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Substrate Report for: DEUP

Name Class
DEUPTypeOrganophosphate
Coumarin
Other_Name (9)
Chemical_Nomenclaturediethyl (2-oxochromen-7-yl) phosphate
FormulaC13H15O6P
CAS_number897-83-6
MW298.23
Paper (5)
CommentDiethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC50 = 11.6 microM. Substrate for testing OP-hydrolase activity (in particular the modified carboxylesterase E3 from Lucilia cuprina).
Gene_locushuman-NCEH1
CID16219277
FamilyCarb_B_Arthropoda
Hormone-sensitive_lipase_like
Arylacetamide_deacetylase
InChIKeyLZXQXHKDCNQUOF-UHFFFAOYSA-N
CanonicalSMILESCCOP(=O)(OCC)OC1=CC2=C(C=C1)C=CC(=O)O2
InChIInChI=1S/C13H15O6P/c1-3-16-20(15,17-4-2)19-11-7-5-10-6-8-13(14)18-12(10)9-11/h5-9H,3-4H2,1-2H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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