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Inhibitor Report for: DEUP

Name Class
DEUPType (2)
Other_Name (9)
Chemical_Nomenclaturediethyl (2-oxochromen-7-yl) phosphate
FormulaC13H15O6P
CAS_number897-83-6
MW298.23
Paper (7)
Structure4UBI
4UBJ
4UBK
4UBL
4UBM
4UBN
4UBO
4W1P
4W1Q
4W1R
4W1S
4QWM
4FNM
5CH5
5IVK
5IVI
CommentDiethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC50 = 11.6 microM. Substrate for testing OP-hydrolase activity (in particular the modified carboxylesterase E3 from Lucilia cuprina).
Gene_locushuman-NCEH1
luccu-E3aest7
CID16219277
FamilyCholesterol_esterase
Hormone-sensitive_lipase_like
Arylacetamide_deacetylase
Carb_B_Arthropoda
InChIKeyLZXQXHKDCNQUOF-UHFFFAOYSA-N
CanonicalSMILESCCOP(=O)(OCC)OC1=CC2=C(C=C1)C=CC(=O)O2
InChIInChI=1S/C13H15O6P/c1-3-16-20(15,17-4-2)19-11-7-5-10-6-8-13(14)18-12(10)9-11/h5-9H,3-4H2,1-2H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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