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News Report for: DECEMBER-27-2017

Name Class
DECEMBER-27-2017Paper (5)
Structure (10)
DateDecember 27, 2017
Comment With best wishes for the holidays! from the ESTHER Team. The latest Newsletter is available Newsletter9 Structural basis for lipid binding and mechanism of the Mycobacterium tuberculosis Rv3802 phospholipase is published by Goins et al. and structure is available (5W95 ) Structures of the G119S insecticide-resistant mutant acetylcholinesterase of the malaria vector Anopheles gambiae are published by Cheung et al. and will be availble soon (6ARX, 6ARX) Burger et al. show that Acyl-protein thioesterase structures present a long tunnel for accommodation of long-chain fatty acids and release the product by use of a flexible loop tunnel lid. Homologous deacetylases use a hydrophobic residue to fix the lid and another residue to close the tunnel entrance. This causes loop rigidity changing the catalytic preference to deacetylation. ZmB6T1C9 as its paralogue in Arabidopsis At5G20060 is an acylprotein thioesterase and not an protein deacetylase. Structures are available (6AVV, 6AVW, 6AVX, 6AVY) Azetidine and piperidine carbamates as efficient, covalent inhibitors of monoacylglycerol lipase are published by Butler et al. and structure is available(6AX1) Crystal structures of a highly thermostable carboxyl esterase from Bacillus coagulans are available (5OLU, 5O7G) and published by De Vitis et al.

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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