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Inhibitor Report for: Fragment-863

Name Class
Fragment-863TypeFragment inhibitor of Notum
Pyrazole
Other_Name (6)
Chemical_Nomenclature3-anilino-2-methyl-1H-pyrazol-5-one
FormulaC10H11N3O
CAS_number1005952-86-2
MW189.21
PaperZhao_2022_ACS.Chem.Neurosci_13_2060
Structure7BD6
CommentNot inhibitor of Notum. Compound 49 Fragment 863 IC50 550+/-93 microM
Gene_locushuman-NOTUM
CID2818508
FamilyPectinacetylesterase-Notum
InChIKeyJAPKWXYUAJYHCE-UHFFFAOYSA-N
CanonicalSMILESCN1C(=CC(=O)N1)NC2=CC=CC=C2
InChIInChI=1S/C10H11N3O/c1-13-9(7-10(14)12-13)11-8-5-3-2-4-6-8/h2-7,11H,1H3,(H,12,14)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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