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Family Report for: FSH1

Name Class
Gene_locus (123)
Gene_locus_Frgt (19)
Paper (11)
InterproIPR005645 Serine hydrolase FSH FSH_dom
CommentFamily of serine hydrolase 1(FSH1). Previously: Domain of unknown function (DUF341). Contains human-OVCA2 Human Candidate tumor suppressor in ovarian cancer and yeast-FSH3 regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae, may be involved in folate metabolism. Contains also the gene (dfr1) encoding FSH1 linked to a domain corresponding to dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe. Fsh1p was identified as a lysophospholipase that specifically acts on lysophosphatidylserine (LPS) and impacts the lipid homeostasis in S. cerevisiae. Contains also Aspergillus terreus esterase LovG, which catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis. OVCA2 has a strong preference for long-chain alkyl ester substrates (>10-carbons) and high selectivity against a variety of short, branched, and substituted esters
PfamPF03959 FSH1

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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