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Type_inhibitor Report for: Derivative of Irinotecan

Name Class
Derivative of IrinotecanInhibitor4-piperidino-piperidine
CommentIrinotecan (CPT-11), an anticancer prodrug is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to its active metabolite SN-38 (7-ethyl-10-hydroxycamptothecin) a potent inhibitor of topoisomerase I. CPT-11 is hydrolysed by carboxylesterases in human pig and rabbit. Horse BChE hydrolyses 200 times faster CPT-11 than human BChE

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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