p.D70G/S425P Asp70Gly/Ser425Pro (p.D98G/S453P Asp98Gly/Ser453Pro in primary sequence with 28 amino-acids signal peptide) The S425P could be considered as natural but was only found in clones of neuroblastomas and gliostomas, as such are somatic mutations not found in families as abnormal plasma cholinesterases