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Inhibitor Report for: Alogliptin

Name Class
AlogliptinType (5)
Other_Name (6)
Chemical_Nomenclature2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile
FormulaC18H21N5O2
CAS_number850649-61-5
MW339.39
Paper (23)
Structure3G0B
2ONC
CommentAlogliptin is a selective, orally bioavailable, pyrimidinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Almost identical to Trelagliptin which is a fluride derivative (Alogliptin cation CID 26322458 in structure 3G0B)
Gene_locushuman-DPP4
CID11450633
FamilyDPP4N_Peptidase_S9
InChIKeyZSBOMTDTBDDKMP-OAHLLOKOSA-N
CanonicalSMILESCN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N
InChIInChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1
IupharLig6319
WikipediaAlogliptin

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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