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Substrate Report for: Ciclesonide

Name Class
CiclesonideTypeNot A/B H target
Pro-Drug
Butyrate
Drug
Other_NameOmnaris
Alvesco
Zetonna
DB01410
Chemical_Nomenclature(R)-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate
FormulaC32H44O7
CAS_number126544-47-6
MW540.69
PaperMutch_2007_Biochem.Pharmacol_73_1657
CommentCiclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. It is a pro-drug that is enzymatically hydrolyzed to a pharmacologically active metabolite, C21-desisobutyryl-ciclesonide (des-ciclesonide). Des-ciclesonide has anti-inflammatory activity with affinity for the glucocorticoid receptor
Gene_locushuman-CES1
CID6918155
FamilyCarb_B_Chordata
WikipediaCiclesonide

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