                                      
REMARK 465     GLY E   848                                                      
REMARK 465     LEU E   849                                                      
REMARK 465     THR E   850                                                      
REMARK 465     ALA E   851                                                      
REMARK 465     GLU E   852                                                      
REMARK 465     ASP E   853                                                      
REMARK 465     CYS E   854                                                      
REMARK 465     LYS E   855                                                      
REMARK 465     ASP E   856                                                      
REMARK 465     LEU E   857                                                      
REMARK 465     ALA E   858                                                      
REMARK 465     PHE E   859                                                      
REMARK 465     GLY E   860                                                      
REMARK 465     LEU E   861                                                      
REMARK 465     ARG E   862                                                      
REMARK 465     ALA E   863                                                      
REMARK 465     ASN E   864                                                      
REMARK 465     GLN E   865                                                      
REMARK 465     THR E   866                                                      
REMARK 465     LEU E   867                                                      
REMARK 465     THR E   868                                                      
REMARK 465     GLU E   869                                                      
REMARK 465     LEU E   870                                                      
REMARK 465     ASP E   871                                                      
REMARK 465     LEU E   872                                                      
REMARK 465     SER E   873                                                      
REMARK 465     PHE E   874                                                      
REMARK 465     ASN E   875                                                      
REMARK 465     VAL E   876                                                      
REMARK 465     LEU E   877                                                      
REMARK 465     THR E   878                                                      
REMARK 465     ASP E   879                                                      
REMARK 465     ALA E   880                                                      
REMARK 465     GLY E   881                                                      
REMARK 465     ALA E   882                                                      
REMARK 465     LYS E   883                                                      
REMARK 465     HIS E   884                                                      
REMARK 465     LEU E   885                                                      
REMARK 465     CYS E   886                                                      
REMARK 465     GLN E   887                                                      
REMARK 465     ARG E   888                                                      
REMARK 465     LEU E   889                                                      
REMARK 465     ARG E   890                                                      
REMARK 465     GLN E   891                                                      
REMARK 465     PRO E   892                                                      
REMARK 465     SER E   893                                                      
REMARK 465     CYS E   894                                                      
REMARK 465     LYS E   895                                                      
REMARK 465     LEU E   896                                                      
REMARK 465     GLN E   897                                                      
REMARK 465     ARG E   898                                                      
REMARK 465     LEU E   899                                                      
REMARK 465     GLN E   900                                                      
REMARK 465     LEU E   901                                                      
REMARK 465     VAL E   902                                                      
REMARK 465     SER E   903                                                      
REMARK 465     CYS E   904                                                      
REMARK 465     GLY E   905                                                      
REMARK 465     LEU E   906                                                      
REMARK 465     THR E   907                                                      
REMARK 465     SER E   908                                                      
REMARK 465     ASP E   909                                                      
REMARK 465     CYS E   910                                                      
REMARK 465     CYS E   911                                                      
REMARK 465     GLN E   912                                                      
REMARK 465     ASP E   913                                                      
REMARK 465     LEU E   914                                                      
REMARK 465     ALA E   915                                                      
REMARK 465     SER E   916                                                      
REMARK 465     VAL E   917                                                      
REMARK 465     LEU E   918                                                      
REMARK 465     SER E   919                                                      
REMARK 465     ALA E   920                                                      
REMARK 465     SER E   921                                                      
REMARK 465     PRO E   922                                                      
REMARK 465     SER E   923                                                      
REMARK 465     LEU E   924                                                      
REMARK 465     LYS E   925                                                      
REMARK 465     GLU E   926                                                      
REMARK 465     LEU E   927                                                      
REMARK 465     ASP E   928                                                      
REMARK 465     LEU E   929                                                      
REMARK 465     GLN E   930                                                      
REMARK 465     GLN E   931                                                      
REMARK 465     ASN E   932                                                      
REMARK 465     ASN E   933                                                      
REMARK 465     LEU E   934                                                      
REMARK 465     ASP E   935                                                      
REMARK 465     ASP E   936                                                      
REMARK 465     VAL E   937                                                      
REMARK 465     GLY E   938                                                      
REMARK 465     VAL E   939                                                      
REMARK 465     ARG E   940                                                      
REMARK 465     LEU E   941                                                      
REMARK 465     LEU E   942                                                      
REMARK 465     CYS E   943                                                      
REMARK 465     GLU E   944                                                      
REMARK 465     GLY E   945                                                      
REMARK 465     LEU E   946                                                      
REMARK 465     ARG E   947                                                      
REMARK 465     HIS E   948                                                      
REMARK 465     PRO E   949                                                      
REMARK 465     ALA E   950                                                      
REMARK 465     CYS E   951                                                      
REMARK 465     LYS E   952                                                      
REMARK 465     LEU E   953                                                      
REMARK 465     ILE E   954                                                      
REMARK 465     ARG E   955                                                      
REMARK 465     LEU E   956                                                      
REMARK 465     GLY E   957                                                      
REMARK 465     LEU E   958                                                      
REMARK 465     ASP E   959                                                      
REMARK 465     GLN E   960                                                      
REMARK 465     THR E   961                                                      
REMARK 465     THR E   962                                                      
REMARK 465     LEU E   963                                                      
REMARK 465     SER E   964                                                      
REMARK 465     ASP E   965                                                      
REMARK 465     GLU E   966                                                      
REMARK 465     MET E   967                                                      
REMARK 465     ARG E   968                                                      
REMARK 465     GLN E   969                                                      
REMARK 465     GLU E   970                                                      
REMARK 465     LEU E   971                                                      
REMARK 465     ARG E   972                                                      
REMARK 465     ALA E   973                                                      
REMARK 465     LEU E   974                                                      
REMARK 465     GLU E   975                                                      
REMARK 465     GLN E   976                                                      
REMARK 465     GLU E   977                                                      
REMARK 465     LYS E   978                                                      
REMARK 465     PRO E   979                                                      
REMARK 465     GLN E   980                                                      
REMARK 465     LEU E   981                                                      
REMARK 465     LEU E   982                                                      
REMARK 465     ILE E   983                                                      
REMARK 465     PHE E   984                                                      
REMARK 465     SER E   985                                                      
REMARK 465     ARG E   986                                                      
REMARK 465     ARG E   987                                                      
REMARK 465     LYS E   988                                                      
REMARK 465     PRO E   989                                                      
REMARK 465     SER E   990                                                      
REMARK 465     VAL E   991                                                      
REMARK 465     MET E   992                                                      
REMARK 465     THR E   993                                                      
REMARK 465     PRO E   994                                                      
REMARK 465     THR E   995                                                      
REMARK 465     GLU E   996                                                      
REMARK 465     GLY E   997                                                      
REMARK 465     LEU E   998                                                      
REMARK 465     ASP E   999                                                      
REMARK 465     THR E  1000                                                      
REMARK 465     GLY E  1001                                                      
REMARK 465     GLU E  1002                                                      
REMARK 465     MET E  1003                                                      
REMARK 465     SER E  1004                                                      
REMARK 465     ASN E  1005                                                      
REMARK 465     SER E  1006                                                      
REMARK 465     THR E  1007                                                      
REMARK 465     SER E  1008                                                      
REMARK 465     SER E  1009                                                      
REMARK 465     LEU E  1010                                                      
REMARK 465     LYS E  1011                                                      
REMARK 465     ARG E  1012                                                      
REMARK 465     GLN E  1013                                                      
REMARK 465     ARG E  1014                                                      
REMARK 465     LEU E  1015                                                      
REMARK 465     GLY E  1016                                                      
REMARK 465     SER E  1017                                                      
REMARK 465     GLU E  1018                                                      
REMARK 465     ARG E  1019                                                      
REMARK 465     ALA E  1020                                                      
REMARK 465     ALA E  1021                                                      
REMARK 465     SER E  1022                                                      
REMARK 465     HIS E  1023                                                      
REMARK 465     VAL E  1024                                                      
REMARK 465     ALA E  1025                                                      
REMARK 465     GLN E  1026                                                      
REMARK 465     ALA E  1027                                                      
REMARK 465     ASN E  1028                                                      
REMARK 465     LEU E  1029                                                      
REMARK 465     LYS E  1030                                                      
REMARK 465     LEU E  1031                                                      
REMARK 465     LEU E  1032                                                      
REMARK 465     ASP E  1033                                                      
REMARK 465     VAL E  1034                                                      
REMARK 465     SER E  1035                                                      
REMARK 465     LYS E  1036                                                      
REMARK 465     ILE E  1037                                                      
REMARK 465     PHE E  1038                                                      
REMARK 465     PRO E  1039                                                      
REMARK 465     ILE E  1040                                                      
REMARK 465     ALA E  1041                                                      
REMARK 465     GLU E  1042                                                      
REMARK 465     ILE E  1043                                                      
REMARK 465     ALA E  1044                                                      
REMARK 465     GLU E  1045                                                      
REMARK 465     GLU E  1046                                                      
REMARK 465     SER E  1047                                                      
REMARK 465     SER E  1048                                                      
REMARK 465     PRO E  1049                                                      
REMARK 465     GLU E  1050                                                      
REMARK 465     VAL E  1051                                                      
REMARK 465     VAL E  1052                                                      
REMARK 465     PRO E  1053                                                      
REMARK 465     VAL E  1054                                                      
REMARK 465     GLU E  1055                                                      
REMARK 465     LEU E  1056                                                      
REMARK 465     LEU E  1057                                                      
REMARK 465     CYS E  1058                                                      
REMARK 465     VAL E  1059                                                      
REMARK 465     PRO E  1060                                                      
REMARK 465     SER E  1061                                                      
REMARK 465     PRO E  1062                                                      
REMARK 465     ALA E  1063                                                      
REMARK 465     SER E  1064                                                      
REMARK 465     GLN E  1065                                                      
REMARK 465     GLY E  1066                                                      
REMARK 465     ASP E  1067                                                      
REMARK 465     LEU E  1068                                                      
REMARK 465     HIS E  1069                                                      
REMARK 465     THR E  1070                                                      
REMARK 465     LYS E  1071                                                      
REMARK 465     PRO E  1072                                                      
REMARK 465     LEU E  1073                                                      
REMARK 465     GLY E  1074                                                      
REMARK 465     THR E  1075                                                      
REMARK 465     ASP E  1076                                                      
REMARK 465     ASP E  1077                                                      
REMARK 465     ASP E  1078                                                      
REMARK 465     SER E  1213                                                      
REMARK 465     PRO E  1214                                                      
REMARK 465     LEU E  1215                                                      
REMARK 465     GLY E  1216                                                      
REMARK 465     VAL E  1217                                                      
REMARK 465     LEU E  1218                                                      
REMARK 465     LEU E  1219                                                      
REMARK 465     LYS E  1220                                                      
REMARK 465     MET E  1221                                                      
REMARK 465     ILE E  1222                                                      
REMARK 465     HIS E  1223                                                      
REMARK 465     ASN E  1224                                                      
REMARK 465     ALA E  1225                                                      
REMARK 465     LEU E  1226                                                      
REMARK 465     ARG E  1227                                                      
REMARK 465     PHE E  1228                                                      
REMARK 465     ILE E  1229                                                      
REMARK 465     PRO E  1230                                                      
REMARK 465     VAL E  1231                                                      
REMARK 465     THR E  1232                                                      
REMARK 465     SER E  1233                                                      
REMARK 465     VAL E  1234                                                      
REMARK 465     VAL E  1235                                                      
REMARK 465     LEU E  1236                                                      
REMARK 465     LEU E  1237                                                      
REMARK 465     TYR E  1238                                                      
REMARK 465     HIS E  1239                                                      
REMARK 465     ARG E  1240                                                      
REMARK 465     VAL E  1241                                                      
REMARK 465     HIS E  1242                                                      
REMARK 465     PRO E  1243                                                      
REMARK 465     GLU E  1244                                                      
REMARK 465     GLU E  1245                                                      
REMARK 465     VAL E  1246                                                      
REMARK 465     THR E  1247                                                      
REMARK 465     PHE E  1248                                                      
REMARK 465     HIS E  1249                                                      
REMARK 465     LEU E  1250                                                      
REMARK 465     TYR E  1251                                                      
REMARK 465     LEU E  1252                                                      
REMARK 465     ILE E  1253                                                      
REMARK 465     PRO E  1254                                                      
REMARK 465     SER E  1255                                                      
REMARK 465     ASP E  1256                                                      
REMARK 465     CYS E  1257                                                      
REMARK 465     SER E  1258                                                      
REMARK 465     ILE E  1259                                                      
REMARK 465     ARG E  1260                                                      
REMARK 465     LYS E  1261                                                      
REMARK 465     ALA E  1262                                                      
REMARK 465     ILE E  1263                                                      
REMARK 465     ASP E  1264                                                      
REMARK 465     ASP E  1265                                                      
REMARK 465     LEU E  1266                                                      
REMARK 465     GLU E  1267                                                      
REMARK 465     MET E  1268                                                      
REMARK 465     LYS E  1269                                                      
REMARK 465     PHE E  1270                                                      
REMARK 465     GLN E  1271                                                      
REMARK 465     PHE E  1272                                                      
REMARK 465     VAL E  1273                                                      
REMARK 465     ARG E  1274                                                      
REMARK 465     ILE E  1275                                                      
REMARK 465     HIS E  1276                                                      
REMARK 465     LYS E  1277                                                      
REMARK 465     PRO E  1278                                                      
REMARK 465     PRO E  1279                                                      
REMARK 465     PRO E  1280                                                      
REMARK 465     LEU E  1281                                                      
REMARK 465     THR E  1282                                                      
REMARK 465     PRO E  1283                                                      
REMARK 465     LEU E  1284                                                      
REMARK 465     TYR E  1285                                                      
REMARK 465     MET E  1286                                                      
REMARK 465     GLY E  1287                                                      
REMARK 465     CYS E  1288                                                      
REMARK 465     ARG E  1289                                                      
REMARK 465     TYR E  1290                                                      
REMARK 465     THR E  1291                                                      
REMARK 465     VAL E  1292                                                      
REMARK 465     SER E  1293                                                      
REMARK 465     GLY E  1294                                                      
REMARK 465     SER E  1295                                                      
REMARK 465     GLY E  1296                                                      
REMARK 465     SER E  1297                                                      
REMARK 465     GLY E  1298                                                      
REMARK 465     MET E  1299                                                      
REMARK 465     LEU E  1300                                                      
REMARK 465     GLU E  1301                                                      
REMARK 465     ILE E  1302                                                      
REMARK 465     LEU E  1303                                                      
REMARK 465     PRO E  1304                                                      
REMARK 465     LYS E  1305                                                      
REMARK 465     GLU E  1306                                                      
REMARK 465     LEU E  1307                                                      
REMARK 465     GLU E  1308                                                      
REMARK 465     LEU E  1309                                                      
REMARK 465     CYS E  1310                                                      
REMARK 465     TYR E  1311                                                      
REMARK 465     ARG E  1312                                                      
REMARK 465     SER E  1313                                                      
REMARK 465     PRO E  1314                                                      
REMARK 465     GLY E  1315                                                      
REMARK 465     GLU E  1316                                                      
REMARK 465     ASP E  1317                                                      
REMARK 465     GLN E  1318                                                      
REMARK 465     LEU E  1319                                                      
REMARK 465     PHE E  1320                                                      
REMARK 465     SER E  1321                                                      
REMARK 465     GLU E  1322                                                      
REMARK 465     PHE E  1323                                                      
REMARK 465     TYR E  1324                                                      
REMARK 465     VAL E  1325                                                      
REMARK 465     GLY E  1326                                                      
REMARK 465     HIS E  1327                                                      
REMARK 465     LEU E  1328                                                      
REMARK 465     GLY E  1329                                                      
REMARK 465     SER E  1330                                                      
REMARK 465     GLY E  1331                                                      
REMARK 465     ILE E  1332                                                      
REMARK 465     ARG E  1333                                                      
REMARK 465     LEU E  1334                                                      
REMARK 465     GLN E  1335                                                      
REMARK 465     VAL E  1336                                                      
REMARK 465     LYS E  1337                                                      
REMARK 465     ASP E  1338                                                      
REMARK 465     LYS E  1339                                                      
REMARK 465     LYS E  1340                                                      
REMARK 465     ASP E  1341                                                      
REMARK 465     GLU E  1342                                                      
REMARK 465     THR E  1343                                                      
REMARK 465     LEU E  1344                                                      
REMARK 465     VAL E  1345                                                      
REMARK 465     TRP E  1346                                                      
REMARK 465     GLU E  1347                                                      
REMARK 465     ALA E  1348                                                      
REMARK 465     LEU E  1349                                                      
REMARK 465     VAL E  1350                                                      
REMARK 465     LYS E  1351                                                      
REMARK 465     PRO E  1352                                                      
REMARK 465     GLY E  1353                                                      
REMARK 465     ASP E  1354                                                      
REMARK 465     LEU E  1355                                                      
REMARK 465     MET E  1356                                                      
REMARK 465     PRO E  1357                                                      
REMARK 465     ALA E  1358                                                      
REMARK 465     THR E  1359                                                      
REMARK 465     THR E  1360                                                      
REMARK 465     LEU E  1361                                                      
REMARK 465     ILE E  1362                                                      
REMARK 465     PRO E  1363                                                      
REMARK 465     PRO E  1364                                                      
REMARK 465     ALA E  1365                                                      
REMARK 465     ARG E  1366                                                      
REMARK 465     ILE E  1367                                                      
REMARK 465     ALA E  1368                                                      
REMARK 465     VAL E  1369                                                      
REMARK 465     PRO E  1370                                                      
REMARK 465     SER E  1371                                                      
REMARK 465     PRO E  1372                                                      
REMARK 465     LEU E  1373                                                      
REMARK 465     ASP E  1374                                                      
REMARK 465     ALA E  1375                                                      
REMARK 465     PRO E  1376                                                      
REMARK 465     GLN E  1377                                                      
REMARK 465     LEU E  1378                                                      
REMARK 465     LEU E  1379                                                      
REMARK 465     HIS E  1380                                                      
REMARK 465     PHE E  1381                                                      
REMARK 465     VAL E  1382                                                      
REMARK 465     ASP E  1383                                                      
REMARK 465     GLN E  1384                                                      
REMARK 465     TYR E  1385                                                      
REMARK 465     ARG E  1386                                                      
REMARK 465     GLU E  1387                                                      
REMARK 465     GLN E  1388                                                      
REMARK 465     LEU E  1389                                                      
REMARK 465     ILE E  1390                                                      
REMARK 465     ALA E  1391                                                      
REMARK 465     ARG E  1392                                                      
REMARK 465     VAL E  1393                                                      
REMARK 465     THR E  1394                                                      
REMARK 465     SER E  1395                                                      
REMARK 465     VAL E  1396                                                      
REMARK 465     GLU E  1397                                                      
REMARK 465     VAL E  1398                                                      
REMARK 465     VAL E  1399                                                      
REMARK 465     LEU E  1400                                                      
REMARK 465     ASP E  1401                                                      
REMARK 465     LYS E  1402                                                      
REMARK 465     LEU E  1403                                                      
REMARK 465     HIS E  1404                                                      
REMARK 465     GLY E  1405                                                      
REMARK 465     GLN E  1406                                                      
REMARK 465     VAL E  1407                                                      
REMARK 465     LEU E  1408                                                      
REMARK 465     SER E  1409                                                      
REMARK 465     GLN E  1410                                                      
REMARK 465     GLU E  1411                                                      
REMARK 465     GLN E  1412                                                      
REMARK 465     TYR E  1413                                                      
REMARK 465     GLU E  1414                                                      
REMARK 465     ARG E  1415                                                      
REMARK 465     VAL E  1416                                                      
REMARK 465     LEU E  1417                                                      
REMARK 465     ALA E  1418                                                      
REMARK 465     GLU E  1419                                                      
REMARK 465     ASN E  1420                                                      
REMARK 465     THR E  1421                                                      
REMARK 465     ARG E  1422                                                      
REMARK 465     PRO E  1423                                                      
REMARK 465     SER E  1424                                                      
REMARK 465     GLN E  1425                                                      
REMARK 465     MET E  1426                                                      
REMARK 465     ARG E  1427                                                      
REMARK 465     LYS E  1428                                                      
REMARK 465     LEU E  1429                                                      
REMARK 465     PHE E  1430                                                      
REMARK 465     SER E  1431                                                      
REMARK 465     LEU E  1432                                                      
REMARK 465     SER E  1433                                                      
REMARK 465     GLN E  1434                                                      
REMARK 465     SER E  1435                                                      
REMARK 465     TRP E  1436                                                      
REMARK 465     ASP E  1437                                                      
REMARK 465     ARG E  1438                                                      
REMARK 465     LYS E  1439                                                      
REMARK 465     CYS E  1440                                                      
REMARK 465     LYS E  1441                                                      
REMARK 465     ASP E  1442                                                      
REMARK 465     GLY E  1443                                                      
REMARK 465     LEU E  1444                                                      
REMARK 465     TYR E  1445                                                      
REMARK 465     GLN E  1446                                                      
REMARK 465     ALA E  1447                                                      
REMARK 465     LEU E  1448                                                      
REMARK 465     LYS E  1449                                                      
REMARK 465     GLU E  1450                                                      
REMARK 465     THR E  1451                                                      
REMARK 465     HIS E  1452                                                      
REMARK 465     PRO E  1453                                                      
REMARK 465     HIS E  1454                                                      
REMARK 465     LEU E  1455                                                      
REMARK 465     ILE E  1456                                                      
REMARK 465     MET E  1457                                                      
REMARK 465     GLU E  1458                                                      
REMARK 465     LEU E  1459                                                      
REMARK 465     TRP E  1460                                                      
REMARK 465     GLU E  1461                                                      
REMARK 465     LYS E  1462                                                      
REMARK 465     GLY E  1463                                                      
REMARK 465     SER E  1464                                                      
REMARK 465     LYS E  1465                                                      
REMARK 465     LYS E  1466                                                      
REMARK 465     GLY E  1467                                                      
REMARK 465     LEU E  1468                                                      
REMARK 465     LEU E  1469                                                      
REMARK 465     PRO E  1470                                                      
REMARK 465     LEU E  1471                                                      
REMARK 465     SER E  1472                                                      
REMARK 465     SER E  1473                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     GLY F     3                                                      
REMARK 465     GLY F     4                                                      
REMARK 465     ALA F     5                                                      
REMARK 465     TRP F     6                                                      
REMARK 465     GLY F     7                                                      
REMARK 465     ARG F     8                                                      
REMARK 465     LEU F     9                                                      
REMARK 465     ALA F    10                                                      
REMARK 465     CYS F    11                                                      
REMARK 465     TYR F    12                                                      
REMARK 465     LEU F    13                                                      
REMARK 465     GLU F    14                                                      
REMARK 465     PHE F    15                                                      
REMARK 465     LEU F    16                                                      
REMARK 465     LYS F    17                                                      
REMARK 465     LYS F    18                                                      
REMARK 465     GLU F    19                                                      
REMARK 465     GLU F    20                                                      
REMARK 465     LEU F    21                                                      
REMARK 465     LYS F    22                                                      
REMARK 465     GLU F    23                                                      
REMARK 465     PHE F    24                                                      
REMARK 465     GLN F    25                                                      
REMARK 465     LEU F    26                                                      
REMARK 465     LEU F    27                                                      
REMARK 465     LEU F    28                                                      
REMARK 465     ALA F    29                                                      
REMARK 465     ASN F    30                                                      
REMARK 465     LYS F    31                                                      
REMARK 465     ALA F    32                                                      
REMARK 465     HIS F    33                                                      
REMARK 465     SER F    34                                                      
REMARK 465     ARG F    35                                                      
REMARK 465     SER F    36                                                      
REMARK 465     SER F    37                                                      
REMARK 465     SER F    38                                                      
REMARK 465     GLY F    39                                                      
REMARK 465     GLU F    40                                                      
REMARK 465     THR F    41                                                      
REMARK 465     PRO F    42                                                      
REMARK 465     ALA F    43                                                      
REMARK 465     GLN F    44                                                      
REMARK 465     PRO F    45                                                      
REMARK 465     GLU F    46                                                      
REMARK 465     LYS F    47                                                      
REMARK 465     THR F    48                                                      
REMARK 465     SER F    49                                                      
REMARK 465     GLY F    50                                                      
REMARK 465     MET F    51                                                      
REMARK 465     GLU F    52                                                      
REMARK 465     VAL F    53                                                      
REMARK 465     ALA F    54                                                      
REMARK 465     SER F    55                                                      
REMARK 465     TYR F    56                                                      
REMARK 465     LEU F    57                                                      
REMARK 465     VAL F    58                                                      
REMARK 465     ALA F    59                                                      
REMARK 465     GLN F    60                                                      
REMARK 465     TYR F    61                                                      
REMARK 465     GLY F    62                                                      
REMARK 465     GLU F    63                                                      
REMARK 465     GLN F    64                                                      
REMARK 465     ARG F    65                                                      
REMARK 465     ALA F    66                                                      
REMARK 465     TRP F    67                                                      
REMARK 465     ASP F    68                                                      
REMARK 465     LEU F    69                                                      
REMARK 465     ALA F    70                                                      
REMARK 465     LEU F    71                                                      
REMARK 465     HIS F    72                                                      
REMARK 465     THR F    73                                                      
REMARK 465     TRP F    74                                                      
REMARK 465     GLU F    75                                                      
REMARK 465     GLN F    76                                                      
REMARK 465     MET F    77                                                      
REMARK 465     GLY F    78                                                      
REMARK 465     LEU F    79                                                      
REMARK 465     ARG F    80                                                      
REMARK 465     SER F    81                                                      
REMARK 465     LEU F    82                                                      
REMARK 465     CYS F    83                                                      
REMARK 465     ALA F    84                                                      
REMARK 465     GLN F    85                                                      
REMARK 465     ALA F    86                                                      
REMARK 465     GLN F    87                                                      
REMARK 465     GLU F    88                                                      
REMARK 465     GLY F    89                                                      
REMARK 465     ALA F    90                                                      
REMARK 465     GLY F    91                                                      
REMARK 465     HIS F    92                                                      
REMARK 465     SER F    93                                                      
REMARK 465     PRO F    94                                                      
REMARK 465     SER F    95                                                      
REMARK 465     PHE F    96                                                      
REMARK 465     PRO F    97                                                      
REMARK 465     TYR F    98                                                      
REMARK 465     SER F    99                                                      
REMARK 465     PRO F   100                                                      
REMARK 465     SER F   101                                                      
REMARK 465     GLU F   102                                                      
REMARK 465     PRO F   103                                                      
REMARK 465     HIS F   104                                                      
REMARK 465     LEU F   105                                                      
REMARK 465     GLY F   106                                                      
REMARK 465     SER F   107                                                      
REMARK 465     PRO F   108                                                      
REMARK 465     SER F   109                                                      
REMARK 465     GLN F   110                                                      
REMARK 465     PRO F   111                                                      
REMARK 465     THR F   112                                                      
REMARK 465     SER F   113                                                      
REMARK 465     THR F   114                                                      
REMARK 465     ALA F   115                                                      
REMARK 465     VAL F   116                                                      
REMARK 465     LEU F   117                                                      
REMARK 465     MET F   118                                                      
REMARK 465     PRO F   119                                                      
REMARK 465     TRP F   120                                                      
REMARK 465     ILE F   121                                                      
REMARK 465     HIS F   122                                                      
REMARK 465     GLU F   123                                                      
REMARK 465     LEU F   124                                                      
REMARK 465     PRO F   125                                                      
REMARK 465     ALA F   126                                                      
REMARK 465     GLY F   127                                                      
REMARK 465     CYS F   128                                                      
REMARK 465     THR F   129                                                      
REMARK 465     GLN F   130                                                      
REMARK 465     GLY F   131                                                      
REMARK 465     SER F   132                                                      
REMARK 465     GLU F   133                                                      
REMARK 465     ARG F   134                                                      
REMARK 465     ARG F   135                                                      
REMARK 465     VAL F   136                                                      
REMARK 465     LEU F   137                                                      
REMARK 465     ARG F   138                                                      
REMARK 465     GLN F   139                                                      
REMARK 465     LEU F   140                                                      
REMARK 465     PRO F   141                                                      
REMARK 465     ASP F   142                                                      
REMARK 465     THR F   143                                                      
REMARK 465     SER F   144                                                      
REMARK 465     GLY F   145                                                      
REMARK 465     ARG F   146                                                      
REMARK 465     ARG F   147                                                      
REMARK 465     TRP F   148                                                      
REMARK 465     ARG F   149                                                      
REMARK 465     GLU F   150                                                      
REMARK 465     ILE F   151                                                      
REMARK 465     SER F   152                                                      
REMARK 465     ALA F   153                                                      
REMARK 465     SER F   154                                                      
REMARK 465     LEU F   155                                                      
REMARK 465     LEU F   156                                                      
REMARK 465     TYR F   157                                                      
REMARK 465     GLN F   158                                                      
REMARK 465     ALA F   159                                                      
REMARK 465     LEU F   160                                                      
REMARK 465     PRO F   161                                                      
REMARK 465     SER F   162                                                      
REMARK 465     SER F   163                                                      
REMARK 465     PRO F   164                                                      
REMARK 465     ASP F   165                                                      
REMARK 465     HIS F   166                                                      
REMARK 465     GLU F   167                                                      
REMARK 465     SER F   168                                                      
REMARK 465     PRO F   169                                                      
REMARK 465     SER F   170                                                      
REMARK 465     GLN F   171                                                      
REMARK 465     GLU F   172                                                      
REMARK 465     SER F   173                                                      
REMARK 465     PRO F   174                                                      
REMARK 465     ASN F   175                                                      
REMARK 465     ALA F   176                                                      
REMARK 465     PRO F   177                                                      
REMARK 465     THR F   178                                                      
REMARK 465     SER F   179                                                      
REMARK 465     THR F   180                                                      
REMARK 465     ALA F   181                                                      
REMARK 465     VAL F   182                                                      
REMARK 465     LEU F   183                                                      
REMARK 465     GLY F   184                                                      
REMARK 465     SER F   185                                                      
REMARK 465     TRP F   186                                                      
REMARK 465     GLY F   187                                                      
REMARK 465     SER F   188                                                      
REMARK 465     PRO F   189                                                      
REMARK 465     PRO F   190                                                      
REMARK 465     GLN F   191                                                      
REMARK 465     PRO F   192                                                      
REMARK 465     SER F   193                                                      
REMARK 465     LEU F   194                                                      
REMARK 465     ALA F   195                                                      
REMARK 465     PRO F   196                                                      
REMARK 465     ARG F   197                                                      
REMARK 465     GLU F   198                                                      
REMARK 465     GLN F   199                                                      
REMARK 465     GLU F   200                                                      
REMARK 465     ALA F   201                                                      
REMARK 465     PRO F   202                                                      
REMARK 465     GLY F   203                                                      
REMARK 465     THR F   204                                                      
REMARK 465     GLN F   205                                                      
REMARK 465     TRP F   206                                                      
REMARK 465     PRO F   207                                                      
REMARK 465     LEU F   208                                                      
REMARK 465     ASP F   209                                                      
REMARK 465     GLU F   210                                                      
REMARK 465     THR F   211                                                      
REMARK 465     SER F   212                                                      
REMARK 465     GLY F   213                                                      
REMARK 465     ILE F   214                                                      
REMARK 465     TYR F   215                                                      
REMARK 465     TYR F   216                                                      
REMARK 465     THR F   217                                                      
REMARK 465     GLU F   218                                                      
REMARK 465     ILE F   219                                                      
REMARK 465     ARG F   220                                                      
REMARK 465     GLU F   221                                                      
REMARK 465     ARG F   222                                                      
REMARK 465     GLU F   223                                                      
REMARK 465     ARG F   224                                                      
REMARK 465     GLU F   225                                                      
REMARK 465     LYS F   226                                                      
REMARK 465     SER F   227                                                      
REMARK 465     GLU F   228                                                      
REMARK 465     LYS F   229                                                      
REMARK 465     GLY F   230                                                      
REMARK 465     ARG F   231                                                      
REMARK 465     PRO F   232                                                      
REMARK 465     PRO F   233                                                      
REMARK 465     TRP F   234                                                      
REMARK 465     ALA F   235                                                      
REMARK 465     ALA F   236                                                      
REMARK 465     VAL F   237                                                      
REMARK 465     VAL F   238                                                      
REMARK 465     GLY F   239                                                      
REMARK 465     THR F   240                                                      
REMARK 465     PRO F   241                                                      
REMARK 465     PRO F   242                                                      
REMARK 465     GLN F   243                                                      
REMARK 465     ALA F   244                                                      
REMARK 465     HIS F   245                                                      
REMARK 465     THR F   246                                                      
REMARK 465     SER F   247                                                      
REMARK 465     LEU F   248                                                      
REMARK 465     GLN F   249                                                      
REMARK 465     PRO F   250                                                      
REMARK 465     HIS F   251                                                      
REMARK 465     HIS F   252                                                      
REMARK 465     HIS F   253                                                      
REMARK 465     PRO F   254                                                      
REMARK 465     TRP F   255                                                      
REMARK 465     GLU F   256                                                      
REMARK 465     PRO F   257                                                      
REMARK 465     SER F   258                                                      
REMARK 465     VAL F   259                                                      
REMARK 465     ARG F   260                                                      
REMARK 465     GLU F   261                                                      
REMARK 465     SER F   262                                                      
REMARK 465     LEU F   263                                                      
REMARK 465     CYS F   264                                                      
REMARK 465     SER F   265                                                      
REMARK 465     THR F   266                                                      
REMARK 465     TRP F   267                                                      
REMARK 465     PRO F   268                                                      
REMARK 465     TRP F   269                                                      
REMARK 465     LYS F   270                                                      
REMARK 465     ASN F   271                                                      
REMARK 465     GLU F   272                                                      
REMARK 465     ASP F   273                                                      
REMARK 465     PHE F   274                                                      
REMARK 465     ASN F   275                                                      
REMARK 465     GLN F   276                                                      
REMARK 465     LYS F   277                                                      
REMARK 465     PHE F   278                                                      
REMARK 465     THR F   279                                                      
REMARK 465     GLN F   280                                                      
REMARK 465     LEU F   281                                                      
REMARK 465     LEU F   282                                                      
REMARK 465     LEU F   283                                                      
REMARK 465     LEU F   284                                                      
REMARK 465     GLN F   285                                                      
REMARK 465     ARG F   286                                                      
REMARK 465     PRO F   287                                                      
REMARK 465     HIS F   288                                                      
REMARK 465     PRO F   289                                                      
REMARK 465     ARG F   290                                                      
REMARK 465     SER F   291                                                      
REMARK 465     GLN F   292                                                      
REMARK 465     ASP F   293                                                      
REMARK 465     PRO F   294                                                      
REMARK 465     LEU F   295                                                      
REMARK 465     VAL F   296                                                      
REMARK 465     LYS F   297                                                      
REMARK 465     ARG F   298                                                      
REMARK 465     SER F   299                                                      
REMARK 465     TRP F   300                                                      
REMARK 465     PRO F   301                                                      
REMARK 465     ASP F   302                                                      
REMARK 465     TYR F   303                                                      
REMARK 465     VAL F   304                                                      
REMARK 465     GLU F   305                                                      
REMARK 465     GLU F   306                                                      
REMARK 465     ASN F   307                                                      
REMARK 465     ARG F   308                                                      
REMARK 465     GLY F   309                                                      
REMARK 465     HIS F   310                                                      
REMARK 465     LEU F   311                                                      
REMARK 465     ILE F   312                                                      
REMARK 465     GLU F   313                                                      
REMARK 465     ILE F   314                                                      
REMARK 465     ARG F   315                                                      
REMARK 465     ASP F   316                                                      
REMARK 465     LEU F   317                                                      
REMARK 465     PHE F   318                                                      
REMARK 465     GLY F   319                                                      
REMARK 465     PRO F   320                                                      
REMARK 465     GLY F   321                                                      
REMARK 465     LEU F   322                                                      
REMARK 465     ASP F   323                                                      
REMARK 465     THR F   324                                                      
REMARK 465     GLN F   325                                                      
REMARK 465     GLU F   326                                                      
REMARK 465     PRO F   327                                                      
REMARK 465     ARG F   328                                                      
REMARK 465     ILE F   329                                                      
REMARK 465     VAL F   330                                                      
REMARK 465     ILE F   331                                                      
REMARK 465     LEU F   332                                                      
REMARK 465     GLN F   333                                                      
REMARK 465     GLY F   334                                                      
REMARK 465     ALA F   335                                                      
REMARK 465     ALA F   336                                                      
REMARK 465     GLY F   337                                                      
REMARK 465     ILE F   338                                                      
REMARK 465     GLY F   339                                                      
REMARK 465     LYS F   340                                                      
REMARK 465     SER F   341                                                      
REMARK 465     THR F   342                                                      
REMARK 465     LEU F   343                                                      
REMARK 465     ALA F   344                                                      
REMARK 465     ARG F   345                                                      
REMARK 465     GLN F   346                                                      
REMARK 465     VAL F   347                                                      
REMARK 465     LYS F   348                                                      
REMARK 465     GLU F   349                                                      
REMARK 465     ALA F   350                                                      
REMARK 465     TRP F   351                                                      
REMARK 465     GLY F   352                                                      
REMARK 465     ARG F   353                                                      
REMARK 465     GLY F   354                                                      
REMARK 465     GLN F   355                                                      
REMARK 465     LEU F   356                                                      
REMARK 465     TYR F   357                                                      
REMARK 465     GLY F   358                                                      
REMARK 465     ASP F   359                                                      
REMARK 465     ARG F   360                                                      
REMARK 465     PHE F   361                                                      
REMARK 465     GLN F   362                                                      
REMARK 465     HIS F   363                                                      
REMARK 465     VAL F   364                                                      
REMARK 465     PHE F   365                                                      
REMARK 465     TYR F   366                                                      
REMARK 465     PHE F   367                                                      
REMARK 465     SER F   368                                                      
REMARK 465     CYS F   369                                                      
REMARK 465     ARG F   370                                                      
REMARK 465     GLU F   371                                                      
REMARK 465     LEU F   372                                                      
REMARK 465     ALA F   373                                                      
REMARK 465     GLN F   374                                                      
REMARK 465     SER F   375                                                      
REMARK 465     LYS F   376                                                      
REMARK 465     VAL F   377                                                      
REMARK 465     VAL F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     LEU F   380                                                      
REMARK 465     ALA F   381                                                      
REMARK 465     GLU F   382                                                      
REMARK 465     LEU F   383                                                      
REMARK 465     ILE F   384                                                      
REMARK 465     GLY F   385                                                      
REMARK 465     LYS F   386                                                      
REMARK 465     ASP F   387                                                      
REMARK 465     GLY F   388                                                      
REMARK 465     THR F   389                                                      
REMARK 465     ALA F   390                                                      
REMARK 465     THR F   391                                                      
REMARK 465     PRO F   392                                                      
REMARK 465     ALA F   393                                                      
REMARK 465     PRO F   394                                                      
REMARK 465     ILE F   395                                                      
REMARK 465     ARG F   396                                                      
REMARK 465     GLN F   397                                                      
REMARK 465     ILE F   398                                                      
REMARK 465     LEU F   399                                                      
REMARK 465     SER F   400                                                      
REMARK 465     ARG F   401                                                      
REMARK 465     PRO F   402                                                      
REMARK 465     GLU F   403                                                      
REMARK 465     ARG F   404                                                      
REMARK 465     LEU F   405                                                      
REMARK 465     LEU F   406                                                      
REMARK 465     PHE F   407                                                      
REMARK 465     ILE F   408                                                      
REMARK 465     LEU F   409                                                      
REMARK 465     ASP F   410                                                      
REMARK 465     GLY F   411                                                      
REMARK 465     VAL F   412                                                      
REMARK 465     ASP F   413                                                      
REMARK 465     GLU F   414                                                      
REMARK 465     PRO F   415                                                      
REMARK 465     GLY F   416                                                      
REMARK 465     TRP F   417                                                      
REMARK 465     VAL F   418                                                      
REMARK 465     LEU F   419                                                      
REMARK 465     GLN F   420                                                      
REMARK 465     GLU F   421                                                      
REMARK 465     PRO F   422                                                      
REMARK 465     SER F   423                                                      
REMARK 465     SER F   424                                                      
REMARK 465     GLU F   425                                                      
REMARK 465     LEU F   426                                                      
REMARK 465     CYS F   427                                                      
REMARK 465     LEU F   428                                                      
REMARK 465     HIS F   429                                                      
REMARK 465     TRP F   430                                                      
REMARK 465     SER F   431                                                      
REMARK 465     GLN F   432                                                      
REMARK 465     PRO F   433                                                      
REMARK 465     GLN F   434                                                      
REMARK 465     PRO F   435                                                      
REMARK 465     ALA F   436                                                      
REMARK 465     ASP F   437                                                      
REMARK 465     ALA F   438                                                      
REMARK 465     LEU F   439                                                      
REMARK 465     LEU F   440                                                      
REMARK 465     GLY F   441                                                      
REMARK 465     SER F   442                                                      
REMARK 465     LEU F   443                                                      
REMARK 465     LEU F   444                                                      
REMARK 465     GLY F   445                                                      
REMARK 465     LYS F   446                                                      
REMARK 465     THR F   447                                                      
REMARK 465     ILE F   448                                                      
REMARK 465     LEU F   449                                                      
REMARK 465     PRO F   450                                                      
REMARK 465     GLU F   451                                                      
REMARK 465     ALA F   452                                                      
REMARK 465     SER F   453                                                      
REMARK 465     PHE F   454                                                      
REMARK 465     LEU F   455                                                      
REMARK 465     ILE F   456                                                      
REMARK 465     THR F   457                                                      
REMARK 465     ALA F   458                                                      
REMARK 465     ARG F   459                                                      
REMARK 465     THR F   460                                                      
REMARK 465     THR F   461                                                      
REMARK 465     ALA F   462                                                      
REMARK 465     LEU F   463                                                      
REMARK 465     GLN F   464                                                      
REMARK 465     ASN F   465                                                      
REMARK 465     LEU F   466                                                      
REMARK 465     ILE F   467                                                      
REMARK 465     PRO F   468                                                      
REMARK 465     SER F   469                                                      
REMARK 465     LEU F   470                                                      
REMARK 465     GLU F   471                                                      
REMARK 465     GLN F   472                                                      
REMARK 465     ALA F   473                                                      
REMARK 465     ARG F   474                                                      
REMARK 465     TRP F   475                                                      
REMARK 465     VAL F   476                                                      
REMARK 465     GLU F   477                                                      
REMARK 465     VAL F   478                                                      
REMARK 465     LEU F   479                                                      
REMARK 465     GLY F   480                                                      
REMARK 465     PHE F   481                                                      
REMARK 465     SER F   482                                                      
REMARK 465     GLU F   483                                                      
REMARK 465     SER F   484                                                      
REMARK 465     SER F   485                                                      
REMARK 465     ARG F   486                                                      
REMARK 465     LYS F   487                                                      
REMARK 465     GLU F   488                                                      
REMARK 465     TYR F   489                                                      
REMARK 465     PHE F   490                                                      
REMARK 465     TYR F   491                                                      
REMARK 465     ARG F   492                                                      
REMARK 465     TYR F   493                                                      
REMARK 465     PHE F   494                                                      
REMARK 465     THR F   495                                                      
REMARK 465     ASP F   496                                                      
REMARK 465     GLU F   497                                                      
REMARK 465     ARG F   498                                                      
REMARK 465     GLN F   499                                                      
REMARK 465     ALA F   500                                                      
REMARK 465     ILE F   501                                                      
REMARK 465     ARG F   502                                                      
REMARK 465     ALA F   503                                                      
REMARK 465     PHE F   504                                                      
REMARK 465     ARG F   505                                                      
REMARK 465     LEU F   506                                                      
REMARK 465     VAL F   507                                                      
REMARK 465     LYS F   508                                                      
REMARK 465     SER F   509                                                      
REMARK 465     ASN F   510                                                      
REMARK 465     LYS F   511                                                      
REMARK 465     GLU F   512                                                      
REMARK 465     LEU F   513                                                      
REMARK 465     TRP F   514                                                      
REMARK 465     ALA F   515                                                      
REMARK 465     LEU F   516                                                      
REMARK 465     CYS F   517                                                      
REMARK 465     LEU F   518                                                      
REMARK 465     VAL F   519                                                      
REMARK 465     PRO F   520                                                      
REMARK 465     TRP F   521                                                      
REMARK 465     VAL F   522                                                      
REMARK 465     SER F   523                                                      
REMARK 465     TRP F   524                                                      
REMARK 465     LEU F   525                                                      
REMARK 465     ALA F   526                                                      
REMARK 465     CYS F   527                                                      
REMARK 465     THR F   528                                                      
REMARK 465     CYS F   529                                                      
REMARK 465     LEU F   530                                                      
REMARK 465     MET F   531                                                      
REMARK 465     GLN F   532                                                      
REMARK 465     GLN F   533                                                      
REMARK 465     MET F   534                                                      
REMARK 465     LYS F   535                                                      
REMARK 465     ARG F   536                                                      
REMARK 465     LYS F   537                                                      
REMARK 465     GLU F   538                                                      
REMARK 465     LYS F   539                                                      
REMARK 465     LEU F   540                                                      
REMARK 465     THR F   541                                                      
REMARK 465     LEU F   542                                                      
REMARK 465     THR F   543                                                      
REMARK 465     SER F   544                                                      
REMARK 465     LYS F   545                                                      
REMARK 465     THR F   546                                                      
REMARK 465     THR F   547                                                      
REMARK 465     THR F   548                                                      
REMARK 465     THR F   549                                                      
REMARK 465     LEU F   550                                                      
REMARK 465     CYS F   551                                                      
REMARK 465     LEU F   552                                                      
REMARK 465     HIS F   553                                                      
REMARK 465     TYR F   554                                                      
REMARK 465     LEU F   555                                                      
REMARK 465     ALA F   556                                                      
REMARK 465     GLN F   557                                                      
REMARK 465     ALA F   558                                                      
REMARK 465     LEU F   559                                                      
REMARK 465     GLN F   560                                                      
REMARK 465     ALA F   561                                                      
REMARK 465     GLN F   562                                                      
REMARK 465     PRO F   563                                                      
REMARK 465     LEU F   564                                                      
REMARK 465     GLY F   565                                                      
REMARK 465     PRO F   566                                                      
REMARK 465     GLN F   567                                                      
REMARK 465     LEU F   568                                                      
REMARK 465     ARG F   569                                                      
REMARK 465     ASP F   570                                                      
REMARK 465     LEU F   571                                                      
REMARK 465     CYS F   572                                                      
REMARK 465     SER F   573                                                      
REMARK 465     LEU F   574                                                      
REMARK 465     ALA F   575                                                      
REMARK 465     ALA F   576                                                      
REMARK 465     GLU F   577                                                      
REMARK 465     GLY F   578                                                      
REMARK 465     ILE F   579                                                      
REMARK 465     TRP F   580                                                      
REMARK 465     GLN F   581                                                      
REMARK 465     LYS F   582                                                      
REMARK 465     LYS F   583                                                      
REMARK 465     THR F   584                                                      
REMARK 465     LEU F   585                                                      
REMARK 465     PHE F   586                                                      
REMARK 465     SER F   587                                                      
REMARK 465     PRO F   588                                                      
REMARK 465     ASP F   589                                                      
REMARK 465     ASP F   590                                                      
REMARK 465     LEU F   591                                                      
REMARK 465     ARG F   592                                                      
REMARK 465     LYS F   593                                                      
REMARK 465     HIS F   594                                                      
REMARK 465     GLY F   595                                                      
REMARK 465     LEU F   596                                                      
REMARK 465     ASP F   597                                                      
REMARK 465     GLY F   598                                                      
REMARK 465     ALA F   599                                                      
REMARK 465     ILE F   600                                                      
REMARK 465     ILE F   601                                                      
REMARK 465     SER F   602                                                      
REMARK 465     THR F   603                                                      
REMARK 465     PHE F   604                                                      
REMARK 465     LEU F   605                                                      
REMARK 465     LYS F   606                                                      
REMARK 465     MET F   607                                                      
REMARK 465     GLY F   608                                                      
REMARK 465     ILE F   609                                                      
REMARK 465     LEU F   610                                                      
REMARK 465     GLN F   611                                                      
REMARK 465     GLU F   612                                                      
REMARK 465     HIS F   613                                                      
REMARK 465     PRO F   614                                                      
REMARK 465     ILE F   615                                                      
REMARK 465     PRO F   616                                                      
REMARK 465     LEU F   617                                                      
REMARK 465     SER F   618                                                      
REMARK 465     TYR F   619                                                      
REMARK 465     SER F   620                                                      
REMARK 465     PHE F   621                                                      
REMARK 465     ILE F   622                                                      
REMARK 465     HIS F   623                                                      
REMARK 465     LEU F   624                                                      
REMARK 465     CYS F   625                                                      
REMARK 465     PHE F   626                                                      
REMARK 465     GLN F   627                                                      
REMARK 465     GLU F   628                                                      
REMARK 465     PHE F   629                                                      
REMARK 465     PHE F   630                                                      
REMARK 465     ALA F   631                                                      
REMARK 465     ALA F   632                                                      
REMARK 465     MET F   633                                                      
REMARK 465     SER F   634                                                      
REMARK 465     TYR F   635                                                      
REMARK 465     VAL F   636                                                      
REMARK 465     LEU F   637                                                      
REMARK 465     GLU F   638                                                      
REMARK 465     ASP F   639                                                      
REMARK 465     GLU F   640                                                      
REMARK 465     LYS F   641                                                      
REMARK 465     GLY F   642                                                      
REMARK 465     ARG F   643                                                      
REMARK 465     GLY F   644                                                      
REMARK 465     LYS F   645                                                      
REMARK 465     HIS F   646                                                      
REMARK 465     SER F   647                                                      
REMARK 465     ASN F   648                                                      
REMARK 465     CYS F   649                                                      
REMARK 465     ILE F   650                                                      
REMARK 465     ILE F   651                                                      
REMARK 465     ASP F   652                                                      
REMARK 465     LEU F   653                                                      
REMARK 465     GLU F   654                                                      
REMARK 465     LYS F   655                                                      
REMARK 465     THR F   656                                                      
REMARK 465     LEU F   657                                                      
REMARK 465     GLU F   658                                                      
REMARK 465     ALA F   659                                                      
REMARK 465     TYR F   660                                                      
REMARK 465     GLY F   661                                                      
REMARK 465     ILE F   662                                                      
REMARK 465     HIS F   663                                                      
REMARK 465     GLY F   664                                                      
REMARK 465     LEU F   665                                                      
REMARK 465     PHE F   666                                                      
REMARK 465     GLY F   667                                                      
REMARK 465     ALA F   668                                                      
REMARK 465     SER F   669                                                      
REMARK 465     THR F   670                                                      
REMARK 465     THR F   671                                                      
REMARK 465     ARG F   672                                                      
REMARK 465     PHE F   673                                                      
REMARK 465     LEU F   674                                                      
REMARK 465     LEU F   675                                                      
REMARK 465     GLY F   676                                                      
REMARK 465     LEU F   677                                                      
REMARK 465     LEU F   678                                                      
REMARK 465     SER F   679                                                      
REMARK 465     ASP F   680                                                      
REMARK 465     GLU F   681                                                      
REMARK 465     GLY F   682                                                      
REMARK 465     GLU F   683                                                      
REMARK 465     ARG F   684                                                      
REMARK 465     GLU F   685                                                      
REMARK 465     MET F   686                                                      
REMARK 465     GLU F   687                                                      
REMARK 465     ASN F   688                                                      
REMARK 465     ILE F   689                                                      
REMARK 465     PHE F   690                                                      
REMARK 465     HIS F   691                                                      
REMARK 465     CYS F   692                                                      
REMARK 465     ARG F   693                                                      
REMARK 465     LEU F   694                                                      
REMARK 465     SER F   695                                                      
REMARK 465     GLN F   696                                                      
REMARK 465     GLY F   697                                                      
REMARK 465     ARG F   698                                                      
REMARK 465     ASN F   699                                                      
REMARK 465     LEU F   700                                                      
REMARK 465     MET F   701                                                      
REMARK 465     GLN F   702                                                      
REMARK 465     TRP F   703                                                      
REMARK 465     VAL F   704                                                      
REMARK 465     PRO F   705                                                      
REMARK 465     SER F   706                                                      
REMARK 465     LEU F   707                                                      
REMARK 465     GLN F   708                                                      
REMARK 465     LEU F   709                                                      
REMARK 465     LEU F   710                                                      
REMARK 465     LEU F   711                                                      
REMARK 465     GLN F   712                                                      
REMARK 465     PRO F   713                                                      
REMARK 465     HIS F   714                                                      
REMARK 465     SER F   715                                                      
REMARK 465     LEU F   716                                                      
REMARK 465     GLU F   717                                                      
REMARK 465     SER F   718                                                      
REMARK 465     LEU F   719                                                      
REMARK 465     HIS F   720                                                      
REMARK 465     CYS F   721                                                      
REMARK 465     LEU F   722                                                      
REMARK 465     TYR F   723                                                      
REMARK 465     GLU F   724                                                      
REMARK 465     THR F   725                                                      
REMARK 465     ARG F   726                                                      
REMARK 465     ASN F   727                                                      
REMARK 465     LYS F   728                                                      
REMARK 465     THR F   729                                                      
REMARK 465     PHE F   730                                                      
REMARK 465     LEU F   731                                                      
REMARK 465     THR F   732                                                      
REMARK 465     GLN F   733                                                      
REMARK 465     VAL F   734                                                      
REMARK 465     MET F   735                                                      
REMARK 465     ALA F   736                                                      
REMARK 465     HIS F   737                                                      
REMARK 465     PHE F   738                                                      
REMARK 465     GLU F   739                                                      
REMARK 465     GLU F   740                                                      
REMARK 465     MET F   741                                                      
REMARK 465     GLY F   742                                                      
REMARK 465     MET F   743                                                      
REMARK 465     CYS F   744                                                      
REMARK 465     VAL F   745                                                      
REMARK 465     GLU F   746                                                      
REMARK 465     THR F   747                                                      
REMARK 465     ASP F   748                                                      
REMARK 465     MET F   749                                                      
REMARK 465     GLU F   750                                                      
REMARK 465     LEU F   751                                                      
REMARK 465     LEU F   752                                                      
REMARK 465     VAL F   753                                                      
REMARK 465     CYS F   754                                                      
REMARK 465     THR F   755                                                      
REMARK 465     PHE F   756                                                      
REMARK 465     CYS F   757                                                      
REMARK 465     ILE F   758                                                      
REMARK 465     LYS F   759                                                      
REMARK 465     PHE F   760                                                      
REMARK 465     SER F   761                                                      
REMARK 465     ARG F   762                                                      
REMARK 465     HIS F   763                                                      
REMARK 465     VAL F   764                                                      
REMARK 465     LYS F   765                                                      
REMARK 465     LYS F   766                                                      
REMARK 465     LEU F   767                                                      
REMARK 465     GLN F   768                                                      
REMARK 465     LEU F   769                                                      
REMARK 465     ILE F   770                                                      
REMARK 465     GLU F   771                                                      
REMARK 465     GLY F   772                                                      
REMARK 465     ARG F   773                                                      
REMARK 465     GLN F   774                                                      
REMARK 465     HIS F   775                                                      
REMARK 465     ARG F   776                                                      
REMARK 465     SER F   777                                                      
REMARK 465     THR F   778                                                      
REMARK 465     TRP F   779                                                      
REMARK 465     SER F   780                                                      
REMARK 465     PRO F   781                                                      
REMARK 465     THR F   782                                                      
REMARK 465     MET F   783                                                      
REMARK 465     VAL F   784                                                      
REMARK 465     VAL F   785                                                      
REMARK 465     LEU F   786                                                      
REMARK 465     PHE F   787                                                      
REMARK 465     ARG F   788                                                      
REMARK 465     TRP F   789                                                      
REMARK 465     VAL F   790                                                      
REMARK 465     PRO F   791                                                      
REMARK 465     VAL F   792                                                      
REMARK 465     THR F   793                                                      
REMARK 465     ASP F   794                                                      
REMARK 465     ALA F   795                                                      
REMARK 465     TYR F   796                                                      
REMARK 465     TRP F   797                                                      
REMARK 465     GLN F   798                                                      
REMARK 465     ILE F   799                                                      
REMARK 465     LEU F   800                                                      
REMARK 465     PHE F   801                                                      
REMARK 465     SER F   802                                                      
REMARK 465     VAL F   803                                                      
REMARK 465     LEU F   804                                                      
REMARK 465     LYS F   805                                                      
REMARK 465     VAL F   806                                                      
REMARK 465     THR F   807                                                      
REMARK 465     ARG F   808                                                      
REMARK 465     ASN F   809                                                      
REMARK 465     LEU F   810                                                      
REMARK 465     LYS F   811                                                      
REMARK 465     GLU F   812                                                      
REMARK 465     LEU F   813                                                      
REMARK 465     ASP F   814                                                      
REMARK 465     LEU F   815                                                      
REMARK 465     SER F   816                                                      
REMARK 465     GLY F   817                                                      
REMARK 465     ASN F   818                                                      
REMARK 465     SER F   819                                                      
REMARK 465     LEU F   820                                                      
REMARK 465     SER F   821                                                      
REMARK 465     HIS F   822                                                      
REMARK 465     SER F   823                                                      
REMARK 465     ALA F   824                                                      
REMARK 465     VAL F   825                                                      
REMARK 465     LYS F   826                                                      
REMARK 465     SER F   827                                                      
REMARK 465     LEU F   828                                                      
REMARK 465     CYS F   829                                                      
REMARK 465     LYS F   830                                                      
REMARK 465     THR F   831                                                      
REMARK 465     LEU F   832                                                      
REMARK 465     ARG F   833                                                      
REMARK 465     ARG F   834                                                      
REMARK 465     PRO F   835                                                      
REMARK 465     ARG F   836                                                      
REMARK 465     CYS F   837                                                      
REMARK 465     LEU F   838                                                      
REMARK 465     LEU F   839                                                      
REMARK 465     GLU F   840                                                      
REMARK 465     THR F   841                                                      
REMARK 465     LEU F   842                                                      
REMARK 465     ARG F   843                                                      
REMARK 465     LEU F   844                                                      
REMARK 465     ALA F   845                                                      
REMARK 465     GLY F   846                                                      
REMARK 465     CYS F   847                                                      
REMARK 465     GLY F   848                                                      
REMARK 465     LEU F   849                                                      
REMARK 465     THR F   850                                                      
REMARK 465     ALA F   851                                                      
REMARK 465     GLU F   852                                                      
REMARK 465     ASP F   853                                                      
REMARK 465     CYS F   854                                                      
REMARK 465     LYS F   855                                                      
REMARK 465     ASP F   856                                                      
REMARK 465     LEU F   857                                                      
REMARK 465     ALA F   858                                                      
REMARK 465     PHE F   859                                                      
REMARK 465     GLY F   860                                                      
REMARK 465     LEU F   861                                                      
REMARK 465     ARG F   862                                                      
REMARK 465     ALA F   863                                                      
REMARK 465     ASN F   864                                                      
REMARK 465     GLN F   865                                                      
REMARK 465     THR F   866                                                      
REMARK 465     LEU F   867                                                      
REMARK 465     THR F   868                                                      
REMARK 465     GLU F   869                                                      
REMARK 465     LEU F   870                                                      
REMARK 465     ASP F   871                                                      
REMARK 465     LEU F   872                                                      
REMARK 465     SER F   873                                                      
REMARK 465     PHE F   874                                                      
REMARK 465     ASN F   875                                                      
REMARK 465     VAL F   876                                                      
REMARK 465     LEU F   877                                                      
REMARK 465     THR F   878                                                      
REMARK 465     ASP F   879                                                      
REMARK 465     ALA F   880                                                      
REMARK 465     GLY F   881                                                      
REMARK 465     ALA F   882                                                      
REMARK 465     LYS F   883                                                      
REMARK 465     HIS F   884                                                      
REMARK 465     LEU F   885                                                      
REMARK 465     CYS F   886                                                      
REMARK 465     GLN F   887                                                      
REMARK 465     ARG F   888                                                      
REMARK 465     LEU F   889                                                      
REMARK 465     ARG F   890                                                      
REMARK 465     GLN F   891                                                      
REMARK 465     PRO F   892                                                      
REMARK 465     SER F   893                                                      
REMARK 465     CYS F   894                                                      
REMARK 465     LYS F   895                                                      
REMARK 465     LEU F   896                                                      
REMARK 465     GLN F   897                                                      
REMARK 465     ARG F   898                                                      
REMARK 465     LEU F   899                                                      
REMARK 465     GLN F   900                                                      
REMARK 465     LEU F   901                                                      
REMARK 465     VAL F   902                                                      
REMARK 465     SER F   903                                                      
REMARK 465     CYS F   904                                                      
REMARK 465     GLY F   905                                                      
REMARK 465     LEU F   906                                                      
REMARK 465     THR F   907                                                      
REMARK 465     SER F   908                                                      
REMARK 465     ASP F   909                                                      
REMARK 465     CYS F   910                                                      
REMARK 465     CYS F   911                                                      
REMARK 465     GLN F   912                                                      
REMARK 465     ASP F   913                                                      
REMARK 465     LEU F   914                                                      
REMARK 465     ALA F   915                                                      
REMARK 465     SER F   916                                                      
REMARK 465     VAL F   917                                                      
REMARK 465     LEU F   918                                                      
REMARK 465     SER F   919                                                      
REMARK 465     ALA F   920                                                      
REMARK 465     SER F   921                                                      
REMARK 465     PRO F   922                                                      
REMARK 465     SER F   923                                                      
REMARK 465     LEU F   924                                                      
REMARK 465     LYS F   925                                                      
REMARK 465     GLU F   926                                                      
REMARK 465     LEU F   927                                                      
REMARK 465     ASP F   928                                                      
REMARK 465     LEU F   929                                                      
REMARK 465     GLN F   930                                                      
REMARK 465     GLN F   931                                                      
REMARK 465     ASN F   932                                                      
REMARK 465     ASN F   933                                                      
REMARK 465     LEU F   934                                                      
REMARK 465     ASP F   935                                                      
REMARK 465     ASP F   936                                                      
REMARK 465     VAL F   937                                                      
REMARK 465     GLY F   938                                                      
REMARK 465     VAL F   939                                                      
REMARK 465     ARG F   940                                                      
REMARK 465     LEU F   941                                                      
REMARK 465     LEU F   942                                                      
REMARK 465     CYS F   943                                                      
REMARK 465     GLU F   944                                                      
REMARK 465     GLY F   945                                                      
REMARK 465     LEU F   946                                                      
REMARK 465     ARG F   947                                                      
REMARK 465     HIS F   948                                                      
REMARK 465     PRO F   949                                                      
REMARK 465     ALA F   950                                                      
REMARK 465     CYS F   951                                                      
REMARK 465     LYS F   952                                                      
REMARK 465     LEU F   953                                                      
REMARK 465     ILE F   954                                                      
REMARK 465     ARG F   955                                                      
REMARK 465     LEU F   956                                                      
REMARK 465     GLY F   957                                                      
REMARK 465     LEU F   958                                                      
REMARK 465     ASP F   959                                                      
REMARK 465     GLN F   960                                                      
REMARK 465     THR F   961                                                      
REMARK 465     THR F   962                                                      
REMARK 465     LEU F   963                                                      
REMARK 465     SER F   964                                                      
REMARK 465     ASP F   965                                                      
REMARK 465     GLU F   966                                                      
REMARK 465     MET F   967                                                      
REMARK 465     ARG F   968                                                      
REMARK 465     GLN F   969                                                      
REMARK 465     GLU F   970                                                      
REMARK 465     LEU F   971                                                      
REMARK 465     ARG F   972                                                      
REMARK 465     ALA F   973                                                      
REMARK 465     LEU F   974                                                      
REMARK 465     GLU F   975                                                      
REMARK 465     GLN F   976                                                      
REMARK 465     GLU F   977                                                      
REMARK 465     LYS F   978                                                      
REMARK 465     PRO F   979                                                      
REMARK 465     GLN F   980                                                      
REMARK 465     LEU F   981                                                      
REMARK 465     LEU F   982                                                      
REMARK 465     ILE F   983                                                      
REMARK 465     PHE F   984                                                      
REMARK 465     SER F   985                                                      
REMARK 465     ARG F   986                                                      
REMARK 465     ARG F   987                                                      
REMARK 465     LYS F   988                                                      
REMARK 465     PRO F   989                                                      
REMARK 465     SER F   990                                                      
REMARK 465     VAL F   991                                                      
REMARK 465     MET F   992                                                      
REMARK 465     THR F   993                                                      
REMARK 465     PRO F   994                                                      
REMARK 465     THR F   995                                                      
REMARK 465     GLU F   996                                                      
REMARK 465     GLY F   997                                                      
REMARK 465     LEU F   998                                                      
REMARK 465     ASP F   999                                                      
REMARK 465     THR F  1000                                                      
REMARK 465     GLY F  1001                                                      
REMARK 465     GLU F  1002                                                      
REMARK 465     MET F  1003                                                      
REMARK 465     SER F  1004                                                      
REMARK 465     ASN F  1005                                                      
REMARK 465     SER F  1006                                                      
REMARK 465     THR F  1007                                                      
REMARK 465     SER F  1008                                                      
REMARK 465     SER F  1009                                                      
REMARK 465     LEU F  1010                                                      
REMARK 465     LYS F  1011                                                      
REMARK 465     ARG F  1012                                                      
REMARK 465     GLN F  1013                                                      
REMARK 465     ARG F  1014                                                      
REMARK 465     LEU F  1015                                                      
REMARK 465     GLY F  1016                                                      
REMARK 465     SER F  1017                                                      
REMARK 465     GLU F  1018                                                      
REMARK 465     ARG F  1019                                                      
REMARK 465     ALA F  1020                                                      
REMARK 465     ALA F  1021                                                      
REMARK 465     SER F  1022                                                      
REMARK 465     HIS F  1023                                                      
REMARK 465     VAL F  1024                                                      
REMARK 465     ALA F  1025                                                      
REMARK 465     GLN F  1026                                                      
REMARK 465     ALA F  1027                                                      
REMARK 465     ASN F  1028                                                      
REMARK 465     LEU F  1029                                                      
REMARK 465     LYS F  1030                                                      
REMARK 465     LEU F  1031                                                      
REMARK 465     LEU F  1032                                                      
REMARK 465     ASP F  1033                                                      
REMARK 465     VAL F  1034                                                      
REMARK 465     SER F  1035                                                      
REMARK 465     LYS F  1036                                                      
REMARK 465     ILE F  1037                                                      
REMARK 465     PHE F  1038                                                      
REMARK 465     PRO F  1039                                                      
REMARK 465     ILE F  1040                                                      
REMARK 465     ALA F  1041                                                      
REMARK 465     GLU F  1042                                                      
REMARK 465     ILE F  1043                                                      
REMARK 465     ALA F  1044                                                      
REMARK 465     GLU F  1045                                                      
REMARK 465     GLU F  1046                                                      
REMARK 465     SER F  1047                                                      
REMARK 465     SER F  1048                                                      
REMARK 465     PRO F  1049                                                      
REMARK 465     GLU F  1050                                                      
REMARK 465     VAL F  1051                                                      
REMARK 465     VAL F  1052                                                      
REMARK 465     PRO F  1053                                                      
REMARK 465     VAL F  1054                                                      
REMARK 465     GLU F  1055                                                      
REMARK 465     LEU F  1056                                                      
REMARK 465     LEU F  1057                                                      
REMARK 465     CYS F  1058                                                      
REMARK 465     VAL F  1059                                                      
REMARK 465     PRO F  1060                                                      
REMARK 465     SER F  1061                                                      
REMARK 465     PRO F  1062                                                      
REMARK 465     ALA F  1063                                                      
REMARK 465     SER F  1064                                                      
REMARK 465     GLN F  1065                                                      
REMARK 465     GLY F  1066                                                      
REMARK 465     ASP F  1067                                                      
REMARK 465     LEU F  1068                                                      
REMARK 465     HIS F  1069                                                      
REMARK 465     THR F  1070                                                      
REMARK 465     LYS F  1071                                                      
REMARK 465     PRO F  1072                                                      
REMARK 465     LEU F  1073                                                      
REMARK 465     GLY F  1074                                                      
REMARK 465     THR F  1075                                                      
REMARK 465     ASP F  1076                                                      
REMARK 465     ASP F  1077                                                      
REMARK 465     ASP F  1078                                                      
REMARK 465     PHE F  1079                                                      
REMARK 465     TRP F  1080                                                      
REMARK 465     GLY F  1081                                                      
REMARK 465     PRO F  1082                                                      
REMARK 465     THR F  1083                                                      
REMARK 465     GLY F  1084                                                      
REMARK 465     PRO F  1085                                                      
REMARK 465     VAL F  1086                                                      
REMARK 465     ALA F  1087                                                      
REMARK 465     THR F  1088                                                      
REMARK 465     GLU F  1089                                                      
REMARK 465     VAL F  1090                                                      
REMARK 465     VAL F  1091                                                      
REMARK 465     ASP F  1092                                                      
REMARK 465     LYS F  1093                                                      
REMARK 465     GLU F  1094                                                      
REMARK 465     LYS F  1095                                                      
REMARK 465     ASN F  1096                                                      
REMARK 465     LEU F  1097                                                      
REMARK 465     TYR F  1098                                                      
REMARK 465     ARG F  1099                                                      
REMARK 465     VAL F  1100                                                      
REMARK 465     HIS F  1101                                                      
REMARK 465     PHE F  1102                                                      
REMARK 465     PRO F  1103                                                      
REMARK 465     VAL F  1104                                                      
REMARK 465     ALA F  1105                                                      
REMARK 465     GLY F  1106                                                      
REMARK 465     SER F  1107                                                      
REMARK 465     TYR F  1108                                                      
REMARK 465     ARG F  1109                                                      
REMARK 465     TRP F  1110                                                      
REMARK 465     PRO F  1111                                                      
REMARK 465     ASN F  1112                                                      
REMARK 465     THR F  1113                                                      
REMARK 465     GLY F  1114                                                      
REMARK 465     LEU F  1115                                                      
REMARK 465     CYS F  1116                                                      
REMARK 465     PHE F  1117                                                      
REMARK 465     VAL F  1118                                                      
REMARK 465     MET F  1119                                                      
REMARK 465     ARG F  1120                                                      
REMARK 465     GLU F  1121                                                      
REMARK 465     ALA F  1122                                                      
REMARK 465     VAL F  1123                                                      
REMARK 465     THR F  1124                                                      
REMARK 465     VAL F  1125                                                      
REMARK 465     GLU F  1126                                                      
REMARK 465     ILE F  1127                                                      
REMARK 465     GLU F  1128                                                      
REMARK 465     PHE F  1129                                                      
REMARK 465     CYS F  1130                                                      
REMARK 465     VAL F  1131                                                      
REMARK 465     TRP F  1132                                                      
REMARK 465     ASP F  1133                                                      
REMARK 465     GLN F  1134                                                      
REMARK 465     PHE F  1135                                                      
REMARK 465     LEU F  1136                                                      
REMARK 465     GLY F  1137                                                      
REMARK 465     GLU F  1138                                                      
REMARK 465     ILE F  1139                                                      
REMARK 465     ASN F  1140                                                      
REMARK 465     PRO F  1141                                                      
REMARK 465     GLN F  1142                                                      
REMARK 465     HIS F  1143                                                      
REMARK 465     SER F  1144                                                      
REMARK 465     TRP F  1145                                                      
REMARK 465     MET F  1146                                                      
REMARK 465     VAL F  1147                                                      
REMARK 465     ALA F  1148                                                      
REMARK 465     GLY F  1149                                                      
REMARK 465     PRO F  1150                                                      
REMARK 465     LEU F  1151                                                      
REMARK 465     LEU F  1152                                                      
REMARK 465     ASP F  1153                                                      
REMARK 465     ILE F  1154                                                      
REMARK 465     LYS F  1155                                                      
REMARK 465     ALA F  1156                                                      
REMARK 465     GLU F  1157                                                      
REMARK 465     PRO F  1158                                                      
REMARK 465     GLY F  1159                                                      
REMARK 465     ALA F  1160                                                      
REMARK 465     VAL F  1161                                                      
REMARK 465     GLU F  1162                                                      
REMARK 465     ALA F  1163                                                      
REMARK 465     VAL F  1164                                                      
REMARK 465     HIS F  1165                                                      
REMARK 465     LEU F  1166                                                      
REMARK 465     PRO F  1167                                                      
REMARK 465     HIS F  1168                                                      
REMARK 465     PHE F  1169                                                      
REMARK 465     VAL F  1170                                                      
REMARK 465     ALA F  1171                                                      
REMARK 465     LEU F  1172                                                      
REMARK 465     GLN F  1173                                                      
REMARK 465     GLY F  1174                                                      
REMARK 465     GLY F  1175                                                      
REMARK 465     HIS F  1176                                                      
REMARK 465     VAL F  1177                                                      
REMARK 465     ASP F  1178                                                      
REMARK 465     THR F  1179                                                      
REMARK 465     SER F  1180                                                      
REMARK 465     LEU F  1181                                                      
REMARK 465     PHE F  1182                                                      
REMARK 465     GLN F  1183                                                      
REMARK 465     MET F  1184                                                      
REMARK 465     ALA F  1185                                                      
REMARK 465     HIS F  1186                                                      
REMARK 465     PHE F  1187                                                      
REMARK 465     LYS F  1188                                                      
REMARK 465     GLU F  1189                                                      
REMARK 465     GLU F  1190                                                      
REMARK 465     GLY F  1191                                                      
REMARK 465     MET F  1192                                                      
REMARK 465     LEU F  1193                                                      
REMARK 465     LEU F  1194                                                      
REMARK 465     GLU F  1195                                                      
REMARK 465     LYS F  1196                                                      
REMARK 465     PRO F  1197                                                      
REMARK 465     ALA F  1198                                                      
REMARK 465     ARG F  1199                                                      
REMARK 465     VAL F  1200                                                      
REMARK 465     GLU F  1201                                                      
REMARK 465     LEU F  1202                                                      
REMARK 465     HIS F  1203                                                      
REMARK 465     HIS F  1204                                                      
REMARK 465     ILE F  1205                                                      
REMARK 465     VAL F  1206                                                      
REMARK 465     LEU F  1207                                                      
REMARK 465     GLU F  1208                                                      
REMARK 465     ASN F  1209                                                      
REMARK 465     PRO F  1210                                                      
REMARK 465     SER F  1211                                                      
REMARK 465     PHE F  1212                                                      
REMARK 465     LYS F  1351                                                      
REMARK 465     PRO F  1352                                                      
REMARK 465     GLY F  1353                                                      
REMARK 465     ASP F  1354                                                      
REMARK 465     LEU F  1355                                                      
REMARK 465     MET F  1356                                                      
REMARK 465     PRO F  1357                                                      
REMARK 465     ALA F  1358                                                      
REMARK 465     THR F  1359                                                      
REMARK 465     THR F  1360                                                      
REMARK 465     LEU F  1361                                                      
REMARK 465     ILE F  1362                                                      
REMARK 465     PRO F  1363                                                      
REMARK 465     PRO F  1364                                                      
REMARK 465     ALA F  1365                                                      
REMARK 465     ARG F  1366                                                      
REMARK 465     ILE F  1367                                                      
REMARK 465     ALA F  1368                                                      
REMARK 465     VAL F  1369                                                      
REMARK 465     PRO F  1370                                                      
REMARK 465     SER F  1371                                                      
REMARK 465     PRO F  1372                                                      
REMARK 465     LEU F  1373                                                      
REMARK 465     ASP F  1374                                                      
REMARK 465     ALA F  1375                                                      
REMARK 465     PRO F  1376                                                      
REMARK 465     GLN F  1377                                                      
REMARK 465     LEU F  1378                                                      
REMARK 465     LEU F  1379                                                      
REMARK 465     HIS F  1380                                                      
REMARK 465     PHE F  1381                                                      
REMARK 465     VAL F  1382                                                      
REMARK 465     ASP F  1383                                                      
REMARK 465     GLN F  1384                                                      
REMARK 465     TYR F  1385                                                      
REMARK 465     ARG F  1386                                                      
REMARK 465     GLU F  1387                                                      
REMARK 465     GLN F  1388                                                      
REMARK 465     LEU F  1389                                                      
REMARK 465     ILE F  1390                                                      
REMARK 465     ALA F  1391                                                      
REMARK 465     ARG F  1392                                                      
REMARK 465     VAL F  1393                                                      
REMARK 465     THR F  1394                                                      
REMARK 465     SER F  1395                                                      
REMARK 465     VAL F  1396                                                      
REMARK 465     GLU F  1397                                                      
REMARK 465     VAL F  1398                                                      
REMARK 465     VAL F  1399                                                      
REMARK 465     LEU F  1400                                                      
REMARK 465     ASP F  1401                                                      
REMARK 465     LYS F  1402                                                      
REMARK 465     LEU F  1403                                                      
REMARK 465     HIS F  1404                                                      
REMARK 465     GLY F  1405                                                      
REMARK 465     GLN F  1406                                                      
REMARK 465     VAL F  1407                                                      
REMARK 465     LEU F  1408                                                      
REMARK 465     SER F  1409                                                      
REMARK 465     GLN F  1410                                                      
REMARK 465     GLU F  1411                                                      
REMARK 465     GLN F  1412                                                      
REMARK 465     TYR F  1413                                                      
REMARK 465     GLU F  1414                                                      
REMARK 465     ARG F  1415                                                      
REMARK 465     VAL F  1416                                                      
REMARK 465     LEU F  1417                                                      
REMARK 465     ALA F  1418                                                      
REMARK 465     GLU F  1419                                                      
REMARK 465     ASN F  1420                                                      
REMARK 465     THR F  1421                                                      
REMARK 465     ARG F  1422                                                      
REMARK 465     PRO F  1423                                                      
REMARK 465     SER F  1424                                                      
REMARK 465     GLN F  1425                                                      
REMARK 465     MET F  1426                                                      
REMARK 465     ARG F  1427                                                      
REMARK 465     LYS F  1428                                                      
REMARK 465     LEU F  1429                                                      
REMARK 465     PHE F  1430                                                      
REMARK 465     SER F  1431                                                      
REMARK 465     LEU F  1432                                                      
REMARK 465     SER F  1433                                                      
REMARK 465     GLN F  1434                                                      
REMARK 465     SER F  1435                                                      
REMARK 465     TRP F  1436                                                      
REMARK 465     ASP F  1437                                                      
REMARK 465     ARG F  1438                                                      
REMARK 465     LYS F  1439                                                      
REMARK 465     CYS F  1440                                                      
REMARK 465     LYS F  1441                                                      
REMARK 465     ASP F  1442                                                      
REMARK 465     GLY F  1443                                                      
REMARK 465     LEU F  1444                                                      
REMARK 465     TYR F  1445                                                      
REMARK 465     GLN F  1446                                                      
REMARK 465     ALA F  1447                                                      
REMARK 465     LEU F  1448                                                      
REMARK 465     LYS F  1449                                                      
REMARK 465     GLU F  1450                                                      
REMARK 465     THR F  1451                                                      
REMARK 465     HIS F  1452                                                      
REMARK 465     PRO F  1453                                                      
REMARK 465     HIS F  1454                                                      
REMARK 465     LEU F  1455                                                      
REMARK 465     ILE F  1456                                                      
REMARK 465     MET F  1457                                                      
REMARK 465     GLU F  1458                                                      
REMARK 465     LEU F  1459                                                      
REMARK 465     TRP F  1460                                                      
REMARK 465     GLU F  1461                                                      
REMARK 465     LYS F  1462                                                      
REMARK 465     GLY F  1463                                                      
REMARK 465     SER F  1464                                                      
REMARK 465     LYS F  1465                                                      
REMARK 465     LYS F  1466                                                      
REMARK 465     GLY F  1467                                                      
REMARK 465     LEU F  1468                                                      
REMARK 465     LEU F  1469                                                      
REMARK 465     PRO F  1470                                                      
REMARK 465     LEU F  1471                                                      
REMARK 465     SER F  1472                                                      
REMARK 465     SER F  1473                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ASP A  18    CG   OD1  OD2                                       
REMARK 470     GLU A  64    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 233    CG   CD1  CD2                                       
REMARK 470     ASP A 234    CG   OD1  OD2                                       
REMARK 470     GLU A 265    CG   CD   OE1  OE2                                  
REMARK 470     ASP D  18    CG   OD1  OD2                                       
REMARK 470     GLU D  64    CG   CD   OE1  OE2                                  
REMARK 470     LEU D 233    CG   CD1  CD2                                       
REMARK 470     ASP D 234    CG   OD1  OD2                                       
REMARK 470     GLU D 265    CG   CD   OE1  OE2                                  
REMARK 470     SER F1213    N                                                   
REMARK 470     VAL F1350    CG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OG   SER A   730     O16  GK2 A   901              1.83            
REMARK 500   OG   SER D   730     O17  GK2 D   901              1.88            
REMARK 500   OG   SER A   730     O17  GK2 A   901              2.05            
REMARK 500   OG   SER D   730     O16  GK2 D   901              2.07            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP A 110       58.67    -93.15                                   
REMARK 500    SER A 156     -126.91     55.80                                   
REMARK 500    ARG A 220      121.83   -171.16                                   
REMARK 500    SER A 230     -157.57   -150.14                                   
REMARK 500    GLU A 268      -65.43   -120.25                                   
REMARK 500    GLU A 282       45.76    -91.16                                   
REMARK 500    ALA A 316      149.51   -170.65                                   
REMARK 500    GLN A 373       62.84     63.10                                   
REMARK 500    GLN A 374       19.77   -143.15                                   
REMARK 500    VAL A 419      -80.57   -102.94                                   
REMARK 500    GLU A 438       70.32     61.13                                   
REMARK 500    CYS A 452      107.52    -59.87                                   
REMARK 500    GLU A 493       41.10    -96.78                                   
REMARK 500    ALA A 498      -41.83   -130.89                                   
REMARK 500    ASP A 618       45.35     75.45                                   
REMARK 500    TYR A 644      -67.02   -127.70                                   
REMARK 500    ASN A 695       15.74     57.99                                   
REMARK 500    GLN A 696       48.05   -151.43                                   
REMARK 500    SER A 730     -115.74     59.29                                   
REMARK 500    ASP A 772     -178.88     76.16                                   
REMARK 500    ASN A 777       67.69   -106.61                                   
REMARK 500    ASN A 810      -79.42   -104.28                                   
REMARK 500    ARG A 839      -76.87    -85.05                                   
REMARK 500    ALA D  21       40.16   -142.35                                   
REMARK 500    ARG D  82       32.11    -90.84                                   
REMARK 500    ALA D 155     -154.97   -101.60                                   
REMARK 500    SER D 156      -74.54    -60.50                                   
REMARK 500    ARG D 220      121.80   -171.01                                   
REMARK 500    PHE D 224       47.04   -141.37                                   
REMARK 500    SER D 230     -157.24   -157.94                                   
REMARK 500    GLU D 268      -63.89   -121.20                                   
REMARK 500    GLU D 282       45.20    -91.25                                   
REMARK 500    ALA D 316      149.02   -170.69                                   
REMARK 500    GLN D 334      121.17   -170.25                                   
REMARK 500    GLN D 373       62.99     63.42                                   
REMARK 500    GLN D 374       19.86   -143.01                                   
REMARK 500    VAL D 419      -80.41   -102.86                                   
REMARK 500    ASP D 425       44.76    -82.33                                   
REMARK 500    GLU D 436        2.59     55.23                                   
REMARK 500    CYS D 452      108.17    -59.85                                   
REMARK 500    GLU D 493       40.71    -96.70                                   
REMARK 500    ALA D 498      -41.00   -131.08                                   
REMARK 500    ASP D 618       44.51     75.32                                   
REMARK 500    TYR D 644      -72.85   -137.98                                   
REMARK 500    ASN D 695       17.11     51.42                                   
REMARK 500    GLN D 696       51.65   -151.63                                   
REMARK 500    SER D 730     -122.46     60.66                                   
REMARK 500    ASN D 777       69.66   -107.08                                   
REMARK 500    ASN D 810      -76.24   -100.51                                   
REMARK 500    ARG D 839     -128.96    -96.53                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      52 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-22075   RELATED DB: EMDB                             
REMARK 900 IMMUNE SYSTEM                                                        
DBREF  6X6C A    1   863  UNP    Q86TI2   DPP9_HUMAN       1    863             
DBREF  6X6C D    1   863  UNP    Q86TI2   DPP9_HUMAN       1    863             
DBREF  6X6C E    1  1473  UNP    Q9C000   NLRP1_HUMAN      1   1473             
DBREF  6X6C F    1  1473  UNP    Q9C000   NLRP1_HUMAN      1   1473             
SEQADV 6X6C MET A  -27  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C SER A  -26  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR A  -25  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR A  -24  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS A  -23  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS A  -22  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS A  -21  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS A  -20  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS A  -19  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS A  -18  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ASP A  -17  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR A  -16  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ASP A  -15  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ILE A  -14  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C PRO A  -13  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C THR A  -12  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C THR A  -11  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLU A  -10  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ASN A   -9  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C LEU A   -8  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR A   -7  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C PHE A   -6  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLN A   -5  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLY A   -4  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ALA A   -3  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C MET A   -2  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLY A   -1  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C SER A    0  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C MET D  -27  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C SER D  -26  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR D  -25  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR D  -24  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS D  -23  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS D  -22  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS D  -21  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS D  -20  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS D  -19  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C HIS D  -18  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ASP D  -17  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR D  -16  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ASP D  -15  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ILE D  -14  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C PRO D  -13  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C THR D  -12  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C THR D  -11  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLU D  -10  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ASN D   -9  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C LEU D   -8  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C TYR D   -7  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C PHE D   -6  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLN D   -5  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLY D   -4  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C ALA D   -3  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C MET D   -2  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C GLY D   -1  UNP  Q86TI2              EXPRESSION TAG                 
SEQADV 6X6C SER D    0  UNP  Q86TI2              EXPRESSION TAG                 
SEQRES   1 A  891  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 A  891  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 A  891  GLY SER MET ALA THR THR GLY THR PRO THR ALA ASP ARG          
SEQRES   4 A  891  GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE          
SEQRES   5 A  891  GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE          
SEQRES   6 A  891  ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN          
SEQRES   7 A  891  LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP          
SEQRES   8 A  891  GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY          
SEQRES   9 A  891  MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER          
SEQRES  10 A  891  GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU          
SEQRES  11 A  891  LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR          
SEQRES  12 A  891  PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU          
SEQRES  13 A  891  ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER          
SEQRES  14 A  891  TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN          
SEQRES  15 A  891  ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS          
SEQRES  16 A  891  ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE          
SEQRES  17 A  891  LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE          
SEQRES  18 A  891  CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN          
SEQRES  19 A  891  SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU          
SEQRES  20 A  891  ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL          
SEQRES  21 A  891  LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL          
SEQRES  22 A  891  ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP          
SEQRES  23 A  891  CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS          
SEQRES  24 A  891  THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU          
SEQRES  25 A  891  VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU          
SEQRES  26 A  891  ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY SER          
SEQRES  27 A  891  LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN          
SEQRES  28 A  891  THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS          
SEQRES  29 A  891  GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL          
SEQRES  30 A  891  GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS          
SEQRES  31 A  891  TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP          
SEQRES  32 A  891  LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO          
SEQRES  33 A  891  SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG          
SEQRES  34 A  891  ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU          
SEQRES  35 A  891  GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE          
SEQRES  36 A  891  TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS          
SEQRES  37 A  891  PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS          
SEQRES  38 A  891  LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR          
SEQRES  39 A  891  ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE          
SEQRES  40 A  891  LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY          
SEQRES  41 A  891  GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP          
SEQRES  42 A  891  VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR          
SEQRES  43 A  891  LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER          
SEQRES  44 A  891  TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO          
SEQRES  45 A  891  GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE ASP          
SEQRES  46 A  891  MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO PRO          
SEQRES  47 A  891  CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP          
SEQRES  48 A  891  PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET          
SEQRES  49 A  891  GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU          
SEQRES  50 A  891  ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR          
SEQRES  51 A  891  GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS          
SEQRES  52 A  891  LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN          
SEQRES  53 A  891  VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR          
SEQRES  54 A  891  LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL          
SEQRES  55 A  891  VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU          
SEQRES  56 A  891  ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL          
SEQRES  57 A  891  GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA          
SEQRES  58 A  891  GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE          
SEQRES  59 A  891  HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY          
SEQRES  60 A  891  LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA          
SEQRES  61 A  891  GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY          
SEQRES  62 A  891  TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN          
SEQRES  63 A  891  HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU          
SEQRES  64 A  891  LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS          
SEQRES  65 A  891  GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN          
SEQRES  66 A  891  PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR          
SEQRES  67 A  891  GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG          
SEQRES  68 A  891  CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU          
SEQRES  69 A  891  HIS PHE LEU GLN GLU TYR LEU                                  
SEQRES   1 D  891  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 D  891  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 D  891  GLY SER MET ALA THR THR GLY THR PRO THR ALA ASP ARG          
SEQRES   4 D  891  GLY ASP ALA ALA ALA THR ASP ASP PRO ALA ALA ARG PHE          
SEQRES   5 D  891  GLN VAL GLN LYS HIS SER TRP ASP GLY LEU ARG SER ILE          
SEQRES   6 D  891  ILE HIS GLY SER ARG LYS TYR SER GLY LEU ILE VAL ASN          
SEQRES   7 D  891  LYS ALA PRO HIS ASP PHE GLN PHE VAL GLN LYS THR ASP          
SEQRES   8 D  891  GLU SER GLY PRO HIS SER HIS ARG LEU TYR TYR LEU GLY          
SEQRES   9 D  891  MET PRO TYR GLY SER ARG GLU ASN SER LEU LEU TYR SER          
SEQRES  10 D  891  GLU ILE PRO LYS LYS VAL ARG LYS GLU ALA LEU LEU LEU          
SEQRES  11 D  891  LEU SER TRP LYS GLN MET LEU ASP HIS PHE GLN ALA THR          
SEQRES  12 D  891  PRO HIS HIS GLY VAL TYR SER ARG GLU GLU GLU LEU LEU          
SEQRES  13 D  891  ARG GLU ARG LYS ARG LEU GLY VAL PHE GLY ILE THR SER          
SEQRES  14 D  891  TYR ASP PHE HIS SER GLU SER GLY LEU PHE LEU PHE GLN          
SEQRES  15 D  891  ALA SER ASN SER LEU PHE HIS CYS ARG ASP GLY GLY LYS          
SEQRES  16 D  891  ASN GLY PHE MET VAL SER PRO MET LYS PRO LEU GLU ILE          
SEQRES  17 D  891  LYS THR GLN CYS SER GLY PRO ARG MET ASP PRO LYS ILE          
SEQRES  18 D  891  CYS PRO ALA ASP PRO ALA PHE PHE SER PHE ILE ASN ASN          
SEQRES  19 D  891  SER ASP LEU TRP VAL ALA ASN ILE GLU THR GLY GLU GLU          
SEQRES  20 D  891  ARG ARG LEU THR PHE CYS HIS GLN GLY LEU SER ASN VAL          
SEQRES  21 D  891  LEU ASP ASP PRO LYS SER ALA GLY VAL ALA THR PHE VAL          
SEQRES  22 D  891  ILE GLN GLU GLU PHE ASP ARG PHE THR GLY TYR TRP TRP          
SEQRES  23 D  891  CYS PRO THR ALA SER TRP GLU GLY SER GLU GLY LEU LYS          
SEQRES  24 D  891  THR LEU ARG ILE LEU TYR GLU GLU VAL ASP GLU SER GLU          
SEQRES  25 D  891  VAL GLU VAL ILE HIS VAL PRO SER PRO ALA LEU GLU GLU          
SEQRES  26 D  891  ARG LYS THR ASP SER TYR ARG TYR PRO ARG THR GLY SER          
SEQRES  27 D  891  LYS ASN PRO LYS ILE ALA LEU LYS LEU ALA GLU PHE GLN          
SEQRES  28 D  891  THR ASP SER GLN GLY LYS ILE VAL SER THR GLN GLU LYS          
SEQRES  29 D  891  GLU LEU VAL GLN PRO PHE SER SER LEU PHE PRO LYS VAL          
SEQRES  30 D  891  GLU TYR ILE ALA ARG ALA GLY TRP THR ARG ASP GLY LYS          
SEQRES  31 D  891  TYR ALA TRP ALA MET PHE LEU ASP ARG PRO GLN GLN TRP          
SEQRES  32 D  891  LEU GLN LEU VAL LEU LEU PRO PRO ALA LEU PHE ILE PRO          
SEQRES  33 D  891  SER THR GLU ASN GLU GLU GLN ARG LEU ALA SER ALA ARG          
SEQRES  34 D  891  ALA VAL PRO ARG ASN VAL GLN PRO TYR VAL VAL TYR GLU          
SEQRES  35 D  891  GLU VAL THR ASN VAL TRP ILE ASN VAL HIS ASP ILE PHE          
SEQRES  36 D  891  TYR PRO PHE PRO GLN SER GLU GLY GLU ASP GLU LEU CYS          
SEQRES  37 D  891  PHE LEU ARG ALA ASN GLU CYS LYS THR GLY PHE CYS HIS          
SEQRES  38 D  891  LEU TYR LYS VAL THR ALA VAL LEU LYS SER GLN GLY TYR          
SEQRES  39 D  891  ASP TRP SER GLU PRO PHE SER PRO GLY GLU ASP GLU PHE          
SEQRES  40 D  891  LYS CYS PRO ILE LYS GLU GLU ILE ALA LEU THR SER GLY          
SEQRES  41 D  891  GLU TRP GLU VAL LEU ALA ARG HIS GLY SER LYS ILE TRP          
SEQRES  42 D  891  VAL ASN GLU GLU THR LYS LEU VAL TYR PHE GLN GLY THR          
SEQRES  43 D  891  LYS ASP THR PRO LEU GLU HIS HIS LEU TYR VAL VAL SER          
SEQRES  44 D  891  TYR GLU ALA ALA GLY GLU ILE VAL ARG LEU THR THR PRO          
SEQRES  45 D  891  GLY PHE SER HIS SER CYS SER MET SER GLN ASN PHE ASP          
SEQRES  46 D  891  MET PHE VAL SER HIS TYR SER SER VAL SER THR PRO PRO          
SEQRES  47 D  891  CYS VAL HIS VAL TYR LYS LEU SER GLY PRO ASP ASP ASP          
SEQRES  48 D  891  PRO LEU HIS LYS GLN PRO ARG PHE TRP ALA SER MET MET          
SEQRES  49 D  891  GLU ALA ALA SER CYS PRO PRO ASP TYR VAL PRO PRO GLU          
SEQRES  50 D  891  ILE PHE HIS PHE HIS THR ARG SER ASP VAL ARG LEU TYR          
SEQRES  51 D  891  GLY MET ILE TYR LYS PRO HIS ALA LEU GLN PRO GLY LYS          
SEQRES  52 D  891  LYS HIS PRO THR VAL LEU PHE VAL TYR GLY GLY PRO GLN          
SEQRES  53 D  891  VAL GLN LEU VAL ASN ASN SER PHE LYS GLY ILE LYS TYR          
SEQRES  54 D  891  LEU ARG LEU ASN THR LEU ALA SER LEU GLY TYR ALA VAL          
SEQRES  55 D  891  VAL VAL ILE ASP GLY ARG GLY SER CYS GLN ARG GLY LEU          
SEQRES  56 D  891  ARG PHE GLU GLY ALA LEU LYS ASN GLN MET GLY GLN VAL          
SEQRES  57 D  891  GLU ILE GLU ASP GLN VAL GLU GLY LEU GLN PHE VAL ALA          
SEQRES  58 D  891  GLU LYS TYR GLY PHE ILE ASP LEU SER ARG VAL ALA ILE          
SEQRES  59 D  891  HIS GLY TRP SER TYR GLY GLY PHE LEU SER LEU MET GLY          
SEQRES  60 D  891  LEU ILE HIS LYS PRO GLN VAL PHE LYS VAL ALA ILE ALA          
SEQRES  61 D  891  GLY ALA PRO VAL THR VAL TRP MET ALA TYR ASP THR GLY          
SEQRES  62 D  891  TYR THR GLU ARG TYR MET ASP VAL PRO GLU ASN ASN GLN          
SEQRES  63 D  891  HIS GLY TYR GLU ALA GLY SER VAL ALA LEU HIS VAL GLU          
SEQRES  64 D  891  LYS LEU PRO ASN GLU PRO ASN ARG LEU LEU ILE LEU HIS          
SEQRES  65 D  891  GLY PHE LEU ASP GLU ASN VAL HIS PHE PHE HIS THR ASN          
SEQRES  66 D  891  PHE LEU VAL SER GLN LEU ILE ARG ALA GLY LYS PRO TYR          
SEQRES  67 D  891  GLN LEU GLN ILE TYR PRO ASN GLU ARG HIS SER ILE ARG          
SEQRES  68 D  891  CYS PRO GLU SER GLY GLU HIS TYR GLU VAL THR LEU LEU          
SEQRES  69 D  891  HIS PHE LEU GLN GLU TYR LEU                                  
SEQRES   1 E 1473  MET ALA GLY GLY ALA TRP GLY ARG LEU ALA CYS TYR LEU          
SEQRES   2 E 1473  GLU PHE LEU LYS LYS GLU GLU LEU LYS GLU PHE GLN LEU          
SEQRES   3 E 1473  LEU LEU ALA ASN LYS ALA HIS SER ARG SER SER SER GLY          
SEQRES   4 E 1473  GLU THR PRO ALA GLN PRO GLU LYS THR SER GLY MET GLU          
SEQRES   5 E 1473  VAL ALA SER TYR LEU VAL ALA GLN TYR GLY GLU GLN ARG          
SEQRES   6 E 1473  ALA TRP ASP LEU ALA LEU HIS THR TRP GLU GLN MET GLY          
SEQRES   7 E 1473  LEU ARG SER LEU CYS ALA GLN ALA GLN GLU GLY ALA GLY          
SEQRES   8 E 1473  HIS SER PRO SER PHE PRO TYR SER PRO SER GLU PRO HIS          
SEQRES   9 E 1473  LEU GLY SER PRO SER GLN PRO THR SER THR ALA VAL LEU          
SEQRES  10 E 1473  MET PRO TRP ILE HIS GLU LEU PRO ALA GLY CYS THR GLN          
SEQRES  11 E 1473  GLY SER GLU ARG ARG VAL LEU ARG GLN LEU PRO ASP THR          
SEQRES  12 E 1473  SER GLY ARG ARG TRP ARG GLU ILE SER ALA SER LEU LEU          
SEQRES  13 E 1473  TYR GLN ALA LEU PRO SER SER PRO ASP HIS GLU SER PRO          
SEQRES  14 E 1473  SER GLN GLU SER PRO ASN ALA PRO THR SER THR ALA VAL          
SEQRES  15 E 1473  LEU GLY SER TRP GLY SER PRO PRO GLN PRO SER LEU ALA          
SEQRES  16 E 1473  PRO ARG GLU GLN GLU ALA PRO GLY THR GLN TRP PRO LEU          
SEQRES  17 E 1473  ASP GLU THR SER GLY ILE TYR TYR THR GLU ILE ARG GLU          
SEQRES  18 E 1473  ARG GLU ARG GLU LYS SER GLU LYS GLY ARG PRO PRO TRP          
SEQRES  19 E 1473  ALA ALA VAL VAL GLY THR PRO PRO GLN ALA HIS THR SER          
SEQRES  20 E 1473  LEU GLN PRO HIS HIS HIS PRO TRP GLU PRO SER VAL ARG          
SEQRES  21 E 1473  GLU SER LEU CYS SER THR TRP PRO TRP LYS ASN GLU ASP          
SEQRES  22 E 1473  PHE ASN GLN LYS PHE THR GLN LEU LEU LEU LEU GLN ARG          
SEQRES  23 E 1473  PRO HIS PRO ARG SER GLN ASP PRO LEU VAL LYS ARG SER          
SEQRES  24 E 1473  TRP PRO ASP TYR VAL GLU GLU ASN ARG GLY HIS LEU ILE          
SEQRES  25 E 1473  GLU ILE ARG ASP LEU PHE GLY PRO GLY LEU ASP THR GLN          
SEQRES  26 E 1473  GLU PRO ARG ILE VAL ILE LEU GLN GLY ALA ALA GLY ILE          
SEQRES  27 E 1473  GLY LYS SER THR LEU ALA ARG GLN VAL LYS GLU ALA TRP          
SEQRES  28 E 1473  GLY ARG GLY GLN LEU TYR GLY ASP ARG PHE GLN HIS VAL          
SEQRES  29 E 1473  PHE TYR PHE SER CYS ARG GLU LEU ALA GLN SER LYS VAL          
SEQRES  30 E 1473  VAL SER LEU ALA GLU LEU ILE GLY LYS ASP GLY THR ALA          
SEQRES  31 E 1473  THR PRO ALA PRO ILE ARG GLN ILE LEU SER ARG PRO GLU          
SEQRES  32 E 1473  ARG LEU LEU PHE ILE LEU ASP GLY VAL ASP GLU PRO GLY          
SEQRES  33 E 1473  TRP VAL LEU GLN GLU PRO SER SER GLU LEU CYS LEU HIS          
SEQRES  34 E 1473  TRP SER GLN PRO GLN PRO ALA ASP ALA LEU LEU GLY SER          
SEQRES  35 E 1473  LEU LEU GLY LYS THR ILE LEU PRO GLU ALA SER PHE LEU          
SEQRES  36 E 1473  ILE THR ALA ARG THR THR ALA LEU GLN ASN LEU ILE PRO          
SEQRES  37 E 1473  SER LEU GLU GLN ALA ARG TRP VAL GLU VAL LEU GLY PHE          
SEQRES  38 E 1473  SER GLU SER SER ARG LYS GLU TYR PHE TYR ARG TYR PHE          
SEQRES  39 E 1473  THR ASP GLU ARG GLN ALA ILE ARG ALA PHE ARG LEU VAL          
SEQRES  40 E 1473  LYS SER ASN LYS GLU LEU TRP ALA LEU CYS LEU VAL PRO          
SEQRES  41 E 1473  TRP VAL SER TRP LEU ALA CYS THR CYS LEU MET GLN GLN          
SEQRES  42 E 1473  MET LYS ARG LYS GLU LYS LEU THR LEU THR SER LYS THR          
SEQRES  43 E 1473  THR THR THR LEU CYS LEU HIS TYR LEU ALA GLN ALA LEU          
SEQRES  44 E 1473  GLN ALA GLN PRO LEU GLY PRO GLN LEU ARG ASP LEU CYS          
SEQRES  45 E 1473  SER LEU ALA ALA GLU GLY ILE TRP GLN LYS LYS THR LEU          
SEQRES  46 E 1473  PHE SER PRO ASP ASP LEU ARG LYS HIS GLY LEU ASP GLY          
SEQRES  47 E 1473  ALA ILE ILE SER THR PHE LEU LYS MET GLY ILE LEU GLN          
SEQRES  48 E 1473  GLU HIS PRO ILE PRO LEU SER TYR SER PHE ILE HIS LEU          
SEQRES  49 E 1473  CYS PHE GLN GLU PHE PHE ALA ALA MET SER TYR VAL LEU          
SEQRES  50 E 1473  GLU ASP GLU LYS GLY ARG GLY LYS HIS SER ASN CYS ILE          
SEQRES  51 E 1473  ILE ASP LEU GLU LYS THR LEU GLU ALA TYR GLY ILE HIS          
SEQRES  52 E 1473  GLY LEU PHE GLY ALA SER THR THR ARG PHE LEU LEU GLY          
SEQRES  53 E 1473  LEU LEU SER ASP GLU GLY GLU ARG GLU MET GLU ASN ILE          
SEQRES  54 E 1473  PHE HIS CYS ARG LEU SER GLN GLY ARG ASN LEU MET GLN          
SEQRES  55 E 1473  TRP VAL PRO SER LEU GLN LEU LEU LEU GLN PRO HIS SER          
SEQRES  56 E 1473  LEU GLU SER LEU HIS CYS LEU TYR GLU THR ARG ASN LYS          
SEQRES  57 E 1473  THR PHE LEU THR GLN VAL MET ALA HIS PHE GLU GLU MET          
SEQRES  58 E 1473  GLY MET CYS VAL GLU THR ASP MET GLU LEU LEU VAL CYS          
SEQRES  59 E 1473  THR PHE CYS ILE LYS PHE SER ARG HIS VAL LYS LYS LEU          
SEQRES  60 E 1473  GLN LEU ILE GLU GLY ARG GLN HIS ARG SER THR TRP SER          
SEQRES  61 E 1473  PRO THR MET VAL VAL LEU PHE ARG TRP VAL PRO VAL THR          
SEQRES  62 E 1473  ASP ALA TYR TRP GLN ILE LEU PHE SER VAL LEU LYS VAL          
SEQRES  63 E 1473  THR ARG ASN LEU LYS GLU LEU ASP LEU SER GLY ASN SER          
SEQRES  64 E 1473  LEU SER HIS SER ALA VAL LYS SER LEU CYS LYS THR LEU          
SEQRES  65 E 1473  ARG ARG PRO ARG CYS LEU LEU GLU THR LEU ARG LEU ALA          
SEQRES  66 E 1473  GLY CYS GLY LEU THR ALA GLU ASP CYS LYS ASP LEU ALA          
SEQRES  67 E 1473  PHE GLY LEU ARG ALA ASN GLN THR LEU THR GLU LEU ASP          
SEQRES  68 E 1473  LEU SER PHE ASN VAL LEU THR ASP ALA GLY ALA LYS HIS          
SEQRES  69 E 1473  LEU CYS GLN ARG LEU ARG GLN PRO SER CYS LYS LEU GLN          
SEQRES  70 E 1473  ARG LEU GLN LEU VAL SER CYS GLY LEU THR SER ASP CYS          
SEQRES  71 E 1473  CYS GLN ASP LEU ALA SER VAL LEU SER ALA SER PRO SER          
SEQRES  72 E 1473  LEU LYS GLU LEU ASP LEU GLN GLN ASN ASN LEU ASP ASP          
SEQRES  73 E 1473  VAL GLY VAL ARG LEU LEU CYS GLU GLY LEU ARG HIS PRO          
SEQRES  74 E 1473  ALA CYS LYS LEU ILE ARG LEU GLY LEU ASP GLN THR THR          
SEQRES  75 E 1473  LEU SER ASP GLU MET ARG GLN GLU LEU ARG ALA LEU GLU          
SEQRES  76 E 1473  GLN GLU LYS PRO GLN LEU LEU ILE PHE SER ARG ARG LYS          
SEQRES  77 E 1473  PRO SER VAL MET THR PRO THR GLU GLY LEU ASP THR GLY          
SEQRES  78 E 1473  GLU MET SER ASN SER THR SER SER LEU LYS ARG GLN ARG          
SEQRES  79 E 1473  LEU GLY SER GLU ARG ALA ALA SER HIS VAL ALA GLN ALA          
SEQRES  80 E 1473  ASN LEU LYS LEU LEU ASP VAL SER LYS ILE PHE PRO ILE          
SEQRES  81 E 1473  ALA GLU ILE ALA GLU GLU SER SER PRO GLU VAL VAL PRO          
SEQRES  82 E 1473  VAL GLU LEU LEU CYS VAL PRO SER PRO ALA SER GLN GLY          
SEQRES  83 E 1473  ASP LEU HIS THR LYS PRO LEU GLY THR ASP ASP ASP PHE          
SEQRES  84 E 1473  TRP GLY PRO THR GLY PRO VAL ALA THR GLU VAL VAL ASP          
SEQRES  85 E 1473  LYS GLU LYS ASN LEU TYR ARG VAL HIS PHE PRO VAL ALA          
SEQRES  86 E 1473  GLY SER TYR ARG TRP PRO ASN THR GLY LEU CYS PHE VAL          
SEQRES  87 E 1473  MET ARG GLU ALA VAL THR VAL GLU ILE GLU PHE CYS VAL          
SEQRES  88 E 1473  TRP ASP GLN PHE LEU GLY GLU ILE ASN PRO GLN HIS SER          
SEQRES  89 E 1473  TRP MET VAL ALA GLY PRO LEU LEU ASP ILE LYS ALA GLU          
SEQRES  90 E 1473  PRO GLY ALA VAL GLU ALA VAL HIS LEU PRO HIS PHE VAL          
SEQRES  91 E 1473  ALA LEU GLN GLY GLY HIS VAL ASP THR SER LEU PHE GLN          
SEQRES  92 E 1473  MET ALA HIS PHE LYS GLU GLU GLY MET LEU LEU GLU LYS          
SEQRES  93 E 1473  PRO ALA ARG VAL GLU LEU HIS HIS ILE VAL LEU GLU ASN          
SEQRES  94 E 1473  PRO SER PHE SER PRO LEU GLY VAL LEU LEU LYS MET ILE          
SEQRES  95 E 1473  HIS ASN ALA LEU ARG PHE ILE PRO VAL THR SER VAL VAL          
SEQRES  96 E 1473  LEU LEU TYR HIS ARG VAL HIS PRO GLU GLU VAL THR PHE          
SEQRES  97 E 1473  HIS LEU TYR LEU ILE PRO SER ASP CYS SER ILE ARG LYS          
SEQRES  98 E 1473  ALA ILE ASP ASP LEU GLU MET LYS PHE GLN PHE VAL ARG          
SEQRES  99 E 1473  ILE HIS LYS PRO PRO PRO LEU THR PRO LEU TYR MET GLY          
SEQRES 100 E 1473  CYS ARG TYR THR VAL SER GLY SER GLY SER GLY MET LEU          
SEQRES 101 E 1473  GLU ILE LEU PRO LYS GLU LEU GLU LEU CYS TYR ARG SER          
SEQRES 102 E 1473  PRO GLY GLU ASP GLN LEU PHE SER GLU PHE TYR VAL GLY          
SEQRES 103 E 1473  HIS LEU GLY SER GLY ILE ARG LEU GLN VAL LYS ASP LYS          
SEQRES 104 E 1473  LYS ASP GLU THR LEU VAL TRP GLU ALA LEU VAL LYS PRO          
SEQRES 105 E 1473  GLY ASP LEU MET PRO ALA THR THR LEU ILE PRO PRO ALA          
SEQRES 106 E 1473  ARG ILE ALA VAL PRO SER PRO LEU ASP ALA PRO GLN LEU          
SEQRES 107 E 1473  LEU HIS PHE VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA          
SEQRES 108 E 1473  ARG VAL THR SER VAL GLU VAL VAL LEU ASP LYS LEU HIS          
SEQRES 109 E 1473  GLY GLN VAL LEU SER GLN GLU GLN TYR GLU ARG VAL LEU          
SEQRES 110 E 1473  ALA GLU ASN THR ARG PRO SER GLN MET ARG LYS LEU PHE          
SEQRES 111 E 1473  SER LEU SER GLN SER TRP ASP ARG LYS CYS LYS ASP GLY          
SEQRES 112 E 1473  LEU TYR GLN ALA LEU LYS GLU THR HIS PRO HIS LEU ILE          
SEQRES 113 E 1473  MET GLU LEU TRP GLU LYS GLY SER LYS LYS GLY LEU LEU          
SEQRES 114 E 1473  PRO LEU SER SER                                              
SEQRES   1 F 1473  MET ALA GLY GLY ALA TRP GLY ARG LEU ALA CYS TYR LEU          
SEQRES   2 F 1473  GLU PHE LEU LYS LYS GLU GLU LEU LYS GLU PHE GLN LEU          
SEQRES   3 F 1473  LEU LEU ALA ASN LYS ALA HIS SER ARG SER SER SER GLY          
SEQRES   4 F 1473  GLU THR PRO ALA GLN PRO GLU LYS THR SER GLY MET GLU          
SEQRES   5 F 1473  VAL ALA SER TYR LEU VAL ALA GLN TYR GLY GLU GLN ARG          
SEQRES   6 F 1473  ALA TRP ASP LEU ALA LEU HIS THR TRP GLU GLN MET GLY          
SEQRES   7 F 1473  LEU ARG SER LEU CYS ALA GLN ALA GLN GLU GLY ALA GLY          
SEQRES   8 F 1473  HIS SER PRO SER PHE PRO TYR SER PRO SER GLU PRO HIS          
SEQRES   9 F 1473  LEU GLY SER PRO SER GLN PRO THR SER THR ALA VAL LEU          
SEQRES  10 F 1473  MET PRO TRP ILE HIS GLU LEU PRO ALA GLY CYS THR GLN          
SEQRES  11 F 1473  GLY SER GLU ARG ARG VAL LEU ARG GLN LEU PRO ASP THR          
SEQRES  12 F 1473  SER GLY ARG ARG TRP ARG GLU ILE SER ALA SER LEU LEU          
SEQRES  13 F 1473  TYR GLN ALA LEU PRO SER SER PRO ASP HIS GLU SER PRO          
SEQRES  14 F 1473  SER GLN GLU SER PRO ASN ALA PRO THR SER THR ALA VAL          
SEQRES  15 F 1473  LEU GLY SER TRP GLY SER PRO PRO GLN PRO SER LEU ALA          
SEQRES  16 F 1473  PRO ARG GLU GLN GLU ALA PRO GLY THR GLN TRP PRO LEU          
SEQRES  17 F 1473  ASP GLU THR SER GLY ILE TYR TYR THR GLU ILE ARG GLU          
SEQRES  18 F 1473  ARG GLU ARG GLU LYS SER GLU LYS GLY ARG PRO PRO TRP          
SEQRES  19 F 1473  ALA ALA VAL VAL GLY THR PRO PRO GLN ALA HIS THR SER          
SEQRES  20 F 1473  LEU GLN PRO HIS HIS HIS PRO TRP GLU PRO SER VAL ARG          
SEQRES  21 F 1473  GLU SER LEU CYS SER THR TRP PRO TRP LYS ASN GLU ASP          
SEQRES  22 F 1473  PHE ASN GLN LYS PHE THR GLN LEU LEU LEU LEU GLN ARG          
SEQRES  23 F 1473  PRO HIS PRO ARG SER GLN ASP PRO LEU VAL LYS ARG SER          
SEQRES  24 F 1473  TRP PRO ASP TYR VAL GLU GLU ASN ARG GLY HIS LEU ILE          
SEQRES  25 F 1473  GLU ILE ARG ASP LEU PHE GLY PRO GLY LEU ASP THR GLN          
SEQRES  26 F 1473  GLU PRO ARG ILE VAL ILE LEU GLN GLY ALA ALA GLY ILE          
SEQRES  27 F 1473  GLY LYS SER THR LEU ALA ARG GLN VAL LYS GLU ALA TRP          
SEQRES  28 F 1473  GLY ARG GLY GLN LEU TYR GLY ASP ARG PHE GLN HIS VAL          
SEQRES  29 F 1473  PHE TYR PHE SER CYS ARG GLU LEU ALA GLN SER LYS VAL          
SEQRES  30 F 1473  VAL SER LEU ALA GLU LEU ILE GLY LYS ASP GLY THR ALA          
SEQRES  31 F 1473  THR PRO ALA PRO ILE ARG GLN ILE LEU SER ARG PRO GLU          
SEQRES  32 F 1473  ARG LEU LEU PHE ILE LEU ASP GLY VAL ASP GLU PRO GLY          
SEQRES  33 F 1473  TRP VAL LEU GLN GLU PRO SER SER GLU LEU CYS LEU HIS          
SEQRES  34 F 1473  TRP SER GLN PRO GLN PRO ALA ASP ALA LEU LEU GLY SER          
SEQRES  35 F 1473  LEU LEU GLY LYS THR ILE LEU PRO GLU ALA SER PHE LEU          
SEQRES  36 F 1473  ILE THR ALA ARG THR THR ALA LEU GLN ASN LEU ILE PRO          
SEQRES  37 F 1473  SER LEU GLU GLN ALA ARG TRP VAL GLU VAL LEU GLY PHE          
SEQRES  38 F 1473  SER GLU SER SER ARG LYS GLU TYR PHE TYR ARG TYR PHE          
SEQRES  39 F 1473  THR ASP GLU ARG GLN ALA ILE ARG ALA PHE ARG LEU VAL          
SEQRES  40 F 1473  LYS SER ASN LYS GLU LEU TRP ALA LEU CYS LEU VAL PRO          
SEQRES  41 F 1473  TRP VAL SER TRP LEU ALA CYS THR CYS LEU MET GLN GLN          
SEQRES  42 F 1473  MET LYS ARG LYS GLU LYS LEU THR LEU THR SER LYS THR          
SEQRES  43 F 1473  THR THR THR LEU CYS LEU HIS TYR LEU ALA GLN ALA LEU          
SEQRES  44 F 1473  GLN ALA GLN PRO LEU GLY PRO GLN LEU ARG ASP LEU CYS          
SEQRES  45 F 1473  SER LEU ALA ALA GLU GLY ILE TRP GLN LYS LYS THR LEU          
SEQRES  46 F 1473  PHE SER PRO ASP ASP LEU ARG LYS HIS GLY LEU ASP GLY          
SEQRES  47 F 1473  ALA ILE ILE SER THR PHE LEU LYS MET GLY ILE LEU GLN          
SEQRES  48 F 1473  GLU HIS PRO ILE PRO LEU SER TYR SER PHE ILE HIS LEU          
SEQRES  49 F 1473  CYS PHE GLN GLU PHE PHE ALA ALA MET SER TYR VAL LEU          
SEQRES  50 F 1473  GLU ASP GLU LYS GLY ARG GLY LYS HIS SER ASN CYS ILE          
SEQRES  51 F 1473  ILE ASP LEU GLU LYS THR LEU GLU ALA TYR GLY ILE HIS          
SEQRES  52 F 1473  GLY LEU PHE GLY ALA SER THR THR ARG PHE LEU LEU GLY          
SEQRES  53 F 1473  LEU LEU SER ASP GLU GLY GLU ARG GLU MET GLU ASN ILE          
SEQRES  54 F 1473  PHE HIS CYS ARG LEU SER GLN GLY ARG ASN LEU MET GLN          
SEQRES  55 F 1473  TRP VAL PRO SER LEU GLN LEU LEU LEU GLN PRO HIS SER          
SEQRES  56 F 1473  LEU GLU SER LEU HIS CYS LEU TYR GLU THR ARG ASN LYS          
SEQRES  57 F 1473  THR PHE LEU THR GLN VAL MET ALA HIS PHE GLU GLU MET          
SEQRES  58 F 1473  GLY MET CYS VAL GLU THR ASP MET GLU LEU LEU VAL CYS          
SEQRES  59 F 1473  THR PHE CYS ILE LYS PHE SER ARG HIS VAL LYS LYS LEU          
SEQRES  60 F 1473  GLN LEU ILE GLU GLY ARG GLN HIS ARG SER THR TRP SER          
SEQRES  61 F 1473  PRO THR MET VAL VAL LEU PHE ARG TRP VAL PRO VAL THR          
SEQRES  62 F 1473  ASP ALA TYR TRP GLN ILE LEU PHE SER VAL LEU LYS VAL          
SEQRES  63 F 1473  THR ARG ASN LEU LYS GLU LEU ASP LEU SER GLY ASN SER          
SEQRES  64 F 1473  LEU SER HIS SER ALA VAL LYS SER LEU CYS LYS THR LEU          
SEQRES  65 F 1473  ARG ARG PRO ARG CYS LEU LEU GLU THR LEU ARG LEU ALA          
SEQRES  66 F 1473  GLY CYS GLY LEU THR ALA GLU ASP CYS LYS ASP LEU ALA          
SEQRES  67 F 1473  PHE GLY LEU ARG ALA ASN GLN THR LEU THR GLU LEU ASP          
SEQRES  68 F 1473  LEU SER PHE ASN VAL LEU THR ASP ALA GLY ALA LYS HIS          
SEQRES  69 F 1473  LEU CYS GLN ARG LEU ARG GLN PRO SER CYS LYS LEU GLN          
SEQRES  70 F 1473  ARG LEU GLN LEU VAL SER CYS GLY LEU THR SER ASP CYS          
SEQRES  71 F 1473  CYS GLN ASP LEU ALA SER VAL LEU SER ALA SER PRO SER          
SEQRES  72 F 1473  LEU LYS GLU LEU ASP LEU GLN GLN ASN ASN LEU ASP ASP          
SEQRES  73 F 1473  VAL GLY VAL ARG LEU LEU CYS GLU GLY LEU ARG HIS PRO          
SEQRES  74 F 1473  ALA CYS LYS LEU ILE ARG LEU GLY LEU ASP GLN THR THR          
SEQRES  75 F 1473  LEU SER ASP GLU MET ARG GLN GLU LEU ARG ALA LEU GLU          
SEQRES  76 F 1473  GLN GLU LYS PRO GLN LEU LEU ILE PHE SER ARG ARG LYS          
SEQRES  77 F 1473  PRO SER VAL MET THR PRO THR GLU GLY LEU ASP THR GLY          
SEQRES  78 F 1473  GLU MET SER ASN SER THR SER SER LEU LYS ARG GLN ARG          
SEQRES  79 F 1473  LEU GLY SER GLU ARG ALA ALA SER HIS VAL ALA GLN ALA          
SEQRES  80 F 1473  ASN LEU LYS LEU LEU ASP VAL SER LYS ILE PHE PRO ILE          
SEQRES  81 F 1473  ALA GLU ILE ALA GLU GLU SER SER PRO GLU VAL VAL PRO          
SEQRES  82 F 1473  VAL GLU LEU LEU CYS VAL PRO SER PRO ALA SER GLN GLY          
SEQRES  83 F 1473  ASP LEU HIS THR LYS PRO LEU GLY THR ASP ASP ASP PHE          
SEQRES  84 F 1473  TRP GLY PRO THR GLY PRO VAL ALA THR GLU VAL VAL ASP          
SEQRES  85 F 1473  LYS GLU LYS ASN LEU TYR ARG VAL HIS PHE PRO VAL ALA          
SEQRES  86 F 1473  GLY SER TYR ARG TRP PRO ASN THR GLY LEU CYS PHE VAL          
SEQRES  87 F 1473  MET ARG GLU ALA VAL THR VAL GLU ILE GLU PHE CYS VAL          
SEQRES  88 F 1473  TRP ASP GLN PHE LEU GLY GLU ILE ASN PRO GLN HIS SER          
SEQRES  89 F 1473  TRP MET VAL ALA GLY PRO LEU LEU ASP ILE LYS ALA GLU          
SEQRES  90 F 1473  PRO GLY ALA VAL GLU ALA VAL HIS LEU PRO HIS PHE VAL          
SEQRES  91 F 1473  ALA LEU GLN GLY GLY HIS VAL ASP THR SER LEU PHE GLN          
SEQRES  92 F 1473  MET ALA HIS PHE LYS GLU GLU GLY MET LEU LEU GLU LYS          
SEQRES  93 F 1473  PRO ALA ARG VAL GLU LEU HIS HIS ILE VAL LEU GLU ASN          
SEQRES  94 F 1473  PRO SER PHE SER PRO LEU GLY VAL LEU LEU LYS MET ILE          
SEQRES  95 F 1473  HIS ASN ALA LEU ARG PHE ILE PRO VAL THR SER VAL VAL          
SEQRES  96 F 1473  LEU LEU TYR HIS ARG VAL HIS PRO GLU GLU VAL THR PHE          
SEQRES  97 F 1473  HIS LEU TYR LEU ILE PRO SER ASP CYS SER ILE ARG LYS          
SEQRES  98 F 1473  ALA ILE ASP ASP LEU GLU MET LYS PHE GLN PHE VAL ARG          
SEQRES  99 F 1473  ILE HIS LYS PRO PRO PRO LEU THR PRO LEU TYR MET GLY          
SEQRES 100 F 1473  CYS ARG TYR THR VAL SER GLY SER GLY SER GLY MET LEU          
SEQRES 101 F 1473  GLU ILE LEU PRO LYS GLU LEU GLU LEU CYS TYR ARG SER          
SEQRES 102 F 1473  PRO GLY GLU ASP GLN LEU PHE SER GLU PHE TYR VAL GLY          
SEQRES 103 F 1473  HIS LEU GLY SER GLY ILE ARG LEU GLN VAL LYS ASP LYS          
SEQRES 104 F 1473  LYS ASP GLU THR LEU VAL TRP GLU ALA LEU VAL LYS PRO          
SEQRES 105 F 1473  GLY ASP LEU MET PRO ALA THR THR LEU ILE PRO PRO ALA          
SEQRES 106 F 1473  ARG ILE ALA VAL PRO SER PRO LEU ASP ALA PRO GLN LEU          
SEQRES 107 F 1473  LEU HIS PHE VAL ASP GLN TYR ARG GLU GLN LEU ILE ALA          
SEQRES 108 F 1473  ARG VAL THR SER VAL GLU VAL VAL LEU ASP LYS LEU HIS          
SEQRES 109 F 1473  GLY GLN VAL LEU SER GLN GLU GLN TYR GLU ARG VAL LEU          
SEQRES 110 F 1473  ALA GLU ASN THR ARG PRO SER GLN MET ARG LYS LEU PHE          
SEQRES 111 F 1473  SER LEU SER GLN SER TRP ASP ARG LYS CYS LYS ASP GLY          
SEQRES 112 F 1473  LEU TYR GLN ALA LEU LYS GLU THR HIS PRO HIS LEU ILE          
SEQRES 113 F 1473  MET GLU LEU TRP GLU LYS GLY SER LYS LYS GLY LEU LEU          
SEQRES 114 F 1473  PRO LEU SER SER                                              
HET    GK2  A 901      15                                                       
HET    GK2  D 901      15                                                       
HETNAM     GK2 [(2~{R})-1-[(2~{R})-2-AZANYL-3-METHYL-                           
HETNAM   2 GK2  BUTANOYL]PYRROLIDIN-2-YL]BORONIC ACID                           
FORMUL   5  GK2    2(C9 H19 B N2 O3)                                            
HELIX    1 AA1 ASP A   19  ARG A   23  5                                   5    
HELIX    2 AA2 SER A   30  ARG A   42  1                                  13    
HELIX    3 AA3 TYR A   44  VAL A   49  1                                   6    
HELIX    4 AA4 PRO A  116  VAL A  120  5                                   5    
HELIX    5 AA5 SER A  122  LYS A  132  1                                  11    
HELIX    6 AA6 THR A  243  GLU A  249  1                                   7    
HELIX    7 AA7 ALA A  294  ARG A  298  5                                   5    
HELIX    8 AA8 PRO A  341  PHE A  346  1                                   6    
HELIX    9 AA9 PRO A  382  ALA A  384  5                                   3    
HELIX   10 AB1 ASN A  392  VAL A  403  1                                  12    
HELIX   11 AB2 TYR A  661  GLY A  671  1                                  11    
HELIX   12 AB3 GLY A  686  GLY A  691  1                                   6    
HELIX   13 AB4 ALA A  692  LYS A  694  5                                   3    
HELIX   14 AB5 VAL A  700  TYR A  716  1                                  17    
HELIX   15 AB6 SER A  730  LYS A  743  1                                  14    
HELIX   16 AB7 VAL A  758  TYR A  762  5                                   5    
HELIX   17 AB8 ASP A  763  ASP A  772  1                                  10    
HELIX   18 AB9 ASN A  777  GLY A  784  1                                   8    
HELIX   19 AC1 SER A  785  LEU A  793  5                                   9    
HELIX   20 AC2 HIS A  812  GLY A  827  1                                  16    
HELIX   21 AC3 CYS A  844  LEU A  863  1                                  20    
HELIX   22 AC4 SER D   30  ARG D   42  1                                  13    
HELIX   23 AC5 TYR D   44  VAL D   49  1                                   6    
HELIX   24 AC6 PRO D  116  VAL D  120  5                                   5    
HELIX   25 AC7 SER D  122  ARG D  133  1                                  12    
HELIX   26 AC8 THR D  243  PHE D  250  1                                   8    
HELIX   27 AC9 ALA D  294  ARG D  298  5                                   5    
HELIX   28 AD1 PRO D  341  PHE D  346  1                                   6    
HELIX   29 AD2 PRO D  382  ALA D  384  5                                   3    
HELIX   30 AD3 ASN D  392  VAL D  403  1                                  12    
HELIX   31 AD4 ASP D  583  LYS D  587  5                                   5    
HELIX   32 AD5 TYR D  661  GLY D  671  1                                  11    
HELIX   33 AD6 GLY D  686  GLY D  691  1                                   6    
HELIX   34 AD7 ALA D  692  LYS D  694  5                                   3    
HELIX   35 AD8 VAL D  700  TYR D  716  1                                  17    
HELIX   36 AD9 SER D  730  LYS D  743  1                                  14    
HELIX   37 AE1 VAL D  758  TYR D  762  5                                   5    
HELIX   38 AE2 ASP D  763  MET D  771  1                                   9    
HELIX   39 AE3 ASN D  777  GLY D  784  1                                   8    
HELIX   40 AE4 SER D  785  LEU D  793  5                                   9    
HELIX   41 AE5 PHE D  813  GLY D  827  1                                  15    
HELIX   42 AE6 CYS D  844  LEU D  863  1                                  20    
HELIX   43 AE7 VAL E 1131  ILE E 1139  1                                   9    
HELIX   44 AE8 ASP F 1256  PHE F 1270  1                                  15    
SHEET    1 AA1 4 HIS A  54  GLN A  60  0                                        
SHEET    2 AA1 4 HIS A  68  GLY A  76 -1  O  LEU A  75   N  HIS A  54           
SHEET    3 AA1 4 SER A  85  PRO A  92 -1  O  LEU A  87   N  TYR A  74           
SHEET    4 AA1 4 LYS A 106  GLN A 107 -1  O  LYS A 106   N  TYR A  88           
SHEET    1 AA2 3 LEU A 100  LEU A 102  0                                        
SHEET    2 AA2 3 GLY E1191  GLU E1195 -1  O  LEU E1194   N  LEU A 100           
SHEET    3 AA2 3 MET E1184  LYS E1188 -1  N  MET E1184   O  GLU E1195           
SHEET    1 AA3 4 TYR A 142  HIS A 145  0                                        
SHEET    2 AA3 4 LEU A 150  ALA A 155 -1  O  LEU A 152   N  ASP A 143           
SHEET    3 AA3 4 SER A 158  ARG A 163 -1  O  CYS A 162   N  PHE A 151           
SHEET    4 AA3 4 LEU A 178  ILE A 180 -1  O  ILE A 180   N  LEU A 159           
SHEET    1 AA4 4 ARG A 188  ILE A 193  0                                        
SHEET    2 AA4 4 PHE A 200  ASN A 205 -1  O  ILE A 204   N  MET A 189           
SHEET    3 AA4 4 ASP A 208  ASN A 213 -1  O  TRP A 210   N  PHE A 203           
SHEET    4 AA4 4 GLU A 219  ARG A 221 -1  O  ARG A 220   N  VAL A 211           
SHEET    1 AA5 3 LYS A 237  ALA A 239  0                                        
SHEET    2 AA5 3 LYS A 271  ASP A 281 -1  O  VAL A 280   N  SER A 238           
SHEET    3 AA5 3 SER A 263  TRP A 264 -1  N  SER A 263   O  THR A 272           
SHEET    1 AA6 5 TYR A 256  TRP A 258  0                                        
SHEET    2 AA6 5 LYS A 271  ASP A 281 -1  O  LEU A 276   N  TRP A 257           
SHEET    3 AA6 5 LYS A 314  THR A 324 -1  O  ALA A 320   N  ILE A 275           
SHEET    4 AA6 5 ILE A 330  LEU A 338 -1  O  GLN A 334   N  GLU A 321           
SHEET    5 AA6 5 PHE A 386  PRO A 388 -1  O  ILE A 387   N  GLU A 337           
SHEET    1 AA7 2 VAL A 287  PRO A 291  0                                        
SHEET    2 AA7 2 THR A 300  ARG A 304 -1  O  ASP A 301   N  VAL A 290           
SHEET    1 AA8 4 TYR A 351  TRP A 357  0                                        
SHEET    2 AA8 4 ALA A 364  LEU A 369 -1  O  TRP A 365   N  GLY A 356           
SHEET    3 AA8 4 TRP A 375  LEU A 381 -1  O  GLN A 377   N  PHE A 368           
SHEET    4 AA8 4 TYR A 410  VAL A 416 -1  O  GLU A 415   N  LEU A 376           
SHEET    1 AA9 3 CYS A 440  ASN A 445  0                                        
SHEET    2 AA9 3 HIS A 453  ALA A 459 -1  O  VAL A 457   N  PHE A 441           
SHEET    3 AA9 3 ILE A 483  ALA A 488 -1  O  LYS A 484   N  THR A 458           
SHEET    1 AB1 4 TRP A 505  ASN A 507  0                                        
SHEET    2 AB1 4 LEU A 512  GLY A 517 -1  O  TYR A 514   N  TRP A 505           
SHEET    3 AB1 4 HIS A 526  SER A 531 -1  O  VAL A 530   N  VAL A 513           
SHEET    4 AB1 4 VAL A 539  ARG A 540 -1  O  VAL A 539   N  VAL A 529           
SHEET    1 AB2 4 SER A 547  MET A 552  0                                        
SHEET    2 AB2 4 MET A 558  SER A 564 -1  O  SER A 564   N  SER A 547           
SHEET    3 AB2 4 CYS A 571  SER A 578 -1  O  HIS A 573   N  SER A 561           
SHEET    4 AB2 4 GLN A 588  MET A 596 -1  O  ALA A 593   N  VAL A 574           
SHEET    1 AB3 8 GLU A 609  HIS A 614  0                                        
SHEET    2 AB3 8 ARG A 620  TYR A 626 -1  O  ILE A 625   N  GLU A 609           
SHEET    3 AB3 8 ALA A 673  ILE A 677 -1  O  VAL A 676   N  MET A 624           
SHEET    4 AB3 8 HIS A 637  PHE A 642  1  N  VAL A 640   O  ALA A 673           
SHEET    5 AB3 8 ILE A 719  TRP A 729  1  O  ALA A 725   N  LEU A 641           
SHEET    6 AB3 8 VAL A 749  GLY A 753  1  O  ILE A 751   N  ILE A 726           
SHEET    7 AB3 8 LEU A 800  GLY A 805  1  O  LEU A 803   N  ALA A 752           
SHEET    8 AB3 8 GLN A 831  TYR A 835  1  O  GLN A 831   N  ILE A 802           
SHEET    1 AB4 4 HIS D  54  GLN D  60  0                                        
SHEET    2 AB4 4 HIS D  68  GLY D  76 -1  O  LEU D  75   N  HIS D  54           
SHEET    3 AB4 4 SER D  85  PRO D  92 -1  O  LEU D  87   N  TYR D  74           
SHEET    4 AB4 4 LYS D 106  GLN D 107 -1  O  LYS D 106   N  TYR D  88           
SHEET    1 AB5 4 TYR D 142  HIS D 145  0                                        
SHEET    2 AB5 4 LEU D 150  GLN D 154 -1  O  LEU D 152   N  ASP D 143           
SHEET    3 AB5 4 LEU D 159  CYS D 162 -1  O  CYS D 162   N  PHE D 151           
SHEET    4 AB5 4 LEU D 178  ILE D 180 -1  O  ILE D 180   N  LEU D 159           
SHEET    1 AB6 4 MET D 189  ILE D 193  0                                        
SHEET    2 AB6 4 PHE D 200  ASN D 205 -1  O  ILE D 204   N  MET D 189           
SHEET    3 AB6 4 ASP D 208  ASN D 213 -1  O  TRP D 210   N  PHE D 203           
SHEET    4 AB6 4 GLU D 219  ARG D 221 -1  O  ARG D 220   N  VAL D 211           
SHEET    1 AB7 5 LYS D 237  ALA D 239  0                                        
SHEET    2 AB7 5 ILE D 275  ASP D 281 -1  O  VAL D 280   N  SER D 238           
SHEET    3 AB7 5 LYS D 314  THR D 324 -1  O  LYS D 318   N  TYR D 277           
SHEET    4 AB7 5 LYS D 271  LEU D 273 -1  N  LYS D 271   O  THR D 324           
SHEET    5 AB7 5 SER D 263  TRP D 264 -1  N  SER D 263   O  THR D 272           
SHEET    1 AB8 5 TYR D 256  TRP D 258  0                                        
SHEET    2 AB8 5 ILE D 275  ASP D 281 -1  O  LEU D 276   N  TRP D 257           
SHEET    3 AB8 5 LYS D 314  THR D 324 -1  O  LYS D 318   N  TYR D 277           
SHEET    4 AB8 5 ILE D 330  LEU D 338 -1  O  GLN D 334   N  GLU D 321           
SHEET    5 AB8 5 PHE D 386  PRO D 388 -1  O  ILE D 387   N  GLU D 337           
SHEET    1 AB9 2 VAL D 287  PRO D 291  0                                        
SHEET    2 AB9 2 THR D 300  ARG D 304 -1  O  ASP D 301   N  VAL D 290           
SHEET    1 AC1 4 TYR D 351  ALA D 355  0                                        
SHEET    2 AC1 4 ALA D 364  LEU D 369 -1  O  MET D 367   N  ARG D 354           
SHEET    3 AC1 4 TRP D 375  LEU D 381 -1  O  GLN D 377   N  PHE D 368           
SHEET    4 AC1 4 TYR D 410  VAL D 416 -1  O  GLU D 415   N  LEU D 376           
SHEET    1 AC2 4 PHE D 427  PRO D 429  0                                        
SHEET    2 AC2 4 LEU D 439  ASN D 445 -1  O  LEU D 442   N  TYR D 428           
SHEET    3 AC2 4 HIS D 453  ALA D 459 -1  O  VAL D 457   N  PHE D 441           
SHEET    4 AC2 4 ILE D 483  ALA D 488 -1  O  LYS D 484   N  THR D 458           
SHEET    1 AC3 4 TRP D 505  ASN D 507  0                                        
SHEET    2 AC3 4 LEU D 512  GLY D 517 -1  O  TYR D 514   N  TRP D 505           
SHEET    3 AC3 4 HIS D 526  SER D 531 -1  O  TYR D 528   N  PHE D 515           
SHEET    4 AC3 4 VAL D 539  ARG D 540 -1  O  VAL D 539   N  VAL D 529           
SHEET    1 AC4 4 SER D 547  MET D 552  0                                        
SHEET    2 AC4 4 MET D 558  SER D 564 -1  O  SER D 564   N  SER D 547           
SHEET    3 AC4 4 CYS D 571  SER D 578 -1  O  CYS D 571   N  TYR D 563           
SHEET    4 AC4 4 GLN D 588  MET D 596 -1  O  ALA D 593   N  VAL D 574           
SHEET    1 AC5 8 GLU D 609  HIS D 614  0                                        
SHEET    2 AC5 8 ARG D 620  TYR D 626 -1  O  GLY D 623   N  PHE D 611           
SHEET    3 AC5 8 ALA D 673  ILE D 677 -1  O  VAL D 676   N  MET D 624           
SHEET    4 AC5 8 HIS D 637  VAL D 643  1  N  VAL D 640   O  ALA D 673           
SHEET    5 AC5 8 ILE D 719  TRP D 729  1  O  ALA D 725   N  LEU D 641           
SHEET    6 AC5 8 VAL D 749  GLY D 753  1  O  GLY D 753   N  GLY D 728           
SHEET    7 AC5 8 LEU D 800  GLY D 805  1  O  LEU D 803   N  ALA D 752           
SHEET    8 AC5 8 GLN D 831  TYR D 835  1  O  GLN D 831   N  ILE D 802           
SHEET    1 AC6 2 TRP E1080  GLY E1081  0                                        
SHEET    2 AC6 2 GLY E1084  PRO E1085 -1  O  GLY E1084   N  GLY E1081           
SHEET    1 AC7 4 GLU E1089  ASP E1092  0                                        
SHEET    2 AC7 4 LEU E1097  PHE E1102 -1  O  ARG E1099   N  GLU E1089           
SHEET    3 AC7 4 VAL E1123  PHE E1129 -1  O  ILE E1127   N  TYR E1098           
SHEET    4 AC7 4 LEU E1152  LYS E1155 -1  O  ASP E1153   N  GLU E1128           
SHEET    1 AC8 4 CYS E1116  VAL E1118  0                                        
SHEET    2 AC8 4 ALA E1163  LEU E1166 -1  O  ALA E1163   N  VAL E1118           
SHEET    3 AC8 4 ILE E1205  VAL E1206 -1  O  ILE E1205   N  LEU E1166           
SHEET    4 AC8 4 ARG E1199  VAL E1200 -1  N  ARG E1199   O  VAL E1206           
SHEET    1 AC9 2 TRP E1145  VAL E1147  0                                        
SHEET    2 AC9 2 LEU F1218  LYS F1220 -1  O  LEU F1219   N  MET E1146           
SHEET    1 AD1 2 PRO F1230  VAL F1231  0                                        
SHEET    2 AD1 2 LEU F1284  TYR F1285 -1  O  LEU F1284   N  VAL F1231           
SHEET    1 AD2 3 VAL F1234  LEU F1236  0                                        
SHEET    2 AD2 3 VAL F1246  ILE F1253 -1  O  TYR F1251   N  LEU F1236           
SHEET    3 AD2 3 PHE F1320  GLY F1326 -1  O  SER F1321   N  LEU F1250           
SHEET    1 AD3 2 TYR F1238  HIS F1239  0                                        
SHEET    2 AD3 2 VAL F1273  ARG F1274 -1  O  VAL F1273   N  HIS F1239           
SHEET    1 AD4 4 GLU F1306  GLU F1308  0                                        
SHEET    2 AD4 4 ARG F1289  GLY F1294 -1  N  TYR F1290   O  LEU F1307           
SHEET    3 AD4 4 ARG F1333  ASP F1338 -1  O  GLN F1335   N  SER F1293           
SHEET    4 AD4 4 LEU F1344  LEU F1349 -1  O  TRP F1346   N  VAL F1336           
LINK         OG  SER A 730                 B15 GK2 A 901     1555   1555  1.41  
LINK         OG  SER D 730                 B15 GK2 D 901     1555   1555  1.40  
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
TER    6817      LEU A 863                                                      
TER   13634      LEU D 863                                                      
TER   14703      PHE E1212                                                      
TER   15809      VAL F1350                                                      
MASTER     2970    0    2   44  119    0    0    615835    4   32  366          
END                                                                             

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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