Family Report for: CIB-CCG1-interacting-factor-B
CIB-CCG1-interacting-factor-B | Rank | 2 |
| Family | Abhydrolase_6 |
| Gene_locus (92) |
| Gene_locus_Frgt (8) |
| Block | X |
| LED_Database | abH08.14 |
| Paper (5) |
| Structure | 3BDI |
| | 1IMJ |
| Interpro | IPR026764 Alpha/beta hydrolase domain containing protein 14B |
| Comment | Alpha/beta hydrolase domain-containing protein 14B. The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription. TFIID interactor CCG1/TAF(II)250-interacting factor B (CIB) activates transcription and has hydrolase activity towards p-nitrophenyl butyrate (in vitro). Dorz1 (ABHD14A,ABHEA) was identified and characterized as one of the most significantly down-regulated genes in Zic1-deficient cerebellum (Zic1: zinc finger protein that controls vertebrate neural development) Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum has also been released. ABHD14B is able to transfer an acetyl group from a post-translationally acetylated-lysine to coenzyme A (CoA) and yield acetyl-CoA, while re-generating the free amine of protein lysine residues (Rajendran et al. 2020): lysine deacetylase |
| Pfam | PF12695 Abhydrolase_5 |
| Substrate | Coenzyme-A |
| | Paranitrophenylacetate |
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