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Family Report for: Arylacetamide_deacetylase

Name Class
Arylacetamide_deacetylaseRank1
Gene_locus (454)
Gene_locus_Frgtmacfa-q4r6u2
fical-u3jrd0
BlockH
PaperWang_2022_BMC.Cancer_22_635
Jiang_2017_Front.Pharmacol_8_846
Gibbons_2004_Biochem.Soc.Trans_32_59
Probst_1994_J.Biol.Chem_269_21650
Nomura_2008_Toxicol.Appl.Pharmacol_228_42
Fukami_2015_Eur.J.Pharm.Sci_78_47
InterproIPR017157 Arylacetamide deacetylase
IPR013094 Alpha/beta hydrolase fold-3
CommentAADAC Arylacetamide deacetylase displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. NCEH1 KIAA1363 AADACL1 NCEH1 neutral cholesterol ester hydrolase 1.is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated . Sequence similarities between hormone-sensitive lipase and prokaryotic enzymes was dicovered by Langin and Holm and Hemila et al.
PfamPF07859 Abhydrolase_3
PIRSFPIRSF037251 Arylacetamide_deacetylase
Inhibitor (11)
Substrate (11)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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