Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Carbon-carbon_bond_hydrolase

Name Class
Carbon-carbon_bond_hydrolaseRank2
FamilyEpoxide-hydrolase_like
Alternative_names2,6-Dioxo-6-phenylhexa-3-enoate hydrolase
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (BPHD)
HOHPDA hydrolase
Gene_locus (330)
Gene_locus_Frgt (10)
BlockX
Paper (10)
Structure (45)
EC_number3.7.1.8
InterproIPR000073 Alpha/beta hydrolase fold-1
IPR023791 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
IPR017727 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, BphD
Comment2-hydroxymuconic semialdehyde hydrolase PIRSF037174. Members of this family are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, or HOPD hydrolase, the BphD protein of biphenyl degradation. BphD acts on the product of ring meta-cleavage by BphC. Many species carrying bphC and bphD are capable of degrading polychlorinated biphenyls as well as biphenyl itself (environmental pollutants: BP/PCB). 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. The purified enzyme is a dimeric protein requiring no cofactors for catalytic activity
PfamPF12697 Abhydrolase_6
PIRSFPIRSF037174 2-hydroxymuconic semialdehyde hydrolase
Inhibitor6OR-5JZ9
CyC-31
CyC-17
Benzoic-acid
Substrate (18)
Chemicaln-Butyrate
Isovalerate
2-methylbutanoic-acid

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer