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Inhibitor Report for: Fluoropezil

Name Class
FluoropezilTypeMultitarget
Derivative of Donepezil
Sulfur Compound
Antioxidant
Other_Name (8)
Chemical_Nomenclature2-Fluoro-2-((1-(3-fluorobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydrobenzo[b]thiophene 1,1-dioxide
2-fluoro-2-[[1-[(3-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-3H-1-benzothiophene 1,1-dioxide
FormulaC23H27F2NO4S
MW451.52
PaperLiu_2022_Eur.J.Med.Chem_235_114305
Guo_2022_Bioanalysis_14_817
Guo_2021_Anal.Bioanal.Chem_413_5835
Qian_2022_ResearchSquare__
CommentAChe IC50 = 2.4 nM. 24r is a mixed-type inhibitor against AChE Ki value equal to 0.4 nM. 24r reduced tau phosphorylation at S396 and Abeta aggregation in the presence of AChE
Gene_locushuman-ACHE
CID163409065
FamilyACHE
InChIKeyIVJYMZOWJKEUNR-UHFFFAOYSA-N
CanonicalSMILESC1=CC(=CC(=C1)CN2CCC(CC2)CC4(CC3=CC(=C(C=C3[S]4(=O)=O)OC)OC)F)F
COC1=C(C=C2C(=C1)CC(S2(=O)=O)(CC3CCN(CC3)CC4=CC(=CC=C4)F)F)OC
InChIInChI=1S/C23H27F2NO4S/c1-29-20-11-18-14-23(25,31(27,28)22(18)12-21(20)30-2)13-16-6-8-26(9-7-16)15-17-4-3-5-19(24)10-17/h3-5,10-12,16H,6-9,13-15H2,1-2H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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