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Inhibitor Report for: Evogliptin

Name Class
EvogliptinTypeDrug
Gliptin
Trifluoro
Other_Name (5)
Chemical_Nomenclature(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one
FormulaC19H26F3N3O3
CAS_number1222102-29-5
MW401.43
Paper (19)
Structure5Y7K
CommentDerivative of DA-1266. DDP4 IC50 0.666 nM
Gene_locushuman-DPP4
CID25022354
FamilyDPP4N_Peptidase_S9
InChIKeyLCDDAGSJHKEABN-MLGOLLRUSA-N
CanonicalSMILESCC(C)(C)OCC1C(=O)NCCN1C(=O)CC(CC2=CC(=C(C=C2F)F)F)N
InChIInChI=1S/C19H26F3N3O3/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27)/t12-,16-/m1/s1
WikipediaEvogliptin

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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