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Family Report for: Dienelactone_hydrolase

Name Class
Dienelactone_hydrolaseRank1
Alternative_namesCarboxymethylenebutenolidase
Maleylacetate enol-lactonase
4-Carboxymethylenebut-2-en-4-olide lactonohydrolase
Gene_locus (429)
Gene_locus_Frgt (15)
BlockX
LED_DatabaseabH31
Paper (11)
Structure (23)
EC_number3.1.1.45
InterproIPR002925 Dienelactone hydrolase
CommentDienelactone hydrolases play a crucial role in chlorocatechol degradation via the modified ortho cleavage pathway. Enzymes induced in 4-fluorobenzoate-utilizing bacteria have been classified into three groups on the basis of their specificity towards cis- and trans-dienelactone. The catalytic triad of the prototype psepu-clcd1 consists of Cys123, His202 and Asp171
PfamPF01738 DLH
InhibitorParaoxon
PMSF
SubstrateFluorescein-di(diethylphosphate)
Dienelactone
Paraoxon

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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