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Family Report for: CMBL

Name Class
CMBLRank1
Gene_locus (251)
Gene_locus_Frgt (32)
BlockX
PaperIshizuka_2013_Drug.Metab.Dispos_41_1156
Ishizuka_2010_J.Biol.Chem_285_11892
InterproIPR042946 Carboxymethylenebutenolidase homolog
Comment(from Interpro) Carboxymethylenebutenolidase (CMBL) is a human homologue of Pseudomonas dienelactone hydrolase involved in the bacterial halocatechol degradation pathway. It is a cysteine hydrolase that can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Not inhibited by DFP, PMSF, eserine or EDTA. Strongly inhibited by p-chloromercuribenzoate (PCMB). This entry also includes uncharacterised DLH domain-containing proteins from plants. This family was previously included in Dienelactone_hydrolase
SubstrateCurDD
Olmesartan-medoxomil

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