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Mutation Report for: F297A_human-ACHE

Name Class
F297A_human-ACHEGene_locushuman-ACHE
Torpedo_number290
AA_ChangeF297A
Mode_of_mutationSite directed mutagenesis
ModificationAcyl specificity
SummaryAcyl specificity; Acyl pocket, increases Km for ATC and increase kcat;Ordentlich_1993_J.Biol.Chem_268_17083;Shafferman_1993_Proc.Med.Def.Biosci.Rev_3_1097;Barak_1994_J.Biol.Chem_269_6296;Ordentlich_1995_5th.ChE.Meeting.Madras__221
Paper (5)
Kinetic_parameter (8)
Commentp.F297A Phe297Ala (p.F328A Phe328Ala in primary sequence with 31 amino-acids signal peptide) Acyl pocket, increases Km for ATC and increase kcat

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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