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Inhibitor Report for: Distigmine

Name Class
DistigmineTypeCarbamate
Drug
Pyridine
Other_Name (7)
Chemical_Nomenclature(1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate
FormulaC22H32N4O4+2
CAS_number17299-00-2
MW416.52
Paper (17)
CommentDistigmine (as distigmine bromide) is a parasympathomimetic that inhibit cholinesterases. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.
CID3116
FamilyBCHE
InChIKeyAHZBEVXBKNYXPU-UHFFFAOYSA-N
CanonicalSMILESC[N+]1=CC=CC(=C1)OC(=O)N(C)CCCCCCN(C)C(=O)OC2=C[N+](=CC=C2)C
InChIInChI=1S/C22H32N4O4/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20/h9-14,17-18H,5-8,15-16H2,1-4H3/q+2
WikipediaDistigmine

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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