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LongText Report for: 7b75-pdb

Name Class
7b75-pdb
HEADER    HORMONE                                 09-DEC-20   7B75              
TITLE     CRYO-EM STRUCTURE OF HUMAN THYROGLOBULIN                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: THYROGLOBULIN;                                             
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: TG                                                          
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 ORGAN: THYROID;                                                      
SOURCE   6 TISSUE: THYROID                                                      
KEYWDS    THYROGLOBULIN, T3 AND T4 HORMONOGENESIS, CRYO-EM, HORMONE             
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    R.ADAIXO,R.RIGHETTO,E.M.STEINER,N.M.I.TAYLOR,H.STAHLBERG              
REVDAT   1   29-DEC-21 7B75    0                                                
JRNL        AUTH   R.ADAIXO,E.M.STEINER,R.D.RIGHETTO,A.SCHMIDT,N.M.I.TAYLOR,    
JRNL        AUTH 2 H.STAHLBERG                                                  
JRNL        TITL   CRYO-EM STRUCTURE OF NATIVE HUMAN THYROGLOBULIN              
JRNL        REF    NAT COMMUN                                 2021              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        DOI    10.1038/S41467-021-27693-8                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.20 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : SERIALEM, FOCUS, CTFFIND, COOT, RELION,   
REMARK   3                            RELION, RELION, RELION                    
REMARK   3   RECONSTRUCTION SCHEMA  : BACK PROJECTION                           
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : AB INITIO MODEL                     
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.200                          
REMARK   3   NUMBER OF PARTICLES               : 37619                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 7B75 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 09-DEC-20.                  
REMARK 100 THE DEPOSITION ID IS D_1292111988.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HUMAN THYROGLOBULIN               
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 2.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : HUMAN THYROGLOBULIN PURIFIED      
REMARK 245  FROM THYROID GLAND TISSUE AND NON IN VITRO IODINATED                
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 8119                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : TFS KRIOS                      
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 500.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : 2500.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 5000.00                        
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 215000                         
REMARK 245   CALIBRATED MAGNIFICATION          : 78125                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 30340 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 236890 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 56.0 KCAL/MOL                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     LEU A     3                                                      
REMARK 465     VAL A     4                                                      
REMARK 465     LEU A     5                                                      
REMARK 465     GLU A     6                                                      
REMARK 465     ILE A     7                                                      
REMARK 465     PHE A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     LEU A    10                                                      
REMARK 465     LEU A    11                                                      
REMARK 465     ALA A    12                                                      
REMARK 465     SER A    13                                                      
REMARK 465     ILE A    14                                                      
REMARK 465     CYS A    15                                                      
REMARK 465     TRP A    16                                                      
REMARK 465     VAL A    17                                                      
REMARK 465     SER A    18                                                      
REMARK 465     ALA A    19                                                      
REMARK 465     ASN A    20                                                      
REMARK 465     ILE A    21                                                      
REMARK 465     PHE A    22                                                      
REMARK 465     GLU A    23                                                      
REMARK 465     TYR A    24                                                      
REMARK 465     GLN A    25                                                      
REMARK 465     VAL A    26                                                      
REMARK 465     ASP A    27                                                      
REMARK 465     ALA A    28                                                      
REMARK 465     GLN A    29                                                      
REMARK 465     SER A   106                                                      
REMARK 465     GLY A   107                                                      
REMARK 465     TYR A   108                                                      
REMARK 465     ILE A   109                                                      
REMARK 465     ASN A   110                                                      
REMARK 465     SER A   111                                                      
REMARK 465     THR A   112                                                      
REMARK 465     ASP A   113                                                      
REMARK 465     THR A   114                                                      
REMARK 465     GLY A   381                                                      
REMARK 465     TYR A   382                                                      
REMARK 465     PHE A   383                                                      
REMARK 465     SER A   384                                                      
REMARK 465     GLN A   385                                                      
REMARK 465     HIS A   386                                                      
REMARK 465     ASP A   387                                                      
REMARK 465     LEU A   388                                                      
REMARK 465     PHE A   389                                                      
REMARK 465     SER A   390                                                      
REMARK 465     SER A   391                                                      
REMARK 465     PRO A   392                                                      
REMARK 465     GLU A   393                                                      
REMARK 465     LYS A   394                                                      
REMARK 465     ARG A   395                                                      
REMARK 465     TRP A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     SER A   398                                                      
REMARK 465     PRO A   399                                                      
REMARK 465     ARG A   400                                                      
REMARK 465     VAL A   401                                                      
REMARK 465     ALA A   402                                                      
REMARK 465     ARG A   403                                                      
REMARK 465     PHE A   404                                                      
REMARK 465     PHE A   497                                                      
REMARK 465     SER A   498                                                      
REMARK 465     GLN A   499                                                      
REMARK 465     PHE A   500                                                      
REMARK 465     PHE A   501                                                      
REMARK 465     GLN A   502                                                      
REMARK 465     GLN A   503                                                      
REMARK 465     LEU A   504                                                      
REMARK 465     GLY A   505                                                      
REMARK 465     LEU A   506                                                      
REMARK 465     ALA A   507                                                      
REMARK 465     SER A   508                                                      
REMARK 465     PHE A   509                                                      
REMARK 465     LEU A   510                                                      
REMARK 465     ASN A   511                                                      
REMARK 465     GLY A   512                                                      
REMARK 465     GLY A   513                                                      
REMARK 465     ARG A   514                                                      
REMARK 465     GLN A   515                                                      
REMARK 465     GLU A   516                                                      
REMARK 465     ASP A   517                                                      
REMARK 465     LEU A   518                                                      
REMARK 465     ALA A   519                                                      
REMARK 465     LYS A   520                                                      
REMARK 465     PRO A   521                                                      
REMARK 465     LEU A   522                                                      
REMARK 465     SER A   523                                                      
REMARK 465     VAL A   524                                                      
REMARK 465     GLY A   525                                                      
REMARK 465     LEU A   526                                                      
REMARK 465     ASP A   527                                                      
REMARK 465     SER A   528                                                      
REMARK 465     ASN A   529                                                      
REMARK 465     SER A   530                                                      
REMARK 465     SER A   531                                                      
REMARK 465     THR A   532                                                      
REMARK 465     GLY A   533                                                      
REMARK 465     THR A   534                                                      
REMARK 465     PRO A   535                                                      
REMARK 465     GLU A   536                                                      
REMARK 465     ALA A   537                                                      
REMARK 465     ALA A   538                                                      
REMARK 465     LYS A   539                                                      
REMARK 465     LYS A   540                                                      
REMARK 465     ASP A   541                                                      
REMARK 465     GLY A   542                                                      
REMARK 465     THR A   543                                                      
REMARK 465     MET A   544                                                      
REMARK 465     ASN A   545                                                      
REMARK 465     LYS A   546                                                      
REMARK 465     ALA A   812                                                      
REMARK 465     ALA A   813                                                      
REMARK 465     SER A   814                                                      
REMARK 465     GLY A   815                                                      
REMARK 465     ASN A   816                                                      
REMARK 465     PHE A   817                                                      
REMARK 465     SER A   818                                                      
REMARK 465     LEU A   819                                                      
REMARK 465     PHE A   820                                                      
REMARK 465     ILE A   821                                                      
REMARK 465     GLN A   822                                                      
REMARK 465     SER A   823                                                      
REMARK 465     LEU A   824                                                      
REMARK 465     TYR A   825                                                      
REMARK 465     GLU A   826                                                      
REMARK 465     ALA A   827                                                      
REMARK 465     GLY A   828                                                      
REMARK 465     GLN A   829                                                      
REMARK 465     GLN A   830                                                      
REMARK 465     ASP A   831                                                      
REMARK 465     VAL A   832                                                      
REMARK 465     PHE A   833                                                      
REMARK 465     PRO A   834                                                      
REMARK 465     VAL A   835                                                      
REMARK 465     LEU A   836                                                      
REMARK 465     SER A   837                                                      
REMARK 465     GLN A   838                                                      
REMARK 465     TYR A   839                                                      
REMARK 465     PRO A   840                                                      
REMARK 465     SER A   841                                                      
REMARK 465     GLU A  1232                                                      
REMARK 465     THR A  1233                                                      
REMARK 465     ILE A  1234                                                      
REMARK 465     SER A  1235                                                      
REMARK 465     GLY A  1236                                                      
REMARK 465     PRO A  1237                                                      
REMARK 465     THR A  1238                                                      
REMARK 465     GLY A  1239                                                      
REMARK 465     SER A  1240                                                      
REMARK 465     ALA A  1241                                                      
REMARK 465     MET A  1242                                                      
REMARK 465     PRO A  1261                                                      
REMARK 465     LEU A  1262                                                      
REMARK 465     ILE A  1263                                                      
REMARK 465     CYS A  1264                                                      
REMARK 465     SER A  1265                                                      
REMARK 465     LEU A  1266                                                      
REMARK 465     GLU A  1267                                                      
REMARK 465     SER A  1268                                                      
REMARK 465     GLY A  1269                                                      
REMARK 465     ARG A  1270                                                      
REMARK 465     TRP A  1271                                                      
REMARK 465     GLU A  1272                                                      
REMARK 465     SER A  1273                                                      
REMARK 465     GLN A  1353                                                      
REMARK 465     VAL A  1354                                                      
REMARK 465     GLY A  1355                                                      
REMARK 465     CYS A  1356                                                      
REMARK 465     LEU A  1357                                                      
REMARK 465     THR A  1358                                                      
REMARK 465     ARG A  1359                                                      
REMARK 465     GLU A  1360                                                      
REMARK 465     ARG A  1361                                                      
REMARK 465     LEU A  1362                                                      
REMARK 465     GLY A  1363                                                      
REMARK 465     LYS A  1415                                                      
REMARK 465     THR A  1416                                                      
REMARK 465     PHE A  1417                                                      
REMARK 465     PRO A  1418                                                      
REMARK 465     ALA A  1419                                                      
REMARK 465     GLU A  1420                                                      
REMARK 465     THR A  1421                                                      
REMARK 465     ILE A  1422                                                      
REMARK 465     ARG A  1423                                                      
REMARK 465     PHE A  1424                                                      
REMARK 465     LEU A  1425                                                      
REMARK 465     ASN A  1636                                                      
REMARK 465     VAL A  1637                                                      
REMARK 465     ALA A  1638                                                      
REMARK 465     CYS A  1639                                                      
REMARK 465     MET A  1640                                                      
REMARK 465     THR A  1641                                                      
REMARK 465     SER A  1642                                                      
REMARK 465     ASP A  1643                                                      
REMARK 465     GLN A  1644                                                      
REMARK 465     LYS A  1645                                                      
REMARK 465     ARG A  1646                                                      
REMARK 465     ASP A  1647                                                      
REMARK 465     ALA A  1648                                                      
REMARK 465     LEU A  1649                                                      
REMARK 465     GLY A  1650                                                      
REMARK 465     ASN A  1651                                                      
REMARK 465     SER A  1652                                                      
REMARK 465     LYS A  1653                                                      
REMARK 465     ALA A  1654                                                      
REMARK 465     THR A  1655                                                      
REMARK 465     SER A  1656                                                      
REMARK 465     PHE A  1657                                                      
REMARK 465     GLY A  1658                                                      
REMARK 465     SER A  1659                                                      
REMARK 465     TYR A  1782                                                      
REMARK 465     ASP A  1783                                                      
REMARK 465     GLN A  1784                                                      
REMARK 465     GLU A  1785                                                      
REMARK 465     SER A  1786                                                      
REMARK 465     HIS A  1787                                                      
REMARK 465     GLN A  1788                                                      
REMARK 465     VAL A  1789                                                      
REMARK 465     ILE A  1790                                                      
REMARK 465     LEU A  1791                                                      
REMARK 465     ARG A  1792                                                      
REMARK 465     LEU A  1793                                                      
REMARK 465     GLY A  1794                                                      
REMARK 465     ASP A  1795                                                      
REMARK 465     GLN A  1796                                                      
REMARK 465     GLU A  1797                                                      
REMARK 465     PHE A  1798                                                      
REMARK 465     ILE A  1799                                                      
REMARK 465     LYS A  1800                                                      
REMARK 465     SER A  1801                                                      
REMARK 465     LEU A  1802                                                      
REMARK 465     THR A  1803                                                      
REMARK 465     PRO A  1804                                                      
REMARK 465     LEU A  1805                                                      
REMARK 465     GLU A  1806                                                      
REMARK 465     GLY A  1807                                                      
REMARK 465     THR A  1808                                                      
REMARK 465     GLN A  1809                                                      
REMARK 465     ASP A  1810                                                      
REMARK 465     THR A  1811                                                      
REMARK 465     PHE A  1812                                                      
REMARK 465     THR A  1813                                                      
REMARK 465     SER A  2728                                                      
REMARK 465     ALA A  2729                                                      
REMARK 465     ASP A  2730                                                      
REMARK 465     GLY A  2731                                                      
REMARK 465     ALA A  2732                                                      
REMARK 465     LYS A  2733                                                      
REMARK 465     GLY A  2734                                                      
REMARK 465     GLY A  2735                                                      
REMARK 465     GLN A  2736                                                      
REMARK 465     SER A  2737                                                      
REMARK 465     ALA A  2738                                                      
REMARK 465     GLU A  2739                                                      
REMARK 465     SER A  2740                                                      
REMARK 465     GLU A  2741                                                      
REMARK 465     GLU A  2742                                                      
REMARK 465     GLU A  2743                                                      
REMARK 465     GLU A  2744                                                      
REMARK 465     LEU A  2745                                                      
REMARK 465     THR A  2746                                                      
REMARK 465     ALA A  2747                                                      
REMARK 465     GLY A  2748                                                      
REMARK 465     SER A  2749                                                      
REMARK 465     GLY A  2750                                                      
REMARK 465     LEU A  2751                                                      
REMARK 465     ARG A  2752                                                      
REMARK 465     GLU A  2753                                                      
REMARK 465     ASP A  2754                                                      
REMARK 465     LEU A  2755                                                      
REMARK 465     LEU A  2756                                                      
REMARK 465     SER A  2757                                                      
REMARK 465     LEU A  2758                                                      
REMARK 465     GLN A  2759                                                      
REMARK 465     GLU A  2760                                                      
REMARK 465     PRO A  2761                                                      
REMARK 465     GLY A  2762                                                      
REMARK 465     SER A  2763                                                      
REMARK 465     LYS A  2764                                                      
REMARK 465     THR A  2765                                                      
REMARK 465     TYR A  2766                                                      
REMARK 465     SER A  2767                                                      
REMARK 465     LYS A  2768                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     LEU B     3                                                      
REMARK 465     VAL B     4                                                      
REMARK 465     LEU B     5                                                      
REMARK 465     GLU B     6                                                      
REMARK 465     ILE B     7                                                      
REMARK 465     PHE B     8                                                      
REMARK 465     THR B     9                                                      
REMARK 465     LEU B    10                                                      
REMARK 465     LEU B    11                                                      
REMARK 465     ALA B    12                                                      
REMARK 465     SER B    13                                                      
REMARK 465     ILE B    14                                                      
REMARK 465     CYS B    15                                                      
REMARK 465     TRP B    16                                                      
REMARK 465     VAL B    17                                                      
REMARK 465     SER B    18                                                      
REMARK 465     ALA B    19                                                      
REMARK 465     ASN B    20                                                      
REMARK 465     ILE B    21                                                      
REMARK 465     PHE B    22                                                      
REMARK 465     GLU B    23                                                      
REMARK 465     TYR B    24                                                      
REMARK 465     GLN B    25                                                      
REMARK 465     VAL B    26                                                      
REMARK 465     ASP B    27                                                      
REMARK 465     ALA B    28                                                      
REMARK 465     GLN B    29                                                      
REMARK 465     SER B   106                                                      
REMARK 465     GLY B   107                                                      
REMARK 465     TYR B   108                                                      
REMARK 465     ILE B   109                                                      
REMARK 465     ASN B   110                                                      
REMARK 465     SER B   111                                                      
REMARK 465     THR B   112                                                      
REMARK 465     ASP B   113                                                      
REMARK 465     THR B   114                                                      
REMARK 465     GLY B   381                                                      
REMARK 465     TYR B   382                                                      
REMARK 465     PHE B   383                                                      
REMARK 465     SER B   384                                                      
REMARK 465     GLN B   385                                                      
REMARK 465     HIS B   386                                                      
REMARK 465     ASP B   387                                                      
REMARK 465     LEU B   388                                                      
REMARK 465     PHE B   389                                                      
REMARK 465     SER B   390                                                      
REMARK 465     SER B   391                                                      
REMARK 465     PRO B   392                                                      
REMARK 465     GLU B   393                                                      
REMARK 465     LYS B   394                                                      
REMARK 465     ARG B   395                                                      
REMARK 465     TRP B   396                                                      
REMARK 465     ALA B   397                                                      
REMARK 465     SER B   398                                                      
REMARK 465     PRO B   399                                                      
REMARK 465     ARG B   400                                                      
REMARK 465     VAL B   401                                                      
REMARK 465     ALA B   402                                                      
REMARK 465     ARG B   403                                                      
REMARK 465     PHE B   404                                                      
REMARK 465     PHE B   497                                                      
REMARK 465     SER B   498                                                      
REMARK 465     GLN B   499                                                      
REMARK 465     PHE B   500                                                      
REMARK 465     PHE B   501                                                      
REMARK 465     GLN B   502                                                      
REMARK 465     GLN B   503                                                      
REMARK 465     LEU B   504                                                      
REMARK 465     GLY B   505                                                      
REMARK 465     LEU B   506                                                      
REMARK 465     ALA B   507                                                      
REMARK 465     SER B   508                                                      
REMARK 465     PHE B   509                                                      
REMARK 465     LEU B   510                                                      
REMARK 465     ASN B   511                                                      
REMARK 465     GLY B   512                                                      
REMARK 465     GLY B   513                                                      
REMARK 465     ARG B   514                                                      
REMARK 465     GLN B   515                                                      
REMARK 465     GLU B   516                                                      
REMARK 465     ASP B   517                                                      
REMARK 465     LEU B   518                                                      
REMARK 465     ALA B   519                                                      
REMARK 465     LYS B   520                                                      
REMARK 465     PRO B   521                                                      
REMARK 465     LEU B   522                                                      
REMARK 465     SER B   523                                                      
REMARK 465     VAL B   524                                                      
REMARK 465     GLY B   525                                                      
REMARK 465     LEU B   526                                                      
REMARK 465     ASP B   527                                                      
REMARK 465     SER B   528                                                      
REMARK 465     ASN B   529                                                      
REMARK 465     SER B   530                                                      
REMARK 465     SER B   531                                                      
REMARK 465     THR B   532                                                      
REMARK 465     GLY B   533                                                      
REMARK 465     THR B   534                                                      
REMARK 465     PRO B   535                                                      
REMARK 465     GLU B   536                                                      
REMARK 465     ALA B   537                                                      
REMARK 465     ALA B   538                                                      
REMARK 465     LYS B   539                                                      
REMARK 465     LYS B   540                                                      
REMARK 465     ASP B   541                                                      
REMARK 465     GLY B   542                                                      
REMARK 465     THR B   543                                                      
REMARK 465     MET B   544                                                      
REMARK 465     ASN B   545                                                      
REMARK 465     LYS B   546                                                      
REMARK 465     ALA B   812                                                      
REMARK 465     ALA B   813                                                      
REMARK 465     SER B   814                                                      
REMARK 465     GLY B   815                                                      
REMARK 465     ASN B   816                                                      
REMARK 465     PHE B   817                                                      
REMARK 465     SER B   818                                                      
REMARK 465     LEU B   819                                                      
REMARK 465     PHE B   820                                                      
REMARK 465     ILE B   821                                                      
REMARK 465     GLN B   822                                                      
REMARK 465     SER B   823                                                      
REMARK 465     LEU B   824                                                      
REMARK 465     TYR B   825                                                      
REMARK 465     GLU B   826                                                      
REMARK 465     ALA B   827                                                      
REMARK 465     GLY B   828                                                      
REMARK 465     GLN B   829                                                      
REMARK 465     GLN B   830                                                      
REMARK 465     ASP B   831                                                      
REMARK 465     VAL B   832                                                      
REMARK 465     PHE B   833                                                      
REMARK 465     PRO B   834                                                      
REMARK 465     VAL B   835                                                      
REMARK 465     LEU B   836                                                      
REMARK 465     SER B   837                                                      
REMARK 465     GLN B   838                                                      
REMARK 465     TYR B   839                                                      
REMARK 465     PRO B   840                                                      
REMARK 465     SER B   841                                                      
REMARK 465     GLU B  1232                                                      
REMARK 465     THR B  1233                                                      
REMARK 465     ILE B  1234                                                      
REMARK 465     SER B  1235                                                      
REMARK 465     GLY B  1236                                                      
REMARK 465     PRO B  1237                                                      
REMARK 465     THR B  1238                                                      
REMARK 465     GLY B  1239                                                      
REMARK 465     SER B  1240                                                      
REMARK 465     ALA B  1241                                                      
REMARK 465     MET B  1242                                                      
REMARK 465     PRO B  1261                                                      
REMARK 465     LEU B  1262                                                      
REMARK 465     ILE B  1263                                                      
REMARK 465     CYS B  1264                                                      
REMARK 465     SER B  1265                                                      
REMARK 465     LEU B  1266                                                      
REMARK 465     GLU B  1267                                                      
REMARK 465     SER B  1268                                                      
REMARK 465     GLY B  1269                                                      
REMARK 465     ARG B  1270                                                      
REMARK 465     TRP B  1271                                                      
REMARK 465     GLU B  1272                                                      
REMARK 465     SER B  1273                                                      
REMARK 465     GLN B  1353                                                      
REMARK 465     VAL B  1354                                                      
REMARK 465     GLY B  1355                                                      
REMARK 465     CYS B  1356                                                      
REMARK 465     LEU B  1357                                                      
REMARK 465     THR B  1358                                                      
REMARK 465     ARG B  1359                                                      
REMARK 465     GLU B  1360                                                      
REMARK 465     ARG B  1361                                                      
REMARK 465     LEU B  1362                                                      
REMARK 465     GLY B  1363                                                      
REMARK 465     LYS B  1415                                                      
REMARK 465     THR B  1416                                                      
REMARK 465     PHE B  1417                                                      
REMARK 465     PRO B  1418                                                      
REMARK 465     ALA B  1419                                                      
REMARK 465     GLU B  1420                                                      
REMARK 465     THR B  1421                                                      
REMARK 465     ILE B  1422                                                      
REMARK 465     ARG B  1423                                                      
REMARK 465     PHE B  1424                                                      
REMARK 465     LEU B  1425                                                      
REMARK 465     ASN B  1636                                                      
REMARK 465     VAL B  1637                                                      
REMARK 465     ALA B  1638                                                      
REMARK 465     CYS B  1639                                                      
REMARK 465     MET B  1640                                                      
REMARK 465     THR B  1641                                                      
REMARK 465     SER B  1642                                                      
REMARK 465     ASP B  1643                                                      
REMARK 465     GLN B  1644                                                      
REMARK 465     LYS B  1645                                                      
REMARK 465     ARG B  1646                                                      
REMARK 465     ASP B  1647                                                      
REMARK 465     ALA B  1648                                                      
REMARK 465     LEU B  1649                                                      
REMARK 465     GLY B  1650                                                      
REMARK 465     ASN B  1651                                                      
REMARK 465     SER B  1652                                                      
REMARK 465     LYS B  1653                                                      
REMARK 465     ALA B  1654                                                      
REMARK 465     THR B  1655                                                      
REMARK 465     SER B  1656                                                      
REMARK 465     PHE B  1657                                                      
REMARK 465     GLY B  1658                                                      
REMARK 465     SER B  1659                                                      
REMARK 465     TYR B  1782                                                      
REMARK 465     ASP B  1783                                                      
REMARK 465     GLN B  1784                                                      
REMARK 465     GLU B  1785                                                      
REMARK 465     SER B  1786                                                      
REMARK 465     HIS B  1787                                                      
REMARK 465     GLN B  1788                                                      
REMARK 465     VAL B  1789                                                      
REMARK 465     ILE B  1790                                                      
REMARK 465     LEU B  1791                                                      
REMARK 465     ARG B  1792                                                      
REMARK 465     LEU B  1793                                                      
REMARK 465     GLY B  1794                                                      
REMARK 465     ASP B  1795                                                      
REMARK 465     GLN B  1796                                                      
REMARK 465     GLU B  1797                                                      
REMARK 465     PHE B  1798                                                      
REMARK 465     ILE B  1799                                                      
REMARK 465     LYS B  1800                                                      
REMARK 465     SER B  1801                                                      
REMARK 465     LEU B  1802                                                      
REMARK 465     THR B  1803                                                      
REMARK 465     PRO B  1804                                                      
REMARK 465     LEU B  1805                                                      
REMARK 465     GLU B  1806                                                      
REMARK 465     GLY B  1807                                                      
REMARK 465     THR B  1808                                                      
REMARK 465     GLN B  1809                                                      
REMARK 465     ASP B  1810                                                      
REMARK 465     THR B  1811                                                      
REMARK 465     PHE B  1812                                                      
REMARK 465     THR B  1813                                                      
REMARK 465     SER B  2728                                                      
REMARK 465     ALA B  2729                                                      
REMARK 465     ASP B  2730                                                      
REMARK 465     GLY B  2731                                                      
REMARK 465     ALA B  2732                                                      
REMARK 465     LYS B  2733                                                      
REMARK 465     GLY B  2734                                                      
REMARK 465     GLY B  2735                                                      
REMARK 465     GLN B  2736                                                      
REMARK 465     SER B  2737                                                      
REMARK 465     ALA B  2738                                                      
REMARK 465     GLU B  2739                                                      
REMARK 465     SER B  2740                                                      
REMARK 465     GLU B  2741                                                      
REMARK 465     GLU B  2742                                                      
REMARK 465     GLU B  2743                                                      
REMARK 465     GLU B  2744                                                      
REMARK 465     LEU B  2745                                                      
REMARK 465     THR B  2746                                                      
REMARK 465     ALA B  2747                                                      
REMARK 465     GLY B  2748                                                      
REMARK 465     SER B  2749                                                      
REMARK 465     GLY B  2750                                                      
REMARK 465     LEU B  2751                                                      
REMARK 465     ARG B  2752                                                      
REMARK 465     GLU B  2753                                                      
REMARK 465     ASP B  2754                                                      
REMARK 465     LEU B  2755                                                      
REMARK 465     LEU B  2756                                                      
REMARK 465     SER B  2757                                                      
REMARK 465     LEU B  2758                                                      
REMARK 465     GLN B  2759                                                      
REMARK 465     GLU B  2760                                                      
REMARK 465     PRO B  2761                                                      
REMARK 465     GLY B  2762                                                      
REMARK 465     SER B  2763                                                      
REMARK 465     LYS B  2764                                                      
REMARK 465     THR B  2765                                                      
REMARK 465     TYR B  2766                                                      
REMARK 465     SER B  2767                                                      
REMARK 465     LYS B  2768                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   ND2  ASN B   484     O5   NAG I     1              1.92            
REMARK 500   ND2  ASN B  2122     O5   NAG L     1              1.94            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ASP A 324   CB  -  CG  -  OD2 ANGL. DEV. =   7.8 DEGREES          
REMARK 500    CYS A 705   CA  -  CB  -  SG  ANGL. DEV. =   7.0 DEGREES          
REMARK 500    LEU A1022   CA  -  CB  -  CG  ANGL. DEV. =  15.9 DEGREES          
REMARK 500    CYS A1728   CA  -  CB  -  SG  ANGL. DEV. =   7.6 DEGREES          
REMARK 500    CYS A1760   CA  -  CB  -  SG  ANGL. DEV. =  11.0 DEGREES          
REMARK 500    LEU A2566   CA  -  CB  -  CG  ANGL. DEV. =  16.0 DEGREES          
REMARK 500    ASP B 324   CB  -  CG  -  OD2 ANGL. DEV. =   7.7 DEGREES          
REMARK 500    CYS B 705   CA  -  CB  -  SG  ANGL. DEV. =   7.0 DEGREES          
REMARK 500    LEU B1022   CA  -  CB  -  CG  ANGL. DEV. =  16.0 DEGREES          
REMARK 500    CYS B1728   CA  -  CB  -  SG  ANGL. DEV. =   7.3 DEGREES          
REMARK 500    CYS B1760   CA  -  CB  -  SG  ANGL. DEV. =  10.9 DEGREES          
REMARK 500    LEU B2566   CA  -  CB  -  CG  ANGL. DEV. =  15.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    GLU A  79     -169.92   -104.50                                   
REMARK 500    PHE A 196      -11.00     75.47                                   
REMARK 500    MET A 202       -3.56     76.50                                   
REMARK 500    SER A 269       -7.57     70.78                                   
REMARK 500    SER A 292       -1.77     64.48                                   
REMARK 500    PHE A 295       55.03    -98.67                                   
REMARK 500    GLU A 333      -60.61   -120.88                                   
REMARK 500    GLN A 655       70.49     51.77                                   
REMARK 500    PHE A 699     -167.36   -126.19                                   
REMARK 500    ASP A 707      -61.11    -94.81                                   
REMARK 500    GLU A 709       29.52     44.49                                   
REMARK 500    ILE A 760       80.94     52.90                                   
REMARK 500    ASP A 844     -167.48    -79.23                                   
REMARK 500    PRO A 846     -168.53    -75.96                                   
REMARK 500    LEU A 872      -53.13   -120.20                                   
REMARK 500    SER A 877       -1.30     68.89                                   
REMARK 500    ASP A 885       -8.98     73.91                                   
REMARK 500    SER A 887       49.84    -90.98                                   
REMARK 500    ALA A 904       48.67    -92.89                                   
REMARK 500    LEU A 975       32.14   -140.72                                   
REMARK 500    PHE A1010       45.49    -84.93                                   
REMARK 500    SER A1011       76.75     45.58                                   
REMARK 500    PRO A1012     -163.95    -74.31                                   
REMARK 500    SER A1015     -159.93   -141.68                                   
REMARK 500    ALA A1018       -3.30     68.16                                   
REMARK 500    PHE A1058       72.72     59.86                                   
REMARK 500    ASN A1097       77.56   -162.97                                   
REMARK 500    SER A1120     -168.95   -117.83                                   
REMARK 500    GLU A1197       77.00     62.52                                   
REMARK 500    GLN A1207       77.61     53.01                                   
REMARK 500    GLN A1297       42.99   -109.11                                   
REMARK 500    MET A1305       47.95    -80.59                                   
REMARK 500    ARG A1328       51.76    -90.40                                   
REMARK 500    PHE A1330       -3.50     63.55                                   
REMARK 500    PHE A1338       28.46     44.52                                   
REMARK 500    THR A1432       -3.80     66.55                                   
REMARK 500    SER A1433       68.16   -159.96                                   
REMARK 500    LEU A1488       -9.19     72.17                                   
REMARK 500    THR A1498       73.87     59.86                                   
REMARK 500    SER A1501     -167.98   -100.81                                   
REMARK 500    THR A1556       46.27   -141.29                                   
REMARK 500    GLN A1564       69.25     61.33                                   
REMARK 500    LEU A1566       47.58    -86.53                                   
REMARK 500    ASN A1584       49.27    -85.44                                   
REMARK 500    ALA A1585       58.96   -156.30                                   
REMARK 500    CYS A1607       40.03   -104.49                                   
REMARK 500    CYS A1613      -62.32   -109.77                                   
REMARK 500    SER A1614      -31.77     65.07                                   
REMARK 500    PHE A1615      161.06    178.20                                   
REMARK 500    TYR A1630     -165.09   -122.95                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     167 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 THR A 2057     TYR A 2058                 -148.98                    
REMARK 500 SER B 2121     ASN B 2122                  137.93                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-12073   RELATED DB: EMDB                             
REMARK 900 CRYO-EM STRUCTURE OF HUMAN THYROGLOBULIN                             
DBREF  7B75 A    1  2768  UNP    P01266   THYG_HUMAN       1   2768             
DBREF  7B75 B    1  2768  UNP    P01266   THYG_HUMAN       1   2768             
SEQRES   1 A 2768  MET ALA LEU VAL LEU GLU ILE PHE THR LEU LEU ALA SER          
SEQRES   2 A 2768  ILE CYS TRP VAL SER ALA ASN ILE PHE GLU TYR GLN VAL          
SEQRES   3 A 2768  ASP ALA GLN PRO LEU ARG PRO CYS GLU LEU GLN ARG GLU          
SEQRES   4 A 2768  THR ALA PHE LEU LYS GLN ALA ASP TYR VAL PRO GLN CYS          
SEQRES   5 A 2768  ALA GLU ASP GLY SER PHE GLN THR VAL GLN CYS GLN ASN          
SEQRES   6 A 2768  ASP GLY ARG SER CYS TRP CYS VAL GLY ALA ASN GLY SER          
SEQRES   7 A 2768  GLU VAL LEU GLY SER ARG GLN PRO GLY ARG PRO VAL ALA          
SEQRES   8 A 2768  CYS LEU SER PHE CYS GLN LEU GLN LYS GLN GLN ILE LEU          
SEQRES   9 A 2768  LEU SER GLY TYR ILE ASN SER THR ASP THR SER TYR LEU          
SEQRES  10 A 2768  PRO GLN CYS GLN ASP SER GLY ASP TYR ALA PRO VAL GLN          
SEQRES  11 A 2768  CYS ASP VAL GLN GLN VAL GLN CYS TRP CYS VAL ASP ALA          
SEQRES  12 A 2768  GLU GLY MET GLU VAL TYR GLY THR ARG GLN LEU GLY ARG          
SEQRES  13 A 2768  PRO LYS ARG CYS PRO ARG SER CYS GLU ILE ARG ASN ARG          
SEQRES  14 A 2768  ARG LEU LEU HIS GLY VAL GLY ASP LYS SER PRO PRO GLN          
SEQRES  15 A 2768  CYS SER ALA GLU GLY GLU PHE MET PRO VAL GLN CYS LYS          
SEQRES  16 A 2768  PHE VAL ASN THR THR ASP MET MET ILE PHE ASP LEU VAL          
SEQRES  17 A 2768  HIS SER TYR ASN ARG PHE PRO ASP ALA PHE VAL THR PHE          
SEQRES  18 A 2768  SER SER PHE GLN ARG ARG PHE PRO GLU VAL SER GLY TYR          
SEQRES  19 A 2768  CYS HIS CYS ALA ASP SER GLN GLY ARG GLU LEU ALA GLU          
SEQRES  20 A 2768  THR GLY LEU GLU LEU LEU LEU ASP GLU ILE TYR ASP THR          
SEQRES  21 A 2768  ILE PHE ALA GLY LEU ASP LEU PRO SER THR PHE THR GLU          
SEQRES  22 A 2768  THR THR LEU TYR ARG ILE LEU GLN ARG ARG PHE LEU ALA          
SEQRES  23 A 2768  VAL GLN SER VAL ILE SER GLY ARG PHE ARG CYS PRO THR          
SEQRES  24 A 2768  LYS CYS GLU VAL GLU ARG PHE THR ALA THR SER PHE GLY          
SEQRES  25 A 2768  HIS PRO TYR VAL PRO SER CYS ARG ARG ASN GLY ASP TYR          
SEQRES  26 A 2768  GLN ALA VAL GLN CYS GLN THR GLU GLY PRO CYS TRP CYS          
SEQRES  27 A 2768  VAL ASP ALA GLN GLY LYS GLU MET HIS GLY THR ARG GLN          
SEQRES  28 A 2768  GLN GLY GLU PRO PRO SER CYS ALA GLU GLY GLN SER CYS          
SEQRES  29 A 2768  ALA SER GLU ARG GLN GLN ALA LEU SER ARG LEU TYR PHE          
SEQRES  30 A 2768  GLY THR SER GLY TYR PHE SER GLN HIS ASP LEU PHE SER          
SEQRES  31 A 2768  SER PRO GLU LYS ARG TRP ALA SER PRO ARG VAL ALA ARG          
SEQRES  32 A 2768  PHE ALA THR SER CYS PRO PRO THR ILE LYS GLU LEU PHE          
SEQRES  33 A 2768  VAL ASP SER GLY LEU LEU ARG PRO MET VAL GLU GLY GLN          
SEQRES  34 A 2768  SER GLN GLN PHE SER VAL SER GLU ASN LEU LEU LYS GLU          
SEQRES  35 A 2768  ALA ILE ARG ALA ILE PHE PRO SER ARG GLY LEU ALA ARG          
SEQRES  36 A 2768  LEU ALA LEU GLN PHE THR THR ASN PRO LYS ARG LEU GLN          
SEQRES  37 A 2768  GLN ASN LEU PHE GLY GLY LYS PHE LEU VAL ASN VAL GLY          
SEQRES  38 A 2768  GLN PHE ASN LEU SER GLY ALA LEU GLY THR ARG GLY THR          
SEQRES  39 A 2768  PHE ASN PHE SER GLN PHE PHE GLN GLN LEU GLY LEU ALA          
SEQRES  40 A 2768  SER PHE LEU ASN GLY GLY ARG GLN GLU ASP LEU ALA LYS          
SEQRES  41 A 2768  PRO LEU SER VAL GLY LEU ASP SER ASN SER SER THR GLY          
SEQRES  42 A 2768  THR PRO GLU ALA ALA LYS LYS ASP GLY THR MET ASN LYS          
SEQRES  43 A 2768  PRO THR VAL GLY SER PHE GLY PHE GLU ILE ASN LEU GLN          
SEQRES  44 A 2768  GLU ASN GLN ASN ALA LEU LYS PHE LEU ALA SER LEU LEU          
SEQRES  45 A 2768  GLU LEU PRO GLU PHE LEU LEU PHE LEU GLN HIS ALA ILE          
SEQRES  46 A 2768  SER VAL PRO GLU ASP VAL ALA ARG ASP LEU GLY ASP VAL          
SEQRES  47 A 2768  MET GLU THR VAL LEU SER SER GLN THR CYS GLU GLN THR          
SEQRES  48 A 2768  PRO GLU ARG LEU PHE VAL PRO SER CYS THR THR GLU GLY          
SEQRES  49 A 2768  SER TYR GLU ASP VAL GLN CYS PHE SER GLY GLU CYS TRP          
SEQRES  50 A 2768  CYS VAL ASN SER TRP GLY LYS GLU LEU PRO GLY SER ARG          
SEQRES  51 A 2768  VAL ARG GLY GLY GLN PRO ARG CYS PRO THR ASP CYS GLU          
SEQRES  52 A 2768  LYS GLN ARG ALA ARG MET GLN SER LEU MET GLY SER GLN          
SEQRES  53 A 2768  PRO ALA GLY SER THR LEU PHE VAL PRO ALA CYS THR SER          
SEQRES  54 A 2768  GLU GLY HIS PHE LEU PRO VAL GLN CYS PHE ASN SER GLU          
SEQRES  55 A 2768  CYS TYR CYS VAL ASP ALA GLU GLY GLN ALA ILE PRO GLY          
SEQRES  56 A 2768  THR ARG SER ALA ILE GLY LYS PRO LYS LYS CYS PRO THR          
SEQRES  57 A 2768  PRO CYS GLN LEU GLN SER GLU GLN ALA PHE LEU ARG THR          
SEQRES  58 A 2768  VAL GLN ALA LEU LEU SER ASN SER SER MET LEU PRO THR          
SEQRES  59 A 2768  LEU SER ASP THR TYR ILE PRO GLN CYS SER THR ASP GLY          
SEQRES  60 A 2768  GLN TRP ARG GLN VAL GLN CYS ASN GLY PRO PRO GLU GLN          
SEQRES  61 A 2768  VAL PHE GLU LEU TYR GLN ARG TRP GLU ALA GLN ASN LYS          
SEQRES  62 A 2768  GLY GLN ASP LEU THR PRO ALA LYS LEU LEU VAL LYS ILE          
SEQRES  63 A 2768  MET SER TYR ARG GLU ALA ALA SER GLY ASN PHE SER LEU          
SEQRES  64 A 2768  PHE ILE GLN SER LEU TYR GLU ALA GLY GLN GLN ASP VAL          
SEQRES  65 A 2768  PHE PRO VAL LEU SER GLN TYR PRO SER LEU GLN ASP VAL          
SEQRES  66 A 2768  PRO LEU ALA ALA LEU GLU GLY LYS ARG PRO GLN PRO ARG          
SEQRES  67 A 2768  GLU ASN ILE LEU LEU GLU PRO TYR LEU PHE TRP GLN ILE          
SEQRES  68 A 2768  LEU ASN GLY GLN LEU SER GLN TYR PRO GLY SER TYR SER          
SEQRES  69 A 2768  ASP PHE SER THR PRO LEU ALA HIS PHE ASP LEU ARG ASN          
SEQRES  70 A 2768  CYS TRP CYS VAL ASP GLU ALA GLY GLN GLU LEU GLU GLY          
SEQRES  71 A 2768  MET ARG SER GLU PRO SER LYS LEU PRO THR CYS PRO GLY          
SEQRES  72 A 2768  SER CYS GLU GLU ALA LYS LEU ARG VAL LEU GLN PHE ILE          
SEQRES  73 A 2768  ARG GLU THR GLU GLU ILE VAL SER ALA SER ASN SER SER          
SEQRES  74 A 2768  ARG PHE PRO LEU GLY GLU SER PHE LEU VAL ALA LYS GLY          
SEQRES  75 A 2768  ILE ARG LEU ARG ASN GLU ASP LEU GLY LEU PRO PRO LEU          
SEQRES  76 A 2768  PHE PRO PRO ARG GLU ALA PHE ALA GLU GLN PHE LEU ARG          
SEQRES  77 A 2768  GLY SER ASP TYR ALA ILE ARG LEU ALA ALA GLN SER THR          
SEQRES  78 A 2768  LEU SER PHE TYR GLN ARG ARG ARG PHE SER PRO ASP ASP          
SEQRES  79 A 2768  SER ALA GLY ALA SER ALA LEU LEU ARG SER GLY PRO TYR          
SEQRES  80 A 2768  MET PRO GLN CYS ASP ALA PHE GLY SER TRP GLU PRO VAL          
SEQRES  81 A 2768  GLN CYS HIS ALA GLY THR GLY HIS CYS TRP CYS VAL ASP          
SEQRES  82 A 2768  GLU LYS GLY GLY PHE ILE PRO GLY SER LEU THR ALA ARG          
SEQRES  83 A 2768  SER LEU GLN ILE PRO GLN CYS PRO THR THR CYS GLU LYS          
SEQRES  84 A 2768  SER ARG THR SER GLY LEU LEU SER SER TRP LYS GLN ALA          
SEQRES  85 A 2768  ARG SER GLN GLU ASN PRO SER PRO LYS ASP LEU PHE VAL          
SEQRES  86 A 2768  PRO ALA CYS LEU GLU THR GLY GLU TYR ALA ARG LEU GLN          
SEQRES  87 A 2768  ALA SER GLY ALA GLY THR TRP CYS VAL ASP PRO ALA SER          
SEQRES  88 A 2768  GLY GLU GLU LEU ARG PRO GLY SER SER SER SER ALA GLN          
SEQRES  89 A 2768  CYS PRO SER LEU CYS ASN VAL LEU LYS SER GLY VAL LEU          
SEQRES  90 A 2768  SER ARG ARG VAL SER PRO GLY TYR VAL PRO ALA CYS ARG          
SEQRES  91 A 2768  ALA GLU ASP GLY GLY PHE SER PRO VAL GLN CYS ASP GLN          
SEQRES  92 A 2768  ALA GLN GLY SER CYS TRP CYS VAL MET ASP SER GLY GLU          
SEQRES  93 A 2768  GLU VAL PRO GLY THR ARG VAL THR GLY GLY GLN PRO ALA          
SEQRES  94 A 2768  CYS GLU SER PRO ARG CYS PRO LEU PRO PHE ASN ALA SER          
SEQRES  95 A 2768  GLU VAL VAL GLY GLY THR ILE LEU CYS GLU THR ILE SER          
SEQRES  96 A 2768  GLY PRO THR GLY SER ALA MET GLN GLN CYS GLN LEU LEU          
SEQRES  97 A 2768  CYS ARG GLN GLY SER TRP SER VAL PHE PRO PRO GLY PRO          
SEQRES  98 A 2768  LEU ILE CYS SER LEU GLU SER GLY ARG TRP GLU SER GLN          
SEQRES  99 A 2768  LEU PRO GLN PRO ARG ALA CYS GLN ARG PRO GLN LEU TRP          
SEQRES 100 A 2768  GLN THR ILE GLN THR GLN GLY HIS PHE GLN LEU GLN LEU          
SEQRES 101 A 2768  PRO PRO GLY LYS MET CYS SER ALA ASP TYR ALA ASP LEU          
SEQRES 102 A 2768  LEU GLN THR PHE GLN VAL PHE ILE LEU ASP GLU LEU THR          
SEQRES 103 A 2768  ALA ARG GLY PHE CYS GLN ILE GLN VAL LYS THR PHE GLY          
SEQRES 104 A 2768  THR LEU VAL SER ILE PRO VAL CYS ASN ASN SER SER VAL          
SEQRES 105 A 2768  GLN VAL GLY CYS LEU THR ARG GLU ARG LEU GLY VAL ASN          
SEQRES 106 A 2768  VAL THR TRP LYS SER ARG LEU GLU ASP ILE PRO VAL ALA          
SEQRES 107 A 2768  SER LEU PRO ASP LEU HIS ASP ILE GLU ARG ALA LEU VAL          
SEQRES 108 A 2768  GLY LYS ASP LEU LEU GLY ARG PHE THR ASP LEU ILE GLN          
SEQRES 109 A 2768  SER GLY SER PHE GLN LEU HIS LEU ASP SER LYS THR PHE          
SEQRES 110 A 2768  PRO ALA GLU THR ILE ARG PHE LEU GLN GLY ASP HIS PHE          
SEQRES 111 A 2768  GLY THR SER PRO ARG THR TRP PHE GLY CYS SER GLU GLY          
SEQRES 112 A 2768  PHE TYR GLN VAL LEU THR SER GLU ALA SER GLN ASP GLY          
SEQRES 113 A 2768  LEU GLY CYS VAL LYS CYS PRO GLU GLY SER TYR SER GLN          
SEQRES 114 A 2768  ASP GLU GLU CYS ILE PRO CYS PRO VAL GLY PHE TYR GLN          
SEQRES 115 A 2768  GLU GLN ALA GLY SER LEU ALA CYS VAL PRO CYS PRO VAL          
SEQRES 116 A 2768  GLY ARG THR THR ILE SER ALA GLY ALA PHE SER GLN THR          
SEQRES 117 A 2768  HIS CYS VAL THR ASP CYS GLN ARG ASN GLU ALA GLY LEU          
SEQRES 118 A 2768  GLN CYS ASP GLN ASN GLY GLN TYR ARG ALA SER GLN LYS          
SEQRES 119 A 2768  ASP ARG GLY SER GLY LYS ALA PHE CYS VAL ASP GLY GLU          
SEQRES 120 A 2768  GLY ARG ARG LEU PRO TRP TRP GLU THR GLU ALA PRO LEU          
SEQRES 121 A 2768  GLU ASP SER GLN CYS LEU MET MET GLN LYS PHE GLU LYS          
SEQRES 122 A 2768  VAL PRO GLU SER LYS VAL ILE PHE ASP ALA ASN ALA PRO          
SEQRES 123 A 2768  VAL ALA VAL ARG SER LYS VAL PRO ASP SER GLU PHE PRO          
SEQRES 124 A 2768  VAL MET GLN CYS LEU THR ASP CYS THR GLU ASP GLU ALA          
SEQRES 125 A 2768  CYS SER PHE PHE THR VAL SER THR THR GLU PRO GLU ILE          
SEQRES 126 A 2768  SER CYS ASP PHE TYR ALA TRP THR SER ASP ASN VAL ALA          
SEQRES 127 A 2768  CYS MET THR SER ASP GLN LYS ARG ASP ALA LEU GLY ASN          
SEQRES 128 A 2768  SER LYS ALA THR SER PHE GLY SER LEU ARG CYS GLN VAL          
SEQRES 129 A 2768  LYS VAL ARG SER HIS GLY GLN ASP SER PRO ALA VAL TYR          
SEQRES 130 A 2768  LEU LYS LYS GLY GLN GLY SER THR THR THR LEU GLN LYS          
SEQRES 131 A 2768  ARG PHE GLU PRO THR GLY PHE GLN ASN MET LEU SER GLY          
SEQRES 132 A 2768  LEU TYR ASN PRO ILE VAL PHE SER ALA SER GLY ALA ASN          
SEQRES 133 A 2768  LEU THR ASP ALA HIS LEU PHE CYS LEU LEU ALA CYS ASP          
SEQRES 134 A 2768  ARG ASP LEU CYS CYS ASP GLY PHE VAL LEU THR GLN VAL          
SEQRES 135 A 2768  GLN GLY GLY ALA ILE ILE CYS GLY LEU LEU SER SER PRO          
SEQRES 136 A 2768  SER VAL LEU LEU CYS ASN VAL LYS ASP TRP MET ASP PRO          
SEQRES 137 A 2768  SER GLU ALA TRP ALA ASN ALA THR CYS PRO GLY VAL THR          
SEQRES 138 A 2768  TYR ASP GLN GLU SER HIS GLN VAL ILE LEU ARG LEU GLY          
SEQRES 139 A 2768  ASP GLN GLU PHE ILE LYS SER LEU THR PRO LEU GLU GLY          
SEQRES 140 A 2768  THR GLN ASP THR PHE THR ASN PHE GLN GLN VAL TYR LEU          
SEQRES 141 A 2768  TRP LYS ASP SER ASP MET GLY SER ARG PRO GLU SER MET          
SEQRES 142 A 2768  GLY CYS ARG LYS ASP THR VAL PRO ARG PRO ALA SER PRO          
SEQRES 143 A 2768  THR GLU ALA GLY LEU THR THR GLU LEU PHE SER PRO VAL          
SEQRES 144 A 2768  ASP LEU ASN GLN VAL ILE VAL ASN GLY ASN GLN SER LEU          
SEQRES 145 A 2768  SER SER GLN LYS HIS TRP LEU PHE LYS HIS LEU PHE SER          
SEQRES 146 A 2768  ALA GLN GLN ALA ASN LEU TRP CYS LEU SER ARG CYS VAL          
SEQRES 147 A 2768  GLN GLU HIS SER PHE CYS GLN LEU ALA GLU ILE THR GLU          
SEQRES 148 A 2768  SER ALA SER LEU TYR PHE THR CYS THR LEU TYR PRO GLU          
SEQRES 149 A 2768  ALA GLN VAL CYS ASP ASP ILE MET GLU SER ASN ALA GLN          
SEQRES 150 A 2768  GLY CYS ARG LEU ILE LEU PRO GLN MET PRO LYS ALA LEU          
SEQRES 151 A 2768  PHE ARG LYS LYS VAL ILE LEU GLU ASP LYS VAL LYS ASN          
SEQRES 152 A 2768  PHE TYR THR ARG LEU PRO PHE GLN LYS LEU MET GLY ILE          
SEQRES 153 A 2768  SER ILE ARG ASN LYS VAL PRO MET SER GLU LYS SER ILE          
SEQRES 154 A 2768  SER ASN GLY PHE PHE GLU CYS GLU ARG ARG CYS ASP ALA          
SEQRES 155 A 2768  ASP PRO CYS CYS THR GLY PHE GLY PHE LEU ASN VAL SER          
SEQRES 156 A 2768  GLN LEU LYS GLY GLY GLU VAL THR CYS LEU THR LEU ASN          
SEQRES 157 A 2768  SER LEU GLY ILE GLN MET CYS SER GLU GLU ASN GLY GLY          
SEQRES 158 A 2768  ALA TRP ARG ILE LEU ASP CYS GLY SER PRO ASP ILE GLU          
SEQRES 159 A 2768  VAL HIS THR TYR PRO PHE GLY TRP TYR GLN LYS PRO ILE          
SEQRES 160 A 2768  ALA GLN ASN ASN ALA PRO SER PHE CYS PRO LEU VAL VAL          
SEQRES 161 A 2768  LEU PRO SER LEU THR GLU LYS VAL SER LEU ASP SER TRP          
SEQRES 162 A 2768  GLN SER LEU ALA LEU SER SER VAL VAL VAL ASP PRO SER          
SEQRES 163 A 2768  ILE ARG HIS PHE ASP VAL ALA HIS VAL SER THR ALA ALA          
SEQRES 164 A 2768  THR SER ASN PHE SER ALA VAL ARG ASP LEU CYS LEU SER          
SEQRES 165 A 2768  GLU CYS SER GLN HIS GLU ALA CYS LEU ILE THR THR LEU          
SEQRES 166 A 2768  GLN THR GLN PRO GLY ALA VAL ARG CYS MET PHE TYR ALA          
SEQRES 167 A 2768  ASP THR GLN SER CYS THR HIS SER LEU GLN GLY GLN ASN          
SEQRES 168 A 2768  CYS ARG LEU LEU LEU ARG GLU GLU ALA THR HIS ILE TYR          
SEQRES 169 A 2768  ARG LYS PRO GLY ILE SER LEU LEU SER TYR GLU ALA SER          
SEQRES 170 A 2768  VAL PRO SER VAL PRO ILE SER THR HIS GLY ARG LEU LEU          
SEQRES 171 A 2768  GLY ARG SER GLN ALA ILE GLN VAL GLY THR SER TRP LYS          
SEQRES 172 A 2768  GLN VAL ASP GLN PHE LEU GLY VAL PRO TYR ALA ALA PRO          
SEQRES 173 A 2768  PRO LEU ALA GLU ARG ARG PHE GLN ALA PRO GLU PRO LEU          
SEQRES 174 A 2768  ASN TRP THR GLY SER TRP ASP ALA SER LYS PRO ARG ALA          
SEQRES 175 A 2768  SER CYS TRP GLN PRO GLY THR ARG THR SER THR SER PRO          
SEQRES 176 A 2768  GLY VAL SER GLU ASP CYS LEU TYR LEU ASN VAL PHE ILE          
SEQRES 177 A 2768  PRO GLN ASN VAL ALA PRO ASN ALA SER VAL LEU VAL PHE          
SEQRES 178 A 2768  PHE HIS ASN THR MET ASP ARG GLU GLU SER GLU GLY TRP          
SEQRES 179 A 2768  PRO ALA ILE ASP GLY SER PHE LEU ALA ALA VAL GLY ASN          
SEQRES 180 A 2768  LEU ILE VAL VAL THR ALA SER TYR ARG VAL GLY VAL PHE          
SEQRES 181 A 2768  GLY PHE LEU SER SER GLY SER GLY GLU VAL SER GLY ASN          
SEQRES 182 A 2768  TRP GLY LEU LEU ASP GLN VAL ALA ALA LEU THR TRP VAL          
SEQRES 183 A 2768  GLN THR HIS ILE ARG GLY PHE GLY GLY ASP PRO ARG ARG          
SEQRES 184 A 2768  VAL SER LEU ALA ALA ASP ARG GLY GLY ALA ASP VAL ALA          
SEQRES 185 A 2768  SER ILE HIS LEU LEU THR ALA ARG ALA THR ASN SER GLN          
SEQRES 186 A 2768  LEU PHE ARG ARG ALA VAL LEU MET GLY GLY SER ALA LEU          
SEQRES 187 A 2768  SER PRO ALA ALA VAL ILE SER HIS GLU ARG ALA GLN GLN          
SEQRES 188 A 2768  GLN ALA ILE ALA LEU ALA LYS GLU VAL SER CYS PRO MET          
SEQRES 189 A 2768  SER SER SER GLN GLU VAL VAL SER CYS LEU ARG GLN LYS          
SEQRES 190 A 2768  PRO ALA ASN VAL LEU ASN ASP ALA GLN THR LYS LEU LEU          
SEQRES 191 A 2768  ALA VAL SER GLY PRO PHE HIS TYR TRP GLY PRO VAL ILE          
SEQRES 192 A 2768  ASP GLY HIS PHE LEU ARG GLU PRO PRO ALA ARG ALA LEU          
SEQRES 193 A 2768  LYS ARG SER LEU TRP VAL GLU VAL ASP LEU LEU ILE GLY          
SEQRES 194 A 2768  SER SER GLN ASP ASP GLY LEU ILE ASN ARG ALA LYS ALA          
SEQRES 195 A 2768  VAL LYS GLN PHE GLU GLU SER ARG GLY ARG THR SER SER          
SEQRES 196 A 2768  LYS THR ALA PHE TYR GLN ALA LEU GLN ASN SER LEU GLY          
SEQRES 197 A 2768  GLY GLU ASP SER ASP ALA ARG VAL GLU ALA ALA ALA THR          
SEQRES 198 A 2768  TRP TYR TYR SER LEU GLU HIS SER THR ASP ASP TYR ALA          
SEQRES 199 A 2768  SER PHE SER ARG ALA LEU GLU ASN ALA THR ARG ASP TYR          
SEQRES 200 A 2768  PHE ILE ILE CYS PRO ILE ILE ASP MET ALA SER ALA TRP          
SEQRES 201 A 2768  ALA LYS ARG ALA ARG GLY ASN VAL PHE MET TYR HIS ALA          
SEQRES 202 A 2768  PRO GLU ASN TYR GLY HIS GLY SER LEU GLU LEU LEU ALA          
SEQRES 203 A 2768  ASP VAL GLN PHE ALA LEU GLY LEU PRO PHE TYR PRO ALA          
SEQRES 204 A 2768  TYR GLU GLY GLN PHE SER LEU GLU GLU LYS SER LEU SER          
SEQRES 205 A 2768  LEU LYS ILE MET GLN TYR PHE SER HIS PHE ILE ARG SER          
SEQRES 206 A 2768  GLY ASN PRO ASN TYR PRO TYR GLU PHE SER ARG LYS VAL          
SEQRES 207 A 2768  PRO THR PHE ALA THR PRO TRP PRO ASP PHE VAL PRO ARG          
SEQRES 208 A 2768  ALA GLY GLY GLU ASN TYR LYS GLU PHE SER GLU LEU LEU          
SEQRES 209 A 2768  PRO ASN ARG GLN GLY LEU LYS LYS ALA ASP CYS SER PHE          
SEQRES 210 A 2768  TRP SER LYS TYR ILE SER SER LEU LYS THR SER ALA ASP          
SEQRES 211 A 2768  GLY ALA LYS GLY GLY GLN SER ALA GLU SER GLU GLU GLU          
SEQRES 212 A 2768  GLU LEU THR ALA GLY SER GLY LEU ARG GLU ASP LEU LEU          
SEQRES 213 A 2768  SER LEU GLN GLU PRO GLY SER LYS THR TYR SER LYS              
SEQRES   1 B 2768  MET ALA LEU VAL LEU GLU ILE PHE THR LEU LEU ALA SER          
SEQRES   2 B 2768  ILE CYS TRP VAL SER ALA ASN ILE PHE GLU TYR GLN VAL          
SEQRES   3 B 2768  ASP ALA GLN PRO LEU ARG PRO CYS GLU LEU GLN ARG GLU          
SEQRES   4 B 2768  THR ALA PHE LEU LYS GLN ALA ASP TYR VAL PRO GLN CYS          
SEQRES   5 B 2768  ALA GLU ASP GLY SER PHE GLN THR VAL GLN CYS GLN ASN          
SEQRES   6 B 2768  ASP GLY ARG SER CYS TRP CYS VAL GLY ALA ASN GLY SER          
SEQRES   7 B 2768  GLU VAL LEU GLY SER ARG GLN PRO GLY ARG PRO VAL ALA          
SEQRES   8 B 2768  CYS LEU SER PHE CYS GLN LEU GLN LYS GLN GLN ILE LEU          
SEQRES   9 B 2768  LEU SER GLY TYR ILE ASN SER THR ASP THR SER TYR LEU          
SEQRES  10 B 2768  PRO GLN CYS GLN ASP SER GLY ASP TYR ALA PRO VAL GLN          
SEQRES  11 B 2768  CYS ASP VAL GLN GLN VAL GLN CYS TRP CYS VAL ASP ALA          
SEQRES  12 B 2768  GLU GLY MET GLU VAL TYR GLY THR ARG GLN LEU GLY ARG          
SEQRES  13 B 2768  PRO LYS ARG CYS PRO ARG SER CYS GLU ILE ARG ASN ARG          
SEQRES  14 B 2768  ARG LEU LEU HIS GLY VAL GLY ASP LYS SER PRO PRO GLN          
SEQRES  15 B 2768  CYS SER ALA GLU GLY GLU PHE MET PRO VAL GLN CYS LYS          
SEQRES  16 B 2768  PHE VAL ASN THR THR ASP MET MET ILE PHE ASP LEU VAL          
SEQRES  17 B 2768  HIS SER TYR ASN ARG PHE PRO ASP ALA PHE VAL THR PHE          
SEQRES  18 B 2768  SER SER PHE GLN ARG ARG PHE PRO GLU VAL SER GLY TYR          
SEQRES  19 B 2768  CYS HIS CYS ALA ASP SER GLN GLY ARG GLU LEU ALA GLU          
SEQRES  20 B 2768  THR GLY LEU GLU LEU LEU LEU ASP GLU ILE TYR ASP THR          
SEQRES  21 B 2768  ILE PHE ALA GLY LEU ASP LEU PRO SER THR PHE THR GLU          
SEQRES  22 B 2768  THR THR LEU TYR ARG ILE LEU GLN ARG ARG PHE LEU ALA          
SEQRES  23 B 2768  VAL GLN SER VAL ILE SER GLY ARG PHE ARG CYS PRO THR          
SEQRES  24 B 2768  LYS CYS GLU VAL GLU ARG PHE THR ALA THR SER PHE GLY          
SEQRES  25 B 2768  HIS PRO TYR VAL PRO SER CYS ARG ARG ASN GLY ASP TYR          
SEQRES  26 B 2768  GLN ALA VAL GLN CYS GLN THR GLU GLY PRO CYS TRP CYS          
SEQRES  27 B 2768  VAL ASP ALA GLN GLY LYS GLU MET HIS GLY THR ARG GLN          
SEQRES  28 B 2768  GLN GLY GLU PRO PRO SER CYS ALA GLU GLY GLN SER CYS          
SEQRES  29 B 2768  ALA SER GLU ARG GLN GLN ALA LEU SER ARG LEU TYR PHE          
SEQRES  30 B 2768  GLY THR SER GLY TYR PHE SER GLN HIS ASP LEU PHE SER          
SEQRES  31 B 2768  SER PRO GLU LYS ARG TRP ALA SER PRO ARG VAL ALA ARG          
SEQRES  32 B 2768  PHE ALA THR SER CYS PRO PRO THR ILE LYS GLU LEU PHE          
SEQRES  33 B 2768  VAL ASP SER GLY LEU LEU ARG PRO MET VAL GLU GLY GLN          
SEQRES  34 B 2768  SER GLN GLN PHE SER VAL SER GLU ASN LEU LEU LYS GLU          
SEQRES  35 B 2768  ALA ILE ARG ALA ILE PHE PRO SER ARG GLY LEU ALA ARG          
SEQRES  36 B 2768  LEU ALA LEU GLN PHE THR THR ASN PRO LYS ARG LEU GLN          
SEQRES  37 B 2768  GLN ASN LEU PHE GLY GLY LYS PHE LEU VAL ASN VAL GLY          
SEQRES  38 B 2768  GLN PHE ASN LEU SER GLY ALA LEU GLY THR ARG GLY THR          
SEQRES  39 B 2768  PHE ASN PHE SER GLN PHE PHE GLN GLN LEU GLY LEU ALA          
SEQRES  40 B 2768  SER PHE LEU ASN GLY GLY ARG GLN GLU ASP LEU ALA LYS          
SEQRES  41 B 2768  PRO LEU SER VAL GLY LEU ASP SER ASN SER SER THR GLY          
SEQRES  42 B 2768  THR PRO GLU ALA ALA LYS LYS ASP GLY THR MET ASN LYS          
SEQRES  43 B 2768  PRO THR VAL GLY SER PHE GLY PHE GLU ILE ASN LEU GLN          
SEQRES  44 B 2768  GLU ASN GLN ASN ALA LEU LYS PHE LEU ALA SER LEU LEU          
SEQRES  45 B 2768  GLU LEU PRO GLU PHE LEU LEU PHE LEU GLN HIS ALA ILE          
SEQRES  46 B 2768  SER VAL PRO GLU ASP VAL ALA ARG ASP LEU GLY ASP VAL          
SEQRES  47 B 2768  MET GLU THR VAL LEU SER SER GLN THR CYS GLU GLN THR          
SEQRES  48 B 2768  PRO GLU ARG LEU PHE VAL PRO SER CYS THR THR GLU GLY          
SEQRES  49 B 2768  SER TYR GLU ASP VAL GLN CYS PHE SER GLY GLU CYS TRP          
SEQRES  50 B 2768  CYS VAL ASN SER TRP GLY LYS GLU LEU PRO GLY SER ARG          
SEQRES  51 B 2768  VAL ARG GLY GLY GLN PRO ARG CYS PRO THR ASP CYS GLU          
SEQRES  52 B 2768  LYS GLN ARG ALA ARG MET GLN SER LEU MET GLY SER GLN          
SEQRES  53 B 2768  PRO ALA GLY SER THR LEU PHE VAL PRO ALA CYS THR SER          
SEQRES  54 B 2768  GLU GLY HIS PHE LEU PRO VAL GLN CYS PHE ASN SER GLU          
SEQRES  55 B 2768  CYS TYR CYS VAL ASP ALA GLU GLY GLN ALA ILE PRO GLY          
SEQRES  56 B 2768  THR ARG SER ALA ILE GLY LYS PRO LYS LYS CYS PRO THR          
SEQRES  57 B 2768  PRO CYS GLN LEU GLN SER GLU GLN ALA PHE LEU ARG THR          
SEQRES  58 B 2768  VAL GLN ALA LEU LEU SER ASN SER SER MET LEU PRO THR          
SEQRES  59 B 2768  LEU SER ASP THR TYR ILE PRO GLN CYS SER THR ASP GLY          
SEQRES  60 B 2768  GLN TRP ARG GLN VAL GLN CYS ASN GLY PRO PRO GLU GLN          
SEQRES  61 B 2768  VAL PHE GLU LEU TYR GLN ARG TRP GLU ALA GLN ASN LYS          
SEQRES  62 B 2768  GLY GLN ASP LEU THR PRO ALA LYS LEU LEU VAL LYS ILE          
SEQRES  63 B 2768  MET SER TYR ARG GLU ALA ALA SER GLY ASN PHE SER LEU          
SEQRES  64 B 2768  PHE ILE GLN SER LEU TYR GLU ALA GLY GLN GLN ASP VAL          
SEQRES  65 B 2768  PHE PRO VAL LEU SER GLN TYR PRO SER LEU GLN ASP VAL          
SEQRES  66 B 2768  PRO LEU ALA ALA LEU GLU GLY LYS ARG PRO GLN PRO ARG          
SEQRES  67 B 2768  GLU ASN ILE LEU LEU GLU PRO TYR LEU PHE TRP GLN ILE          
SEQRES  68 B 2768  LEU ASN GLY GLN LEU SER GLN TYR PRO GLY SER TYR SER          
SEQRES  69 B 2768  ASP PHE SER THR PRO LEU ALA HIS PHE ASP LEU ARG ASN          
SEQRES  70 B 2768  CYS TRP CYS VAL ASP GLU ALA GLY GLN GLU LEU GLU GLY          
SEQRES  71 B 2768  MET ARG SER GLU PRO SER LYS LEU PRO THR CYS PRO GLY          
SEQRES  72 B 2768  SER CYS GLU GLU ALA LYS LEU ARG VAL LEU GLN PHE ILE          
SEQRES  73 B 2768  ARG GLU THR GLU GLU ILE VAL SER ALA SER ASN SER SER          
SEQRES  74 B 2768  ARG PHE PRO LEU GLY GLU SER PHE LEU VAL ALA LYS GLY          
SEQRES  75 B 2768  ILE ARG LEU ARG ASN GLU ASP LEU GLY LEU PRO PRO LEU          
SEQRES  76 B 2768  PHE PRO PRO ARG GLU ALA PHE ALA GLU GLN PHE LEU ARG          
SEQRES  77 B 2768  GLY SER ASP TYR ALA ILE ARG LEU ALA ALA GLN SER THR          
SEQRES  78 B 2768  LEU SER PHE TYR GLN ARG ARG ARG PHE SER PRO ASP ASP          
SEQRES  79 B 2768  SER ALA GLY ALA SER ALA LEU LEU ARG SER GLY PRO TYR          
SEQRES  80 B 2768  MET PRO GLN CYS ASP ALA PHE GLY SER TRP GLU PRO VAL          
SEQRES  81 B 2768  GLN CYS HIS ALA GLY THR GLY HIS CYS TRP CYS VAL ASP          
SEQRES  82 B 2768  GLU LYS GLY GLY PHE ILE PRO GLY SER LEU THR ALA ARG          
SEQRES  83 B 2768  SER LEU GLN ILE PRO GLN CYS PRO THR THR CYS GLU LYS          
SEQRES  84 B 2768  SER ARG THR SER GLY LEU LEU SER SER TRP LYS GLN ALA          
SEQRES  85 B 2768  ARG SER GLN GLU ASN PRO SER PRO LYS ASP LEU PHE VAL          
SEQRES  86 B 2768  PRO ALA CYS LEU GLU THR GLY GLU TYR ALA ARG LEU GLN          
SEQRES  87 B 2768  ALA SER GLY ALA GLY THR TRP CYS VAL ASP PRO ALA SER          
SEQRES  88 B 2768  GLY GLU GLU LEU ARG PRO GLY SER SER SER SER ALA GLN          
SEQRES  89 B 2768  CYS PRO SER LEU CYS ASN VAL LEU LYS SER GLY VAL LEU          
SEQRES  90 B 2768  SER ARG ARG VAL SER PRO GLY TYR VAL PRO ALA CYS ARG          
SEQRES  91 B 2768  ALA GLU ASP GLY GLY PHE SER PRO VAL GLN CYS ASP GLN          
SEQRES  92 B 2768  ALA GLN GLY SER CYS TRP CYS VAL MET ASP SER GLY GLU          
SEQRES  93 B 2768  GLU VAL PRO GLY THR ARG VAL THR GLY GLY GLN PRO ALA          
SEQRES  94 B 2768  CYS GLU SER PRO ARG CYS PRO LEU PRO PHE ASN ALA SER          
SEQRES  95 B 2768  GLU VAL VAL GLY GLY THR ILE LEU CYS GLU THR ILE SER          
SEQRES  96 B 2768  GLY PRO THR GLY SER ALA MET GLN GLN CYS GLN LEU LEU          
SEQRES  97 B 2768  CYS ARG GLN GLY SER TRP SER VAL PHE PRO PRO GLY PRO          
SEQRES  98 B 2768  LEU ILE CYS SER LEU GLU SER GLY ARG TRP GLU SER GLN          
SEQRES  99 B 2768  LEU PRO GLN PRO ARG ALA CYS GLN ARG PRO GLN LEU TRP          
SEQRES 100 B 2768  GLN THR ILE GLN THR GLN GLY HIS PHE GLN LEU GLN LEU          
SEQRES 101 B 2768  PRO PRO GLY LYS MET CYS SER ALA ASP TYR ALA ASP LEU          
SEQRES 102 B 2768  LEU GLN THR PHE GLN VAL PHE ILE LEU ASP GLU LEU THR          
SEQRES 103 B 2768  ALA ARG GLY PHE CYS GLN ILE GLN VAL LYS THR PHE GLY          
SEQRES 104 B 2768  THR LEU VAL SER ILE PRO VAL CYS ASN ASN SER SER VAL          
SEQRES 105 B 2768  GLN VAL GLY CYS LEU THR ARG GLU ARG LEU GLY VAL ASN          
SEQRES 106 B 2768  VAL THR TRP LYS SER ARG LEU GLU ASP ILE PRO VAL ALA          
SEQRES 107 B 2768  SER LEU PRO ASP LEU HIS ASP ILE GLU ARG ALA LEU VAL          
SEQRES 108 B 2768  GLY LYS ASP LEU LEU GLY ARG PHE THR ASP LEU ILE GLN          
SEQRES 109 B 2768  SER GLY SER PHE GLN LEU HIS LEU ASP SER LYS THR PHE          
SEQRES 110 B 2768  PRO ALA GLU THR ILE ARG PHE LEU GLN GLY ASP HIS PHE          
SEQRES 111 B 2768  GLY THR SER PRO ARG THR TRP PHE GLY CYS SER GLU GLY          
SEQRES 112 B 2768  PHE TYR GLN VAL LEU THR SER GLU ALA SER GLN ASP GLY          
SEQRES 113 B 2768  LEU GLY CYS VAL LYS CYS PRO GLU GLY SER TYR SER GLN          
SEQRES 114 B 2768  ASP GLU GLU CYS ILE PRO CYS PRO VAL GLY PHE TYR GLN          
SEQRES 115 B 2768  GLU GLN ALA GLY SER LEU ALA CYS VAL PRO CYS PRO VAL          
SEQRES 116 B 2768  GLY ARG THR THR ILE SER ALA GLY ALA PHE SER GLN THR          
SEQRES 117 B 2768  HIS CYS VAL THR ASP CYS GLN ARG ASN GLU ALA GLY LEU          
SEQRES 118 B 2768  GLN CYS ASP GLN ASN GLY GLN TYR ARG ALA SER GLN LYS          
SEQRES 119 B 2768  ASP ARG GLY SER GLY LYS ALA PHE CYS VAL ASP GLY GLU          
SEQRES 120 B 2768  GLY ARG ARG LEU PRO TRP TRP GLU THR GLU ALA PRO LEU          
SEQRES 121 B 2768  GLU ASP SER GLN CYS LEU MET MET GLN LYS PHE GLU LYS          
SEQRES 122 B 2768  VAL PRO GLU SER LYS VAL ILE PHE ASP ALA ASN ALA PRO          
SEQRES 123 B 2768  VAL ALA VAL ARG SER LYS VAL PRO ASP SER GLU PHE PRO          
SEQRES 124 B 2768  VAL MET GLN CYS LEU THR ASP CYS THR GLU ASP GLU ALA          
SEQRES 125 B 2768  CYS SER PHE PHE THR VAL SER THR THR GLU PRO GLU ILE          
SEQRES 126 B 2768  SER CYS ASP PHE TYR ALA TRP THR SER ASP ASN VAL ALA          
SEQRES 127 B 2768  CYS MET THR SER ASP GLN LYS ARG ASP ALA LEU GLY ASN          
SEQRES 128 B 2768  SER LYS ALA THR SER PHE GLY SER LEU ARG CYS GLN VAL          
SEQRES 129 B 2768  LYS VAL ARG SER HIS GLY GLN ASP SER PRO ALA VAL TYR          
SEQRES 130 B 2768  LEU LYS LYS GLY GLN GLY SER THR THR THR LEU GLN LYS          
SEQRES 131 B 2768  ARG PHE GLU PRO THR GLY PHE GLN ASN MET LEU SER GLY          
SEQRES 132 B 2768  LEU TYR ASN PRO ILE VAL PHE SER ALA SER GLY ALA ASN          
SEQRES 133 B 2768  LEU THR ASP ALA HIS LEU PHE CYS LEU LEU ALA CYS ASP          
SEQRES 134 B 2768  ARG ASP LEU CYS CYS ASP GLY PHE VAL LEU THR GLN VAL          
SEQRES 135 B 2768  GLN GLY GLY ALA ILE ILE CYS GLY LEU LEU SER SER PRO          
SEQRES 136 B 2768  SER VAL LEU LEU CYS ASN VAL LYS ASP TRP MET ASP PRO          
SEQRES 137 B 2768  SER GLU ALA TRP ALA ASN ALA THR CYS PRO GLY VAL THR          
SEQRES 138 B 2768  TYR ASP GLN GLU SER HIS GLN VAL ILE LEU ARG LEU GLY          
SEQRES 139 B 2768  ASP GLN GLU PHE ILE LYS SER LEU THR PRO LEU GLU GLY          
SEQRES 140 B 2768  THR GLN ASP THR PHE THR ASN PHE GLN GLN VAL TYR LEU          
SEQRES 141 B 2768  TRP LYS ASP SER ASP MET GLY SER ARG PRO GLU SER MET          
SEQRES 142 B 2768  GLY CYS ARG LYS ASP THR VAL PRO ARG PRO ALA SER PRO          
SEQRES 143 B 2768  THR GLU ALA GLY LEU THR THR GLU LEU PHE SER PRO VAL          
SEQRES 144 B 2768  ASP LEU ASN GLN VAL ILE VAL ASN GLY ASN GLN SER LEU          
SEQRES 145 B 2768  SER SER GLN LYS HIS TRP LEU PHE LYS HIS LEU PHE SER          
SEQRES 146 B 2768  ALA GLN GLN ALA ASN LEU TRP CYS LEU SER ARG CYS VAL          
SEQRES 147 B 2768  GLN GLU HIS SER PHE CYS GLN LEU ALA GLU ILE THR GLU          
SEQRES 148 B 2768  SER ALA SER LEU TYR PHE THR CYS THR LEU TYR PRO GLU          
SEQRES 149 B 2768  ALA GLN VAL CYS ASP ASP ILE MET GLU SER ASN ALA GLN          
SEQRES 150 B 2768  GLY CYS ARG LEU ILE LEU PRO GLN MET PRO LYS ALA LEU          
SEQRES 151 B 2768  PHE ARG LYS LYS VAL ILE LEU GLU ASP LYS VAL LYS ASN          
SEQRES 152 B 2768  PHE TYR THR ARG LEU PRO PHE GLN LYS LEU MET GLY ILE          
SEQRES 153 B 2768  SER ILE ARG ASN LYS VAL PRO MET SER GLU LYS SER ILE          
SEQRES 154 B 2768  SER ASN GLY PHE PHE GLU CYS GLU ARG ARG CYS ASP ALA          
SEQRES 155 B 2768  ASP PRO CYS CYS THR GLY PHE GLY PHE LEU ASN VAL SER          
SEQRES 156 B 2768  GLN LEU LYS GLY GLY GLU VAL THR CYS LEU THR LEU ASN          
SEQRES 157 B 2768  SER LEU GLY ILE GLN MET CYS SER GLU GLU ASN GLY GLY          
SEQRES 158 B 2768  ALA TRP ARG ILE LEU ASP CYS GLY SER PRO ASP ILE GLU          
SEQRES 159 B 2768  VAL HIS THR TYR PRO PHE GLY TRP TYR GLN LYS PRO ILE          
SEQRES 160 B 2768  ALA GLN ASN ASN ALA PRO SER PHE CYS PRO LEU VAL VAL          
SEQRES 161 B 2768  LEU PRO SER LEU THR GLU LYS VAL SER LEU ASP SER TRP          
SEQRES 162 B 2768  GLN SER LEU ALA LEU SER SER VAL VAL VAL ASP PRO SER          
SEQRES 163 B 2768  ILE ARG HIS PHE ASP VAL ALA HIS VAL SER THR ALA ALA          
SEQRES 164 B 2768  THR SER ASN PHE SER ALA VAL ARG ASP LEU CYS LEU SER          
SEQRES 165 B 2768  GLU CYS SER GLN HIS GLU ALA CYS LEU ILE THR THR LEU          
SEQRES 166 B 2768  GLN THR GLN PRO GLY ALA VAL ARG CYS MET PHE TYR ALA          
SEQRES 167 B 2768  ASP THR GLN SER CYS THR HIS SER LEU GLN GLY GLN ASN          
SEQRES 168 B 2768  CYS ARG LEU LEU LEU ARG GLU GLU ALA THR HIS ILE TYR          
SEQRES 169 B 2768  ARG LYS PRO GLY ILE SER LEU LEU SER TYR GLU ALA SER          
SEQRES 170 B 2768  VAL PRO SER VAL PRO ILE SER THR HIS GLY ARG LEU LEU          
SEQRES 171 B 2768  GLY ARG SER GLN ALA ILE GLN VAL GLY THR SER TRP LYS          
SEQRES 172 B 2768  GLN VAL ASP GLN PHE LEU GLY VAL PRO TYR ALA ALA PRO          
SEQRES 173 B 2768  PRO LEU ALA GLU ARG ARG PHE GLN ALA PRO GLU PRO LEU          
SEQRES 174 B 2768  ASN TRP THR GLY SER TRP ASP ALA SER LYS PRO ARG ALA          
SEQRES 175 B 2768  SER CYS TRP GLN PRO GLY THR ARG THR SER THR SER PRO          
SEQRES 176 B 2768  GLY VAL SER GLU ASP CYS LEU TYR LEU ASN VAL PHE ILE          
SEQRES 177 B 2768  PRO GLN ASN VAL ALA PRO ASN ALA SER VAL LEU VAL PHE          
SEQRES 178 B 2768  PHE HIS ASN THR MET ASP ARG GLU GLU SER GLU GLY TRP          
SEQRES 179 B 2768  PRO ALA ILE ASP GLY SER PHE LEU ALA ALA VAL GLY ASN          
SEQRES 180 B 2768  LEU ILE VAL VAL THR ALA SER TYR ARG VAL GLY VAL PHE          
SEQRES 181 B 2768  GLY PHE LEU SER SER GLY SER GLY GLU VAL SER GLY ASN          
SEQRES 182 B 2768  TRP GLY LEU LEU ASP GLN VAL ALA ALA LEU THR TRP VAL          
SEQRES 183 B 2768  GLN THR HIS ILE ARG GLY PHE GLY GLY ASP PRO ARG ARG          
SEQRES 184 B 2768  VAL SER LEU ALA ALA ASP ARG GLY GLY ALA ASP VAL ALA          
SEQRES 185 B 2768  SER ILE HIS LEU LEU THR ALA ARG ALA THR ASN SER GLN          
SEQRES 186 B 2768  LEU PHE ARG ARG ALA VAL LEU MET GLY GLY SER ALA LEU          
SEQRES 187 B 2768  SER PRO ALA ALA VAL ILE SER HIS GLU ARG ALA GLN GLN          
SEQRES 188 B 2768  GLN ALA ILE ALA LEU ALA LYS GLU VAL SER CYS PRO MET          
SEQRES 189 B 2768  SER SER SER GLN GLU VAL VAL SER CYS LEU ARG GLN LYS          
SEQRES 190 B 2768  PRO ALA ASN VAL LEU ASN ASP ALA GLN THR LYS LEU LEU          
SEQRES 191 B 2768  ALA VAL SER GLY PRO PHE HIS TYR TRP GLY PRO VAL ILE          
SEQRES 192 B 2768  ASP GLY HIS PHE LEU ARG GLU PRO PRO ALA ARG ALA LEU          
SEQRES 193 B 2768  LYS ARG SER LEU TRP VAL GLU VAL ASP LEU LEU ILE GLY          
SEQRES 194 B 2768  SER SER GLN ASP ASP GLY LEU ILE ASN ARG ALA LYS ALA          
SEQRES 195 B 2768  VAL LYS GLN PHE GLU GLU SER ARG GLY ARG THR SER SER          
SEQRES 196 B 2768  LYS THR ALA PHE TYR GLN ALA LEU GLN ASN SER LEU GLY          
SEQRES 197 B 2768  GLY GLU ASP SER ASP ALA ARG VAL GLU ALA ALA ALA THR          
SEQRES 198 B 2768  TRP TYR TYR SER LEU GLU HIS SER THR ASP ASP TYR ALA          
SEQRES 199 B 2768  SER PHE SER ARG ALA LEU GLU ASN ALA THR ARG ASP TYR          
SEQRES 200 B 2768  PHE ILE ILE CYS PRO ILE ILE ASP MET ALA SER ALA TRP          
SEQRES 201 B 2768  ALA LYS ARG ALA ARG GLY ASN VAL PHE MET TYR HIS ALA          
SEQRES 202 B 2768  PRO GLU ASN TYR GLY HIS GLY SER LEU GLU LEU LEU ALA          
SEQRES 203 B 2768  ASP VAL GLN PHE ALA LEU GLY LEU PRO PHE TYR PRO ALA          
SEQRES 204 B 2768  TYR GLU GLY GLN PHE SER LEU GLU GLU LYS SER LEU SER          
SEQRES 205 B 2768  LEU LYS ILE MET GLN TYR PHE SER HIS PHE ILE ARG SER          
SEQRES 206 B 2768  GLY ASN PRO ASN TYR PRO TYR GLU PHE SER ARG LYS VAL          
SEQRES 207 B 2768  PRO THR PHE ALA THR PRO TRP PRO ASP PHE VAL PRO ARG          
SEQRES 208 B 2768  ALA GLY GLY GLU ASN TYR LYS GLU PHE SER GLU LEU LEU          
SEQRES 209 B 2768  PRO ASN ARG GLN GLY LEU LYS LYS ALA ASP CYS SER PHE          
SEQRES 210 B 2768  TRP SER LYS TYR ILE SER SER LEU LYS THR SER ALA ASP          
SEQRES 211 B 2768  GLY ALA LYS GLY GLY GLN SER ALA GLU SER GLU GLU GLU          
SEQRES 212 B 2768  GLU LEU THR ALA GLY SER GLY LEU ARG GLU ASP LEU LEU          
SEQRES 213 B 2768  SER LEU GLN GLU PRO GLY SER LYS THR TYR SER LYS              
HET    NAG  C   1      14                                                       
HET    NAG  C   2      14                                                       
HET    NAG  D   1      14                                                       
HET    NAG  D   2      14                                                       
HET    NAG  E   1      14                                                       
HET    NAG  E   2      14                                                       
HET    BMA  E   3      11                                                       
HET    NAG  F   1      14                                                       
HET    NAG  F   2      14                                                       
HET    NAG  G   1      14                                                       
HET    NAG  G   2      14                                                       
HET    BMA  G   3      11                                                       
HET    MAN  G   4      11                                                       
HET    NAG  H   1      14                                                       
HET    NAG  H   2      14                                                       
HET    BMA  H   3      11                                                       
HET    MAN  H   4      11                                                       
HET    MAN  H   5      11                                                       
HET    MAN  H   6      11                                                       
HET    NAG  I   1      14                                                       
HET    NAG  I   2      14                                                       
HET    NAG  J   1      14                                                       
HET    NAG  J   2      14                                                       
HET    NAG  K   1      14                                                       
HET    NAG  K   2      14                                                       
HET    BMA  K   3      11                                                       
HET    NAG  L   1      14                                                       
HET    NAG  L   2      14                                                       
HET    NAG  M   1      14                                                       
HET    NAG  M   2      14                                                       
HET    BMA  M   3      11                                                       
HET    MAN  M   4      11                                                       
HET    NAG  N   1      14                                                       
HET    NAG  N   2      14                                                       
HET    BMA  N   3      11                                                       
HET    MAN  N   4      11                                                       
HET    MAN  N   5      11                                                       
HET    MAN  N   6      11                                                       
HET    NAG  A2801      14                                                       
HET    NAG  A2802      14                                                       
HET    NAG  A2803      14                                                       
HET    NAG  A2804      14                                                       
HET    NAG  A2805      14                                                       
HET    NAG  A2806      14                                                       
HET    NAG  A2807      14                                                       
HET    NAG  A2808      14                                                       
HET    NAG  B2801      14                                                       
HET    NAG  B2802      14                                                       
HET    NAG  B2803      14                                                       
HET    NAG  B2804      14                                                       
HET    NAG  B2805      14                                                       
HET    NAG  B2806      14                                                       
HET    NAG  B2807      14                                                       
HET    NAG  B2808      14                                                       
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE                         
HETNAM     BMA BETA-D-MANNOPYRANOSE                                             
HETNAM     MAN ALPHA-D-MANNOPYRANOSE                                            
HETSYN     NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA-           
HETSYN   2 NAG  D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO-          
HETSYN   3 NAG  2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE                         
HETSYN     BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE                               
HETSYN     MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE                              
FORMUL   3  NAG    40(C8 H15 N O6)                                              
FORMUL   5  BMA    6(C6 H12 O6)                                                 
FORMUL   7  MAN    8(C6 H12 O6)                                                 
HELIX    1 AA1 ARG A   32  LYS A   44  1                                  13    
HELIX    2 AA2 SER A   94  LEU A  105  1                                  12    
HELIX    3 AA3 VAL A  148  ARG A  152  5                                   5    
HELIX    4 AA4 ARG A  162  LEU A  171  1                                  10    
HELIX    5 AA5 VAL A  208  ARG A  213  1                                   6    
HELIX    6 AA6 THR A  220  PHE A  228  1                                   9    
HELIX    7 AA7 THR A  270  GLU A  273  5                                   4    
HELIX    8 AA8 THR A  274  ILE A  291  1                                  18    
HELIX    9 AA9 THR A  299  GLY A  312  1                                  14    
HELIX   10 AB1 MET A  346  ARG A  350  5                                   5    
HELIX   11 AB2 CYS A  364  TYR A  376  1                                  13    
HELIX   12 AB3 LEU A  421  GLU A  427  1                                   7    
HELIX   13 AB4 VAL A  435  PHE A  448  1                                  14    
HELIX   14 AB5 SER A  450  THR A  461  1                                  12    
HELIX   15 AB6 ARG A  466  PHE A  472  1                                   7    
HELIX   16 AB7 LYS A  475  GLN A  482  1                                   8    
HELIX   17 AB8 ASN A  557  GLU A  573  1                                  17    
HELIX   18 AB9 LEU A  574  SER A  586  1                                  13    
HELIX   19 AC1 ASP A  594  SER A  605  1                                  12    
HELIX   20 AC2 GLN A  606  CYS A  608  5                                   3    
HELIX   21 AC3 THR A  660  GLY A  674  1                                  15    
HELIX   22 AC4 THR A  728  LEU A  746  1                                  19    
HELIX   23 AC5 PRO A  778  ASN A  792  1                                  15    
HELIX   24 AC6 ASP A  796  ILE A  806  1                                  11    
HELIX   25 AC7 GLY A  923  SER A  949  1                                  27    
HELIX   26 AC8 GLY A  954  GLY A  962  1                                   9    
HELIX   27 AC9 ASN A  967  GLY A  971  5                                   5    
HELIX   28 AD1 PRO A  978  PHE A  986  1                                   9    
HELIX   29 AD2 SER A  990  ARG A 1009  1                                  20    
HELIX   30 AD3 THR A 1075  SER A 1087  1                                  13    
HELIX   31 AD4 SER A 1147  SER A 1158  1                                  12    
HELIX   32 AD5 LEU A 1300  LYS A 1304  5                                   5    
HELIX   33 AD6 LEU A 1314  ARG A 1328  1                                  15    
HELIX   34 AD7 ASP A 1382  GLY A 1392  1                                  11    
HELIX   35 AD8 LEU A 1395  SER A 1405  1                                  11    
HELIX   36 AD9 SER A 1453  LEU A 1457  5                                   5    
HELIX   37 AE1 SER A 1506  CYS A 1510  5                                   5    
HELIX   38 AE2 THR A 1512  ASN A 1517  1                                   6    
HELIX   39 AE3 PRO A 1552  GLU A 1557  1                                   6    
HELIX   40 AE4 PRO A 1575  VAL A 1579  5                                   5    
HELIX   41 AE5 PHE A 1598  CYS A 1607  1                                  10    
HELIX   42 AE6 THR A 1718  ASP A 1731  1                                  14    
HELIX   43 AE7 GLN A 1888  GLU A 1900  1                                  13    
HELIX   44 AE8 SER A 1988  ASP A 2003  1                                  16    
HELIX   45 AE9 ALA A 2097  SER A 2099  5                                   3    
HELIX   46 AF1 ASN A 2122  HIS A 2137  1                                  16    
HELIX   47 AF2 GLY A 2319  ASN A 2327  1                                   9    
HELIX   48 AF3 ASN A 2353  HIS A 2369  1                                  17    
HELIX   49 AF4 ILE A 2370  PHE A 2373  5                                   4    
HELIX   50 AF5 SER A 2393  THR A 2398  1                                   6    
HELIX   51 AF6 SER A 2425  SER A 2441  1                                  17    
HELIX   52 AF7 SER A 2446  ARG A 2455  1                                  10    
HELIX   53 AF8 PRO A 2458  VAL A 2472  1                                  15    
HELIX   54 AF9 SER A 2473  TYR A 2478  5                                   6    
HELIX   55 AG1 PRO A 2491  LEU A 2496  1                                   6    
HELIX   56 AG2 LYS A 2497  SER A 2499  5                                   3    
HELIX   57 AG3 ILE A 2517  ARG A 2519  5                                   3    
HELIX   58 AG4 ALA A 2520  GLY A 2531  1                                  12    
HELIX   59 AG5 LYS A 2536  GLY A 2548  1                                  13    
HELIX   60 AG6 ASP A 2553  TYR A 2564  1                                  12    
HELIX   61 AG7 ASP A 2572  ILE A 2589  1                                  18    
HELIX   62 AG8 ILE A 2589  ARG A 2603  1                                  15    
HELIX   63 AG9 LEU A 2625  LEU A 2632  1                                   8    
HELIX   64 AH1 GLY A 2633  TYR A 2637  5                                   5    
HELIX   65 AH2 SER A 2645  SER A 2665  1                                  21    
HELIX   66 AH3 LYS A 2711  LYS A 2720  1                                  10    
HELIX   67 AH4 LYS A 2720  THR A 2727  1                                   8    
HELIX   68 AH5 ARG B   32  LYS B   44  1                                  13    
HELIX   69 AH6 SER B   94  LEU B  105  1                                  12    
HELIX   70 AH7 VAL B  148  ARG B  152  5                                   5    
HELIX   71 AH8 ARG B  162  LEU B  171  1                                  10    
HELIX   72 AH9 VAL B  208  ARG B  213  1                                   6    
HELIX   73 AI1 THR B  220  PHE B  228  1                                   9    
HELIX   74 AI2 THR B  270  GLU B  273  5                                   4    
HELIX   75 AI3 THR B  274  ILE B  291  1                                  18    
HELIX   76 AI4 THR B  299  PHE B  311  1                                  13    
HELIX   77 AI5 MET B  346  ARG B  350  5                                   5    
HELIX   78 AI6 CYS B  364  TYR B  376  1                                  13    
HELIX   79 AI7 LEU B  421  GLU B  427  1                                   7    
HELIX   80 AI8 VAL B  435  PHE B  448  1                                  14    
HELIX   81 AI9 SER B  450  THR B  461  1                                  12    
HELIX   82 AJ1 ARG B  466  PHE B  472  1                                   7    
HELIX   83 AJ2 LYS B  475  GLN B  482  1                                   8    
HELIX   84 AJ3 ASN B  557  GLU B  573  1                                  17    
HELIX   85 AJ4 LEU B  574  SER B  586  1                                  13    
HELIX   86 AJ5 ASP B  594  SER B  605  1                                  12    
HELIX   87 AJ6 GLN B  606  CYS B  608  5                                   3    
HELIX   88 AJ7 THR B  660  GLY B  674  1                                  15    
HELIX   89 AJ8 THR B  728  LEU B  746  1                                  19    
HELIX   90 AJ9 PRO B  778  ASN B  792  1                                  15    
HELIX   91 AK1 ASP B  796  ILE B  806  1                                  11    
HELIX   92 AK2 GLY B  923  SER B  949  1                                  27    
HELIX   93 AK3 GLY B  954  GLY B  962  1                                   9    
HELIX   94 AK4 ASN B  967  GLY B  971  5                                   5    
HELIX   95 AK5 PRO B  978  PHE B  986  1                                   9    
HELIX   96 AK6 SER B  990  ARG B 1009  1                                  20    
HELIX   97 AK7 THR B 1075  SER B 1088  1                                  14    
HELIX   98 AK8 SER B 1147  SER B 1158  1                                  12    
HELIX   99 AK9 LEU B 1300  LYS B 1304  5                                   5    
HELIX  100 AL1 LEU B 1314  ARG B 1328  1                                  15    
HELIX  101 AL2 ASP B 1382  GLY B 1392  1                                  11    
HELIX  102 AL3 LEU B 1395  SER B 1405  1                                  11    
HELIX  103 AL4 SER B 1453  LEU B 1457  5                                   5    
HELIX  104 AL5 SER B 1506  CYS B 1510  5                                   5    
HELIX  105 AL6 THR B 1512  ASN B 1517  1                                   6    
HELIX  106 AL7 PRO B 1552  GLU B 1557  1                                   6    
HELIX  107 AL8 PRO B 1575  VAL B 1579  5                                   5    
HELIX  108 AL9 PHE B 1598  CYS B 1607  1                                  10    
HELIX  109 AM1 THR B 1718  ASP B 1731  1                                  14    
HELIX  110 AM2 GLN B 1888  GLU B 1900  1                                  13    
HELIX  111 AM3 SER B 1988  ASP B 2003  1                                  16    
HELIX  112 AM4 ALA B 2097  SER B 2099  5                                   3    
HELIX  113 AM5 ASN B 2122  HIS B 2137  1                                  16    
HELIX  114 AM6 GLY B 2319  ASN B 2327  1                                   9    
HELIX  115 AM7 ASN B 2353  HIS B 2369  1                                  17    
HELIX  116 AM8 ILE B 2370  PHE B 2373  5                                   4    
HELIX  117 AM9 SER B 2393  THR B 2398  1                                   6    
HELIX  118 AN1 SER B 2425  SER B 2441  1                                  17    
HELIX  119 AN2 SER B 2446  ARG B 2455  1                                  10    
HELIX  120 AN3 PRO B 2458  VAL B 2472  1                                  15    
HELIX  121 AN4 SER B 2473  TYR B 2478  5                                   6    
HELIX  122 AN5 PRO B 2491  LEU B 2496  1                                   6    
HELIX  123 AN6 LYS B 2497  SER B 2499  5                                   3    
HELIX  124 AN7 ILE B 2517  ARG B 2519  5                                   3    
HELIX  125 AN8 ALA B 2520  GLY B 2531  1                                  12    
HELIX  126 AN9 LYS B 2536  GLY B 2548  1                                  13    
HELIX  127 AO1 ASP B 2553  TYR B 2564  1                                  12    
HELIX  128 AO2 ASP B 2572  ILE B 2589  1                                  18    
HELIX  129 AO3 ILE B 2589  ARG B 2603  1                                  15    
HELIX  130 AO4 LEU B 2625  LEU B 2632  1                                   8    
HELIX  131 AO5 GLY B 2633  TYR B 2637  5                                   5    
HELIX  132 AO6 SER B 2645  SER B 2665  1                                  21    
HELIX  133 AO7 LYS B 2711  LYS B 2720  1                                  10    
HELIX  134 AO8 LYS B 2720  THR B 2727  1                                   8    
SHEET    1 AA1 2 CYS A  52  ALA A  53  0                                        
SHEET    2 AA1 2 SER A  57  PHE A  58 -1  O  SER A  57   N  ALA A  53           
SHEET    1 AA2 3 VAL A  61  GLN A  62  0                                        
SHEET    2 AA2 3 SER A  69  CYS A  72 -1  O  TRP A  71   N  GLN A  62           
SHEET    3 AA2 3 GLN A  85  PRO A  86 -1  N  GLN A  85   O  CYS A  70           
SHEET    1 AA3 3 GLN A 130  CYS A 131  0                                        
SHEET    2 AA3 3 GLN A 137  TRP A 139 -1  O  TRP A 139   N  GLN A 130           
SHEET    3 AA3 3 GLN A 153  LEU A 154 -1  O  GLN A 153   N  CYS A 138           
SHEET    1 AA4 3 VAL A 192  CYS A 194  0                                        
SHEET    2 AA4 3 GLY A 233  CYS A 237 -1  O  HIS A 236   N  GLN A 193           
SHEET    3 AA4 3 GLU A 251  LEU A 253 -1  O  LEU A 253   N  GLY A 233           
SHEET    1 AA5 2 VAL A 328  CYS A 330  0                                        
SHEET    2 AA5 2 CYS A 336  CYS A 338 -1  O  TRP A 337   N  GLN A 329           
SHEET    1 AA6 2 VAL A 629  PHE A 632  0                                        
SHEET    2 AA6 2 GLU A 635  CYS A 638 -1  O  TRP A 637   N  GLN A 630           
SHEET    1 AA7 3 GLN A 697  CYS A 698  0                                        
SHEET    2 AA7 3 GLU A 702  TYR A 704 -1  O  TYR A 704   N  GLN A 697           
SHEET    3 AA7 3 SER A 718  ALA A 719 -1  O  SER A 718   N  CYS A 703           
SHEET    1 AA8 2 VAL A 772  GLN A 773  0                                        
SHEET    2 AA8 2 TRP A 899  CYS A 900 -1  O  TRP A 899   N  GLN A 773           
SHEET    1 AA9 2 VAL A1040  CYS A1042  0                                        
SHEET    2 AA9 2 CYS A1049  CYS A1051 -1  O  TRP A1050   N  GLN A1041           
SHEET    1 AB1 2 GLN A1091  ALA A1092  0                                        
SHEET    2 AB1 2 LEU A1103  PHE A1104 -1  O  PHE A1104   N  GLN A1091           
SHEET    1 AB2 2 LEU A1117  ALA A1119  0                                        
SHEET    2 AB2 2 THR A1124  CYS A1126 -1  O  TRP A1125   N  GLN A1118           
SHEET    1 AB3 2 GLY A1227  LEU A1230  0                                        
SHEET    2 AB3 2 GLN A1246  CYS A1249 -1  O  GLN A1246   N  LEU A1230           
SHEET    1 AB4 2 TRP A1254  SER A1255  0                                        
SHEET    2 AB4 2 CYS A1281  GLN A1282 -1  O  GLN A1282   N  TRP A1254           
SHEET    1 AB5 3 PRO A1284  GLN A1285  0                                        
SHEET    2 AB5 3 CYS A1459  LYS A1461 -1  O  CYS A1459   N  GLN A1285           
SHEET    3 AB5 3 PHE A1444  GLN A1446 -1  N  TYR A1445   O  VAL A1460           
SHEET    1 AB6 3 ASN A1365  ARG A1371  0                                        
SHEET    2 AB6 3 THR A1289  HIS A1295 -1  N  ILE A1290   O  SER A1370           
SHEET    3 AB6 3 TRP A1437  GLY A1439 -1  O  TRP A1437   N  GLN A1291           
SHEET    1 AB7 2 GLN A1332  THR A1337  0                                        
SHEET    2 AB7 2 THR A1340  PRO A1345 -1  O  VAL A1342   N  VAL A1335           
SHEET    1 AB8 2 SER A1466  SER A1468  0                                        
SHEET    2 AB8 2 CYS A1473  PRO A1475 -1  O  ILE A1474   N  TYR A1467           
SHEET    1 AB9 2 PHE A1480  TYR A1481  0                                        
SHEET    2 AB9 2 VAL A1491  PRO A1492 -1  O  VAL A1491   N  TYR A1481           
SHEET    1 AC1 2 SER A1532  LYS A1534  0                                        
SHEET    2 AC1 2 ALA A1541  CYS A1543 -1  O  PHE A1542   N  GLN A1533           
SHEET    1 AC2 6 THR A1685  THR A1686  0                                        
SHEET    2 AC2 6 ARG A1691  GLU A1693 -1  O  PHE A1692   N  THR A1685           
SHEET    3 AC2 6 PHE A1815  TRP A1821 -1  O  LEU A1820   N  GLU A1693           
SHEET    4 AC2 6 GLY A1736  GLN A1741 -1  N  PHE A1737   O  TYR A1819           
SHEET    5 AC2 6 ILE A1747  LEU A1752 -1  O  ILE A1748   N  THR A1740           
SHEET    6 AC2 6 ILE A1708  PHE A1710 -1  N  ILE A1708   O  CYS A1749           
SHEET    1 AC3 7 PHE A1697  MET A1700  0                                        
SHEET    2 AC3 7 VAL A1757  ASN A1761 -1  O  CYS A1760   N  GLN A1698           
SHEET    3 AC3 7 LYS A1876  PHE A1880 -1  O  LEU A1879   N  LEU A1758           
SHEET    4 AC3 7 PHE A1917  TYR A1922 -1  O  PHE A1917   N  PHE A1880           
SHEET    5 AC3 7 LEU A1906  THR A1910 -1  N  LEU A1906   O  TYR A1922           
SHEET    6 AC3 7 ALA A1949  LYS A1953 -1  O  PHE A1951   N  ALA A1907           
SHEET    7 AC3 7 PHE A1856  PRO A1858 -1  N  SER A1857   O  ARG A1952           
SHEET    1 AC4 3 ILE A1865  VAL A1866  0                                        
SHEET    2 AC4 3 ARG A1940  LEU A1943  1  O  LEU A1943   N  ILE A1865           
SHEET    3 AC4 3 GLN A1926  VAL A1927 -1  N  VAL A1927   O  ARG A1940           
SHEET    1 AC5 5 THR A1966  ARG A1967  0                                        
SHEET    2 AC5 5 TYR A2063  GLN A2064 -1  O  GLN A2064   N  THR A1966           
SHEET    3 AC5 5 GLY A2008  ASN A2013 -1  N  PHE A2009   O  TYR A2063           
SHEET    4 AC5 5 VAL A2022  SER A2029 -1  O  LEU A2025   N  GLY A2010           
SHEET    5 AC5 5 SER A1977  ILE A1978 -1  N  SER A1977   O  ASN A2028           
SHEET    1 AC6 5 THR A1966  ARG A1967  0                                        
SHEET    2 AC6 5 TYR A2063  GLN A2064 -1  O  GLN A2064   N  THR A1966           
SHEET    3 AC6 5 GLY A2008  ASN A2013 -1  N  PHE A2009   O  TYR A2063           
SHEET    4 AC6 5 VAL A2022  SER A2029 -1  O  LEU A2025   N  GLY A2010           
SHEET    5 AC6 5 VAL A1982  PRO A1983 -1  N  VAL A1982   O  CYS A2024           
SHEET    1 AC7 7 LYS A1972  LEU A1973  0                                        
SHEET    2 AC7 7 ILE A2032  MET A2034 -1  O  MET A2034   N  LYS A1972           
SHEET    3 AC7 7 PHE A2110  SER A2116 -1  O  HIS A2114   N  GLN A2033           
SHEET    4 AC7 7 ALA A2151  TYR A2157 -1  O  CYS A2154   N  ALA A2113           
SHEET    5 AC7 7 ILE A2142  THR A2147 -1  N  ILE A2142   O  TYR A2157           
SHEET    6 AC7 7 HIS A2182  ARG A2185 -1  O  HIS A2182   N  LEU A2145           
SHEET    7 AC7 7 GLN A2094  LEU A2096 -1  N  GLN A2094   O  ARG A2185           
SHEET    1 AC8 3 VAL A2101  VAL A2103  0                                        
SHEET    2 AC8 3 ASN A2171  LEU A2176  1  O  LEU A2174   N  VAL A2102           
SHEET    3 AC8 3 GLN A2161  THR A2164 -1  N  THR A2164   O  ASN A2171           
SHEET    1 AC9 4 SER A2193  GLU A2195  0                                        
SHEET    2 AC9 4 VAL A2198  ILE A2203 -1  O  SER A2200   N  SER A2193           
SHEET    3 AC9 4 GLY A2207  LEU A2210 -1  O  GLY A2207   N  ILE A2203           
SHEET    4 AC9 4 GLY A2253  ASP A2256  1  O  GLY A2253   N  ARG A2208           
SHEET    1 AD111 ARG A2212  VAL A2218  0                                        
SHEET    2 AD111 SER A2221  GLN A2227 -1  O  LYS A2223   N  ILE A2216           
SHEET    3 AD111 VAL A2286  PRO A2289 -1  O  ILE A2288   N  ASP A2226           
SHEET    4 AD111 ILE A2329  ALA A2333 -1  O  VAL A2330   N  PHE A2287           
SHEET    5 AD111 ALA A2296  PHE A2302  1  N  PHE A2301   O  VAL A2331           
SHEET    6 AD111 GLY A2375  ASP A2385  1  O  SER A2381   N  VAL A2300           
SHEET    7 AD111 ARG A2409  MET A2413  1  O  VAL A2411   N  LEU A2382           
SHEET    8 AD111 LEU A2506  GLY A2509  1  O  LEU A2507   N  ALA A2410           
SHEET    9 AD111 VAL A2608  HIS A2612  1  O  PHE A2609   N  ILE A2508           
SHEET   10 AD111 TYR A2697  GLU A2699  1  O  LYS A2698   N  MET A2610           
SHEET   11 AD111 ASN A2706  ARG A2707 -1  O  ARG A2707   N  TYR A2697           
SHEET    1 AD2 2 VAL A2231  PRO A2232  0                                        
SHEET    2 AD2 2 TYR A2283  LEU A2284 -1  O  LEU A2284   N  VAL A2231           
SHEET    1 AD3 2 CYS B  52  ALA B  53  0                                        
SHEET    2 AD3 2 SER B  57  PHE B  58 -1  O  SER B  57   N  ALA B  53           
SHEET    1 AD4 3 VAL B  61  GLN B  62  0                                        
SHEET    2 AD4 3 SER B  69  CYS B  72 -1  O  TRP B  71   N  GLN B  62           
SHEET    3 AD4 3 GLN B  85  PRO B  86 -1  O  GLN B  85   N  CYS B  70           
SHEET    1 AD5 3 GLN B 130  CYS B 131  0                                        
SHEET    2 AD5 3 GLN B 137  TRP B 139 -1  O  TRP B 139   N  GLN B 130           
SHEET    3 AD5 3 GLN B 153  LEU B 154 -1  O  GLN B 153   N  CYS B 138           
SHEET    1 AD6 3 VAL B 192  CYS B 194  0                                        
SHEET    2 AD6 3 GLY B 233  CYS B 237 -1  O  HIS B 236   N  GLN B 193           
SHEET    3 AD6 3 GLU B 251  LEU B 253 -1  O  LEU B 253   N  GLY B 233           
SHEET    1 AD7 2 VAL B 328  CYS B 330  0                                        
SHEET    2 AD7 2 CYS B 336  CYS B 338 -1  O  TRP B 337   N  GLN B 329           
SHEET    1 AD8 2 VAL B 629  PHE B 632  0                                        
SHEET    2 AD8 2 GLU B 635  CYS B 638 -1  O  TRP B 637   N  GLN B 630           
SHEET    1 AD9 3 GLN B 697  CYS B 698  0                                        
SHEET    2 AD9 3 GLU B 702  TYR B 704 -1  O  TYR B 704   N  GLN B 697           
SHEET    3 AD9 3 SER B 718  ALA B 719 -1  O  SER B 718   N  CYS B 703           
SHEET    1 AE1 2 VAL B 772  GLN B 773  0                                        
SHEET    2 AE1 2 TRP B 899  CYS B 900 -1  O  TRP B 899   N  GLN B 773           
SHEET    1 AE2 2 VAL B1040  CYS B1042  0                                        
SHEET    2 AE2 2 CYS B1049  CYS B1051 -1  O  TRP B1050   N  GLN B1041           
SHEET    1 AE3 2 GLN B1091  ALA B1092  0                                        
SHEET    2 AE3 2 LEU B1103  PHE B1104 -1  O  PHE B1104   N  GLN B1091           
SHEET    1 AE4 2 LEU B1117  ALA B1119  0                                        
SHEET    2 AE4 2 THR B1124  CYS B1126 -1  O  TRP B1125   N  GLN B1118           
SHEET    1 AE5 2 GLY B1227  LEU B1230  0                                        
SHEET    2 AE5 2 GLN B1246  CYS B1249 -1  O  GLN B1246   N  LEU B1230           
SHEET    1 AE6 2 TRP B1254  SER B1255  0                                        
SHEET    2 AE6 2 CYS B1281  GLN B1282 -1  O  GLN B1282   N  TRP B1254           
SHEET    1 AE7 3 PRO B1284  GLN B1285  0                                        
SHEET    2 AE7 3 CYS B1459  LYS B1461 -1  O  CYS B1459   N  GLN B1285           
SHEET    3 AE7 3 PHE B1444  GLN B1446 -1  N  TYR B1445   O  VAL B1460           
SHEET    1 AE8 3 ASN B1365  ARG B1371  0                                        
SHEET    2 AE8 3 THR B1289  HIS B1295 -1  N  ILE B1290   O  SER B1370           
SHEET    3 AE8 3 TRP B1437  GLY B1439 -1  O  TRP B1437   N  GLN B1291           
SHEET    1 AE9 2 GLN B1332  THR B1337  0                                        
SHEET    2 AE9 2 THR B1340  PRO B1345 -1  O  VAL B1342   N  VAL B1335           
SHEET    1 AF1 2 SER B1466  SER B1468  0                                        
SHEET    2 AF1 2 CYS B1473  PRO B1475 -1  O  ILE B1474   N  TYR B1467           
SHEET    1 AF2 2 PHE B1480  TYR B1481  0                                        
SHEET    2 AF2 2 VAL B1491  PRO B1492 -1  O  VAL B1491   N  TYR B1481           
SHEET    1 AF3 2 SER B1532  LYS B1534  0                                        
SHEET    2 AF3 2 ALA B1541  CYS B1543 -1  O  PHE B1542   N  GLN B1533           
SHEET    1 AF4 6 THR B1685  THR B1686  0                                        
SHEET    2 AF4 6 ARG B1691  GLU B1693 -1  O  PHE B1692   N  THR B1685           
SHEET    3 AF4 6 PHE B1815  TRP B1821 -1  O  LEU B1820   N  GLU B1693           
SHEET    4 AF4 6 GLY B1736  GLN B1741 -1  N  PHE B1737   O  TYR B1819           
SHEET    5 AF4 6 ILE B1747  LEU B1752 -1  O  ILE B1748   N  THR B1740           
SHEET    6 AF4 6 ILE B1708  PHE B1710 -1  N  ILE B1708   O  CYS B1749           
SHEET    1 AF5 7 PHE B1697  MET B1700  0                                        
SHEET    2 AF5 7 VAL B1757  ASN B1761 -1  O  CYS B1760   N  GLN B1698           
SHEET    3 AF5 7 LYS B1876  PHE B1880 -1  O  LEU B1879   N  LEU B1758           
SHEET    4 AF5 7 PHE B1917  TYR B1922 -1  O  PHE B1917   N  PHE B1880           
SHEET    5 AF5 7 LEU B1906  THR B1910 -1  N  LEU B1906   O  TYR B1922           
SHEET    6 AF5 7 ALA B1949  LYS B1953 -1  O  PHE B1951   N  ALA B1907           
SHEET    7 AF5 7 PHE B1856  PRO B1858 -1  N  SER B1857   O  ARG B1952           
SHEET    1 AF6 3 ILE B1865  VAL B1866  0                                        
SHEET    2 AF6 3 ARG B1940  LEU B1943  1  O  LEU B1943   N  ILE B1865           
SHEET    3 AF6 3 GLN B1926  VAL B1927 -1  N  VAL B1927   O  ARG B1940           
SHEET    1 AF7 5 THR B1966  ARG B1967  0                                        
SHEET    2 AF7 5 TYR B2063  GLN B2064 -1  O  GLN B2064   N  THR B1966           
SHEET    3 AF7 5 GLY B2008  ASN B2013 -1  N  PHE B2009   O  TYR B2063           
SHEET    4 AF7 5 VAL B2022  SER B2029 -1  O  LEU B2025   N  GLY B2010           
SHEET    5 AF7 5 SER B1977  ILE B1978 -1  N  SER B1977   O  ASN B2028           
SHEET    1 AF8 5 THR B1966  ARG B1967  0                                        
SHEET    2 AF8 5 TYR B2063  GLN B2064 -1  O  GLN B2064   N  THR B1966           
SHEET    3 AF8 5 GLY B2008  ASN B2013 -1  N  PHE B2009   O  TYR B2063           
SHEET    4 AF8 5 VAL B2022  SER B2029 -1  O  LEU B2025   N  GLY B2010           
SHEET    5 AF8 5 VAL B1982  PRO B1983 -1  N  VAL B1982   O  CYS B2024           
SHEET    1 AF9 7 LYS B1972  LEU B1973  0                                        
SHEET    2 AF9 7 ILE B2032  MET B2034 -1  O  MET B2034   N  LYS B1972           
SHEET    3 AF9 7 PHE B2110  SER B2116 -1  O  HIS B2114   N  GLN B2033           
SHEET    4 AF9 7 ALA B2151  TYR B2157 -1  O  CYS B2154   N  ALA B2113           
SHEET    5 AF9 7 ILE B2142  THR B2147 -1  N  ILE B2142   O  TYR B2157           
SHEET    6 AF9 7 HIS B2182  ARG B2185 -1  O  HIS B2182   N  LEU B2145           
SHEET    7 AF9 7 GLN B2094  LEU B2096 -1  N  GLN B2094   O  ARG B2185           
SHEET    1 AG1 3 VAL B2101  VAL B2103  0                                        
SHEET    2 AG1 3 ASN B2171  LEU B2176  1  O  LEU B2174   N  VAL B2102           
SHEET    3 AG1 3 GLN B2161  THR B2164 -1  N  THR B2164   O  ASN B2171           
SHEET    1 AG2 4 SER B2193  GLU B2195  0                                        
SHEET    2 AG2 4 VAL B2198  ILE B2203 -1  O  SER B2200   N  SER B2193           
SHEET    3 AG2 4 GLY B2207  LEU B2210 -1  O  GLY B2207   N  ILE B2203           
SHEET    4 AG2 4 GLY B2253  ASP B2256  1  O  GLY B2253   N  ARG B2208           
SHEET    1 AG311 ARG B2212  VAL B2218  0                                        
SHEET    2 AG311 SER B2221  GLN B2227 -1  O  LYS B2223   N  ILE B2216           
SHEET    3 AG311 VAL B2286  PRO B2289 -1  O  ILE B2288   N  ASP B2226           
SHEET    4 AG311 ILE B2329  ALA B2333 -1  O  VAL B2330   N  PHE B2287           
SHEET    5 AG311 ALA B2296  PHE B2302  1  N  PHE B2301   O  VAL B2331           
SHEET    6 AG311 GLY B2375  ASP B2385  1  O  SER B2381   N  VAL B2300           
SHEET    7 AG311 ARG B2409  MET B2413  1  O  VAL B2411   N  LEU B2382           
SHEET    8 AG311 LEU B2506  GLY B2509  1  O  LEU B2507   N  ALA B2410           
SHEET    9 AG311 VAL B2608  HIS B2612  1  O  PHE B2609   N  ILE B2508           
SHEET   10 AG311 TYR B2697  GLU B2699  1  O  LYS B2698   N  MET B2610           
SHEET   11 AG311 ASN B2706  ARG B2707 -1  O  ARG B2707   N  TYR B2697           
SHEET    1 AG4 2 VAL B2231  PRO B2232  0                                        
SHEET    2 AG4 2 TYR B2283  LEU B2284 -1  O  LEU B2284   N  VAL B2231           
SSBOND   1 CYS A   34    CYS A   52                          1555   1555  2.03  
SSBOND   2 CYS A   63    CYS A   70                          1555   1555  2.03  
SSBOND   3 CYS A   72    CYS A   92                          1555   1555  2.03  
SSBOND   4 CYS A   96    CYS A  120                          1555   1555  2.03  
SSBOND   5 CYS A  131    CYS A  138                          1555   1555  2.03  
SSBOND   6 CYS A  140    CYS A  160                          1555   1555  2.03  
SSBOND   7 CYS A  164    CYS A  183                          1555   1555  2.03  
SSBOND   8 CYS A  194    CYS A  235                          1555   1555  2.03  
SSBOND   9 CYS A  237    CYS A  297                          1555   1555  2.04  
SSBOND  10 CYS A  301    CYS A  319                          1555   1555  2.03  
SSBOND  11 CYS A  330    CYS A  336                          1555   1555  2.03  
SSBOND  12 CYS A  338    CYS A  358                          1555   1555  2.03  
SSBOND  13 CYS A  364    CYS A  620                          1555   1555  2.03  
SSBOND  14 CYS A  408    CYS A  608                          1555   1555  2.03  
SSBOND  15 CYS A  631    CYS A  636                          1555   1555  2.03  
SSBOND  16 CYS A  638    CYS A  658                          1555   1555  2.04  
SSBOND  17 CYS A  662    CYS A  687                          1555   1555  2.03  
SSBOND  18 CYS A  698    CYS A  703                          1555   1555  2.03  
SSBOND  19 CYS A  705    CYS A  726                          1555   1555  2.03  
SSBOND  20 CYS A  730    CYS A  763                          1555   1555  2.03  
SSBOND  21 CYS A  774    CYS A  898                          1555   1555  2.03  
SSBOND  22 CYS A  900    CYS A  921                          1555   1555  2.03  
SSBOND  23 CYS A  925    CYS A 1031                          1555   1555  2.03  
SSBOND  24 CYS A 1042    CYS A 1049                          1555   1555  2.03  
SSBOND  25 CYS A 1051    CYS A 1073                          1555   1555  2.03  
SSBOND  26 CYS A 1077    CYS A 1108                          1555   1555  2.03  
SSBOND  27 CYS A 1126    CYS A 1145                          1555   1555  2.04  
SSBOND  28 CYS A 1149    CYS A 1169                          1555   1555  2.03  
SSBOND  29 CYS A 1181    CYS A 1188                          1555   1555  2.04  
SSBOND  30 CYS A 1190    CYS A 1210                          1555   1555  2.03  
SSBOND  31 CYS A 1231    CYS A 1245                          1555   1555  2.03  
SSBOND  32 CYS A 1249    CYS A 1281                          1555   1555  2.04  
SSBOND  33 CYS A 1331    CYS A 1347                          1555   1555  2.03  
SSBOND  34 CYS A 1440    CYS A 1459                          1555   1555  2.03  
SSBOND  35 CYS A 1462    CYS A 1473                          1555   1555  2.03  
SSBOND  36 CYS A 1476    CYS A 1490                          1555   1555  2.03  
SSBOND  37 CYS A 1493    CYS A 1510                          1555   1555  2.04  
SSBOND  38 CYS A 1514    CYS A 1523                          1555   1555  2.04  
SSBOND  39 CYS A 1543    CYS A 1565                          1555   1555  2.03  
SSBOND  40 CYS A 1603    CYS A 1627                          1555   1555  2.03  
SSBOND  41 CYS A 1607    CYS A 1613                          1555   1555  2.03  
SSBOND  42 CYS A 1724    CYS A 1749                          1555   1555  2.02  
SSBOND  43 CYS A 1728    CYS A 1734                          1555   1555  2.03  
SSBOND  44 CYS A 1760    CYS A 1777                          1555   1555  2.04  
SSBOND  45 CYS A 1893    CYS A 1919                          1555   1555  2.03  
SSBOND  46 CYS A 1897    CYS A 1904                          1555   1555  2.02  
SSBOND  47 CYS A 1928    CYS A 1939                          1555   1555  2.03  
SSBOND  48 CYS A 1996    CYS A 2024                          1555   1555  2.02  
SSBOND  49 CYS A 2000    CYS A 2006                          1555   1555  2.03  
SSBOND  50 CYS A 2005    CYS A 2076                          1555   1555  2.04  
SSBOND  51 CYS A 2035    CYS A 2048                          1555   1555  2.03  
SSBOND  52 CYS A 2130    CYS A 2154                          1555   1555  2.03  
SSBOND  53 CYS A 2134    CYS A 2140                          1555   1555  2.04  
SSBOND  54 CYS A 2163    CYS A 2172                          1555   1555  2.03  
SSBOND  55 CYS A 2264    CYS A 2281                          1555   1555  2.03  
SSBOND  56 CYS A 2442    CYS A 2453                          1555   1555  2.03  
SSBOND  57 CYS A 2591    CYS A 2715                          1555   1555  2.03  
SSBOND  58 CYS B   34    CYS B   52                          1555   1555  2.03  
SSBOND  59 CYS B   63    CYS B   70                          1555   1555  2.03  
SSBOND  60 CYS B   72    CYS B   92                          1555   1555  2.03  
SSBOND  61 CYS B   96    CYS B  120                          1555   1555  2.03  
SSBOND  62 CYS B  131    CYS B  138                          1555   1555  2.03  
SSBOND  63 CYS B  140    CYS B  160                          1555   1555  2.03  
SSBOND  64 CYS B  164    CYS B  183                          1555   1555  2.03  
SSBOND  65 CYS B  194    CYS B  235                          1555   1555  2.03  
SSBOND  66 CYS B  237    CYS B  297                          1555   1555  2.04  
SSBOND  67 CYS B  301    CYS B  319                          1555   1555  2.03  
SSBOND  68 CYS B  330    CYS B  336                          1555   1555  2.03  
SSBOND  69 CYS B  338    CYS B  358                          1555   1555  2.03  
SSBOND  70 CYS B  364    CYS B  620                          1555   1555  2.03  
SSBOND  71 CYS B  408    CYS B  608                          1555   1555  2.03  
SSBOND  72 CYS B  631    CYS B  636                          1555   1555  2.03  
SSBOND  73 CYS B  638    CYS B  658                          1555   1555  2.04  
SSBOND  74 CYS B  662    CYS B  687                          1555   1555  2.03  
SSBOND  75 CYS B  698    CYS B  703                          1555   1555  2.03  
SSBOND  76 CYS B  705    CYS B  726                          1555   1555  2.02  
SSBOND  77 CYS B  730    CYS B  763                          1555   1555  2.03  
SSBOND  78 CYS B  774    CYS B  898                          1555   1555  2.03  
SSBOND  79 CYS B  900    CYS B  921                          1555   1555  2.03  
SSBOND  80 CYS B  925    CYS B 1031                          1555   1555  2.03  
SSBOND  81 CYS B 1042    CYS B 1049                          1555   1555  2.03  
SSBOND  82 CYS B 1051    CYS B 1073                          1555   1555  2.02  
SSBOND  83 CYS B 1077    CYS B 1108                          1555   1555  2.03  
SSBOND  84 CYS B 1126    CYS B 1145                          1555   1555  2.04  
SSBOND  85 CYS B 1149    CYS B 1169                          1555   1555  2.03  
SSBOND  86 CYS B 1181    CYS B 1188                          1555   1555  2.05  
SSBOND  87 CYS B 1190    CYS B 1210                          1555   1555  2.03  
SSBOND  88 CYS B 1231    CYS B 1245                          1555   1555  2.03  
SSBOND  89 CYS B 1249    CYS B 1281                          1555   1555  2.04  
SSBOND  90 CYS B 1331    CYS B 1347                          1555   1555  2.03  
SSBOND  91 CYS B 1440    CYS B 1459                          1555   1555  2.03  
SSBOND  92 CYS B 1462    CYS B 1473                          1555   1555  2.03  
SSBOND  93 CYS B 1476    CYS B 1490                          1555   1555  2.03  
SSBOND  94 CYS B 1493    CYS B 1510                          1555   1555  2.04  
SSBOND  95 CYS B 1514    CYS B 1523                          1555   1555  2.04  
SSBOND  96 CYS B 1543    CYS B 1565                          1555   1555  2.03  
SSBOND  97 CYS B 1603    CYS B 1627                          1555   1555  2.03  
SSBOND  98 CYS B 1607    CYS B 1613                          1555   1555  2.03  
SSBOND  99 CYS B 1724    CYS B 1749                          1555   1555  2.02  
SSBOND 100 CYS B 1728    CYS B 1734                          1555   1555  2.03  
SSBOND 101 CYS B 1760    CYS B 1777                          1555   1555  2.04  
SSBOND 102 CYS B 1893    CYS B 1919                          1555   1555  2.03  
SSBOND 103 CYS B 1897    CYS B 1904                          1555   1555  2.02  
SSBOND 104 CYS B 1928    CYS B 1939                          1555   1555  2.03  
SSBOND 105 CYS B 1996    CYS B 2024                          1555   1555  2.03  
SSBOND 106 CYS B 2000    CYS B 2006                          1555   1555  2.03  
SSBOND 107 CYS B 2005    CYS B 2076                          1555   1555  2.03  
SSBOND 108 CYS B 2035    CYS B 2048                          1555   1555  2.03  
SSBOND 109 CYS B 2130    CYS B 2154                          1555   1555  2.03  
SSBOND 110 CYS B 2134    CYS B 2140                          1555   1555  2.04  
SSBOND 111 CYS B 2163    CYS B 2172                          1555   1555  2.03  
SSBOND 112 CYS B 2264    CYS B 2281                          1555   1555  2.03  
SSBOND 113 CYS B 2442    CYS B 2453                          1555   1555  2.03  
SSBOND 114 CYS B 2591    CYS B 2715                          1555   1555  2.03  
LINK         ND2 ASN A  76                 C1  NAG A2801     1555   1555  1.45  
LINK         ND2 ASN A 484                 C1  NAG C   1     1555   1555  1.46  
LINK         ND2 ASN A 748                 C1  NAG A2802     1555   1555  1.44  
LINK         ND2 ASN A 947                 C1  NAG A2803     1555   1555  1.44  
LINK         ND2 ASN A1220                 C1  NAG A2804     1555   1555  1.44  
LINK         ND2 ASN A1349                 C1  NAG A2805     1555   1555  1.45  
LINK         ND2 ASN A1365                 C1  NAG A2806     1555   1555  1.44  
LINK         ND2 ASN A1716                 C1  NAG D   1     1555   1555  1.44  
LINK         ND2 ASN A1774                 C1  NAG A2807     1555   1555  1.44  
LINK         ND2 ASN A2013                 C1  NAG E   1     1555   1555  1.50  
LINK         ND2 ASN A2122                 C1  NAG F   1     1555   1555  1.44  
LINK         ND2 ASN A2250                 C1  NAG A2808     1555   1555  1.44  
LINK         ND2 ASN A2295                 C1  NAG G   1     1555   1555  1.44  
LINK         ND2 ASN A2582                 C1  NAG H   1     1555   1555  1.44  
LINK         ND2 ASN B  76                 C1  NAG B2801     1555   1555  1.44  
LINK         ND2 ASN B 484                 C1  NAG I   1     1555   1555  1.42  
LINK         ND2 ASN B 748                 C1  NAG B2802     1555   1555  1.44  
LINK         ND2 ASN B 947                 C1  NAG B2803     1555   1555  1.44  
LINK         ND2 ASN B1220                 C1  NAG B2804     1555   1555  1.44  
LINK         ND2 ASN B1349                 C1  NAG B2805     1555   1555  1.45  
LINK         ND2 ASN B1365                 C1  NAG B2806     1555   1555  1.44  
LINK         ND2 ASN B1716                 C1  NAG J   1     1555   1555  1.44  
LINK         ND2 ASN B1774                 C1  NAG B2807     1555   1555  1.46  
LINK         ND2 ASN B2013                 C1  NAG K   1     1555   1555  1.46  
LINK         ND2 ASN B2122                 C1  NAG L   1     1555   1555  1.43  
LINK         ND2 ASN B2250                 C1  NAG B2808     1555   1555  1.44  
LINK         ND2 ASN B2295                 C1  NAG M   1     1555   1555  1.44  
LINK         ND2 ASN B2582                 C1  NAG N   1     1555   1555  1.44  
LINK         O4  NAG C   1                 C1  NAG C   2     1555   1555  1.45  
LINK         O4  NAG D   1                 C1  NAG D   2     1555   1555  1.45  
LINK         O4  NAG E   1                 C1  NAG E   2     1555   1555  1.44  
LINK         O4  NAG E   2                 C1  BMA E   3     1555   1555  1.44  
LINK         O4  NAG F   1                 C1  NAG F   2     1555   1555  1.44  
LINK         O4  NAG G   1                 C1  NAG G   2     1555   1555  1.45  
LINK         O4  NAG G   2                 C1  BMA G   3     1555   1555  1.45  
LINK         O3  BMA G   3                 C1  MAN G   4     1555   1555  1.45  
LINK         O4  NAG H   1                 C1  NAG H   2     1555   1555  1.45  
LINK         O4  NAG H   2                 C1  BMA H   3     1555   1555  1.44  
LINK         O3  BMA H   3                 C1  MAN H   4     1555   1555  1.44  
LINK         O6  BMA H   3                 C1  MAN H   6     1555   1555  1.46  
LINK         O3  MAN H   4                 C1  MAN H   5     1555   1555  1.44  
LINK         O4  NAG I   1                 C1  NAG I   2     1555   1555  1.43  
LINK         O4  NAG J   1                 C1  NAG J   2     1555   1555  1.44  
LINK         O4  NAG K   1                 C1  NAG K   2     1555   1555  1.45  
LINK         O4  NAG K   2                 C1  BMA K   3     1555   1555  1.44  
LINK         O4  NAG L   1                 C1  NAG L   2     1555   1555  1.43  
LINK         O4  NAG M   1                 C1  NAG M   2     1555   1555  1.45  
LINK         O4  NAG M   2                 C1  BMA M   3     1555   1555  1.45  
LINK         O3  BMA M   3                 C1  MAN M   4     1555   1555  1.45  
LINK         O4  NAG N   1                 C1  NAG N   2     1555   1555  1.45  
LINK         O4  NAG N   2                 C1  BMA N   3     1555   1555  1.44  
LINK         O3  BMA N   3                 C1  MAN N   4     1555   1555  1.44  
LINK         O6  BMA N   3                 C1  MAN N   6     1555   1555  1.46  
LINK         O3  MAN N   4                 C1  MAN N   5     1555   1555  1.44  
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
TER   19205      THR A2727                                                      
TER   38410      THR B2727                                                      
MASTER      805    0   54  134  194    0    0    639122    2  970  426          
END                                                                             

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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