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Mutation Report for: D390N_human-ACHE

Name Class
D390N_human-ACHEGene_locushuman-ACHE
Torpedo_number383
AA_ChangeD390N
Mode_of_mutationSite directed mutagenesis
ModificationElectrostatic
SummaryElectrostatic;Electrostatic attraction hypothesis, minor effect on catalysis;Shafferman_1994_EMBO.J_13_3448
PaperShafferman_1994_EMBO.J_13_3448
Kinetic_parameterAcetylthiocholine_D390N_human-ACHE
3,3-dimethylbutylthioacetate_D390N_human-ACHE
Edrophonium_D390N_human-ACHE
Commentp.D390N Asp390Asn (p.D421N Asp421Asn in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesis, minor effect on catalysis

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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