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Inhibitor Report for: Amiloride

Name Class
AmilorideTypeCarboxamide
Drug
Pyridine
Not A/B H target
Other_Name (6)
Chemical_Nomenclature3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
FormulaC6H8ClN7O
MW229.62
PaperZemach_1990_FEBS.Lett_263_166
Kuijpers_1984_Biochim.Biophys.Acta_804_237
Clery_1995_Biochim.Biophys.Acta_1250_19
CommentA pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). Inhibition or activation of cholinesterases depending on substrates
CID16231
FamilyACHE
BCHE
InChIKeyXSDQTOBWRPYKKA-UHFFFAOYSA-N
CanonicalSMILESC1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
InChIInChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
IupharLig2421
WikipediaAmiloride

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