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Inhibitor Report for: Cpd35-Rivastigmine-5-HT6

Name Class
Cpd35-Rivastigmine-5-HT6Type (9)
Chemical_Nomenclature3-(((2-((2-((1-(Phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)ethyl)amino)methyl)phenyl ethyl(methyl)carbamate
FormulaC29H34N4O5S
MW550.67
Pick_me_to_calldisplay_scriptCpd35-Rivastigmine-5-HT6
PaperWichur_2021_Eur.J.Med.Chem_225_113783
Commentselective, pseudo-irreversible inhibitor of butyrylcholinesterase (IC50 = 455 nM). Inhibit aggregation of amyloid-beta in vitro 68% at 10 microM. 5-HT6R antagonist Ki 15 nM
FamilyBCHE
InChIKeyICTMWXFVTKPBCM-UHFFFAOYSA-N
CanonicalSMILESC1(=CC=CC2=C1C=C[N]2[S](=O)(=O)C3=CC=CC=C3)OCCNCCNCC4=CC(=CC=C4)OC(=O)N(C)CC
InChIInChI=1S/C29H34N4O5S/c1-3-32(2)29(34)38-24-10-7-9-23(21-24)22-31-17-16-30-18-20-37-28-14-8-13-27-26(28)15-19-33(27)39(35,36)25-11-5-4-6-12-25/h4-15,19,21,30-31H,3,16-18,20,22H2,1-2H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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