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LongText Report for: 6qz2-pdb

Name Class
6qz2-pdb
HEADER    HYDROLASE                               10-MAR-19   6QZ2              
TITLE     STRUCTURE OF MHETASE FROM IDEONELLA SAKAIENSIS                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: MONO(2-HYDROXYETHYL) TEREPHTHALATE HYDROLASE;              
COMPND   3 CHAIN: A, B, C, D, E, F, G, H, I, J;                                 
COMPND   4 SYNONYM: MHETASE;                                                    
COMPND   5 EC: 3.1.1.102;                                                       
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: IDEONELLA SAKAIENSIS;                           
SOURCE   3 ORGANISM_TAXID: 1547922;                                             
SOURCE   4 GENE: ISF6_0224;                                                     
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   7 EXPRESSION_SYSTEM_VARIANT: C41;                                      
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PCJ136                                    
KEYWDS    MHETASE, PET DEGRADATION, STRUCTURAL GENOMICS, PLASTIC-BINDING        
KEYWDS   2 PROTEIN, HYDROLASE                                                   
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    M.D.ALLEN,C.W.JOHNSON,B.C.KNOTT,G.T.BECKHAM,J.E.MCGEEHAN              
REVDAT   1   30-SEP-20 6QZ2    0                                                
JRNL        AUTH   M.D.ALLEN,C.W.JOHNSON,B.C.KNOTT,G.T.BECKHAM,J.E.MCGEEHAN     
JRNL        TITL   STRUCTURE OF FROM MHETASE FROM IDEONELLA SAKAIENSIS          
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    1.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (1.13_2998: ???)                              
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.90                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 57.62                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.960                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 93.6                           
REMARK   3   NUMBER OF REFLECTIONS             : 506771                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.186                           
REMARK   3   R VALUE            (WORKING SET) : 0.185                           
REMARK   3   FREE R VALUE                     : 0.205                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.910                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 24886                           
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 57.6459 -  5.9017    0.96    16428   864  0.1686 0.1717        
REMARK   3     2  5.9017 -  4.6850    0.94    16053   924  0.1611 0.1792        
REMARK   3     3  4.6850 -  4.0930    0.95    16157   892  0.1466 0.1597        
REMARK   3     4  4.0930 -  3.7188    0.95    16286   867  0.1625 0.1695        
REMARK   3     5  3.7188 -  3.4523    0.95    16409   771  0.1703 0.1867        
REMARK   3     6  3.4523 -  3.2488    0.95    16318   798  0.1776 0.1866        
REMARK   3     7  3.2488 -  3.0861    0.95    16450   775  0.1835 0.2070        
REMARK   3     8  3.0861 -  2.9518    0.95    16187   839  0.1790 0.1925        
REMARK   3     9  2.9518 -  2.8381    0.95    16392   828  0.1885 0.2133        
REMARK   3    10  2.8381 -  2.7402    0.95    16386   889  0.1875 0.2134        
REMARK   3    11  2.7402 -  2.6545    0.95    16207   817  0.1937 0.2170        
REMARK   3    12  2.6545 -  2.5787    0.94    16428   671  0.1920 0.2136        
REMARK   3    13  2.5787 -  2.5108    0.94    16068   840  0.1905 0.2188        
REMARK   3    14  2.5108 -  2.4495    0.93    16014   920  0.1907 0.2242        
REMARK   3    15  2.4495 -  2.3938    0.93    15861   814  0.1938 0.2262        
REMARK   3    16  2.3938 -  2.3429    0.93    15907   824  0.1945 0.2201        
REMARK   3    17  2.3429 -  2.2960    0.92    15878   831  0.1983 0.2258        
REMARK   3    18  2.2960 -  2.2527    0.93    15878   853  0.1961 0.2226        
REMARK   3    19  2.2527 -  2.2125    0.93    15995   860  0.1962 0.2262        
REMARK   3    20  2.2125 -  2.1749    0.93    16056   814  0.2044 0.2310        
REMARK   3    21  2.1749 -  2.1399    0.93    15907   831  0.2053 0.2308        
REMARK   3    22  2.1399 -  2.1069    0.93    15839   844  0.2094 0.2339        
REMARK   3    23  2.1069 -  2.0760    0.92    15728   852  0.2154 0.2520        
REMARK   3    24  2.0760 -  2.0467    0.92    15766   810  0.2252 0.2585        
REMARK   3    25  2.0467 -  2.0190    0.93    16000   848  0.2277 0.2658        
REMARK   3    26  2.0190 -  1.9928    0.93    15986   800  0.2267 0.2519        
REMARK   3    27  1.9928 -  1.9679    0.92    15725   827  0.2320 0.2605        
REMARK   3    28  1.9679 -  1.9442    0.93    16026   801  0.2439 0.2795        
REMARK   3    29  1.9442 -  1.9216    0.92    15823   808  0.2499 0.2734        
REMARK   3    30  1.9216 -  1.9000    0.92    15727   774  0.2647 0.2976        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : NULL                                          
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.190            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 21.110           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.003          42546                                  
REMARK   3   ANGLE     :  0.576          57971                                  
REMARK   3   CHIRALITY :  0.041           6082                                  
REMARK   3   PLANARITY :  0.004           7761                                  
REMARK   3   DIHEDRAL  :  4.955          24792                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 6QZ2 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE.                               
REMARK 100 THE DEPOSITION ID IS D_1292101165.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 18-OCT-18                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 5.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : DIAMOND                            
REMARK 200  BEAMLINE                       : I03                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9795                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 S 6M              
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 506864                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.900                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 95.300                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 93.7                               
REMARK 200  DATA REDUNDANCY                : 1.700                              
REMARK 200  R MERGE                    (I) : 0.05700                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : 7.1000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.90                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.25400                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : 2.600                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 6QZ1                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 55.44                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.76                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M SODIUM CITRATE (PH 5.5), 1.0 M     
REMARK 280  AMMONIUM PHOSPHATE MONOBASIC, VAPOR DIFFUSION, SITTING DROP,        
REMARK 280  TEMPERATURE 290K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10                           
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 5                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 6                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 7                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 8                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 9                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 10                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: J                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLN A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     THR A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     THR A     7                                                      
REMARK 465     MET A     8                                                      
REMARK 465     LEU A     9                                                      
REMARK 465     LEU A    10                                                      
REMARK 465     ALA A    11                                                      
REMARK 465     SER A    12                                                      
REMARK 465     VAL A    13                                                      
REMARK 465     ALA A    14                                                      
REMARK 465     LEU A    15                                                      
REMARK 465     ALA A    16                                                      
REMARK 465     ALA A    17                                                      
REMARK 465     CYS A    18                                                      
REMARK 465     ALA A    19                                                      
REMARK 465     GLY A    20                                                      
REMARK 465     GLY A    21                                                      
REMARK 465     GLY A    22                                                      
REMARK 465     SER A    23                                                      
REMARK 465     THR A    24                                                      
REMARK 465     PRO A    25                                                      
REMARK 465     LEU A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     LEU A    28                                                      
REMARK 465     PRO A    29                                                      
REMARK 465     GLN A    30                                                      
REMARK 465     GLN A    31                                                      
REMARK 465     GLN A    32                                                      
REMARK 465     PRO A    33                                                      
REMARK 465     PRO A    34                                                      
REMARK 465     GLN A    35                                                      
REMARK 465     GLN A    36                                                      
REMARK 465     GLU A    37                                                      
REMARK 465     PRO A    38                                                      
REMARK 465     PRO A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     PRO A    41                                                      
REMARK 465     LEU A   604                                                      
REMARK 465     GLU A   605                                                      
REMARK 465     HIS A   606                                                      
REMARK 465     HIS A   607                                                      
REMARK 465     HIS A   608                                                      
REMARK 465     HIS A   609                                                      
REMARK 465     HIS A   610                                                      
REMARK 465     HIS A   611                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLN B     2                                                      
REMARK 465     THR B     3                                                      
REMARK 465     THR B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     THR B     6                                                      
REMARK 465     THR B     7                                                      
REMARK 465     MET B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     LEU B    10                                                      
REMARK 465     ALA B    11                                                      
REMARK 465     SER B    12                                                      
REMARK 465     VAL B    13                                                      
REMARK 465     ALA B    14                                                      
REMARK 465     LEU B    15                                                      
REMARK 465     ALA B    16                                                      
REMARK 465     ALA B    17                                                      
REMARK 465     CYS B    18                                                      
REMARK 465     ALA B    19                                                      
REMARK 465     GLY B    20                                                      
REMARK 465     GLY B    21                                                      
REMARK 465     GLY B    22                                                      
REMARK 465     SER B    23                                                      
REMARK 465     THR B    24                                                      
REMARK 465     PRO B    25                                                      
REMARK 465     LEU B    26                                                      
REMARK 465     PRO B    27                                                      
REMARK 465     LEU B    28                                                      
REMARK 465     PRO B    29                                                      
REMARK 465     GLN B    30                                                      
REMARK 465     GLN B    31                                                      
REMARK 465     GLN B    32                                                      
REMARK 465     PRO B    33                                                      
REMARK 465     PRO B    34                                                      
REMARK 465     GLN B    35                                                      
REMARK 465     GLN B    36                                                      
REMARK 465     GLU B    37                                                      
REMARK 465     PRO B    38                                                      
REMARK 465     PRO B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     PRO B    41                                                      
REMARK 465     PRO B    42                                                      
REMARK 465     LEU B   604                                                      
REMARK 465     GLU B   605                                                      
REMARK 465     HIS B   606                                                      
REMARK 465     HIS B   607                                                      
REMARK 465     HIS B   608                                                      
REMARK 465     HIS B   609                                                      
REMARK 465     HIS B   610                                                      
REMARK 465     HIS B   611                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLN C     2                                                      
REMARK 465     THR C     3                                                      
REMARK 465     THR C     4                                                      
REMARK 465     VAL C     5                                                      
REMARK 465     THR C     6                                                      
REMARK 465     THR C     7                                                      
REMARK 465     MET C     8                                                      
REMARK 465     LEU C     9                                                      
REMARK 465     LEU C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     SER C    12                                                      
REMARK 465     VAL C    13                                                      
REMARK 465     ALA C    14                                                      
REMARK 465     LEU C    15                                                      
REMARK 465     ALA C    16                                                      
REMARK 465     ALA C    17                                                      
REMARK 465     CYS C    18                                                      
REMARK 465     ALA C    19                                                      
REMARK 465     GLY C    20                                                      
REMARK 465     GLY C    21                                                      
REMARK 465     GLY C    22                                                      
REMARK 465     SER C    23                                                      
REMARK 465     THR C    24                                                      
REMARK 465     PRO C    25                                                      
REMARK 465     LEU C    26                                                      
REMARK 465     PRO C    27                                                      
REMARK 465     LEU C    28                                                      
REMARK 465     PRO C    29                                                      
REMARK 465     GLN C    30                                                      
REMARK 465     GLN C    31                                                      
REMARK 465     GLN C    32                                                      
REMARK 465     PRO C    33                                                      
REMARK 465     PRO C    34                                                      
REMARK 465     GLN C    35                                                      
REMARK 465     GLN C    36                                                      
REMARK 465     GLU C    37                                                      
REMARK 465     PRO C    38                                                      
REMARK 465     PRO C    39                                                      
REMARK 465     PRO C    40                                                      
REMARK 465     PRO C    41                                                      
REMARK 465     PRO C    42                                                      
REMARK 465     LEU C   604                                                      
REMARK 465     GLU C   605                                                      
REMARK 465     HIS C   606                                                      
REMARK 465     HIS C   607                                                      
REMARK 465     HIS C   608                                                      
REMARK 465     HIS C   609                                                      
REMARK 465     HIS C   610                                                      
REMARK 465     HIS C   611                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLN D     2                                                      
REMARK 465     THR D     3                                                      
REMARK 465     THR D     4                                                      
REMARK 465     VAL D     5                                                      
REMARK 465     THR D     6                                                      
REMARK 465     THR D     7                                                      
REMARK 465     MET D     8                                                      
REMARK 465     LEU D     9                                                      
REMARK 465     LEU D    10                                                      
REMARK 465     ALA D    11                                                      
REMARK 465     SER D    12                                                      
REMARK 465     VAL D    13                                                      
REMARK 465     ALA D    14                                                      
REMARK 465     LEU D    15                                                      
REMARK 465     ALA D    16                                                      
REMARK 465     ALA D    17                                                      
REMARK 465     CYS D    18                                                      
REMARK 465     ALA D    19                                                      
REMARK 465     GLY D    20                                                      
REMARK 465     GLY D    21                                                      
REMARK 465     GLY D    22                                                      
REMARK 465     SER D    23                                                      
REMARK 465     THR D    24                                                      
REMARK 465     PRO D    25                                                      
REMARK 465     LEU D    26                                                      
REMARK 465     PRO D    27                                                      
REMARK 465     LEU D    28                                                      
REMARK 465     PRO D    29                                                      
REMARK 465     GLN D    30                                                      
REMARK 465     GLN D    31                                                      
REMARK 465     GLN D    32                                                      
REMARK 465     PRO D    33                                                      
REMARK 465     PRO D    34                                                      
REMARK 465     GLN D    35                                                      
REMARK 465     GLN D    36                                                      
REMARK 465     GLU D    37                                                      
REMARK 465     PRO D    38                                                      
REMARK 465     PRO D    39                                                      
REMARK 465     PRO D    40                                                      
REMARK 465     PRO D    41                                                      
REMARK 465     PRO D    42                                                      
REMARK 465     LEU D   604                                                      
REMARK 465     GLU D   605                                                      
REMARK 465     HIS D   606                                                      
REMARK 465     HIS D   607                                                      
REMARK 465     HIS D   608                                                      
REMARK 465     HIS D   609                                                      
REMARK 465     HIS D   610                                                      
REMARK 465     HIS D   611                                                      
REMARK 465     MET E     1                                                      
REMARK 465     GLN E     2                                                      
REMARK 465     THR E     3                                                      
REMARK 465     THR E     4                                                      
REMARK 465     VAL E     5                                                      
REMARK 465     THR E     6                                                      
REMARK 465     THR E     7                                                      
REMARK 465     MET E     8                                                      
REMARK 465     LEU E     9                                                      
REMARK 465     LEU E    10                                                      
REMARK 465     ALA E    11                                                      
REMARK 465     SER E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     ALA E    14                                                      
REMARK 465     LEU E    15                                                      
REMARK 465     ALA E    16                                                      
REMARK 465     ALA E    17                                                      
REMARK 465     CYS E    18                                                      
REMARK 465     ALA E    19                                                      
REMARK 465     GLY E    20                                                      
REMARK 465     GLY E    21                                                      
REMARK 465     GLY E    22                                                      
REMARK 465     SER E    23                                                      
REMARK 465     THR E    24                                                      
REMARK 465     PRO E    25                                                      
REMARK 465     LEU E    26                                                      
REMARK 465     PRO E    27                                                      
REMARK 465     LEU E    28                                                      
REMARK 465     PRO E    29                                                      
REMARK 465     GLN E    30                                                      
REMARK 465     GLN E    31                                                      
REMARK 465     GLN E    32                                                      
REMARK 465     PRO E    33                                                      
REMARK 465     PRO E    34                                                      
REMARK 465     GLN E    35                                                      
REMARK 465     GLN E    36                                                      
REMARK 465     GLU E    37                                                      
REMARK 465     PRO E    38                                                      
REMARK 465     PRO E    39                                                      
REMARK 465     PRO E    40                                                      
REMARK 465     PRO E    41                                                      
REMARK 465     PRO E    42                                                      
REMARK 465     LEU E   604                                                      
REMARK 465     GLU E   605                                                      
REMARK 465     HIS E   606                                                      
REMARK 465     HIS E   607                                                      
REMARK 465     HIS E   608                                                      
REMARK 465     HIS E   609                                                      
REMARK 465     HIS E   610                                                      
REMARK 465     HIS E   611                                                      
REMARK 465     MET F     1                                                      
REMARK 465     GLN F     2                                                      
REMARK 465     THR F     3                                                      
REMARK 465     THR F     4                                                      
REMARK 465     VAL F     5                                                      
REMARK 465     THR F     6                                                      
REMARK 465     THR F     7                                                      
REMARK 465     MET F     8                                                      
REMARK 465     LEU F     9                                                      
REMARK 465     LEU F    10                                                      
REMARK 465     ALA F    11                                                      
REMARK 465     SER F    12                                                      
REMARK 465     VAL F    13                                                      
REMARK 465     ALA F    14                                                      
REMARK 465     LEU F    15                                                      
REMARK 465     ALA F    16                                                      
REMARK 465     ALA F    17                                                      
REMARK 465     CYS F    18                                                      
REMARK 465     ALA F    19                                                      
REMARK 465     GLY F    20                                                      
REMARK 465     GLY F    21                                                      
REMARK 465     GLY F    22                                                      
REMARK 465     SER F    23                                                      
REMARK 465     THR F    24                                                      
REMARK 465     PRO F    25                                                      
REMARK 465     LEU F    26                                                      
REMARK 465     PRO F    27                                                      
REMARK 465     LEU F    28                                                      
REMARK 465     PRO F    29                                                      
REMARK 465     GLN F    30                                                      
REMARK 465     GLN F    31                                                      
REMARK 465     GLN F    32                                                      
REMARK 465     PRO F    33                                                      
REMARK 465     PRO F    34                                                      
REMARK 465     GLN F    35                                                      
REMARK 465     GLN F    36                                                      
REMARK 465     GLU F    37                                                      
REMARK 465     PRO F    38                                                      
REMARK 465     PRO F    39                                                      
REMARK 465     PRO F    40                                                      
REMARK 465     PRO F    41                                                      
REMARK 465     PRO F    42                                                      
REMARK 465     LEU F   604                                                      
REMARK 465     GLU F   605                                                      
REMARK 465     HIS F   606                                                      
REMARK 465     HIS F   607                                                      
REMARK 465     HIS F   608                                                      
REMARK 465     HIS F   609                                                      
REMARK 465     HIS F   610                                                      
REMARK 465     HIS F   611                                                      
REMARK 465     MET G     1                                                      
REMARK 465     GLN G     2                                                      
REMARK 465     THR G     3                                                      
REMARK 465     THR G     4                                                      
REMARK 465     VAL G     5                                                      
REMARK 465     THR G     6                                                      
REMARK 465     THR G     7                                                      
REMARK 465     MET G     8                                                      
REMARK 465     LEU G     9                                                      
REMARK 465     LEU G    10                                                      
REMARK 465     ALA G    11                                                      
REMARK 465     SER G    12                                                      
REMARK 465     VAL G    13                                                      
REMARK 465     ALA G    14                                                      
REMARK 465     LEU G    15                                                      
REMARK 465     ALA G    16                                                      
REMARK 465     ALA G    17                                                      
REMARK 465     CYS G    18                                                      
REMARK 465     ALA G    19                                                      
REMARK 465     GLY G    20                                                      
REMARK 465     GLY G    21                                                      
REMARK 465     GLY G    22                                                      
REMARK 465     SER G    23                                                      
REMARK 465     THR G    24                                                      
REMARK 465     PRO G    25                                                      
REMARK 465     LEU G    26                                                      
REMARK 465     PRO G    27                                                      
REMARK 465     LEU G    28                                                      
REMARK 465     PRO G    29                                                      
REMARK 465     GLN G    30                                                      
REMARK 465     GLN G    31                                                      
REMARK 465     GLN G    32                                                      
REMARK 465     PRO G    33                                                      
REMARK 465     PRO G    34                                                      
REMARK 465     GLN G    35                                                      
REMARK 465     GLN G    36                                                      
REMARK 465     GLU G    37                                                      
REMARK 465     PRO G    38                                                      
REMARK 465     PRO G    39                                                      
REMARK 465     PRO G    40                                                      
REMARK 465     PRO G   603                                                      
REMARK 465     LEU G   604                                                      
REMARK 465     GLU G   605                                                      
REMARK 465     HIS G   606                                                      
REMARK 465     HIS G   607                                                      
REMARK 465     HIS G   608                                                      
REMARK 465     HIS G   609                                                      
REMARK 465     HIS G   610                                                      
REMARK 465     HIS G   611                                                      
REMARK 465     MET H     1                                                      
REMARK 465     GLN H     2                                                      
REMARK 465     THR H     3                                                      
REMARK 465     THR H     4                                                      
REMARK 465     VAL H     5                                                      
REMARK 465     THR H     6                                                      
REMARK 465     THR H     7                                                      
REMARK 465     MET H     8                                                      
REMARK 465     LEU H     9                                                      
REMARK 465     LEU H    10                                                      
REMARK 465     ALA H    11                                                      
REMARK 465     SER H    12                                                      
REMARK 465     VAL H    13                                                      
REMARK 465     ALA H    14                                                      
REMARK 465     LEU H    15                                                      
REMARK 465     ALA H    16                                                      
REMARK 465     ALA H    17                                                      
REMARK 465     CYS H    18                                                      
REMARK 465     ALA H    19                                                      
REMARK 465     GLY H    20                                                      
REMARK 465     GLY H    21                                                      
REMARK 465     GLY H    22                                                      
REMARK 465     SER H    23                                                      
REMARK 465     THR H    24                                                      
REMARK 465     PRO H    25                                                      
REMARK 465     LEU H    26                                                      
REMARK 465     PRO H    27                                                      
REMARK 465     LEU H    28                                                      
REMARK 465     PRO H    29                                                      
REMARK 465     GLN H    30                                                      
REMARK 465     GLN H    31                                                      
REMARK 465     GLN H    32                                                      
REMARK 465     PRO H    33                                                      
REMARK 465     PRO H    34                                                      
REMARK 465     GLN H    35                                                      
REMARK 465     GLN H    36                                                      
REMARK 465     GLU H    37                                                      
REMARK 465     PRO H    38                                                      
REMARK 465     PRO H    39                                                      
REMARK 465     PRO H    40                                                      
REMARK 465     PRO H    41                                                      
REMARK 465     LEU H   604                                                      
REMARK 465     GLU H   605                                                      
REMARK 465     HIS H   606                                                      
REMARK 465     HIS H   607                                                      
REMARK 465     HIS H   608                                                      
REMARK 465     HIS H   609                                                      
REMARK 465     HIS H   610                                                      
REMARK 465     HIS H   611                                                      
REMARK 465     MET I     1                                                      
REMARK 465     GLN I     2                                                      
REMARK 465     THR I     3                                                      
REMARK 465     THR I     4                                                      
REMARK 465     VAL I     5                                                      
REMARK 465     THR I     6                                                      
REMARK 465     THR I     7                                                      
REMARK 465     MET I     8                                                      
REMARK 465     LEU I     9                                                      
REMARK 465     LEU I    10                                                      
REMARK 465     ALA I    11                                                      
REMARK 465     SER I    12                                                      
REMARK 465     VAL I    13                                                      
REMARK 465     ALA I    14                                                      
REMARK 465     LEU I    15                                                      
REMARK 465     ALA I    16                                                      
REMARK 465     ALA I    17                                                      
REMARK 465     CYS I    18                                                      
REMARK 465     ALA I    19                                                      
REMARK 465     GLY I    20                                                      
REMARK 465     GLY I    21                                                      
REMARK 465     GLY I    22                                                      
REMARK 465     SER I    23                                                      
REMARK 465     THR I    24                                                      
REMARK 465     PRO I    25                                                      
REMARK 465     LEU I    26                                                      
REMARK 465     PRO I    27                                                      
REMARK 465     LEU I    28                                                      
REMARK 465     PRO I    29                                                      
REMARK 465     GLN I    30                                                      
REMARK 465     GLN I    31                                                      
REMARK 465     GLN I    32                                                      
REMARK 465     PRO I    33                                                      
REMARK 465     PRO I    34                                                      
REMARK 465     GLN I    35                                                      
REMARK 465     GLN I    36                                                      
REMARK 465     GLU I    37                                                      
REMARK 465     PRO I    38                                                      
REMARK 465     PRO I    39                                                      
REMARK 465     PRO I    40                                                      
REMARK 465     PRO I    41                                                      
REMARK 465     PRO I    42                                                      
REMARK 465     LEU I   604                                                      
REMARK 465     GLU I   605                                                      
REMARK 465     HIS I   606                                                      
REMARK 465     HIS I   607                                                      
REMARK 465     HIS I   608                                                      
REMARK 465     HIS I   609                                                      
REMARK 465     HIS I   610                                                      
REMARK 465     HIS I   611                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLN J     2                                                      
REMARK 465     THR J     3                                                      
REMARK 465     THR J     4                                                      
REMARK 465     VAL J     5                                                      
REMARK 465     THR J     6                                                      
REMARK 465     THR J     7                                                      
REMARK 465     MET J     8                                                      
REMARK 465     LEU J     9                                                      
REMARK 465     LEU J    10                                                      
REMARK 465     ALA J    11                                                      
REMARK 465     SER J    12                                                      
REMARK 465     VAL J    13                                                      
REMARK 465     ALA J    14                                                      
REMARK 465     LEU J    15                                                      
REMARK 465     ALA J    16                                                      
REMARK 465     ALA J    17                                                      
REMARK 465     CYS J    18                                                      
REMARK 465     ALA J    19                                                      
REMARK 465     GLY J    20                                                      
REMARK 465     GLY J    21                                                      
REMARK 465     GLY J    22                                                      
REMARK 465     SER J    23                                                      
REMARK 465     THR J    24                                                      
REMARK 465     PRO J    25                                                      
REMARK 465     LEU J    26                                                      
REMARK 465     PRO J    27                                                      
REMARK 465     LEU J    28                                                      
REMARK 465     PRO J    29                                                      
REMARK 465     GLN J    30                                                      
REMARK 465     GLN J    31                                                      
REMARK 465     GLN J    32                                                      
REMARK 465     PRO J    33                                                      
REMARK 465     PRO J    34                                                      
REMARK 465     GLN J    35                                                      
REMARK 465     GLN J    36                                                      
REMARK 465     GLU J    37                                                      
REMARK 465     PRO J    38                                                      
REMARK 465     PRO J    39                                                      
REMARK 465     PRO J    40                                                      
REMARK 465     PRO J    41                                                      
REMARK 465     PRO J    42                                                      
REMARK 465     PRO J   603                                                      
REMARK 465     LEU J   604                                                      
REMARK 465     GLU J   605                                                      
REMARK 465     HIS J   606                                                      
REMARK 465     HIS J   607                                                      
REMARK 465     HIS J   608                                                      
REMARK 465     HIS J   609                                                      
REMARK 465     HIS J   610                                                      
REMARK 465     HIS J   611                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    HOH E  1378     O    HOH E  1536              1.51            
REMARK 500   O    HOH A  1511     O    HOH A  1572              1.80            
REMARK 500   O    HOH A  1666     O    HOH A  1674              1.81            
REMARK 500   O    HOH C  1226     O    HOH C  1569              1.81            
REMARK 500   O    HOH G  1253     O    HOH G  1296              1.81            
REMARK 500   O    HOH E  1364     O    HOH E  1497              1.81            
REMARK 500   O    HOH F  1671     O    HOH F  1673              1.82            
REMARK 500   O    HOH D   953     O    HOH D  1280              1.83            
REMARK 500   O    HOH A  1417     O    HOH A  1445              1.83            
REMARK 500   O    HOH B  1325     O    HOH B  1423              1.84            
REMARK 500   O    HOH E  1392     O    HOH E  1460              1.84            
REMARK 500   O    HOH B  1428     O    HOH B  1498              1.85            
REMARK 500   O    HOH D  1456     O    HOH F  1597              1.85            
REMARK 500   O    HOH E  1259     O    HOH E  1411              1.85            
REMARK 500   O    HOH D  1404     O    HOH H  1207              1.85            
REMARK 500   O    HOH C  1617     O    HOH C  1640              1.85            
REMARK 500   O    HOH C  1331     O    HOH C  1451              1.86            
REMARK 500   O    HOH F  1344     O    HOH F  1565              1.86            
REMARK 500   OG   SER D   405     O    HOH D   901              1.86            
REMARK 500   O    HOH C   965     O    HOH C  1593              1.86            
REMARK 500   O    HOH C  1242     O    HOH C  1486              1.86            
REMARK 500   O    HOH B  1490     O    HOH B  1524              1.87            
REMARK 500   O    PRO E   602     O    HOH E   901              1.87            
REMARK 500   O    HOH J  1112     O    HOH J  1113              1.88            
REMARK 500   O    HOH G  1009     O    HOH G  1369              1.88            
REMARK 500   O    HOH D  1307     O    HOH D  1460              1.88            
REMARK 500   O    HOH F  1578     O    HOH F  1618              1.88            
REMARK 500   O    HOH C  1236     O    HOH C  1605              1.89            
REMARK 500   O    HOH D  1001     O    HOH D  1482              1.89            
REMARK 500   O    HOH H   999     O    HOH H  1273              1.89            
REMARK 500   NH1  ARG C    48     O    HOH C   901              1.90            
REMARK 500   O    HOH H  1291     O    HOH H  1308              1.90            
REMARK 500   O    HOH D   958     O    HOH D  1462              1.90            
REMARK 500   O    HOH H   934     O    HOH H   946              1.90            
REMARK 500   O    HOH F   902     O    HOH F   919              1.91            
REMARK 500   N    THR E   388     O    HOH E   902              1.92            
REMARK 500   O    HOH C  1419     O    HOH C  1455              1.92            
REMARK 500   O    HOH F  1419     O    HOH F  1538              1.92            
REMARK 500   O    HOH F  1463     O    HOH F  1608              1.92            
REMARK 500   OE2  GLU I   549     O    HOH I   901              1.93            
REMARK 500   O    HOH D  1445     O    HOH D  1520              1.93            
REMARK 500   O    HOH A  1613     O    HOH A  1630              1.93            
REMARK 500   O    HOH D  1174     O    HOH D  1398              1.93            
REMARK 500   O    HOH B  1504     O    HOH C  1421              1.94            
REMARK 500   O    HOH A  1634     O    HOH A  1641              1.94            
REMARK 500   O    HOH E  1517     O    HOH E  1552              1.94            
REMARK 500   NE2  GLN I   336     O    HOH I   902              1.94            
REMARK 500   O    HOH E   924     O    HOH E  1546              1.94            
REMARK 500   O    HOH D  1408     O    HOH D  1436              1.94            
REMARK 500   O    HOH B  1504     O    HOH C  1624              1.95            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     329 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   O    HOH E  1449     O    HOH H  1218     1655     1.83            
REMARK 500   O    HOH D  1450     O    HOH E  1566     1455     1.92            
REMARK 500   O    HOH A  1307     O    HOH G  1262     1655     1.93            
REMARK 500   O    HOH A  1530     O    HOH G  1310     1655     2.01            
REMARK 500   O    HOH D  1176     O    HOH E  1039     1455     2.02            
REMARK 500   O    HOH E  1548     O    HOH H  1292     1655     2.02            
REMARK 500   O    HOH C  1669     O    HOH D  1586     1645     2.05            
REMARK 500   O    HOH C  1188     O    HOH E  1226     1545     2.06            
REMARK 500   O    HOH B  1369     O    HOH F  1518     1556     2.08            
REMARK 500   O    HOH E  1591     O    HOH H  1342     1655     2.09            
REMARK 500   O    HOH E   904     O    HOH J  1039     1655     2.13            
REMARK 500   O    HOH C  1261     O    HOH E  1262     1545     2.18            
REMARK 500   O    HOH A  1480     O    HOH G  1347     1655     2.19            
REMARK 500   O    HOH A  1307     O    HOH G  1372     1655     2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  67       35.27    -91.02                                   
REMARK 500    ASN A 134     -145.38     60.27                                   
REMARK 500    TYR A 194      -30.33   -151.03                                   
REMARK 500    SER A 225     -119.50     66.30                                   
REMARK 500    ALA A 249       53.91     36.52                                   
REMARK 500    ASP A 311       16.04   -148.28                                   
REMARK 500    TYR A 373      -95.70   -139.63                                   
REMARK 500    SER A 383     -144.92   -142.06                                   
REMARK 500    ASN A 408       14.95   -141.78                                   
REMARK 500    VAL A 412      -60.65    -98.71                                   
REMARK 500    ASN A 527     -148.55    -83.96                                   
REMARK 500    CYS A 529      -23.48     69.07                                   
REMARK 500    ALA B  67       32.98    -86.07                                   
REMARK 500    ASN B 134     -148.28     58.25                                   
REMARK 500    TYR B 194      -29.90   -152.78                                   
REMARK 500    SER B 225     -119.55     66.94                                   
REMARK 500    ALA B 249       57.97     33.85                                   
REMARK 500    ASP B 311       10.24   -149.91                                   
REMARK 500    TYR B 373      -94.18   -143.55                                   
REMARK 500    SER B 383     -141.40   -137.37                                   
REMARK 500    ASN B 408       10.34   -145.00                                   
REMARK 500    VAL B 412      -61.24    -95.84                                   
REMARK 500    SER B 456      105.46   -164.14                                   
REMARK 500    SER B 491       32.04    -97.90                                   
REMARK 500    ASN B 527     -148.68    -86.72                                   
REMARK 500    CYS B 529      -33.51     71.27                                   
REMARK 500    ALA C  67       42.88    -92.30                                   
REMARK 500    ASN C 134     -146.58     57.82                                   
REMARK 500    ASN C 171       55.97    -91.68                                   
REMARK 500    TYR C 194      -30.20   -151.32                                   
REMARK 500    SER C 225     -119.35     70.42                                   
REMARK 500    ALA C 249       56.19     33.51                                   
REMARK 500    ASP C 311       10.96   -141.20                                   
REMARK 500    TYR C 373      -94.43   -147.40                                   
REMARK 500    SER C 383     -142.52   -136.96                                   
REMARK 500    VAL C 412      -60.51    -94.67                                   
REMARK 500    SER C 456      107.08   -161.55                                   
REMARK 500    SER C 491       32.93    -99.67                                   
REMARK 500    ASN C 527     -150.02    -86.95                                   
REMARK 500    CYS C 529      -31.17     70.66                                   
REMARK 500    ALA D  67       35.25    -94.92                                   
REMARK 500    ASN D 134     -149.54     57.95                                   
REMARK 500    TYR D 194      -29.68   -150.15                                   
REMARK 500    SER D 225     -121.48     65.28                                   
REMARK 500    ALA D 249       57.34     32.07                                   
REMARK 500    TYR D 373      -95.71   -146.59                                   
REMARK 500    SER D 383     -137.52   -136.79                                   
REMARK 500    SER D 456      114.46   -162.78                                   
REMARK 500    ASN D 527     -154.98    -88.45                                   
REMARK 500    CYS D 529      -30.35     69.53                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     125 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH A1671        DISTANCE =  5.82 ANGSTROMS                       
REMARK 525    HOH A1672        DISTANCE =  6.30 ANGSTROMS                       
REMARK 525    HOH A1673        DISTANCE =  6.63 ANGSTROMS                       
REMARK 525    HOH A1674        DISTANCE =  6.64 ANGSTROMS                       
REMARK 525    HOH A1675        DISTANCE =  6.99 ANGSTROMS                       
REMARK 525    HOH A1676        DISTANCE =  7.77 ANGSTROMS                       
REMARK 525    HOH A1677        DISTANCE =  7.78 ANGSTROMS                       
REMARK 525    HOH B1648        DISTANCE =  5.87 ANGSTROMS                       
REMARK 525    HOH B1649        DISTANCE =  5.92 ANGSTROMS                       
REMARK 525    HOH B1650        DISTANCE =  5.99 ANGSTROMS                       
REMARK 525    HOH B1651        DISTANCE =  5.99 ANGSTROMS                       
REMARK 525    HOH B1652        DISTANCE =  6.09 ANGSTROMS                       
REMARK 525    HOH B1653        DISTANCE =  6.09 ANGSTROMS                       
REMARK 525    HOH B1654        DISTANCE =  6.17 ANGSTROMS                       
REMARK 525    HOH B1655        DISTANCE =  6.19 ANGSTROMS                       
REMARK 525    HOH B1656        DISTANCE =  6.31 ANGSTROMS                       
REMARK 525    HOH B1657        DISTANCE =  6.31 ANGSTROMS                       
REMARK 525    HOH B1658        DISTANCE =  6.42 ANGSTROMS                       
REMARK 525    HOH B1659        DISTANCE =  6.98 ANGSTROMS                       
REMARK 525    HOH C1673        DISTANCE =  5.87 ANGSTROMS                       
REMARK 525    HOH C1674        DISTANCE =  5.88 ANGSTROMS                       
REMARK 525    HOH C1675        DISTANCE =  6.12 ANGSTROMS                       
REMARK 525    HOH C1676        DISTANCE =  6.17 ANGSTROMS                       
REMARK 525    HOH C1677        DISTANCE =  6.28 ANGSTROMS                       
REMARK 525    HOH C1678        DISTANCE =  6.97 ANGSTROMS                       
REMARK 525    HOH C1679        DISTANCE =  7.18 ANGSTROMS                       
REMARK 525    HOH C1680        DISTANCE =  7.89 ANGSTROMS                       
REMARK 525    HOH C1681        DISTANCE =  8.35 ANGSTROMS                       
REMARK 525    HOH C1682        DISTANCE =  8.78 ANGSTROMS                       
REMARK 525    HOH C1683        DISTANCE =  9.07 ANGSTROMS                       
REMARK 525    HOH C1684        DISTANCE =  9.73 ANGSTROMS                       
REMARK 525    HOH C1685        DISTANCE = 10.08 ANGSTROMS                       
REMARK 525    HOH D1602        DISTANCE =  5.93 ANGSTROMS                       
REMARK 525    HOH D1603        DISTANCE =  6.18 ANGSTROMS                       
REMARK 525    HOH D1604        DISTANCE =  6.58 ANGSTROMS                       
REMARK 525    HOH D1605        DISTANCE =  6.73 ANGSTROMS                       
REMARK 525    HOH D1606        DISTANCE =  7.12 ANGSTROMS                       
REMARK 525    HOH E1614        DISTANCE =  5.82 ANGSTROMS                       
REMARK 525    HOH E1615        DISTANCE =  5.87 ANGSTROMS                       
REMARK 525    HOH E1616        DISTANCE =  5.95 ANGSTROMS                       
REMARK 525    HOH E1617        DISTANCE =  6.05 ANGSTROMS                       
REMARK 525    HOH E1618        DISTANCE =  6.11 ANGSTROMS                       
REMARK 525    HOH E1619        DISTANCE =  6.22 ANGSTROMS                       
REMARK 525    HOH E1620        DISTANCE =  6.26 ANGSTROMS                       
REMARK 525    HOH E1621        DISTANCE =  6.35 ANGSTROMS                       
REMARK 525    HOH E1622        DISTANCE =  6.43 ANGSTROMS                       
REMARK 525    HOH E1623        DISTANCE =  6.70 ANGSTROMS                       
REMARK 525    HOH E1624        DISTANCE =  7.22 ANGSTROMS                       
REMARK 525    HOH F1660        DISTANCE =  6.23 ANGSTROMS                       
REMARK 525    HOH F1661        DISTANCE =  6.23 ANGSTROMS                       
REMARK 525    HOH F1662        DISTANCE =  6.24 ANGSTROMS                       
REMARK 525    HOH F1663        DISTANCE =  6.25 ANGSTROMS                       
REMARK 525    HOH F1664        DISTANCE =  6.57 ANGSTROMS                       
REMARK 525    HOH F1665        DISTANCE =  6.74 ANGSTROMS                       
REMARK 525    HOH F1666        DISTANCE =  6.97 ANGSTROMS                       
REMARK 525    HOH F1667        DISTANCE =  7.37 ANGSTROMS                       
REMARK 525    HOH F1668        DISTANCE =  8.20 ANGSTROMS                       
REMARK 525    HOH F1669        DISTANCE = 12.16 ANGSTROMS                       
REMARK 525    HOH F1670        DISTANCE = 12.57 ANGSTROMS                       
REMARK 525    HOH F1671        DISTANCE = 13.03 ANGSTROMS                       
REMARK 525    HOH F1672        DISTANCE = 13.27 ANGSTROMS                       
REMARK 525    HOH F1673        DISTANCE = 13.60 ANGSTROMS                       
REMARK 525    HOH G1461        DISTANCE =  5.84 ANGSTROMS                       
REMARK 525    HOH G1462        DISTANCE =  5.88 ANGSTROMS                       
REMARK 525    HOH G1463        DISTANCE =  5.93 ANGSTROMS                       
REMARK 525    HOH G1464        DISTANCE =  5.97 ANGSTROMS                       
REMARK 525    HOH G1465        DISTANCE =  5.99 ANGSTROMS                       
REMARK 525    HOH G1466        DISTANCE =  5.99 ANGSTROMS                       
REMARK 525    HOH G1467        DISTANCE =  6.60 ANGSTROMS                       
REMARK 525    HOH H1359        DISTANCE =  6.01 ANGSTROMS                       
REMARK 525    HOH H1360        DISTANCE =  6.73 ANGSTROMS                       
REMARK 525    HOH H1361        DISTANCE =  7.29 ANGSTROMS                       
REMARK 525    HOH I1241        DISTANCE =  6.04 ANGSTROMS                       
REMARK 525    HOH J1128        DISTANCE =  5.92 ANGSTROMS                       
REMARK 525    HOH J1129        DISTANCE =  6.30 ANGSTROMS                       
REMARK 525    HOH J1130        DISTANCE =  6.42 ANGSTROMS                       
REMARK 525    HOH J1131        DISTANCE =  6.47 ANGSTROMS                       
REMARK 525    HOH J1132        DISTANCE =  6.58 ANGSTROMS                       
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 304   O                                                      
REMARK 620 2 ASP A 304   OD1  68.7                                              
REMARK 620 3 ASP A 307   OD1  71.9 135.0                                        
REMARK 620 4 ASP A 307   OD2  79.2 136.1  51.4                                  
REMARK 620 5 LEU A 309   O    82.0  83.0  70.7 122.1                            
REMARK 620 6 ASP A 311   OD1 141.4  73.8 135.8 137.4  84.6                      
REMARK 620 7 ILE A 313   O    99.3  77.3 130.6  79.3 158.1  80.9                
REMARK 620 8 HOH A 911   O   145.9 144.9  75.1  73.8  95.0  71.1  95.8          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA B 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP B 304   O                                                      
REMARK 620 2 ASP B 304   OD1  69.7                                              
REMARK 620 3 ASP B 307   OD1  73.2 137.8                                        
REMARK 620 4 ASP B 307   OD2  77.5 135.1  50.0                                  
REMARK 620 5 LEU B 309   O    78.9  82.9  70.7 120.2                            
REMARK 620 6 ASP B 311   OD1 142.4  74.0 134.2 138.3  87.3                      
REMARK 620 7 ILE B 313   O    98.3  76.5 129.0  79.0 158.8  82.4                
REMARK 620 8 HOH B1034   O   145.3 144.4  72.7  75.8  95.9  70.3  97.9          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 304   O                                                      
REMARK 620 2 ASP C 304   OD1  70.8                                              
REMARK 620 3 ASP C 307   OD1  68.9 134.4                                        
REMARK 620 4 ASP C 307   OD2  73.5 132.6  50.5                                  
REMARK 620 5 LEU C 309   O    81.2  82.5  71.2 121.4                            
REMARK 620 6 ASP C 311   OD1 146.0  76.7 134.7 139.0  85.3                      
REMARK 620 7 ILE C 313   O    97.9  80.0 125.7  75.1 161.7  85.6                
REMARK 620 8 HOH C 943   O   142.4 146.2  74.4  77.1  94.8  69.5  96.8          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA D 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP D 304   O                                                      
REMARK 620 2 ASP D 304   OD1  70.7                                              
REMARK 620 3 ASP D 307   OD1  75.3 141.3                                        
REMARK 620 4 ASP D 307   OD2  77.9 134.8  50.2                                  
REMARK 620 5 LEU D 309   O    82.7  86.6  71.1 121.0                            
REMARK 620 6 ASP D 311   OD1 142.5  72.9 134.1 137.0  86.7                      
REMARK 620 7 ILE D 313   O    99.2  77.6 126.4  76.4 162.4  81.2                
REMARK 620 8 HOH D1027   O   144.1 145.1  69.8  73.4  93.9  72.3  94.6          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E 304   O                                                      
REMARK 620 2 ASP E 304   OD1  69.7                                              
REMARK 620 3 ASP E 307   OD1  72.5 137.3                                        
REMARK 620 4 ASP E 307   OD2  79.5 136.3  50.7                                  
REMARK 620 5 LEU E 309   O    80.5  82.0  72.7 123.2                            
REMARK 620 6 ASP E 311   OD1 142.7  74.6 133.8 136.5  84.0                      
REMARK 620 7 ILE E 313   O    98.7  77.6 127.9  77.3 158.4  83.8                
REMARK 620 8 HOH E 915   O   143.8 146.3  72.5  71.2  97.9  71.9  95.2          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP F 304   O                                                      
REMARK 620 2 ASP F 304   OD1  69.5                                              
REMARK 620 3 ASP F 307   OD1  72.4 135.9                                        
REMARK 620 4 ASP F 307   OD2  77.9 136.3  50.7                                  
REMARK 620 5 LEU F 309   O    78.0  80.6  70.4 120.6                            
REMARK 620 6 ASP F 311   OD1 143.3  76.1 130.7 138.2  84.3                      
REMARK 620 7 ILE F 313   O   102.6  80.3 129.9  79.3 159.2  83.3                
REMARK 620 8 HOH F 933   O   142.6 146.6  70.8  73.8  95.8  70.5  95.7          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA G 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP G 304   O                                                      
REMARK 620 2 ASP G 304   OD1  69.3                                              
REMARK 620 3 ASP G 307   OD1  73.1 140.1                                        
REMARK 620 4 ASP G 307   OD2  78.2 129.4  51.4                                  
REMARK 620 5 LEU G 309   O    79.1  85.7  74.6 125.4                            
REMARK 620 6 ASP G 311   OD1 142.3  75.3 135.3 137.0  85.7                      
REMARK 620 7 ILE G 313   O    99.3  71.3 128.6  77.2 155.7  80.9                
REMARK 620 8 HOH G 962   O   144.8 145.9  72.9  73.5 100.5  71.8  94.5          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA H 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP H 304   O                                                      
REMARK 620 2 ASP H 304   OD1  72.0                                              
REMARK 620 3 ASP H 307   OD1  74.8 142.9                                        
REMARK 620 4 ASP H 307   OD2  77.4 132.6  51.7                                  
REMARK 620 5 LEU H 309   O    77.1  83.8  73.1 123.3                            
REMARK 620 6 ASP H 311   OD1 145.2  76.9 127.6 136.8  84.7                      
REMARK 620 7 ILE H 313   O   102.4  76.2 127.4  76.2 159.0  84.6                
REMARK 620 8 HOH H 969   O   143.1 144.7  69.0  74.8  98.6  68.4  94.1          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA I 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP I 304   O                                                      
REMARK 620 2 ASP I 304   OD1  77.1                                              
REMARK 620 3 ASP I 307   OD1  73.8 146.1                                        
REMARK 620 4 ASP I 307   OD2  74.8 136.1  49.8                                  
REMARK 620 5 LEU I 309   O    78.3  87.5  69.8 118.4                            
REMARK 620 6 ASP I 311   OD1 150.4  78.6 121.7 134.9  83.9                      
REMARK 620 7 ILE I 313   O   114.4  83.4 124.6  78.3 162.1  79.1                
REMARK 620 8 HOH I 963   O   134.6 148.2  63.5  66.4  99.9  71.6  80.4          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA J 801  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP J 304   O                                                      
REMARK 620 2 ASP J 304   OD1  77.4                                              
REMARK 620 3 ASP J 307   OD1  76.5 151.3                                        
REMARK 620 4 ASP J 307   OD2  80.8 135.0  50.8                                  
REMARK 620 5 LEU J 309   O    75.8  88.9  73.2 122.9                            
REMARK 620 6 ASP J 311   OD1 148.1  76.0 123.7 130.9  86.5                      
REMARK 620 7 ILE J 313   O   112.3  76.2 125.3  76.5 160.5  77.8                
REMARK 620 8 HOH J 968   O   142.2 139.2  65.7  75.7  92.6  63.4  90.7          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA B 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA C 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA D 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA F 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA G 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA H 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA I 801                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA J 801                  
DBREF1 6QZ2 A    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 A     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 B    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 B     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 C    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 C     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 D    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 D     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 E    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 E     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 F    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 F     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 G    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 G     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 H    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 H     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 I    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 I     A0A0K8P8E7                          1         603             
DBREF1 6QZ2 J    1   603  UNP                  MHETH_IDESA                      
DBREF2 6QZ2 J     A0A0K8P8E7                          1         603             
SEQADV 6QZ2 LEU A  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU A  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS A  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS A  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS A  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS A  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS A  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS A  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU B  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU B  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS B  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS B  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS B  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS B  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS B  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS B  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU C  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU C  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS C  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS C  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS C  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS C  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS C  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS C  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU D  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU D  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS D  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS D  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS D  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS D  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS D  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS D  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU E  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU E  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS E  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS E  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS E  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS E  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS E  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS E  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU F  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU F  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS F  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS F  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS F  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS F  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS F  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS F  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU G  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU G  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS G  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS G  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS G  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS G  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS G  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS G  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU H  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU H  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS H  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS H  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS H  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS H  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS H  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS H  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU I  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU I  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS I  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS I  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS I  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS I  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS I  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS I  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 LEU J  604  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 GLU J  605  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS J  606  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS J  607  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS J  608  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS J  609  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS J  610  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQADV 6QZ2 HIS J  611  UNP  A0A0K8P8E           EXPRESSION TAG                 
SEQRES   1 A  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 A  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 A  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 A  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 A  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 A  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 A  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 A  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 A  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 A  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 A  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 A  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 A  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 A  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 A  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 A  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 A  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 A  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 A  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 A  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 A  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 A  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 A  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 A  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 A  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 A  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 A  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 A  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 A  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 A  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 A  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 A  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 A  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 A  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 A  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 A  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 A  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 A  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 A  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 A  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 A  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 A  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 A  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 A  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 A  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 A  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 A  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 B  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 B  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 B  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 B  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 B  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 B  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 B  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 B  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 B  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 B  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 B  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 B  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 B  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 B  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 B  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 B  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 B  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 B  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 B  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 B  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 B  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 B  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 B  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 B  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 B  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 B  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 B  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 B  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 B  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 B  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 B  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 B  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 B  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 B  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 B  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 B  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 B  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 B  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 B  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 B  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 B  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 B  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 B  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 B  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 B  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 B  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 B  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 C  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 C  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 C  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 C  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 C  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 C  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 C  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 C  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 C  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 C  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 C  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 C  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 C  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 C  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 C  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 C  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 C  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 C  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 C  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 C  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 C  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 C  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 C  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 C  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 C  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 C  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 C  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 C  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 C  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 C  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 C  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 C  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 C  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 C  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 C  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 C  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 C  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 C  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 C  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 C  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 C  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 C  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 C  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 C  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 C  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 C  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 C  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 D  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 D  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 D  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 D  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 D  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 D  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 D  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 D  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 D  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 D  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 D  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 D  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 D  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 D  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 D  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 D  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 D  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 D  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 D  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 D  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 D  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 D  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 D  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 D  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 D  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 D  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 D  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 D  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 D  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 D  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 D  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 D  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 D  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 D  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 D  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 D  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 D  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 D  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 D  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 D  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 D  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 D  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 D  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 D  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 D  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 D  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 D  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 E  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 E  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 E  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 E  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 E  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 E  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 E  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 E  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 E  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 E  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 E  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 E  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 E  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 E  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 E  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 E  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 E  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 E  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 E  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 E  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 E  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 E  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 E  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 E  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 E  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 E  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 E  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 E  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 E  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 E  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 E  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 E  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 E  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 E  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 E  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 E  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 E  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 E  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 E  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 E  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 E  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 E  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 E  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 E  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 E  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 E  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 E  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 F  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 F  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 F  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 F  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 F  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 F  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 F  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 F  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 F  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 F  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 F  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 F  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 F  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 F  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 F  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 F  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 F  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 F  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 F  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 F  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 F  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 F  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 F  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 F  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 F  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 F  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 F  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 F  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 F  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 F  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 F  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 F  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 F  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 F  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 F  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 F  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 F  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 F  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 F  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 F  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 F  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 F  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 F  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 F  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 F  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 F  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 F  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 G  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 G  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 G  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 G  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 G  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 G  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 G  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 G  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 G  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 G  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 G  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 G  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 G  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 G  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 G  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 G  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 G  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 G  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 G  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 G  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 G  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 G  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 G  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 G  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 G  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 G  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 G  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 G  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 G  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 G  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 G  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 G  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 G  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 G  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 G  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 G  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 G  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 G  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 G  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 G  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 G  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 G  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 G  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 G  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 G  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 G  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 G  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 H  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 H  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 H  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 H  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 H  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 H  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 H  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 H  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 H  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 H  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 H  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 H  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 H  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 H  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 H  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 H  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 H  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 H  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 H  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 H  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 H  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 H  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 H  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 H  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 H  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 H  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 H  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 H  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 H  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 H  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 H  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 H  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 H  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 H  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 H  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 H  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 H  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 H  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 H  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 H  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 H  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 H  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 H  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 H  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 H  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 H  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 H  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 I  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 I  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 I  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 I  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 I  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 I  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 I  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 I  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 I  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 I  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 I  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 I  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 I  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 I  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 I  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 I  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 I  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 I  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 I  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 I  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 I  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 I  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 I  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 I  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 I  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 I  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 I  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 I  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 I  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 I  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 I  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 I  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 I  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 I  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 I  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 I  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 I  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 I  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 I  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 I  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 I  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 I  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 I  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 I  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 I  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 I  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 I  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 J  611  MET GLN THR THR VAL THR THR MET LEU LEU ALA SER VAL          
SEQRES   2 J  611  ALA LEU ALA ALA CYS ALA GLY GLY GLY SER THR PRO LEU          
SEQRES   3 J  611  PRO LEU PRO GLN GLN GLN PRO PRO GLN GLN GLU PRO PRO          
SEQRES   4 J  611  PRO PRO PRO VAL PRO LEU ALA SER ARG ALA ALA CYS GLU          
SEQRES   5 J  611  ALA LEU LYS ASP GLY ASN GLY ASP MET VAL TRP PRO ASN          
SEQRES   6 J  611  ALA ALA THR VAL VAL GLU VAL ALA ALA TRP ARG ASP ALA          
SEQRES   7 J  611  ALA PRO ALA THR ALA SER ALA ALA ALA LEU PRO GLU HIS          
SEQRES   8 J  611  CYS GLU VAL SER GLY ALA ILE ALA LYS ARG THR GLY ILE          
SEQRES   9 J  611  ASP GLY TYR PRO TYR GLU ILE LYS PHE ARG LEU ARG MET          
SEQRES  10 J  611  PRO ALA GLU TRP ASN GLY ARG PHE PHE MET GLU GLY GLY          
SEQRES  11 J  611  SER GLY THR ASN GLY SER LEU SER ALA ALA THR GLY SER          
SEQRES  12 J  611  ILE GLY GLY GLY GLN ILE ALA SER ALA LEU SER ARG ASN          
SEQRES  13 J  611  PHE ALA THR ILE ALA THR ASP GLY GLY HIS ASP ASN ALA          
SEQRES  14 J  611  VAL ASN ASP ASN PRO ASP ALA LEU GLY THR VAL ALA PHE          
SEQRES  15 J  611  GLY LEU ASP PRO GLN ALA ARG LEU ASP MET GLY TYR ASN          
SEQRES  16 J  611  SER TYR ASP GLN VAL THR GLN ALA GLY LYS ALA ALA VAL          
SEQRES  17 J  611  ALA ARG PHE TYR GLY ARG ALA ALA ASP LYS SER TYR PHE          
SEQRES  18 J  611  ILE GLY CYS SER GLU GLY GLY ARG GLU GLY MET MET LEU          
SEQRES  19 J  611  SER GLN ARG PHE PRO SER HIS TYR ASP GLY ILE VAL ALA          
SEQRES  20 J  611  GLY ALA PRO GLY TYR GLN LEU PRO LYS ALA GLY ILE SER          
SEQRES  21 J  611  GLY ALA TRP THR THR GLN SER LEU ALA PRO ALA ALA VAL          
SEQRES  22 J  611  GLY LEU ASP ALA GLN GLY VAL PRO LEU ILE ASN LYS SER          
SEQRES  23 J  611  PHE SER ASP ALA ASP LEU HIS LEU LEU SER GLN ALA ILE          
SEQRES  24 J  611  LEU GLY THR CYS ASP ALA LEU ASP GLY LEU ALA ASP GLY          
SEQRES  25 J  611  ILE VAL ASP ASN TYR ARG ALA CYS GLN ALA ALA PHE ASP          
SEQRES  26 J  611  PRO ALA THR ALA ALA ASN PRO ALA ASN GLY GLN ALA LEU          
SEQRES  27 J  611  GLN CYS VAL GLY ALA LYS THR ALA ASP CYS LEU SER PRO          
SEQRES  28 J  611  VAL GLN VAL THR ALA ILE LYS ARG ALA MET ALA GLY PRO          
SEQRES  29 J  611  VAL ASN SER ALA GLY THR PRO LEU TYR ASN ARG TRP ALA          
SEQRES  30 J  611  TRP ASP ALA GLY MET SER GLY LEU SER GLY THR THR TYR          
SEQRES  31 J  611  ASN GLN GLY TRP ARG SER TRP TRP LEU GLY SER PHE ASN          
SEQRES  32 J  611  SER SER ALA ASN ASN ALA GLN ARG VAL SER GLY PHE SER          
SEQRES  33 J  611  ALA ARG SER TRP LEU VAL ASP PHE ALA THR PRO PRO GLU          
SEQRES  34 J  611  PRO MET PRO MET THR GLN VAL ALA ALA ARG MET MET LYS          
SEQRES  35 J  611  PHE ASP PHE ASP ILE ASP PRO LEU LYS ILE TRP ALA THR          
SEQRES  36 J  611  SER GLY GLN PHE THR GLN SER SER MET ASP TRP HIS GLY          
SEQRES  37 J  611  ALA THR SER THR ASP LEU ALA ALA PHE ARG ASP ARG GLY          
SEQRES  38 J  611  GLY LYS MET ILE LEU TYR HIS GLY MET SER ASP ALA ALA          
SEQRES  39 J  611  PHE SER ALA LEU ASP THR ALA ASP TYR TYR GLU ARG LEU          
SEQRES  40 J  611  GLY ALA ALA MET PRO GLY ALA ALA GLY PHE ALA ARG LEU          
SEQRES  41 J  611  PHE LEU VAL PRO GLY MET ASN HIS CYS SER GLY GLY PRO          
SEQRES  42 J  611  GLY THR ASP ARG PHE ASP MET LEU THR PRO LEU VAL ALA          
SEQRES  43 J  611  TRP VAL GLU ARG GLY GLU ALA PRO ASP GLN ILE SER ALA          
SEQRES  44 J  611  TRP SER GLY THR PRO GLY TYR PHE GLY VAL ALA ALA ARG          
SEQRES  45 J  611  THR ARG PRO LEU CYS PRO TYR PRO GLN ILE ALA ARG TYR          
SEQRES  46 J  611  LYS GLY SER GLY ASP ILE ASN THR GLU ALA ASN PHE ALA          
SEQRES  47 J  611  CYS ALA ALA PRO PRO LEU GLU HIS HIS HIS HIS HIS HIS          
HET     CA  A 801       1                                                       
HET     CA  B 801       1                                                       
HET     CA  C 801       1                                                       
HET     CA  D 801       1                                                       
HET     CA  E 801       1                                                       
HET     CA  F 801       1                                                       
HET     CA  G 801       1                                                       
HET     CA  H 801       1                                                       
HET     CA  I 801       1                                                       
HET     CA  J 801       1                                                       
HETNAM      CA CALCIUM ION                                                      
FORMUL  11   CA    10(CA 2+)                                                    
FORMUL  21  HOH   *6125(H2 O)                                                   
HELIX    1 AA1 SER A   47  ALA A   53  1                                   7    
HELIX    2 AA2 ALA A  152  ASN A  156  5                                   5    
HELIX    3 AA3 LEU A  177  LEU A  184  5                                   8    
HELIX    4 AA4 ASP A  185  TYR A  194  1                                  10    
HELIX    5 AA5 TYR A  194  GLY A  213  1                                  20    
HELIX    6 AA6 SER A  225  PHE A  238  1                                  14    
HELIX    7 AA7 GLN A  253  PRO A  255  5                                   3    
HELIX    8 AA8 LYS A  256  ALA A  269  1                                  14    
HELIX    9 AA9 PRO A  270  ALA A  272  5                                   3    
HELIX   10 AB1 LEU A  282  SER A  286  5                                   5    
HELIX   11 AB2 SER A  288  ASP A  304  1                                  17    
HELIX   12 AB3 ALA A  305  GLY A  308  5                                   4    
HELIX   13 AB4 ASN A  316  PHE A  324  1                                   9    
HELIX   14 AB5 SER A  350  GLY A  363  1                                  14    
HELIX   15 AB6 ASP A  379  SER A  383  5                                   5    
HELIX   16 AB7 TRP A  394  LEU A  399  1                                   6    
HELIX   17 AB8 GLY A  414  PHE A  424  1                                  11    
HELIX   18 AB9 PRO A  432  THR A  434  5                                   3    
HELIX   19 AC1 GLN A  435  LYS A  442  1                                   8    
HELIX   20 AC2 ILE A  447  TRP A  453  5                                   7    
HELIX   21 AC3 SER A  462  HIS A  467  1                                   6    
HELIX   22 AC4 LEU A  474  ARG A  480  1                                   7    
HELIX   23 AC5 SER A  496  MET A  511  1                                  16    
HELIX   24 AC6 GLY A  513  GLY A  516  5                                   4    
HELIX   25 AC7 MET A  540  GLY A  551  1                                  12    
HELIX   26 AC8 THR A  563  GLY A  568  5                                   6    
HELIX   27 AC9 THR A  593  ALA A  595  5                                   3    
HELIX   28 AD1 SER B   47  ALA B   53  1                                   7    
HELIX   29 AD2 ALA B  152  ASN B  156  5                                   5    
HELIX   30 AD3 ASN B  173  LEU B  184  5                                  12    
HELIX   31 AD4 ASP B  185  TYR B  194  1                                  10    
HELIX   32 AD5 TYR B  194  GLY B  213  1                                  20    
HELIX   33 AD6 SER B  225  PHE B  238  1                                  14    
HELIX   34 AD7 GLN B  253  PRO B  255  5                                   3    
HELIX   35 AD8 LYS B  256  ALA B  269  1                                  14    
HELIX   36 AD9 PRO B  270  ALA B  272  5                                   3    
HELIX   37 AE1 LEU B  282  SER B  286  5                                   5    
HELIX   38 AE2 SER B  288  ASP B  304  1                                  17    
HELIX   39 AE3 ALA B  305  GLY B  308  5                                   4    
HELIX   40 AE4 ASN B  316  PHE B  324  1                                   9    
HELIX   41 AE5 SER B  350  GLY B  363  1                                  14    
HELIX   42 AE6 ASP B  379  SER B  383  5                                   5    
HELIX   43 AE7 TRP B  394  LEU B  399  1                                   6    
HELIX   44 AE8 GLY B  414  PHE B  424  1                                  11    
HELIX   45 AE9 PRO B  432  THR B  434  5                                   3    
HELIX   46 AF1 GLN B  435  LYS B  442  1                                   8    
HELIX   47 AF2 ILE B  447  TRP B  453  5                                   7    
HELIX   48 AF3 SER B  462  HIS B  467  1                                   6    
HELIX   49 AF4 LEU B  474  ARG B  480  1                                   7    
HELIX   50 AF5 SER B  496  MET B  511  1                                  16    
HELIX   51 AF6 GLY B  513  GLY B  516  5                                   4    
HELIX   52 AF7 MET B  540  GLY B  551  1                                  12    
HELIX   53 AF8 THR B  563  GLY B  568  5                                   6    
HELIX   54 AF9 THR B  593  ALA B  595  5                                   3    
HELIX   55 AG1 SER C   47  ALA C   53  1                                   7    
HELIX   56 AG2 ALA C  152  ASN C  156  5                                   5    
HELIX   57 AG3 LEU C  177  LEU C  184  5                                   8    
HELIX   58 AG4 ASP C  185  TYR C  194  1                                  10    
HELIX   59 AG5 TYR C  194  GLY C  213  1                                  20    
HELIX   60 AG6 SER C  225  PHE C  238  1                                  14    
HELIX   61 AG7 GLN C  253  PRO C  255  5                                   3    
HELIX   62 AG8 LYS C  256  ALA C  269  1                                  14    
HELIX   63 AG9 PRO C  270  ALA C  272  5                                   3    
HELIX   64 AH1 LEU C  282  SER C  286  5                                   5    
HELIX   65 AH2 SER C  288  ASP C  304  1                                  17    
HELIX   66 AH3 ALA C  305  GLY C  308  5                                   4    
HELIX   67 AH4 ASN C  316  PHE C  324  1                                   9    
HELIX   68 AH5 SER C  350  GLY C  363  1                                  14    
HELIX   69 AH6 ASP C  379  SER C  383  5                                   5    
HELIX   70 AH7 TRP C  394  LEU C  399  1                                   6    
HELIX   71 AH8 GLY C  414  PHE C  424  1                                  11    
HELIX   72 AH9 PRO C  432  THR C  434  5                                   3    
HELIX   73 AI1 GLN C  435  LYS C  442  1                                   8    
HELIX   74 AI2 ILE C  447  TRP C  453  5                                   7    
HELIX   75 AI3 SER C  462  GLY C  468  1                                   7    
HELIX   76 AI4 LEU C  474  ARG C  480  1                                   7    
HELIX   77 AI5 SER C  496  MET C  511  1                                  16    
HELIX   78 AI6 GLY C  513  GLY C  516  5                                   4    
HELIX   79 AI7 MET C  540  GLY C  551  1                                  12    
HELIX   80 AI8 THR C  563  GLY C  568  5                                   6    
HELIX   81 AI9 THR C  593  ALA C  595  5                                   3    
HELIX   82 AJ1 SER D   47  ALA D   53  1                                   7    
HELIX   83 AJ2 ALA D  152  ASN D  156  5                                   5    
HELIX   84 AJ3 LEU D  177  LEU D  184  5                                   8    
HELIX   85 AJ4 ASP D  185  TYR D  194  1                                  10    
HELIX   86 AJ5 TYR D  194  GLY D  213  1                                  20    
HELIX   87 AJ6 SER D  225  PHE D  238  1                                  14    
HELIX   88 AJ7 GLN D  253  PRO D  255  5                                   3    
HELIX   89 AJ8 LYS D  256  ALA D  269  1                                  14    
HELIX   90 AJ9 PRO D  270  ALA D  272  5                                   3    
HELIX   91 AK1 LEU D  282  SER D  286  5                                   5    
HELIX   92 AK2 SER D  288  ASP D  304  1                                  17    
HELIX   93 AK3 ALA D  305  GLY D  308  5                                   4    
HELIX   94 AK4 ASN D  316  PHE D  324  1                                   9    
HELIX   95 AK5 SER D  350  GLY D  363  1                                  14    
HELIX   96 AK6 ASP D  379  SER D  383  5                                   5    
HELIX   97 AK7 TRP D  394  LEU D  399  1                                   6    
HELIX   98 AK8 GLY D  414  PHE D  424  1                                  11    
HELIX   99 AK9 PRO D  432  THR D  434  5                                   3    
HELIX  100 AL1 GLN D  435  PHE D  443  1                                   9    
HELIX  101 AL2 ILE D  447  TRP D  453  5                                   7    
HELIX  102 AL3 SER D  462  HIS D  467  1                                   6    
HELIX  103 AL4 LEU D  474  ARG D  480  1                                   7    
HELIX  104 AL5 SER D  496  MET D  511  1                                  16    
HELIX  105 AL6 GLY D  513  GLY D  516  5                                   4    
HELIX  106 AL7 MET D  540  GLY D  551  1                                  12    
HELIX  107 AL8 THR D  563  GLY D  568  5                                   6    
HELIX  108 AL9 THR D  593  ALA D  595  5                                   3    
HELIX  109 AM1 SER E   47  ALA E   53  1                                   7    
HELIX  110 AM2 ALA E  152  ASN E  156  5                                   5    
HELIX  111 AM3 LEU E  177  LEU E  184  5                                   8    
HELIX  112 AM4 ASP E  185  TYR E  194  1                                  10    
HELIX  113 AM5 TYR E  194  GLY E  213  1                                  20    
HELIX  114 AM6 SER E  225  PHE E  238  1                                  14    
HELIX  115 AM7 GLN E  253  PRO E  255  5                                   3    
HELIX  116 AM8 LYS E  256  ALA E  269  1                                  14    
HELIX  117 AM9 PRO E  270  ALA E  272  5                                   3    
HELIX  118 AN1 LEU E  282  PHE E  287  5                                   6    
HELIX  119 AN2 SER E  288  ASP E  304  1                                  17    
HELIX  120 AN3 ALA E  305  GLY E  308  5                                   4    
HELIX  121 AN4 ASN E  316  PHE E  324  1                                   9    
HELIX  122 AN5 SER E  350  GLY E  363  1                                  14    
HELIX  123 AN6 ASP E  379  SER E  383  5                                   5    
HELIX  124 AN7 TRP E  394  LEU E  399  1                                   6    
HELIX  125 AN8 GLY E  414  PHE E  424  1                                  11    
HELIX  126 AN9 PRO E  432  THR E  434  5                                   3    
HELIX  127 AO1 GLN E  435  LYS E  442  1                                   8    
HELIX  128 AO2 ILE E  447  TRP E  453  5                                   7    
HELIX  129 AO3 SER E  462  GLY E  468  1                                   7    
HELIX  130 AO4 LEU E  474  ARG E  480  1                                   7    
HELIX  131 AO5 SER E  496  MET E  511  1                                  16    
HELIX  132 AO6 GLY E  513  GLY E  516  5                                   4    
HELIX  133 AO7 MET E  540  GLY E  551  1                                  12    
HELIX  134 AO8 THR E  563  GLY E  568  5                                   6    
HELIX  135 AO9 THR E  593  ALA E  595  5                                   3    
HELIX  136 AP1 SER F   47  ALA F   53  1                                   7    
HELIX  137 AP2 LEU F  177  LEU F  184  5                                   8    
HELIX  138 AP3 ASP F  185  TYR F  194  1                                  10    
HELIX  139 AP4 TYR F  194  GLY F  213  1                                  20    
HELIX  140 AP5 SER F  225  PHE F  238  1                                  14    
HELIX  141 AP6 GLN F  253  PRO F  255  5                                   3    
HELIX  142 AP7 LYS F  256  ALA F  269  1                                  14    
HELIX  143 AP8 PRO F  270  ALA F  272  5                                   3    
HELIX  144 AP9 LEU F  282  SER F  286  5                                   5    
HELIX  145 AQ1 SER F  288  ASP F  304  1                                  17    
HELIX  146 AQ2 ALA F  305  GLY F  308  5                                   4    
HELIX  147 AQ3 ASN F  316  PHE F  324  1                                   9    
HELIX  148 AQ4 SER F  350  GLY F  363  1                                  14    
HELIX  149 AQ5 ASP F  379  SER F  383  5                                   5    
HELIX  150 AQ6 TRP F  394  LEU F  399  1                                   6    
HELIX  151 AQ7 GLY F  414  PHE F  424  1                                  11    
HELIX  152 AQ8 PRO F  432  THR F  434  5                                   3    
HELIX  153 AQ9 GLN F  435  LYS F  442  1                                   8    
HELIX  154 AR1 ILE F  447  TRP F  453  5                                   7    
HELIX  155 AR2 SER F  462  GLY F  468  1                                   7    
HELIX  156 AR3 LEU F  474  ARG F  480  1                                   7    
HELIX  157 AR4 SER F  496  MET F  511  1                                  16    
HELIX  158 AR5 GLY F  513  GLY F  516  5                                   4    
HELIX  159 AR6 MET F  540  GLY F  551  1                                  12    
HELIX  160 AR7 THR F  563  GLY F  568  5                                   6    
HELIX  161 AR8 THR F  593  ALA F  595  5                                   3    
HELIX  162 AR9 SER G   47  LEU G   54  1                                   8    
HELIX  163 AS1 ALA G  152  ASN G  156  5                                   5    
HELIX  164 AS2 LEU G  177  LEU G  184  5                                   8    
HELIX  165 AS3 ASP G  185  TYR G  194  1                                  10    
HELIX  166 AS4 TYR G  194  GLY G  213  1                                  20    
HELIX  167 AS5 SER G  225  PHE G  238  1                                  14    
HELIX  168 AS6 GLN G  253  PRO G  255  5                                   3    
HELIX  169 AS7 LYS G  256  ALA G  269  1                                  14    
HELIX  170 AS8 PRO G  270  ALA G  272  5                                   3    
HELIX  171 AS9 LEU G  282  PHE G  287  5                                   6    
HELIX  172 AT1 SER G  288  ASP G  304  1                                  17    
HELIX  173 AT2 ALA G  305  GLY G  308  5                                   4    
HELIX  174 AT3 ASN G  316  PHE G  324  1                                   9    
HELIX  175 AT4 SER G  350  GLY G  363  1                                  14    
HELIX  176 AT5 ASP G  379  SER G  383  5                                   5    
HELIX  177 AT6 TRP G  394  LEU G  399  1                                   6    
HELIX  178 AT7 GLY G  414  PHE G  424  1                                  11    
HELIX  179 AT8 PRO G  432  THR G  434  5                                   3    
HELIX  180 AT9 GLN G  435  LYS G  442  1                                   8    
HELIX  181 AU1 ILE G  447  TRP G  453  5                                   7    
HELIX  182 AU2 SER G  462  GLY G  468  1                                   7    
HELIX  183 AU3 LEU G  474  ARG G  480  1                                   7    
HELIX  184 AU4 SER G  496  MET G  511  1                                  16    
HELIX  185 AU5 GLY G  513  GLY G  516  5                                   4    
HELIX  186 AU6 MET G  540  GLY G  551  1                                  12    
HELIX  187 AU7 THR G  563  GLY G  568  5                                   6    
HELIX  188 AU8 THR G  593  ALA G  595  5                                   3    
HELIX  189 AU9 SER H   47  LEU H   54  1                                   8    
HELIX  190 AV1 ALA H  152  ASN H  156  5                                   5    
HELIX  191 AV2 LEU H  177  LEU H  184  5                                   8    
HELIX  192 AV3 ASP H  185  TYR H  194  1                                  10    
HELIX  193 AV4 TYR H  194  GLY H  213  1                                  20    
HELIX  194 AV5 SER H  225  PHE H  238  1                                  14    
HELIX  195 AV6 GLN H  253  PRO H  255  5                                   3    
HELIX  196 AV7 LYS H  256  ALA H  269  1                                  14    
HELIX  197 AV8 PRO H  270  ALA H  272  5                                   3    
HELIX  198 AV9 LEU H  282  SER H  286  5                                   5    
HELIX  199 AW1 SER H  288  ASP H  304  1                                  17    
HELIX  200 AW2 ALA H  305  GLY H  308  5                                   4    
HELIX  201 AW3 ASN H  316  PHE H  324  1                                   9    
HELIX  202 AW4 SER H  350  GLY H  363  1                                  14    
HELIX  203 AW5 ASP H  379  SER H  383  5                                   5    
HELIX  204 AW6 TRP H  394  LEU H  399  1                                   6    
HELIX  205 AW7 GLY H  414  ASP H  423  1                                  10    
HELIX  206 AW8 PRO H  432  THR H  434  5                                   3    
HELIX  207 AW9 GLN H  435  LYS H  442  1                                   8    
HELIX  208 AX1 ILE H  447  TRP H  453  5                                   7    
HELIX  209 AX2 SER H  462  HIS H  467  1                                   6    
HELIX  210 AX3 LEU H  474  ARG H  480  1                                   7    
HELIX  211 AX4 SER H  496  MET H  511  1                                  16    
HELIX  212 AX5 GLY H  513  GLY H  516  5                                   4    
HELIX  213 AX6 MET H  540  GLY H  551  1                                  12    
HELIX  214 AX7 THR H  563  GLY H  568  5                                   6    
HELIX  215 AX8 THR H  593  ALA H  595  5                                   3    
HELIX  216 AX9 SER I   47  ALA I   53  1                                   7    
HELIX  217 AY1 LEU I  177  LEU I  184  5                                   8    
HELIX  218 AY2 ASP I  185  TYR I  194  1                                  10    
HELIX  219 AY3 TYR I  194  GLY I  213  1                                  20    
HELIX  220 AY4 SER I  225  PHE I  238  1                                  14    
HELIX  221 AY5 GLN I  253  PRO I  255  5                                   3    
HELIX  222 AY6 LYS I  256  ALA I  269  1                                  14    
HELIX  223 AY7 PRO I  270  ALA I  272  5                                   3    
HELIX  224 AY8 LEU I  282  SER I  286  5                                   5    
HELIX  225 AY9 SER I  288  ASP I  304  1                                  17    
HELIX  226 AZ1 ALA I  305  GLY I  308  5                                   4    
HELIX  227 AZ2 ASN I  316  PHE I  324  1                                   9    
HELIX  228 AZ3 SER I  350  GLY I  363  1                                  14    
HELIX  229 AZ4 ASP I  379  SER I  383  5                                   5    
HELIX  230 AZ5 TRP I  394  LEU I  399  1                                   6    
HELIX  231 AZ6 GLY I  414  PHE I  424  1                                  11    
HELIX  232 AZ7 PRO I  432  THR I  434  5                                   3    
HELIX  233 AZ8 GLN I  435  LYS I  442  1                                   8    
HELIX  234 AZ9 ILE I  447  TRP I  453  5                                   7    
HELIX  235 BA1 SER I  462  GLY I  468  1                                   7    
HELIX  236 BA2 LEU I  474  ARG I  480  1                                   7    
HELIX  237 BA3 SER I  496  MET I  511  1                                  16    
HELIX  238 BA4 GLY I  513  GLY I  516  5                                   4    
HELIX  239 BA5 MET I  540  GLY I  551  1                                  12    
HELIX  240 BA6 THR I  563  GLY I  568  5                                   6    
HELIX  241 BA7 THR I  593  ALA I  595  5                                   3    
HELIX  242 BA8 SER J   47  GLU J   52  1                                   6    
HELIX  243 BA9 ALA J   53  LYS J   55  5                                   3    
HELIX  244 BB1 ALA J  152  ASN J  156  5                                   5    
HELIX  245 BB2 LEU J  177  LEU J  184  5                                   8    
HELIX  246 BB3 ASP J  185  TYR J  194  1                                  10    
HELIX  247 BB4 TYR J  194  TYR J  212  1                                  19    
HELIX  248 BB5 SER J  225  PHE J  238  1                                  14    
HELIX  249 BB6 GLN J  253  PRO J  255  5                                   3    
HELIX  250 BB7 LYS J  256  ALA J  269  1                                  14    
HELIX  251 BB8 PRO J  270  ALA J  272  5                                   3    
HELIX  252 BB9 LEU J  282  PHE J  287  5                                   6    
HELIX  253 BC1 SER J  288  ASP J  304  1                                  17    
HELIX  254 BC2 ALA J  305  GLY J  308  5                                   4    
HELIX  255 BC3 ASN J  316  PHE J  324  1                                   9    
HELIX  256 BC4 SER J  350  GLY J  363  1                                  14    
HELIX  257 BC5 ASP J  379  SER J  383  5                                   5    
HELIX  258 BC6 TRP J  394  LEU J  399  1                                   6    
HELIX  259 BC7 GLY J  414  ASP J  423  1                                  10    
HELIX  260 BC8 PRO J  432  THR J  434  5                                   3    
HELIX  261 BC9 GLN J  435  PHE J  443  1                                   9    
HELIX  262 BD1 ILE J  447  TRP J  453  5                                   7    
HELIX  263 BD2 SER J  462  HIS J  467  1                                   6    
HELIX  264 BD3 LEU J  474  ARG J  480  1                                   7    
HELIX  265 BD4 SER J  496  MET J  511  1                                  16    
HELIX  266 BD5 GLY J  513  GLY J  516  5                                   4    
HELIX  267 BD6 MET J  540  GLY J  551  1                                  12    
HELIX  268 BD7 THR J  563  GLY J  568  5                                   6    
HELIX  269 BD8 THR J  593  ALA J  595  5                                   3    
SHEET    1 AA1 9 THR A  68  ARG A  76  0                                        
SHEET    2 AA1 9 HIS A  91  THR A 102 -1  O  HIS A  91   N  ARG A  76           
SHEET    3 AA1 9 PRO A 108  PRO A 118 -1  O  LEU A 115   N  VAL A  94           
SHEET    4 AA1 9 ALA A 158  THR A 162 -1  O  THR A 159   N  ARG A 116           
SHEET    5 AA1 9 ARG A 124  GLU A 128  1  N  PHE A 126   O  ALA A 158           
SHEET    6 AA1 9 LYS A 218  CYS A 224  1  O  TYR A 220   N  PHE A 125           
SHEET    7 AA1 9 GLY A 244  GLY A 248  1  O  GLY A 248   N  GLY A 223           
SHEET    8 AA1 9 LYS A 483  GLY A 489  1  O  ILE A 485   N  ILE A 245           
SHEET    9 AA1 9 ALA A 518  VAL A 523  1  O  VAL A 523   N  HIS A 488           
SHEET    1 AA2 2 LEU A 385  SER A 386  0                                        
SHEET    2 AA2 2 THR A 389  TYR A 390 -1  O  THR A 389   N  SER A 386           
SHEET    1 AA3 2 ILE A 557  TRP A 560  0                                        
SHEET    2 AA3 2 THR A 573  LEU A 576 -1  O  LEU A 576   N  ILE A 557           
SHEET    1 AA4 2 ILE A 582  TYR A 585  0                                        
SHEET    2 AA4 2 PHE A 597  ALA A 600 -1  O  ALA A 600   N  ILE A 582           
SHEET    1 AA5 9 THR B  68  ARG B  76  0                                        
SHEET    2 AA5 9 HIS B  91  THR B 102 -1  O  HIS B  91   N  ARG B  76           
SHEET    3 AA5 9 PRO B 108  PRO B 118 -1  O  LEU B 115   N  VAL B  94           
SHEET    4 AA5 9 ALA B 158  THR B 162 -1  O  THR B 159   N  ARG B 116           
SHEET    5 AA5 9 ARG B 124  GLU B 128  1  N  PHE B 126   O  ALA B 158           
SHEET    6 AA5 9 LYS B 218  CYS B 224  1  O  TYR B 220   N  PHE B 125           
SHEET    7 AA5 9 GLY B 244  GLY B 248  1  O  GLY B 248   N  GLY B 223           
SHEET    8 AA5 9 LYS B 483  GLY B 489  1  O  ILE B 485   N  ILE B 245           
SHEET    9 AA5 9 ALA B 518  VAL B 523  1  O  ARG B 519   N  LEU B 486           
SHEET    1 AA6 2 LEU B 385  SER B 386  0                                        
SHEET    2 AA6 2 THR B 389  TYR B 390 -1  O  THR B 389   N  SER B 386           
SHEET    1 AA7 2 ILE B 557  TRP B 560  0                                        
SHEET    2 AA7 2 THR B 573  LEU B 576 -1  O  LEU B 576   N  ILE B 557           
SHEET    1 AA8 2 ILE B 582  TYR B 585  0                                        
SHEET    2 AA8 2 PHE B 597  ALA B 600 -1  O  ALA B 600   N  ILE B 582           
SHEET    1 AA9 9 THR C  68  ARG C  76  0                                        
SHEET    2 AA9 9 HIS C  91  THR C 102 -1  O  HIS C  91   N  ARG C  76           
SHEET    3 AA9 9 PRO C 108  PRO C 118 -1  O  LEU C 115   N  VAL C  94           
SHEET    4 AA9 9 ALA C 158  THR C 162 -1  O  THR C 159   N  ARG C 116           
SHEET    5 AA9 9 ARG C 124  GLU C 128  1  N  ARG C 124   O  ALA C 158           
SHEET    6 AA9 9 LYS C 218  CYS C 224  1  O  TYR C 220   N  PHE C 125           
SHEET    7 AA9 9 GLY C 244  GLY C 248  1  O  GLY C 248   N  GLY C 223           
SHEET    8 AA9 9 LYS C 483  GLY C 489  1  O  ILE C 485   N  ILE C 245           
SHEET    9 AA9 9 ALA C 518  VAL C 523  1  O  ARG C 519   N  LEU C 486           
SHEET    1 AB1 2 LEU C 385  SER C 386  0                                        
SHEET    2 AB1 2 THR C 389  TYR C 390 -1  O  THR C 389   N  SER C 386           
SHEET    1 AB2 2 ILE C 557  TRP C 560  0                                        
SHEET    2 AB2 2 THR C 573  LEU C 576 -1  O  LEU C 576   N  ILE C 557           
SHEET    1 AB3 2 ILE C 582  TYR C 585  0                                        
SHEET    2 AB3 2 PHE C 597  ALA C 600 -1  O  ALA C 600   N  ILE C 582           
SHEET    1 AB4 9 THR D  68  ARG D  76  0                                        
SHEET    2 AB4 9 HIS D  91  THR D 102 -1  O  HIS D  91   N  ARG D  76           
SHEET    3 AB4 9 PRO D 108  PRO D 118 -1  O  LEU D 115   N  VAL D  94           
SHEET    4 AB4 9 ALA D 158  THR D 162 -1  O  THR D 159   N  ARG D 116           
SHEET    5 AB4 9 ARG D 124  GLU D 128  1  N  PHE D 126   O  ALA D 158           
SHEET    6 AB4 9 LYS D 218  CYS D 224  1  O  TYR D 220   N  PHE D 125           
SHEET    7 AB4 9 GLY D 244  GLY D 248  1  O  GLY D 248   N  GLY D 223           
SHEET    8 AB4 9 LYS D 483  GLY D 489  1  O  ILE D 485   N  ILE D 245           
SHEET    9 AB4 9 ALA D 518  VAL D 523  1  O  ARG D 519   N  LEU D 486           
SHEET    1 AB5 2 LEU D 385  SER D 386  0                                        
SHEET    2 AB5 2 THR D 389  TYR D 390 -1  O  THR D 389   N  SER D 386           
SHEET    1 AB6 3 ARG D 537  PHE D 538  0                                        
SHEET    2 AB6 3 ILE D 557  TRP D 560 -1  O  TRP D 560   N  ARG D 537           
SHEET    3 AB6 3 THR D 573  LEU D 576 -1  O  LEU D 576   N  ILE D 557           
SHEET    1 AB7 2 ILE D 582  TYR D 585  0                                        
SHEET    2 AB7 2 PHE D 597  ALA D 600 -1  O  ALA D 600   N  ILE D 582           
SHEET    1 AB8 9 THR E  68  ARG E  76  0                                        
SHEET    2 AB8 9 HIS E  91  THR E 102 -1  O  HIS E  91   N  ARG E  76           
SHEET    3 AB8 9 PRO E 108  PRO E 118 -1  O  LEU E 115   N  VAL E  94           
SHEET    4 AB8 9 ALA E 158  THR E 162 -1  O  THR E 159   N  ARG E 116           
SHEET    5 AB8 9 ARG E 124  GLU E 128  1  N  PHE E 126   O  ALA E 158           
SHEET    6 AB8 9 LYS E 218  CYS E 224  1  O  TYR E 220   N  PHE E 125           
SHEET    7 AB8 9 GLY E 244  GLY E 248  1  O  GLY E 248   N  GLY E 223           
SHEET    8 AB8 9 LYS E 483  GLY E 489  1  O  ILE E 485   N  ILE E 245           
SHEET    9 AB8 9 ALA E 518  VAL E 523  1  O  ARG E 519   N  LEU E 486           
SHEET    1 AB9 2 LEU E 385  SER E 386  0                                        
SHEET    2 AB9 2 THR E 389  TYR E 390 -1  O  THR E 389   N  SER E 386           
SHEET    1 AC1 2 ILE E 557  TRP E 560  0                                        
SHEET    2 AC1 2 THR E 573  LEU E 576 -1  O  LEU E 576   N  ILE E 557           
SHEET    1 AC2 2 ILE E 582  TYR E 585  0                                        
SHEET    2 AC2 2 PHE E 597  ALA E 600 -1  O  ALA E 600   N  ILE E 582           
SHEET    1 AC3 9 THR F  68  ARG F  76  0                                        
SHEET    2 AC3 9 HIS F  91  THR F 102 -1  O  HIS F  91   N  ARG F  76           
SHEET    3 AC3 9 PRO F 108  PRO F 118 -1  O  LEU F 115   N  VAL F  94           
SHEET    4 AC3 9 ALA F 158  THR F 162 -1  O  THR F 159   N  ARG F 116           
SHEET    5 AC3 9 ARG F 124  GLU F 128  1  N  ARG F 124   O  ALA F 158           
SHEET    6 AC3 9 LYS F 218  CYS F 224  1  O  TYR F 220   N  PHE F 125           
SHEET    7 AC3 9 GLY F 244  GLY F 248  1  O  GLY F 248   N  GLY F 223           
SHEET    8 AC3 9 LYS F 483  GLY F 489  1  O  ILE F 485   N  ILE F 245           
SHEET    9 AC3 9 ALA F 518  VAL F 523  1  O  ARG F 519   N  LEU F 486           
SHEET    1 AC4 2 LEU F 385  SER F 386  0                                        
SHEET    2 AC4 2 THR F 389  TYR F 390 -1  O  THR F 389   N  SER F 386           
SHEET    1 AC5 2 ILE F 557  TRP F 560  0                                        
SHEET    2 AC5 2 THR F 573  LEU F 576 -1  O  LEU F 576   N  ILE F 557           
SHEET    1 AC6 2 ILE F 582  TYR F 585  0                                        
SHEET    2 AC6 2 PHE F 597  ALA F 600 -1  O  ALA F 600   N  ILE F 582           
SHEET    1 AC7 9 THR G  68  ARG G  76  0                                        
SHEET    2 AC7 9 HIS G  91  THR G 102 -1  O  HIS G  91   N  ARG G  76           
SHEET    3 AC7 9 PRO G 108  PRO G 118 -1  O  LEU G 115   N  VAL G  94           
SHEET    4 AC7 9 ALA G 158  THR G 162 -1  O  THR G 159   N  ARG G 116           
SHEET    5 AC7 9 ARG G 124  GLU G 128  1  N  PHE G 126   O  ALA G 158           
SHEET    6 AC7 9 LYS G 218  CYS G 224  1  O  TYR G 220   N  PHE G 125           
SHEET    7 AC7 9 GLY G 244  GLY G 248  1  O  GLY G 248   N  GLY G 223           
SHEET    8 AC7 9 LYS G 483  GLY G 489  1  O  ILE G 485   N  ILE G 245           
SHEET    9 AC7 9 ALA G 518  VAL G 523  1  O  ARG G 519   N  LEU G 486           
SHEET    1 AC8 2 LEU G 385  SER G 386  0                                        
SHEET    2 AC8 2 THR G 389  TYR G 390 -1  O  THR G 389   N  SER G 386           
SHEET    1 AC9 2 ILE G 557  TRP G 560  0                                        
SHEET    2 AC9 2 THR G 573  LEU G 576 -1  O  ARG G 574   N  ALA G 559           
SHEET    1 AD1 2 ILE G 582  TYR G 585  0                                        
SHEET    2 AD1 2 PHE G 597  ALA G 600 -1  O  ALA G 600   N  ILE G 582           
SHEET    1 AD2 9 THR H  68  ARG H  76  0                                        
SHEET    2 AD2 9 HIS H  91  THR H 102 -1  O  ALA H  97   N  VAL H  69           
SHEET    3 AD2 9 PRO H 108  PRO H 118 -1  O  LEU H 115   N  VAL H  94           
SHEET    4 AD2 9 ALA H 158  THR H 162 -1  O  THR H 159   N  ARG H 116           
SHEET    5 AD2 9 ARG H 124  GLU H 128  1  N  PHE H 126   O  ALA H 158           
SHEET    6 AD2 9 LYS H 218  CYS H 224  1  O  TYR H 220   N  PHE H 125           
SHEET    7 AD2 9 GLY H 244  GLY H 248  1  O  GLY H 248   N  GLY H 223           
SHEET    8 AD2 9 LYS H 483  GLY H 489  1  O  ILE H 485   N  ILE H 245           
SHEET    9 AD2 9 ALA H 518  VAL H 523  1  O  ARG H 519   N  LEU H 486           
SHEET    1 AD3 2 LEU H 385  SER H 386  0                                        
SHEET    2 AD3 2 THR H 389  TYR H 390 -1  O  THR H 389   N  SER H 386           
SHEET    1 AD4 2 ILE H 557  TRP H 560  0                                        
SHEET    2 AD4 2 THR H 573  LEU H 576 -1  O  LEU H 576   N  ILE H 557           
SHEET    1 AD5 2 ILE H 582  TYR H 585  0                                        
SHEET    2 AD5 2 PHE H 597  ALA H 600 -1  O  ALA H 600   N  ILE H 582           
SHEET    1 AD6 9 THR I  68  ARG I  76  0                                        
SHEET    2 AD6 9 HIS I  91  THR I 102 -1  O  HIS I  91   N  ARG I  76           
SHEET    3 AD6 9 PRO I 108  PRO I 118 -1  O  LEU I 115   N  VAL I  94           
SHEET    4 AD6 9 ALA I 158  THR I 162 -1  O  THR I 159   N  ARG I 116           
SHEET    5 AD6 9 ARG I 124  GLU I 128  1  N  PHE I 126   O  ALA I 158           
SHEET    6 AD6 9 LYS I 218  CYS I 224  1  O  TYR I 220   N  PHE I 125           
SHEET    7 AD6 9 GLY I 244  GLY I 248  1  O  GLY I 248   N  GLY I 223           
SHEET    8 AD6 9 LYS I 483  GLY I 489  1  O  ILE I 485   N  ILE I 245           
SHEET    9 AD6 9 ALA I 518  VAL I 523  1  O  ARG I 519   N  LEU I 486           
SHEET    1 AD7 2 LEU I 385  SER I 386  0                                        
SHEET    2 AD7 2 THR I 389  TYR I 390 -1  O  THR I 389   N  SER I 386           
SHEET    1 AD8 2 ILE I 557  TRP I 560  0                                        
SHEET    2 AD8 2 THR I 573  LEU I 576 -1  O  LEU I 576   N  ILE I 557           
SHEET    1 AD9 2 ILE I 582  TYR I 585  0                                        
SHEET    2 AD9 2 PHE I 597  ALA I 600 -1  O  ALA I 600   N  ILE I 582           
SHEET    1 AE1 9 THR J  68  ARG J  76  0                                        
SHEET    2 AE1 9 HIS J  91  THR J 102 -1  O  HIS J  91   N  ARG J  76           
SHEET    3 AE1 9 PRO J 108  PRO J 118 -1  O  LEU J 115   N  VAL J  94           
SHEET    4 AE1 9 ALA J 158  THR J 162 -1  O  THR J 159   N  ARG J 116           
SHEET    5 AE1 9 ARG J 124  GLU J 128  1  N  PHE J 126   O  ALA J 158           
SHEET    6 AE1 9 LYS J 218  CYS J 224  1  O  TYR J 220   N  PHE J 125           
SHEET    7 AE1 9 GLY J 244  GLY J 248  1  O  VAL J 246   N  PHE J 221           
SHEET    8 AE1 9 LYS J 483  GLY J 489  1  O  LYS J 483   N  ILE J 245           
SHEET    9 AE1 9 ALA J 518  VAL J 523  1  O  ARG J 519   N  LEU J 486           
SHEET    1 AE2 2 LEU J 385  SER J 386  0                                        
SHEET    2 AE2 2 THR J 389  TYR J 390 -1  O  THR J 389   N  SER J 386           
SHEET    1 AE3 3 ARG J 537  PHE J 538  0                                        
SHEET    2 AE3 3 ILE J 557  TRP J 560 -1  O  TRP J 560   N  ARG J 537           
SHEET    3 AE3 3 THR J 573  LEU J 576 -1  O  LEU J 576   N  ILE J 557           
SHEET    1 AE4 2 ILE J 582  TYR J 585  0                                        
SHEET    2 AE4 2 PHE J 597  ALA J 600 -1  O  ALA J 600   N  ILE J 582           
SSBOND   1 CYS A   51    CYS A   92                          1555   1555  2.04  
SSBOND   2 CYS A  224    CYS A  529                          1555   1555  2.05  
SSBOND   3 CYS A  303    CYS A  320                          1555   1555  2.04  
SSBOND   4 CYS A  340    CYS A  348                          1555   1555  2.04  
SSBOND   5 CYS A  577    CYS A  599                          1555   1555  2.04  
SSBOND   6 CYS B   51    CYS B   92                          1555   1555  2.04  
SSBOND   7 CYS B  224    CYS B  529                          1555   1555  2.04  
SSBOND   8 CYS B  303    CYS B  320                          1555   1555  2.04  
SSBOND   9 CYS B  340    CYS B  348                          1555   1555  2.03  
SSBOND  10 CYS B  577    CYS B  599                          1555   1555  2.04  
SSBOND  11 CYS C   51    CYS C   92                          1555   1555  2.04  
SSBOND  12 CYS C  224    CYS C  529                          1555   1555  2.05  
SSBOND  13 CYS C  303    CYS C  320                          1555   1555  2.04  
SSBOND  14 CYS C  340    CYS C  348                          1555   1555  2.03  
SSBOND  15 CYS C  577    CYS C  599                          1555   1555  2.04  
SSBOND  16 CYS D   51    CYS D   92                          1555   1555  2.04  
SSBOND  17 CYS D  224    CYS D  529                          1555   1555  2.05  
SSBOND  18 CYS D  303    CYS D  320                          1555   1555  2.04  
SSBOND  19 CYS D  340    CYS D  348                          1555   1555  2.03  
SSBOND  20 CYS D  577    CYS D  599                          1555   1555  2.03  
SSBOND  21 CYS E   51    CYS E   92                          1555   1555  2.04  
SSBOND  22 CYS E  224    CYS E  529                          1555   1555  2.05  
SSBOND  23 CYS E  303    CYS E  320                          1555   1555  2.04  
SSBOND  24 CYS E  340    CYS E  348                          1555   1555  2.03  
SSBOND  25 CYS E  577    CYS E  599                          1555   1555  2.04  
SSBOND  26 CYS F   51    CYS F   92                          1555   1555  2.04  
SSBOND  27 CYS F  224    CYS F  529                          1555   1555  2.05  
SSBOND  28 CYS F  303    CYS F  320                          1555   1555  2.04  
SSBOND  29 CYS F  340    CYS F  348                          1555   1555  2.03  
SSBOND  30 CYS F  577    CYS F  599                          1555   1555  2.04  
SSBOND  31 CYS G   51    CYS G   92                          1555   1555  2.03  
SSBOND  32 CYS G  224    CYS G  529                          1555   1555  2.05  
SSBOND  33 CYS G  303    CYS G  320                          1555   1555  2.04  
SSBOND  34 CYS G  340    CYS G  348                          1555   1555  2.03  
SSBOND  35 CYS G  577    CYS G  599                          1555   1555  2.03  
SSBOND  36 CYS H   51    CYS H   92                          1555   1555  2.03  
SSBOND  37 CYS H  224    CYS H  529                          1555   1555  2.05  
SSBOND  38 CYS H  303    CYS H  320                          1555   1555  2.04  
SSBOND  39 CYS H  340    CYS H  348                          1555   1555  2.03  
SSBOND  40 CYS H  577    CYS H  599                          1555   1555  2.03  
SSBOND  41 CYS I   51    CYS I   92                          1555   1555  2.03  
SSBOND  42 CYS I  224    CYS I  529                          1555   1555  2.04  
SSBOND  43 CYS I  303    CYS I  320                          1555   1555  2.09  
SSBOND  44 CYS I  340    CYS I  348                          1555   1555  2.03  
SSBOND  45 CYS I  577    CYS I  599                          1555   1555  2.04  
SSBOND  46 CYS J   51    CYS J   92                          1555   1555  2.03  
SSBOND  47 CYS J  224    CYS J  529                          1555   1555  2.04  
SSBOND  48 CYS J  303    CYS J  320                          1555   1555  2.03  
SSBOND  49 CYS J  340    CYS J  348                          1555   1555  2.03  
SSBOND  50 CYS J  577    CYS J  599                          1555   1555  2.03  
LINK         O   ASP A 304                CA    CA A 801     1555   1555  2.50  
LINK         OD1 ASP A 304                CA    CA A 801     1555   1555  2.48  
LINK         OD1 ASP A 307                CA    CA A 801     1555   1555  2.63  
LINK         OD2 ASP A 307                CA    CA A 801     1555   1555  2.42  
LINK         O   LEU A 309                CA    CA A 801     1555   1555  2.38  
LINK         OD1 ASP A 311                CA    CA A 801     1555   1555  2.57  
LINK         O   ILE A 313                CA    CA A 801     1555   1555  2.36  
LINK        CA    CA A 801                 O   HOH A 911     1555   1555  2.50  
LINK         O   ASP B 304                CA    CA B 801     1555   1555  2.45  
LINK         OD1 ASP B 304                CA    CA B 801     1555   1555  2.49  
LINK         OD1 ASP B 307                CA    CA B 801     1555   1555  2.66  
LINK         OD2 ASP B 307                CA    CA B 801     1555   1555  2.52  
LINK         O   LEU B 309                CA    CA B 801     1555   1555  2.42  
LINK         OD1 ASP B 311                CA    CA B 801     1555   1555  2.59  
LINK         O   ILE B 313                CA    CA B 801     1555   1555  2.44  
LINK        CA    CA B 801                 O   HOH B1034     1555   1555  2.46  
LINK         O   ASP C 304                CA    CA C 801     1555   1555  2.52  
LINK         OD1 ASP C 304                CA    CA C 801     1555   1555  2.39  
LINK         OD1 ASP C 307                CA    CA C 801     1555   1555  2.55  
LINK         OD2 ASP C 307                CA    CA C 801     1555   1555  2.57  
LINK         O   LEU C 309                CA    CA C 801     1555   1555  2.41  
LINK         OD1 ASP C 311                CA    CA C 801     1555   1555  2.48  
LINK         O   ILE C 313                CA    CA C 801     1555   1555  2.36  
LINK        CA    CA C 801                 O   HOH C 943     1555   1555  2.64  
LINK         O   ASP D 304                CA    CA D 801     1555   1555  2.43  
LINK         OD1 ASP D 304                CA    CA D 801     1555   1555  2.44  
LINK         OD1 ASP D 307                CA    CA D 801     1555   1555  2.63  
LINK         OD2 ASP D 307                CA    CA D 801     1555   1555  2.55  
LINK         O   LEU D 309                CA    CA D 801     1555   1555  2.35  
LINK         OD1 ASP D 311                CA    CA D 801     1555   1555  2.50  
LINK         O   ILE D 313                CA    CA D 801     1555   1555  2.45  
LINK        CA    CA D 801                 O   HOH D1027     1555   1555  2.46  
LINK         O   ASP E 304                CA    CA E 801     1555   1555  2.48  
LINK         OD1 ASP E 304                CA    CA E 801     1555   1555  2.50  
LINK         OD1 ASP E 307                CA    CA E 801     1555   1555  2.62  
LINK         OD2 ASP E 307                CA    CA E 801     1555   1555  2.49  
LINK         O   LEU E 309                CA    CA E 801     1555   1555  2.35  
LINK         OD1 ASP E 311                CA    CA E 801     1555   1555  2.53  
LINK         O   ILE E 313                CA    CA E 801     1555   1555  2.41  
LINK        CA    CA E 801                 O   HOH E 915     1555   1555  2.55  
LINK         O   ASP F 304                CA    CA F 801     1555   1555  2.51  
LINK         OD1 ASP F 304                CA    CA F 801     1555   1555  2.44  
LINK         OD1 ASP F 307                CA    CA F 801     1555   1555  2.61  
LINK         OD2 ASP F 307                CA    CA F 801     1555   1555  2.51  
LINK         O   LEU F 309                CA    CA F 801     1555   1555  2.45  
LINK         OD1 ASP F 311                CA    CA F 801     1555   1555  2.51  
LINK         O   ILE F 313                CA    CA F 801     1555   1555  2.30  
LINK        CA    CA F 801                 O   HOH F 933     1555   1555  2.46  
LINK         O   ASP G 304                CA    CA G 801     1555   1555  2.57  
LINK         OD1 ASP G 304                CA    CA G 801     1555   1555  2.48  
LINK         OD1 ASP G 307                CA    CA G 801     1555   1555  2.50  
LINK         OD2 ASP G 307                CA    CA G 801     1555   1555  2.56  
LINK         O   LEU G 309                CA    CA G 801     1555   1555  2.32  
LINK         OD1 ASP G 311                CA    CA G 801     1555   1555  2.51  
LINK         O   ILE G 313                CA    CA G 801     1555   1555  2.45  
LINK        CA    CA G 801                 O   HOH G 962     1555   1555  2.50  
LINK         O   ASP H 304                CA    CA H 801     1555   1555  2.47  
LINK         OD1 ASP H 304                CA    CA H 801     1555   1555  2.38  
LINK         OD1 ASP H 307                CA    CA H 801     1555   1555  2.50  
LINK         OD2 ASP H 307                CA    CA H 801     1555   1555  2.54  
LINK         O   LEU H 309                CA    CA H 801     1555   1555  2.35  
LINK         OD1 ASP H 311                CA    CA H 801     1555   1555  2.62  
LINK         O   ILE H 313                CA    CA H 801     1555   1555  2.39  
LINK        CA    CA H 801                 O   HOH H 969     1555   1555  2.44  
LINK         O   ASP I 304                CA    CA I 801     1555   1555  2.30  
LINK         OD1 ASP I 304                CA    CA I 801     1555   1555  2.21  
LINK         OD1 ASP I 307                CA    CA I 801     1555   1555  2.65  
LINK         OD2 ASP I 307                CA    CA I 801     1555   1555  2.55  
LINK         O   LEU I 309                CA    CA I 801     1555   1555  2.32  
LINK         OD1 ASP I 311                CA    CA I 801     1555   1555  2.56  
LINK         O   ILE I 313                CA    CA I 801     1555   1555  2.40  
LINK        CA    CA I 801                 O   HOH I 963     1555   1555  2.06  
LINK         O   ASP J 304                CA    CA J 801     1555   1555  2.40  
LINK         OD1 ASP J 304                CA    CA J 801     1555   1555  2.40  
LINK         OD1 ASP J 307                CA    CA J 801     1555   1555  2.57  
LINK         OD2 ASP J 307                CA    CA J 801     1555   1555  2.55  
LINK         O   LEU J 309                CA    CA J 801     1555   1555  2.34  
LINK         OD1 ASP J 311                CA    CA J 801     1555   1555  2.70  
LINK         O   ILE J 313                CA    CA J 801     1555   1555  2.30  
LINK        CA    CA J 801                 O   HOH J 968     1555   1555  2.15  
CISPEP   1 THR A  426    PRO A  427          0        -1.02                     
CISPEP   2 TYR A  579    PRO A  580          0         5.36                     
CISPEP   3 THR B  426    PRO B  427          0        -2.44                     
CISPEP   4 TYR B  579    PRO B  580          0         3.82                     
CISPEP   5 THR C  426    PRO C  427          0        -2.21                     
CISPEP   6 TYR C  579    PRO C  580          0         5.61                     
CISPEP   7 THR D  426    PRO D  427          0        -0.96                     
CISPEP   8 TYR D  579    PRO D  580          0         2.93                     
CISPEP   9 THR E  426    PRO E  427          0        -0.82                     
CISPEP  10 TYR E  579    PRO E  580          0         3.34                     
CISPEP  11 THR F  426    PRO F  427          0        -2.48                     
CISPEP  12 TYR F  579    PRO F  580          0         5.50                     
CISPEP  13 THR G  426    PRO G  427          0        -0.06                     
CISPEP  14 TYR G  579    PRO G  580          0         3.79                     
CISPEP  15 THR H  426    PRO H  427          0        -0.24                     
CISPEP  16 TYR H  579    PRO H  580          0         3.03                     
CISPEP  17 THR I  426    PRO I  427          0        -0.51                     
CISPEP  18 TYR I  579    PRO I  580          0         2.04                     
CISPEP  19 THR J  426    PRO J  427          0        -2.63                     
CISPEP  20 TYR J  579    PRO J  580          0         1.52                     
SITE     1 AC1  6 ASP A 304  ASP A 307  LEU A 309  ASP A 311                    
SITE     2 AC1  6 ILE A 313  HOH A 911                                          
SITE     1 AC2  6 ASP B 304  ASP B 307  LEU B 309  ASP B 311                    
SITE     2 AC2  6 ILE B 313  HOH B1034                                          
SITE     1 AC3  6 ASP C 304  ASP C 307  LEU C 309  ASP C 311                    
SITE     2 AC3  6 ILE C 313  HOH C 943                                          
SITE     1 AC4  6 ASP D 304  ASP D 307  LEU D 309  ASP D 311                    
SITE     2 AC4  6 ILE D 313  HOH D1027                                          
SITE     1 AC5  6 ASP E 304  ASP E 307  LEU E 309  ASP E 311                    
SITE     2 AC5  6 ILE E 313  HOH E 915                                          
SITE     1 AC6  6 ASP F 304  ASP F 307  LEU F 309  ASP F 311                    
SITE     2 AC6  6 ILE F 313  HOH F 933                                          
SITE     1 AC7  6 ASP G 304  ASP G 307  LEU G 309  ASP G 311                    
SITE     2 AC7  6 ILE G 313  HOH G 962                                          
SITE     1 AC8  6 ASP H 304  ASP H 307  LEU H 309  ASP H 311                    
SITE     2 AC8  6 ILE H 313  HOH H 969                                          
SITE     1 AC9  6 ASP I 304  ASP I 307  LEU I 309  ASP I 311                    
SITE     2 AC9  6 ILE I 313  HOH I 963                                          
SITE     1 AD1  6 ASP J 304  ASP J 307  LEU J 309  ASP J 311                    
SITE     2 AD1  6 ILE J 313  HOH J 968                                          
CRYST1  110.490  135.630  138.150  83.09  67.91  67.57 P 1          10          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.009051 -0.003736 -0.003776        0.00000                         
SCALE2      0.000000  0.007976  0.000216        0.00000                         
SCALE3      0.000000  0.000000  0.007815        0.00000                         
TER    4148      PRO A 603                                                      
TER    8289      PRO B 603                                                      
TER   12430      PRO C 603                                                      
TER   16571      PRO D 603                                                      
TER   20712      PRO E 603                                                      
TER   24853      PRO F 603                                                      
TER   29001      PRO G 602                                                      
TER   33149      PRO H 603                                                      
TER   37290      PRO I 603                                                      
TER   41424      PRO J 602                                                      
MASTER     1200    0   10  269  152    0   20    647549   10  200  470          
END                                                                             

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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