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Family Report for: CIB-CCG1-interacting-factor-B

Name Class
CIB-CCG1-interacting-factor-BRank2
FamilyAbhydrolase_6
Gene_locus (92)
Gene_locus_Frgt (8)
BlockX
PaperRajendran_2022_J.Biol.Chem_298_102128
Rajendran_2020_Biochemistry_59_183
Padmanabhan_2004_J.Biol.Chem_279_9615
Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57
Structure3BDI
1IMJ
InterproIPR026764 Alpha/beta hydrolase domain containing protein 14B
CommentAlpha/beta hydrolase domain-containing protein 14B. The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription. TFIID interactor CCG1/TAF(II)250-interacting factor B (CIB) activates transcription and has hydrolase activity towards p-nitrophenyl butyrate (in vitro). Dorz1 (ABHD14A,ABHEA) was identified and characterized as one of the most significantly down-regulated genes in Zic1-deficient cerebellum (Zic1: zinc finger protein that controls vertebrate neural development) Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum has also been released. ABHD14B is able to transfer an acetyl group from a post-translationally acetylated-lysine to coenzyme A (CoA) and yield acetyl-CoA, while re-generating the free amine of protein lysine residues (Rajendran et al. 2019): lysine deacetylase (Previously IPR026764 Alpha/beta hydrolase domain containing protein 14B)
PfamPF12695 Abhydrolase_5

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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