Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Amiloride

Name Class
AmilorideTypeCarboxamide
Drug
Pyridine
Not A/B H target
Other_Name (6)
Chemical_Nomenclature3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
FormulaC6H8ClN7O
MW229.62
Paper (3)
CommentA pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). Inhibition or activation of cholinesterases depending on substrates
CID16231
FamilyACHE
BCHE
InChIKeyXSDQTOBWRPYKKA-UHFFFAOYSA-N
CanonicalSMILESC1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
InChIInChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
IupharLig2421
WikipediaAmiloride

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer