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Family Report for: Duf_2235

Name Class
Duf_2235Rank1
Gene_locus (33)
Gene_locus_Frgtcyth3-q11xb7
BlockX
PaperRussell_2013_Nature_496_508
Hu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_2175
Flaugnatti_2020_EMBO.J_39_e104129
Structure6SJL
6SKI
4O5P
InterproIPR018712 Protein of unknown function DUF2235
CommentThe type VI lipase effectors Tle1-Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. The Tle1-4 display phospholipase A1 and A2 (PLA1) (PLA2) activities. Tle1 belongs to Duf_2235 family, TLE2 to Lipase_3, TLE3 to alpha/ beta hydrolase and Tle4 belongs to PGAP1. The adjacent genes code for VgrG proteins and putative periplasmic immunity proteins Tle5 are unrelated phospholipase D type. The bacterial type VI secretion system (T6SS) is a macromolecular machine that injects effectors into prokaryotic and eukaryotic cells. In enteroaggregative Escherichia coli, the Tle1 phospholipase binds the C-terminal extension of the VgrG trimeric spike. The inhibition of Tle1 phospholipase activity once bound to VgrG suggests that Tle1 dissociation from VgrG is required upon delivery
PfamPF09994 DUF2235
SubstrateTween-20

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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