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Family Report for: Duf_1749

Name Class
Duf_1749Rank1
Gene_locus (104)
Gene_locus_Frgtactpl-e0eyn8
phano-q0ucs3
thaps-b8c6f2
vitvi-a5bhc3
BlockX
PaperMerritt_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_474
Grundlinger_2013_Appl.Environ.Microbiol_79_7534
Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624
Structure6GUP
2Q0X
InterproIPR013744 Fusarinine C esterase sidJ
CommentGrundlingern et al. show that Aspergillus fumigatus AFUA_3G03390 gene product, SidJ (aspfu-q4wf56) is involved in hydrolysis of siderophore fusarinine C. It is the first functionally characterized member of the family. Structure of siderophore esterase AfSidJ from Aspergillus fumigatus is described by Ecker et al.. A structure of a protein of unknown fucntion is also available (2Q0X) Merritt et al. . However this protein is only representative of trypanosomatid members of this sequence family as these proteins lack some if not all of the catalytic triad residues. Fusarinine C is an intracellular siderophore (an iron-chelating compound that transports iron across membranes) that is crucial for virulence. The closely related siderophore triacetylfusarinine C is not hydrolysed by SidJ. Homologues of SidJ are found in plants and bacteria. (Not to be cofounded with SidJ Calmodulin-dependent glutamylase from Legionella pneumophila)
PfamPF08538 DUF1749
NewsSEPTEMBER-21-2013
MAY-14-2006
SubstrateFusigen

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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