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Mutation Report for: E389Q_human-ACHE

Name Class
E389Q_human-ACHEGene_locushuman-ACHE
Torpedo_number382
AA_ChangeE389Q
Mode_of_mutationSite directed mutagenesis
ModificationElectrostatic
SummaryElectrostatic attraction hypothesis;minor effect on catalysis;Shafferman_1994_EMBO.J_13_3448
PaperShafferman_1994_EMBO.J_13_3448
Kinetic_parameterAcetylthiocholine_E389Q_human-ACHE
3,3-dimethylbutylthioacetate_E389Q_human-ACHE
Edrophonium_E389Q_human-ACHE
Commentp.E389Q Glu389Gln (p.E420Q Glu420Gln in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesis: minor effect on catalysis
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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