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Family Report for: AHL-acylase

Name Class
AHL-acylaseRank2
FamilyAbhydrolase_6
Gene_locus (24)
BlockX
PaperCzajkowski_2011_Environ.Microbiol.Rep_3_59
Czajkowski_2009_Acta.Biochim.Pol_56_1
Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82
Mei_2010_Appl.Environ.Microbiol_76_4933
Structure (6)
CommentBacterial AHL-acylases (acyl homoserine lactonase) (AiiO, AidH) from genus Ochrobactrum and related bacteria are different from previously described AHL-acylases such as PvdQ, QuiP (P.aeriginosa) HacA HacB (P.syringea which belong to Ntn-hydrolase superfamily Czajkowski et al.) and different from AHL-lactonase of B. thuringensis and A. tumefasciens (which are metallo-beta lactamases). AHL-acylase inactivates N-acyl homoserine lactone (AHL) quorum sensing signal molecules (lactonases are also inactivating enzymes). AHL-acylases could be useful for the control of development of infections caused by pathogenic bacteria and their persistence in respective hosts. The three fungi sequences are genes without real introns (horizontal transfer?). There are other N-acyl homoserine lactonase (AiiA) not alpha/beta hydroalses but Metallo-B-lactamases
PfamPF12697 Abhydrolase_6
InhibitorN-Hexanoyl-L-Homoserine
N-butanoyl-L-homoserine
SubstrateN-Ac-DL-MetOMe
(R,S)-DMPM
C6-HSL
3-oxo-C12-HSL

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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