Mutation Report for: D70G/E441G/E443Q_human-BCHE

D70G/E441G/E443Q_human-BCHE	Gene_locus	human-BCHE
	Torpedo_number	72,443,445
		445
		443
		72
	AA_Change	D70G/E441G/E443Q
	Mode_of_mutation	Site directed mutagenesis
	Modification	Succinylcholine hydrolysis
		Dibucaine inhibition
		Catalysis
	Summary	Succinylcholine hydrolysis;Catalysis reduced activity/Succinylcholine hydrolysis/Dibucaine inhibition 441 and 443 bind succinylcholine but mutant do not bind dibucaine;Neville_1992_EMBO.J_11_1641
		Catalysis;Reduced activity;Neville_1992_EMBO.J_11_1641
	Paper	Neville_1992_EMBO.J_11_1641
	Comment	p.D70G/E441G/E443Q Asp70Gly/Glu441Gly/Glu443Gln (p.D98G/E469G/E471Q Asp98Gly/Glu469Gly/Glu4471Gln in primary sequence with 28 amino-acids signal peptide) Succinylcholine hydrolysis/Dibucaine inhibition 441 and 443 bind succinylcholine but mutant do not bind dibucaine

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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