Type_inhibitor Report for: Derivative of Irinotecan
| Derivative of Irinotecan | Inhibitor | 4-piperidino-piperidine |
|---|
| | SN-38 |
| | Irinotecan |
| Comment | Irinotecan (CPT-11), an anticancer prodrug is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to its active metabolite SN-38 (7-ethyl-10-hydroxycamptothecin) a potent inhibitor of topoisomerase I. CPT-11 is hydrolysed by carboxylesterases in human pig and rabbit. Horse BChE hydrolyses 200 times faster CPT-11 than human BChE |
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