With best wishes for the new year! from the ESTHER Team. Crystal structures of a novel family IV esterase in free and substrate-bound form are published by Hoppner et al. and structures are available (6Z69, 6Z68) Discovery of a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with antioxidant activity that alleviates Alzheimer-like pathology in old APP/PS1 Mice is published by Viayna et al. and structures will be available soon (7AIT, 7AIS, 7AIU, 7AIV, 7AIW, 7AIX) Pathogenic paternally inherited NLGN4X deletion in a female with autism spectrum disorder is published by Kopp et al. Sub-functionalization of the two KAI2 versions in the model legume Lotus japonicus is published by Carbonnel et al.